Short-term overeating induces insulin resistance in fat cells in lean human subjects

Molecular Medicine

Volumn 15, Issue 7-8, 2009, Pages 228-234

  Danielsson, Anna ^a   Fagerholm, Siri ^a   Öst, Anita ^a   Franck, Niclas ^a   Kjolhede, Preben ^a   Nystrom, Fredrik H ^a   Strålfors, Peter ^a  

^a LINKÖPING UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1;

ADIPOCYTE; ADULT; ARTICLE; BODY FAT; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; INSULIN RESISTANCE; LEAN BODY WEIGHT; NON INSULIN DEPENDENT DIABETES MELLITUS; NORMAL HUMAN; OVERNUTRITION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; WEIGHT GAIN;

ABSORPTIOMETRY, PHOTON; ADIPOCYTES; ADULT; BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; DIET; FEMALE; HUMANS; HYPERPHAGIA; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; INSULIN RESISTANCE; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SERINE; SIGNAL TRANSDUCTION; THINNESS; TYROSINE;

EID: 67650501859     PISSN: 10761551     EISSN: None     Source Type: Journal    
DOI: 10.2119/molmed.2009.00037     Document Type: Article

References (31)

1. Colditz GA, et al. (1990) Weight as risk factor for clinical diabetes in women. Am. J. Epidemiol. 132:501-13.
2. Biddinger SB, Kahn CR. (2006) From mice to men: insights into the insulin resistance syndromes. Ann. Rev. Physiol. 68:20.21-36.
3. Muoio DM, Newgard CB. (2008) Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nature Rev. Mol. Cell Biol. 9:193-205.
4. Kim Y-B, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB. (1999) Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J. Clin. Inv. 104:733-41.
5. Goodyear L, et al. (1995) Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Inv. 95:2195-204.
6. Cusi K, et al. (2000) Insulin resistance differentially affects the PI 3-kinase and MAP kinasemediated signaling in human muscle. J. Clin. Inv. 105:311-20.
7. Björnholm M, Kawano Y, Lehtihet M, Zierath J. (1997) Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase acitivity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46:524-7.
8. Danielsson A, et al. (2005) Insulin resistance in human adipocytes downstream of IRS1 after surgical cell isolation, but at the level of phosphorylation of IRS1 in type 2 diabetes. FEBS J. 272:141-51.
9. Öst A, et al. (2007) Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes. FASEB J. 21:3696-704.
10. Danielsson A, Nystrom FH, Strålfors P. (2006) Phosphorylation of IRS1 at serine 307 and serine 312 in response to insulin in human adipocytes. Biochem. Biophys. Res. Commun. 342:1183-87.
11. Danielsson A, Öst A, Nystrom FH, Strålfors P. (2005) Attenuation of insulin-stimulated insulin receptor substrate-1 serine 307 phosphorylation in insulin resistance of type 2 diabetes. J. Biol. Chem. 280:34389-92.
12. Gual P, LeMarchand-Brustel Y, Tanti J-F. (2005) Positive and negative regulation of insulin signaling through IRS-1 phosphorylation. Biochemie 87:99-109.
13. Um SH, D'Alessio D, Thomas G. (2006) Nutrient overload, insulin resistance, and ribosomal protein S6 kinase 1, S6K1. Cell Metab. 3:393-402.
14. Hotamisligil GS. (2006) Inflammation and metabolic disorders. Nature 444:860-7.
15. Luca Cd, Olefsky JM. (2008) Inflammation and insulin resistance. FEBS Lett. 582:97-105.
16. Guilherme A, Virbasius JV, Puri V, Czech MP. (2008) Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes. Nature Rev. Mol. Cell Biol. 9:367-77.
17. Petersen KF, et al. (2005) Reversal of nonalcoholic hepatic steatosis, hepatic insulin resistance, and hyperglycemia by moderate weight reduction in patients with type 2 diabetes. Diabetes 54:603-8.
18. Salans LB, Horton ES, Sims EAH. (1971) Experimental obesity in man: cellular character of the adipose tissue. J. Clin. Inv. 50:1005-11.
19. Lammert O, et al. (2000) Effects of isoenergetic overfeeding of either carbohydrate or fat in young men. Br. J. Nutrition 84:233-45.
20. Kechagias S, et al. (2008) Fast food based hyperalimentation can induce rapid and profound elevation of serum alanine aminotransferase in healthy subjects. Gut 57:649-54.
21. Strålfors P, Honnor RC. (1989) Insulin-induced dephosphorylation of hormone-sensitive lipase: correlation with lipolysis and cAMP-dependent protein kinase activity. Eur. J. Biochem. 182:379-85.
22. Olefsky JM. (1976) Decreased insulin binding to adipocytes and circulating monocytes from obese subjects. J. Clin. Inv. 57:1165-72.
23. Puig O, Tjian R. (2006) Transcriptional feedback control of insulin receptor by dFOXO/FOXO1. Genes Dev. 19:2435-46.
24. Rondinone CM, et al. (1997) Insulin receptor substrate (IRS) 1 is reduced and IRS2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin dependent diabetes mellitus. Proc. Natl. Acad. Sci. U S A 94:4171-5.
25. Dixon JB, et al. (2008) Adjustable gastric banding and conventional therapy for type 2 diabetes. J. Am. Med. Assoc. 23:316-23.
26. Greene MW, Sakaue H, Wang L, Alessi DR, Roth RA. (2003) Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation. J. Biol. Chem. 278:8199-211.
27. Törnkvist Å, Parpal S, Gustavsson J, Strålfors P. (1994) Inhibition of raf-1 kinase expression abolishes insulin stimulation of DNA synthesis in H4IIE hepatoma cells. J. Biol. Chem. 269:13919-21.
28. Bost F, et al. (2005) The extracellular signal-regulated kinase isoform ERK1 is specifically required for in vitro and in vivo adipogenesis. Diabetes 54:402-11.
29. Jager J, Gremeaux T, Cormont M, Marchand-Brustel YL. (2007) Interleukin-1 beta-induced insulin resistance in adipocytes through downregulation of insulin receptor substrate-1 expression. Endocrinology 148:241-51.
30. Matthews DR, et al. (1985) Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28:412-9.
31. Katz A, et al. (2000) Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab. 85:2402-10.