Structure of the IRS-1 PTB domain bound to the juxtamembrane region of the insulin receptor

Cell

Volumn 85, Issue 5, 1996, Pages 695-705

  Eck, Michael J ^a,b   Dhe Paganon, Sirano ^b,c   Trüb, Thomas ^b,c   Nolle, Robert T ^a,b   Shoelson, Steven E ^b,c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c JOSLIN DIABETES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BETA CHAIN; CRYSTAL STRUCTURE; JUXTAGLOMERULAR APPARATUS; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN STRUCTURE;

ANIMALIA;

EID: 0030010590     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0092-8674(00)81236-2     Document Type: Article

References (49)

1. Araki, E., Sun, X.-J., Haag, B.L.I., Chuang, L.-M., Zhang, Y., Yang-Feng, T.L., White, M.F., and Kahn, C.R. (1993). Human skeletal muscle insulin receptor substrate-1. Diabetes 42, 1041-1054.
2. Blaikie, P., Immanuel, D., Wu, J., Li, N., Yajnik, V., and Margolis, B. (1994). A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors. J. Biol. Chem. 269, 32031-32034.
3. Bork, P., and Margolis, B. (1995). A phosphotyrosine interaction domain. Cell 80, 693-694.
4. Brunger, A.T. (1992). X-PLOR version 3.1 : a system for x-ray crystallography and NMR (New Haven, Connecticut: Yale University Press).
5. Carson, M. (1991). Ribbons 2.0. J. Appl. Crystallogr. 24, 958-961.
6. Collaborative Computational Project Number 4 (1994). The CCP4 suite: Programs for protein crystallography. Acta Crystallogr. D50, 760-776.
7. Cowtan, K. (1994). "DM": an automated procedure for phase improvement by density modification. Joint CCP4 and ESF-EACBM Newsletter on Protein Crystallography 31, 34-38.
8. Dikic, I., Batzer, A.G., Blaikie, P., Obermeier, A., Ullrich, A., Schlessinger, J., and Margolis, B. (1995). Shc binding to nerve growth factor receptor is mediated by phosphotyrosine interaction domain. J. Biol. Chem. 270, 15125-15129.
9. lck. Nature 362, 87-91.
10. lck. Nature 368, 764-769.
11. Eck, M.J., Pluskey, S., Trüb, T., Harrison, S.C., and Shoelson, S.E. (1996). Spatial constraints on the recognition of phosphoproteins by the tandem SH2 domains of the phosphatase SH-PTP2. Nature 379, 277-280.
12. Ferguson, K., Lemmon, M., Schlessinger, J., and Sigler, P. (1994). Crystal structure at 2.2 Å resolution of the pleckstrin homology domain from human dynamin. Cell 79, 199-209.
13. Ferguson, K.M., Lemmon, M.A., Schlessinger, J., and Sigler, P.B. (1995). Structure of the high affinity complex of inositol triphosphate with a PLC pleckstrin homology domain. Cell 83, 1037-1046.
14. Fiore, F., Zambrano, N., Minopoli, G., Donini, V., Duilio, A., and Russo, T. (1995). The regions of the Fe65 protein to the phosphtyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270, 30853-30856.
15. Gustafson, T.A., He, W., Craparo, A., Schaub, C.D., and O'Neill, T.J. (1995). Phosphotyrosine-dependent interaction of Shc and IRS-1 with the NPEY motif of the insulin receptor via a novel non-SH2 domain. Mol. Cell. Biol. 15, 2500-2508.
16. Hatada, M.H., Lu, X., Laird, E.R., Green, J., Morgenstern, J.P., Lou, M., Marr, C.S., Phillips, T.B., Ram, M.K., Theriault, K., Zoller, M.J., and Karas, J.L. (1995). Molecular basis for the interaction of the protein tyrosine kinase ZAP-70 with the T-cell receptor. Nature 377, 32-38.
17. He, W., O'Neill, T.J., and Gustafson, T.A. (1995). Distinct modes of interaction of SHC and insulin receptor substrate-1 with the insulin receptor NPEY region via non-SH2 domains. J. Biol. Chem. 270, 23258-23262.
18. He, W., Craparo, A., Zhu, Y., O'Neill, T.J., Wang, L.M., Pierce, J.H., and Gustafson, T.A. (1996). Interaction of insulin receptor substrate-2 with the insulin and IGF-1 receptors: evidence for two distinct phosphotyrosine-dependent interaction domains within IRS-2. J. Biol. Chem. 271, 11641-11645.
19. Hubbard, S.R., Wei, L., Ellis, L., and Hendrickson, W.A. (1994). Crystal structure of the tryosine kinase domain of the human insulin receptor. Nature 372, 746-754.
20. Hyvönen, M., Macias, M.J., Nilges, M., Oschkinat, H., Saraste, M., and Wilmanns, M. (1995). Structure of the binding site for inositol phosphates in a PH domain. EMBO J. 14, 4676-4685.
21. Jones, T.A., Bergdoll, M., and Kjeldgaard, M. (1989). Crystallographic Computing and Modeling Methods in Molecular Design, C. Bugg and S. Ealick, eds. (New York: Springer).
22. Kabsch, W.J. (1988). Evaluation of single crystal diffraction data from a position sensitive detector. J. Appl. Crystallogr. 21, 916-924.
23. Kavanaugh, W.M., and Williams, L.T. (1994). An alternative to SH2 domains for binding tyrosine-phosphorylated proteins. Science 266, 1862-1865.
24. Kavanaugh, W.M., Turck, C.W., and Williams, L.T. (1995). PTB domain binding to signaling proteins through a sequence motif containing phosphotyrosine. Science 268, 1177-1179.
25. Lamzin, V.S., and Wilson, K.S. (1993). Acta Crystallogr. D49, 129-147.
26. Lee, C.H., Kominos, D., Jaques, S., Margolis, B., Schlessinger, J., Shoelson, S.E., and Kuriyan, J. (1994). Crystal structures of peptide complexes of the N-terminal SH2 domain of the Syp tyrosine phosphatase. Structure 2, 423-438.
27. Musacchio, A., Gibson, T., Rice, P., Thompson, J., and Saraste, M. (1993). The PH domain: a common piece in a pathwork of signalling proteins. Trends Biochem. Sci. 18, 343-348.
28. Myers, M.G., Grammer, T.C., Brooks, J., Glasheen, E.M., Wang, L.-M., Sun, X.J., Blenis, J., Pierce, J.H., and White, M.F. (1995). The pleckstrin homology domain in insulin receptor substrate-1 sensitizes to insulin signaling. J. Biol. Chem. 270, 11715-11718.
29. Navaza, J. (1992). Molecular Replacement: Proceedings of the CCP4 Study Weekend, E.J. Dodson, S. Cover, and W. Wolf, eds. (Daresbury, UK: SERC), pp. 87-90.
30. Nicholls, A., Sharp, K.A., and Honig, B. (1991). Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281-296.
31. Nolte, R., Eck, M., Schlessinger, J., Shoelson, S., and Harrison, S. (1996). Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes. Nat. Struct. Biol. 3, 364-373.
32. O'Neill, T.J., Craparo, A., and Gustafson, T.A. (1994). Characterization of an interaction between insulin receptor substrate 1 and the insulin receptor by using the two-hybrid system. Mol. Cell. Biol. 14, 6433-6442.
33. Otwinowski, Z. (1991). Maximum likelihood refinement of heavy atom parameters. In Isomorphous Replacement and Anomalous Scattering, W. Wolf, P.R. Evans, and A.G.W. Leslie, eds. (Warrington, United Kingdom: Science and Engineering Council/Daresbury Laboratory), pp. 80-86
34. Piccione, E., Case, R.D., Domchek, S.M., Hu, P., Chaudhuri, M., Backer, J.M., Schlessinger, J., and Shoelson, S.E. (1993). PI 3-kinase p85 SH2 domains specificity defined by direct phosphopeptide/SH2 domain binding. Biochemistry 32, 3197-3202.
35. Sawka-Verheile, D., Tartare-Deckert, S., White, M.F., and Van Obberghen, E. (1996). IRS-2 binds to the insulin receptor through its PTB domain and through a newly identified domain comprising amino acids 591-786. J. Biol. Chem. 271, 5980-5983.
36. Sun, X.J., Rothenberg, P., Kahn, C.R., Backer, J.M., Araki, E., Wilden, P.A., Cahill, D.A., Goldstein, B.J., and White, M.F. (1991). The structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature 352, 73-77.
37. Sun, X.J., Crimmins, D.L., Myers, M.G., Jr., Miralpeix, M., and White, M.F. (1993). Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell. Biol. 13, 7418-7428.
38. Sun, X.J., Wang, L.-M., Zhang, Y., Yenush, L., Myers, M.G., Glasheen, E., Lane, W.S., Pierce, J.H., and White, M.F. (1995). Role of IRS-2 in insulin and cytokine signalling. Nature 377, 173-177.
39. Terwilliger, T.C., and Eisenberg, D. (1988). Isomorphous replacement: effects of errors on the phase probability distribution. Acta Crystallogr. A43, 6-13.
40. Trüb, T., Choi, W.E., Wolf, G., Ottinger, E., Chen, Y., Weiss, M.A., and Shoelson, S.E. (1995). Specificity of the PTB domain of Shc for β turn-forming pentapeptide motifs amino-terminal to phosphotyrosine. J. Biol. Chem. 270, 18205-18208.
41. van der Geer, P., Wiley, S., Lai, V.K.-M., Olivier, J.P., Gish, G.D., Stephens, R., Kaplan, D., Shoelson, S.E., and Pawson, T. (1995). A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated growth factor receptors and phosphopeptides. Curr. Biol. 5, 404-412.
42. Voliovitch, H., Schindler, D.G., Hadari, Y.R., Taylor, S.I., Accili, D., and Zick, Y. (1995). Tyrosine phosphorylation of insulin receptor substrate-1 in vivo depends upon the presence of its pleckstrin homology region. J. Biol. Chem. 270, 18083-18087.
43. Waksman, G., Kominos, D., Robertson, S.C., Pant, N., Baltimore, D., Birge, R.B., Cowburn, D., Hanafusa, H., Mayer, B.J., Overduin, M., Resh, M.D., Rios, C.B., Silverman, L., and Kuriyan, J. (1992). Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine phosphorylated peptides. Nature 358, 646-653
44. Waksman, G., Shoelson, S.E., Pant, N., Cowburn, D., and Kuriyan, J. (1993). Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: crystal structures of the complexed and peptide-free forms. Cell 72, 779-790.
45. White, M.F., Livingston, J.N., Backer, J.M., Lauris, V., Dull, T.J., Ullrich, A., and Kahn, C.R. (1988a). Mutation of the insulin receptor at tyrosine 960 inhibits signal transmission but does not affect tyrosine kinase activity. Cell 54, 641-649.
46. White, M.F., Shoelson, S.E., Keutmann, H., and Kahn, C.R. (1988b). A cascade of tyrosine autophosphorylation in the β-subunit activates the phosphotransferase of the insulin receptor. J. Biol. Chem. 263, 2969-2980.
47. Wolf, G., Trüb, T., Ottinger, E., Groninga, L., Lynch, A., White, M., Miyazaki, M., Lee, J., and Shoelson, S.E. (1995). The PTB domains of IRS-1 and Shc have distinct but overlapping binding specificities. J. Biol. Chem. 270, 27407-27410.
48. Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Harlan, J.E., Wade, W.S., Burakoff, S.J., and Fesik, S.W. (1995). Structure and ligand recognition of the phosphotyrosine binding domain of Shc. Nature 92, 7784-7788.
49. Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trüb, T., Shoelson, S.E., and Fesik, S.W. (1996). Structure basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain. Nat. Struct. Biol. 3, 388-393.