-
1
-
-
33745896155
-
Recent advances in the relationship between obesity, inflammation, and insulin resistance
-
Bastard J.P., et al. Recent advances in the relationship between obesity, inflammation, and insulin resistance. Eur. Cytokine Netw. 2006, 17:4-12.
-
(2006)
Eur. Cytokine Netw.
, vol.17
, pp. 4-12
-
-
Bastard, J.P.1
-
2
-
-
0035856920
-
Global and societal implications of the diabetes epidemic
-
Zimmet P., et al. Global and societal implications of the diabetes epidemic. Nature 2001, 414:782-787.
-
(2001)
Nature
, vol.414
, pp. 782-787
-
-
Zimmet, P.1
-
3
-
-
0031014830
-
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM
-
Boden G. Role of fatty acids in the pathogenesis of insulin resistance and NIDDM. Diabetes 1997, 46:3-10.
-
(1997)
Diabetes
, vol.46
, pp. 3-10
-
-
Boden, G.1
-
4
-
-
33745861300
-
Inflammation and insulin resistance
-
Shoelson S.E., et al. Inflammation and insulin resistance. J. Clin. Invest. 2006, 116:1793-1801.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 1793-1801
-
-
Shoelson, S.E.1
-
5
-
-
33845866857
-
Inflammation and metabolic disorders
-
Hotamisligil G.S. Inflammation and metabolic disorders. Nature 2006, 444:860-867.
-
(2006)
Nature
, vol.444
, pp. 860-867
-
-
Hotamisligil, G.S.1
-
6
-
-
0344305782
-
Insulin signaling in health and disease
-
White M.F. Insulin signaling in health and disease. Science 2003, 302:1710-1711.
-
(2003)
Science
, vol.302
, pp. 1710-1711
-
-
White, M.F.1
-
8
-
-
0034644522
-
Signal transduction by the JNK group of MAP kinases
-
Davis R.J. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103:239-252.
-
(2000)
Cell
, vol.103
, pp. 239-252
-
-
Davis, R.J.1
-
9
-
-
0037153158
-
A central role for JNK in obesity and insulin resistance
-
Hirosumi J., et al. A central role for JNK in obesity and insulin resistance. Nature 2002, 420:333-336.
-
(2002)
Nature
, vol.420
, pp. 333-336
-
-
Hirosumi, J.1
-
10
-
-
33746101818
-
Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance
-
Tuncman G., et al. Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 2006, 103:10741-10746.
-
(2006)
Proc. Natl. Acad. Sci. U. S. A.
, vol.103
, pp. 10741-10746
-
-
Tuncman, G.1
-
11
-
-
6344233096
-
Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes
-
Kaneto H., et al. Oxidative stress and the JNK pathway as a potential therapeutic target for diabetes. Drug News Perspect. 2004, 17:447-453.
-
(2004)
Drug News Perspect.
, vol.17
, pp. 447-453
-
-
Kaneto, H.1
-
12
-
-
8544244943
-
Modulation of the JNK pathway in liver affects insulin resistance status
-
Nakatani Y., et al. Modulation of the JNK pathway in liver affects insulin resistance status. J. Biol. Chem. 2004, 279:45803-45809.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 45803-45809
-
-
Nakatani, Y.1
-
13
-
-
0041302157
-
JNK: a new therapeutic target for diabetes
-
Bennett B.L., et al. JNK: a new therapeutic target for diabetes. Curr. Opin. Pharmacol. 2003, 3:420-425.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 420-425
-
-
Bennett, B.L.1
-
14
-
-
7044230885
-
Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide
-
Kaneto H., et al. Possible novel therapy for diabetes with cell-permeable JNK-inhibitory peptide. Nat. Med. 2004, 10:1128-1132.
-
(2004)
Nat. Med.
, vol.10
, pp. 1128-1132
-
-
Kaneto, H.1
-
15
-
-
55949100580
-
Identification of a new JNK inhibitor targeting the JNK-JIP interaction site
-
Stebbins J.L., et al. Identification of a new JNK inhibitor targeting the JNK-JIP interaction site. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:16809-16813.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 16809-16813
-
-
Stebbins, J.L.1
-
16
-
-
0034992168
-
MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines
-
Tournier C., et al. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev. 2001, 15:1419-1426.
-
(2001)
Genes Dev.
, vol.15
, pp. 1419-1426
-
-
Tournier, C.1
-
17
-
-
77950343252
-
Endoplasmic reticulum stress and the inflammatory basis of metabolic disease
-
Hotamisligil G.S. Endoplasmic reticulum stress and the inflammatory basis of metabolic disease. Cell 2010, 140:900-917.
-
(2010)
Cell
, vol.140
, pp. 900-917
-
-
Hotamisligil, G.S.1
-
18
-
-
58149484392
-
Inflammation and endoplasmic reticulum stress in obesity and diabetes
-
Hotamisligil G.S. Inflammation and endoplasmic reticulum stress in obesity and diabetes. Int. J. Obes. (Lond.) 2008, 32(Suppl. 7):S52-S54.
-
(2008)
Int. J. Obes. (Lond.)
, vol.32
, Issue.SUPPL. 7
-
-
Hotamisligil, G.S.1
-
19
-
-
75749108288
-
Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
-
Nakamura T., et al. Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010, 140:338-348.
-
(2010)
Cell
, vol.140
, pp. 338-348
-
-
Nakamura, T.1
-
20
-
-
34547602916
-
Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance
-
Tsukumo D.M., et al. Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance. Diabetes 2007, 56:1986-1998.
-
(2007)
Diabetes
, vol.56
, pp. 1986-1998
-
-
Tsukumo, D.M.1
-
21
-
-
33750584214
-
TLR4 links innate immunity and fatty acid-induced insulin resistance
-
Shi H., et al. TLR4 links innate immunity and fatty acid-induced insulin resistance. J. Clin. Invest. 2006, 116:3015-3025.
-
(2006)
J. Clin. Invest.
, vol.116
, pp. 3015-3025
-
-
Shi, H.1
-
22
-
-
34547219895
-
Metabolic stress signaling mediated by mixed-lineage kinases
-
Jaeschke A., Davis R.J. Metabolic stress signaling mediated by mixed-lineage kinases. Mol. Cell 2007, 27:498-508.
-
(2007)
Mol. Cell
, vol.27
, pp. 498-508
-
-
Jaeschke, A.1
Davis, R.J.2
-
23
-
-
4043073652
-
An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue
-
Jaeschke A., et al. An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue. Genes Dev. 2004, 18:1976-1980.
-
(2004)
Genes Dev.
, vol.18
, pp. 1976-1980
-
-
Jaeschke, A.1
-
24
-
-
0030756346
-
Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function
-
Uysal K.T., et al. Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function. Nature 1997, 389:610-614.
-
(1997)
Nature
, vol.389
, pp. 610-614
-
-
Uysal, K.T.1
-
25
-
-
57349101675
-
A stress signaling pathway in adipose tissue regulates hepatic insulin resistance
-
Sabio G., et al. A stress signaling pathway in adipose tissue regulates hepatic insulin resistance. Science 2008, 322:1539-1543.
-
(2008)
Science
, vol.322
, pp. 1539-1543
-
-
Sabio, G.1
-
26
-
-
73549091444
-
Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance
-
Sabio G., et al. Role of muscle c-Jun NH2-terminal kinase 1 in obesity-induced insulin resistance. Mol. Cell Biol. 2010, 30:106-115.
-
(2010)
Mol. Cell Biol.
, vol.30
, pp. 106-115
-
-
Sabio, G.1
-
27
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307)
-
Aguirre V., et al. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser(307). J. Biol. Chem. 2000, 275:9047-9054.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9047-9054
-
-
Aguirre, V.1
-
28
-
-
0037474274
-
C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
Lee Y.H., et al. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 2003, 278:2896-2902.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
-
29
-
-
0037059330
-
Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguirre V., et al. Phosphorylation of Ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 2002, 277:1531-1537.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1531-1537
-
-
Aguirre, V.1
-
30
-
-
72649098413
-
Irs1 serine 307 promotes insulin sensitivity in mice
-
Copps K.D., et al. Irs1 serine 307 promotes insulin sensitivity in mice. Cell Metab. 2010, 11:84-92.
-
(2010)
Cell Metab.
, vol.11
, pp. 84-92
-
-
Copps, K.D.1
-
31
-
-
70449724835
-
Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation
-
Tanti J.F., Jager J. Cellular mechanisms of insulin resistance: role of stress-regulated serine kinases and insulin receptor substrates (IRS) serine phosphorylation. Curr. Opin. Pharmacol. 2009, 9:753-762.
-
(2009)
Curr. Opin. Pharmacol.
, vol.9
, pp. 753-762
-
-
Tanti, J.F.1
Jager, J.2
-
32
-
-
34548333594
-
Phosphorylation of Irs1 at SER-522 inhibits insulin signaling
-
Giraud J., et al. Phosphorylation of Irs1 at SER-522 inhibits insulin signaling. Mol. Endocrinol. 2007, 21:2294-2302.
-
(2007)
Mol. Endocrinol.
, vol.21
, pp. 2294-2302
-
-
Giraud, J.1
-
33
-
-
34748845043
-
Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling
-
Luo M., et al. Phosphorylation of human insulin receptor substrate-1 at Serine 629 plays a positive role in insulin signaling. Endocrinology 2007, 148:4895-4905.
-
(2007)
Endocrinology
, vol.148
, pp. 4895-4905
-
-
Luo, M.1
-
34
-
-
24944576051
-
Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223
-
Luo M., et al. Identification of insulin receptor substrate 1 serine/threonine phosphorylation sites using mass spectrometry analysis: regulatory role of serine 1223. Endocrinology 2005, 146:4410-4416.
-
(2005)
Endocrinology
, vol.146
, pp. 4410-4416
-
-
Luo, M.1
-
35
-
-
34249661732
-
Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle
-
Yi Z., et al. Global assessment of regulation of phosphorylation of insulin receptor substrate-1 by insulin in vivo in human muscle. Diabetes 2007, 56:1508-1516.
-
(2007)
Diabetes
, vol.56
, pp. 1508-1516
-
-
Yi, Z.1
-
36
-
-
42649127400
-
IRS1-independent defects define major nodes of insulin resistance
-
Hoehn K.L., et al. IRS1-independent defects define major nodes of insulin resistance. Cell Metab. 2008, 7:421-433.
-
(2008)
Cell Metab.
, vol.7
, pp. 421-433
-
-
Hoehn, K.L.1
-
37
-
-
58249093873
-
Induction of hepatitis by JNK-mediated expression of TNF-alpha
-
Das M., et al. Induction of hepatitis by JNK-mediated expression of TNF-alpha. Cell 2009, 136:249-260.
-
(2009)
Cell
, vol.136
, pp. 249-260
-
-
Das, M.1
-
38
-
-
52349105273
-
A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity
-
Vallerie S.N., et al. A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity. PLoS One 2008, 3:e3151.
-
(2008)
PLoS One
, vol.3
-
-
Vallerie, S.N.1
-
39
-
-
35548943962
-
JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity
-
Solinas G., et al. JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity. Cell Metab. 2007, 6:386-397.
-
(2007)
Cell Metab.
, vol.6
, pp. 386-397
-
-
Solinas, G.1
-
40
-
-
57349199263
-
Cell signaling. Fat stress and liver resistance
-
Ogawa W., Kasuga M. Cell signaling. Fat stress and liver resistance. Science 2008, 322:1483-1484.
-
(2008)
Science
, vol.322
, pp. 1483-1484
-
-
Ogawa, W.1
Kasuga, M.2
-
41
-
-
34347354309
-
Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance
-
Odegaard J.I., et al. Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance. Nature 2007, 447:1116-1120.
-
(2007)
Nature
, vol.447
, pp. 1116-1120
-
-
Odegaard, J.I.1
-
42
-
-
44349112305
-
Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity
-
Kang K., et al. Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity. Cell Metab. 2008, 7:485-495.
-
(2008)
Cell Metab.
, vol.7
, pp. 485-495
-
-
Kang, K.1
-
43
-
-
27444445460
-
JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes
-
Nguyen M.T., et al. JNK and tumor necrosis factor-alpha mediate free fatty acid-induced insulin resistance in 3T3-L1 adipocytes. J. Biol. Chem. 2005, 280:35361-35371.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35361-35371
-
-
Nguyen, M.T.1
-
44
-
-
57849137363
-
Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction
-
Kim T., et al. Knockdown of JNK rescues 3T3-L1 adipocytes from insulin resistance induced by mitochondrial dysfunction. Biochem. Biophys. Res. Commun. 2009, 378:772-776.
-
(2009)
Biochem. Biophys. Res. Commun.
, vol.378
, pp. 772-776
-
-
Kim, T.1
-
45
-
-
48149085566
-
Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes
-
Rozo A.V., et al. Silencing Jnk1 and Jnk2 accelerates basal lipolysis and promotes fatty acid re-esterification in mouse adipocytes. Diabetologia 2008, 51:1493-1504.
-
(2008)
Diabetologia
, vol.51
, pp. 1493-1504
-
-
Rozo, A.V.1
-
46
-
-
0034717062
-
SOCS-3 is an insulin-induced negative regulator of insulin signaling
-
Emanuelli B., et al. SOCS-3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem. 2000, 275:15985-15991.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15985-15991
-
-
Emanuelli, B.1
-
47
-
-
0036830636
-
SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
-
Rui L., et al. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J. Biol. Chem. 2002, 277:42394-42398.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 42394-42398
-
-
Rui, L.1
-
48
-
-
0035854723
-
Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance
-
Mooney R.A., et al. Suppressors of cytokine signaling-1 and -6 associate with and inhibit the insulin receptor. A potential mechanism for cytokine-mediated insulin resistance. J. Biol. Chem. 2001, 276:25889-25893.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25889-25893
-
-
Mooney, R.A.1
-
49
-
-
0037853260
-
Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes
-
Senn J.J., et al. Suppressor of cytokine signaling-3 (SOCS-3), a potential mediator of interleukin-6-dependent insulin resistance in hepatocytes. J. Biol. Chem. 2003, 278:13740-13746.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 13740-13746
-
-
Senn, J.J.1
-
50
-
-
0035930605
-
SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice
-
Emanuelli B., et al. SOCS-3 inhibits insulin signaling and is up-regulated in response to tumor necrosis factor-alpha in the adipose tissue of obese mice. J. Biol. Chem. 2001, 276:47944-47949.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 47944-47949
-
-
Emanuelli, B.1
-
51
-
-
33947518747
-
Counterpoint: interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis
-
discussion 818-819
-
Mooney R.A. Counterpoint: interleukin-6 does not have a beneficial role in insulin sensitivity and glucose homeostasis. J. Appl. Physiol. 2007, 102:816-818. discussion 818-819.
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 816-818
-
-
Mooney, R.A.1
-
52
-
-
33846883060
-
Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis
-
Pedersen B.K., Febbraio M.A. Point: interleukin-6 does have a beneficial role in insulin sensitivity and glucose homeostasis. J. Appl. Physiol. 2007, 102:814-816.
-
(2007)
J. Appl. Physiol.
, vol.102
, pp. 814-816
-
-
Pedersen, B.K.1
Febbraio, M.A.2
-
53
-
-
33645579324
-
Role of hepatic STAT3 in brain-insulin action on hepatic glucose production
-
Inoue H., et al. Role of hepatic STAT3 in brain-insulin action on hepatic glucose production. Cell Metab. 2006, 3:267-275.
-
(2006)
Cell Metab.
, vol.3
, pp. 267-275
-
-
Inoue, H.1
-
54
-
-
0036152683
-
Interleukin-6-deficient mice develop mature-onset obesity
-
Wallenius V., et al. Interleukin-6-deficient mice develop mature-onset obesity. Nat. Med. 2002, 8:75-79.
-
(2002)
Nat. Med.
, vol.8
, pp. 75-79
-
-
Wallenius, V.1
-
55
-
-
0242268894
-
Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice
-
Klover P.J., et al. Chronic exposure to interleukin-6 causes hepatic insulin resistance in mice. Diabetes 2003, 52:2784-2789.
-
(2003)
Diabetes
, vol.52
, pp. 2784-2789
-
-
Klover, P.J.1
-
56
-
-
12144290761
-
Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo
-
Kim H.J., et al. Differential effects of interleukin-6 and -10 on skeletal muscle and liver insulin action in vivo. Diabetes 2004, 53:1060-1067.
-
(2004)
Diabetes
, vol.53
, pp. 1060-1067
-
-
Kim, H.J.1
-
57
-
-
23044468612
-
Interleukin-6 depletion selectively improves hepatic insulin action in obesity
-
Klover P.J., et al. Interleukin-6 depletion selectively improves hepatic insulin action in obesity. Endocrinology 2005, 146:3417-3427.
-
(2005)
Endocrinology
, vol.146
, pp. 3417-3427
-
-
Klover, P.J.1
-
58
-
-
33846512401
-
The dual function of hepatic SOCS3 in insulin resistance in vivo
-
Torisu T., et al. The dual function of hepatic SOCS3 in insulin resistance in vivo. Genes Cells 2007, 12:143-154.
-
(2007)
Genes Cells
, vol.12
, pp. 143-154
-
-
Torisu, T.1
-
59
-
-
34248581989
-
Disordered lipid metabolism and the pathogenesis of insulin resistance
-
Savage D.B., et al. Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol. Rev. 2007, 87:507-520.
-
(2007)
Physiol. Rev.
, vol.87
, pp. 507-520
-
-
Savage, D.B.1
-
60
-
-
77956094473
-
JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes
-
Vijayvargia R., et al. JNK deficiency enhances fatty acid utilization and diverts glucose from oxidation to glycogen storage in cultured myotubes. Obesity 2010, 10.1038/oby.2009.501.
-
(2010)
Obesity
-
-
Vijayvargia, R.1
-
61
-
-
58149347680
-
Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle
-
Morino K., et al. Muscle-specific IRS-1 Ser->Ala transgenic mice are protected from fat-induced insulin resistance in skeletal muscle. Diabetes 2008, 57:2644-2651.
-
(2008)
Diabetes
, vol.57
, pp. 2644-2651
-
-
Morino, K.1
-
62
-
-
63249101983
-
Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues
-
Wang H., et al. Skeletal muscle-specific deletion of lipoprotein lipase enhances insulin signaling in skeletal muscle but causes insulin resistance in liver and other tissues. Diabetes 2009, 58:116-124.
-
(2009)
Diabetes
, vol.58
, pp. 116-124
-
-
Wang, H.1
-
63
-
-
34547942526
-
Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice
-
Yang R., et al. Liver-specific knockdown of JNK1 up-regulates proliferator-activated receptor gamma coactivator 1 beta and increases plasma triglyceride despite reduced glucose and insulin levels in diet-induced obese mice. J. Biol. Chem. 2007, 282:22765-22774.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 22765-22774
-
-
Yang, R.1
-
64
-
-
42149155999
-
Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance
-
Emanuelli B., et al. Overexpression of the dual-specificity phosphatase MKP-4/DUSP-9 protects against stress-induced insulin resistance. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:3545-3550.
-
(2008)
Proc. Natl. Acad. Sci. U. S. A.
, vol.105
, pp. 3545-3550
-
-
Emanuelli, B.1
-
65
-
-
70449927269
-
Prevention of steatosis by hepatic JNK1
-
Sabio G., et al. Prevention of steatosis by hepatic JNK1. Cell Metab. 2009, 10:491-498.
-
(2009)
Cell Metab.
, vol.10
, pp. 491-498
-
-
Sabio, G.1
-
66
-
-
56849099017
-
Central and peripheral regulation of food intake and physical activity: pathways and genes
-
Lenard N.R., Berthoud H.R. Central and peripheral regulation of food intake and physical activity: pathways and genes. Obesity 2008, 16(Suppl. 3):S11-S22.
-
(2008)
Obesity
, vol.16
, Issue.SUPPL. 3
-
-
Lenard, N.R.1
Berthoud, H.R.2
-
67
-
-
76149090834
-
Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1
-
Sabio G., et al. Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1. Genes Dev. 2010, 24:256-264.
-
(2010)
Genes Dev.
, vol.24
, pp. 256-264
-
-
Sabio, G.1
-
68
-
-
77950532905
-
Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism
-
Belgardt B.F., et al. Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism. Proc. Natl. Acad. Sci. U. S. A. 2010, 107:6028-6033.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 6028-6033
-
-
Belgardt, B.F.1
-
69
-
-
33846434443
-
Involvement of oxidative stress in the pathogenesis of diabetes
-
Kaneto H., et al. Involvement of oxidative stress in the pathogenesis of diabetes. Antioxid. Redox Signal. 2007, 9:355-366.
-
(2007)
Antioxid. Redox Signal.
, vol.9
, pp. 355-366
-
-
Kaneto, H.1
-
70
-
-
59149084125
-
Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes
-
Ijaz A., et al. Inhibition of C-jun N-terminal kinase improves insulin sensitivity but worsens albuminuria in experimental diabetes. Kidney Int. 2009, 75:381-388.
-
(2009)
Kidney Int.
, vol.75
, pp. 381-388
-
-
Ijaz, A.1
|