Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1 and Impairs Its Ability to Activate Phosphatidylinositol 3-Kinase in Response to Insulin

Journal of Biological Chemistry

Volumn 276, Issue 5, 2001, Pages 3543-3549

  Ravichandran, Lingamanaidu V ^a   Esposito, Diana L ^b   Chen, Judy ^a   Quon, Michael J ^a  

^a NATIONAL HEART LUNG AND BLOOD INSTITUTE   (United States)

^b UNIVERSITY OF CHIETI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; IMMUNOLOGY; INSULIN; PHYSIOLOGY; PRECIPITATION (CHEMICAL); SUBSTRATES;

KINASES; SIGNALING PATHWAYS;

PROTEINS;

INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE C ZETA; PROTEIN SERINE THREONINE KINASE; TYROSINE; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE C;

ANIMAL CELL; ARTICLE; AUTORADIOGRAPHY; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME SUBSTRATE; IMMUNOPRECIPITATION; MALE; MOUSE; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; ANIMAL; CELL STRAIN 3T3; ENZYME ACTIVATION; ENZYME SPECIFICITY; HUMAN; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; SIGNAL TRANSDUCTION;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; 3T3 CELLS; ANIMALS; ENZYME ACTIVATION; HUMANS; INSULIN; MICE; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 0035793592     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007231200     Document Type: Article

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