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Volumn 50, Issue 12, 2001, Pages 2770-2778

Insulin signal transduction in skeletal muscle from glucose-intolerant relatives with type 2 diabetes

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; ONCOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPROTEIN; PHOSPHOTYROSINE; PROTO ONCOGENE PROTEIN AKT; PROTO ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEIN AKT;

EID: 0035653508     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.50.12.2770     Document Type: Article
Times cited : (78)

References (49)
  • 1
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • DeFronzo RA: Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev 5:177-269, 1997
    • (1997) Diabetes Rev , vol.5 , pp. 177-269
    • DeFronzo, R.A.1
  • 2
    • 0033063033 scopus 로고    scopus 로고
    • On the pathophysiology of late onset non-insulin dependent diabetes mellitus: Current controversies and new insights
    • Vaag A: On the pathophysiology of late onset non-insulin dependent diabetes mellitus: current controversies and new insights. Dan Med Bull 46:197-234, 1999
    • (1999) Dan Med Bull , vol.46 , pp. 197-234
    • Vaag, A.1
  • 3
    • 0033942001 scopus 로고    scopus 로고
    • Insulin action and insulin resistance in human skeletal muscle
    • Zierath JR, Krook A, Wallberg-Henriksson H: Insulin action and insulin resistance in human skeletal muscle. Diabetologia 43:821-835, 2000
    • (2000) Diabetologia , vol.43 , pp. 821-835
    • Zierath, J.R.1    Krook, A.2    Wallberg-Henriksson, H.3
  • 4
    • 0026575758 scopus 로고
    • Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus
    • Vaag A, Henriksen JE, Beck-Nielsen H: Decreased insulin activation of glycogen synthase in skeletal muscles in young nonobese Caucasian first-degree relatives of patients with non-insulin-dependent diabetes mellitus. J Clin Invest 89:782-788, 1992
    • (1992) J Clin Invest , vol.89 , pp. 782-788
    • Vaag, A.1    Henriksen, J.E.2    Beck-Nielsen, H.3
  • 5
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: Prospective studies of Pima Indians
    • Lillioja S, Mott DM, Spraul M, Ferraro R, Foley JE, Ravussin E, Knowler WC, Bennett PH, Bogardus C: Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus: prospective studies of Pima Indians. N Engl J Med 329:1988-1992, 1993
    • (1993) N Engl J Med , vol.329 , pp. 1988-1992
    • Lillioja, S.1    Mott, D.M.2    Spraul, M.3    Ferraro, R.4    Foley, J.E.5    Ravussin, E.6    Knowler, W.C.7    Bennett, P.H.8    Bogardus, C.9
  • 6
    • 0025663581 scopus 로고
    • Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents
    • Warram JH, Martin BC, Krolewski AS, Soeldner JS, Kahn CR: Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents. Ann Intern Med 113:909-915, 1990
    • (1990) Ann Intern Med , vol.113 , pp. 909-915
    • Warram, J.H.1    Martin, B.C.2    Krolewski, A.S.3    Soeldner, J.S.4    Kahn, C.R.5
  • 7
    • 0023683874 scopus 로고
    • An in vitro human muscle preparation suitable for metabolic studies: Decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects
    • Dohm GL, Tapscott EB, Pories WJ, Dabbs DJ, Flickinger EG, Meelheim D, Fushiki T, Atkinson SM, Elton CW, Caro JF: An in vitro human muscle preparation suitable for metabolic studies: decreased insulin stimulation of glucose transport in muscle from morbidly obese and diabetic subjects. J Clin Invest 82:486-494, 1988
    • (1988) J Clin Invest , vol.82 , pp. 486-494
    • Dohm, G.L.1    Tapscott, E.B.2    Pories, W.J.3    Dabbs, D.J.4    Flickinger, E.G.5    Meelheim, D.6    Fushiki, T.7    Atkinson, S.M.8    Elton, C.W.9    Caro, J.F.10
  • 8
    • 0034070580 scopus 로고    scopus 로고
    • Use of a novel impermeable biotinylated photolabeling reagent to assess insulin-and hypoxia-stimulated cell surface GLUT 4 content in skeletal muscle from type 2 diabetic patients
    • Ryder JW, Yang J, Galuska D, Rincon J, Björnholm M, Krook A, Lund S, Pedersen O, Wallberg-Henriksson H, Zierath JR, Holman GD: Use of a novel impermeable biotinylated photolabeling reagent to assess insulin-and hypoxia-stimulated cell surface GLUT 4 content in skeletal muscle from type 2 diabetic patients. Diabetes 49:647-654, 2000
    • (2000) Diabetes , vol.49 , pp. 647-654
    • Ryder, J.W.1    Yang, J.2    Galuska, D.3    Rincon, J.4    Björnholm, M.5    Krook, A.6    Lund, S.7    Pedersen, O.8    Wallberg-Henriksson, H.9    Zierath, J.R.10    Holman, G.D.11
  • 9
    • 0029775874 scopus 로고    scopus 로고
    • Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM
    • Zierath JR, He L, Guma A, Odegoard-Wahlström E, Klip A, Wallberg-Henriksson H: Insulin action on glucose transport and plasma membrane GLUT4 content in skeletal muscle from patients with NIDDM. Diabetologia 39:1180-1189, 1996
    • (1996) Diabetologia , vol.39 , pp. 1180-1189
    • Zierath, J.R.1    He, L.2    Guma, A.3    Odegoard-Wahlström, E.4    Klip, A.5    Wallberg-Henriksson, H.6
  • 10
    • 0025860114 scopus 로고
    • Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus
    • Damsbo P, Vaag A, Hother-Nielsen O, Beck-Nielsen H: Reduced glycogen synthase activity in skeletal muscle from obese patients with and without type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 34:239-245, 1991
    • (1991) Diabetologia , vol.34 , pp. 239-245
    • Damsbo, P.1    Vaag, A.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 11
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
    • Björnholm M, Kawano Y, Lehtihet M, Zierath JR: Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46:524-527, 1997
    • (1997) Diabetes , vol.46 , pp. 524-527
    • Björnholm, M.1    Kawano, Y.2    Lehtihet, M.3    Zierath, J.R.4
  • 13
    • 2642683510 scopus 로고    scopus 로고
    • Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
    • Kerouz NJ, Horsch D, Pons S, Kahn CR: Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J Clin Invest 100:3164-3172, 1997
    • (1997) J Clin Invest , vol.100 , pp. 3164-3172
    • Kerouz, N.J.1    Horsch, D.2    Pons, S.3    Kahn, C.R.4
  • 14
    • 0033595121 scopus 로고    scopus 로고
    • Glucose transporters and insulin action: Implications for insulin resistance and diabetes mellitus
    • Shepherd PR, Kahn BB: Glucose transporters and insulin action: implications for insulin resistance and diabetes mellitus. N Engl J Med 341:248-257, 1999
    • (1999) N Engl J Med , vol.341 , pp. 248-257
    • Shepherd, P.R.1    Kahn, B.B.2
  • 15
    • 0042570843 scopus 로고    scopus 로고
    • Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance
    • Virkamaki A, Ueki K, Kahn CR: Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J Clin Invest 103:931-943, 1999
    • (1999) J Clin Invest , vol.103 , pp. 931-943
    • Virkamaki, A.1    Ueki, K.2    Kahn, C.R.3
  • 16
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789, 1995
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 17
    • 0028881784 scopus 로고
    • Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM
    • Klein HH, Vestergaard H, Kotzke G, Pedersen O: Elevation of serum insulin concentration during euglycemic hyperinsulinemic clamp studies leads to similar activation of insulin receptor kinase in skeletal muscle of subjects with and without NIDDM. Diabetes 44:1310-1317, 1995
    • (1995) Diabetes , vol.44 , pp. 1310-1317
    • Klein, H.H.1    Vestergaard, H.2    Kotzke, G.3    Pedersen, O.4
  • 18
    • 0026636946 scopus 로고
    • Impaired activation of glycogen synthase in people at increased risk for developing NIDDM
    • Schalin-Jantti C, Harkonen M, Groop LC: Impaired activation of glycogen synthase in people at increased risk for developing NIDDM. Diabetes 41:598-604, 1992
    • (1992) Diabetes , vol.41 , pp. 598-604
    • Schalin-Jantti, C.1    Harkonen, M.2    Groop, L.C.3
  • 19
    • 0028079621 scopus 로고
    • Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity
    • Nolan JJ, Freidenberg G, Henry R, Reichart D, Olefsky JM: Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity. J Clin Endocrinol Metab 78:471-477, 1994
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 471-477
    • Nolan, J.J.1    Freidenberg, G.2    Henry, R.3    Reichart, D.4    Olefsky, J.M.5
  • 21
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB: Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104:733-741, 1999
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 22
    • 0031852665 scopus 로고    scopus 로고
    • Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects
    • Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H: Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47:1281-1286, 1998
    • (1998) Diabetes , vol.47 , pp. 1281-1286
    • Krook, A.1    Roth, R.A.2    Jiang, X.J.3    Zierath, J.R.4    Wallberg-Henriksson, H.5
  • 23
    • 0028204464 scopus 로고
    • Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: In vitro reversal of muscular insulin resistance
    • Zierath JR, Galuska D, Nolte LA, Thörne A, Smedegaard-Kristensen J, Wallberg-Henriksson H: Effects of glycaemia on glucose transport in isolated skeletal muscle from patients with NIDDM: in vitro reversal of muscular insulin resistance. Diabetologia 37:270-277, 1994
    • (1994) Diabetologia , vol.37 , pp. 270-277
    • Zierath, J.R.1    Galuska, D.2    Nolte, L.A.3    Thörne, A.4    Smedegaard-Kristensen, J.5    Wallberg-Henriksson, H.6
  • 24
    • 0022387842 scopus 로고
    • Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects
    • Baron AD, Kolterman OG, Bell J, Mandarino LJ, Olefsky JM: Rates of noninsulin-mediated glucose uptake are elevated in type II diabetic subjects. J Clin Invest 76:1782-1788, 1985
    • (1985) J Clin Invest , vol.76 , pp. 1782-1788
    • Baron, A.D.1    Kolterman, O.G.2    Bell, J.3    Mandarino, L.J.4    Olefsky, J.M.5
  • 25
    • 0026598750 scopus 로고
    • Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Vaag A, Damsbo P, Hother-Nielsen O, Beck-Nielsen H: Hyperglycaemia compensates for the defects in insulin-mediated glucose metabolism and in the activation of glycogen synthase in the skeletal muscle of patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 35:80-88, 1992
    • (1992) Diabetologia , vol.35 , pp. 80-88
    • Vaag, A.1    Damsbo, P.2    Hother-Nielsen, O.3    Beck-Nielsen, H.4
  • 27
    • 0032932340 scopus 로고    scopus 로고
    • Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects
    • Grill V, Persson G, Carlsson S, Norman A, Alvarsson M, Östensson CG, Svanström L, Efendic S: Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects. Diabetologia 42:15-23, 1999
    • (1999) Diabetologia , vol.42 , pp. 15-23
    • Grill, V.1    Persson, G.2    Carlsson, S.3    Norman, A.4    Alvarsson, M.5    Östensson, C.G.6    Svanström, L.7    Efendic, S.8
  • 28
    • 0030901358 scopus 로고    scopus 로고
    • Body composition analysis by DEXA by using dynamically changing samarium filtration
    • Gotfredsen A, Baeksgaard L, Hilsted J: Body composition analysis by DEXA by using dynamically changing samarium filtration. J Appl Physiol 82:1200-1209, 1997
    • (1997) J Appl Physiol , vol.82 , pp. 1200-1209
    • Gotfredsen, A.1    Baeksgaard, L.2    Hilsted, J.3
  • 29
    • 0017166537 scopus 로고
    • Effects of arterial versus venous sampling on analysis of glucose kinetics in man
    • McGuire EA, Helderman JH, Tobin JD, Andres R, Berman M: Effects of arterial versus venous sampling on analysis of glucose kinetics in man. J Appl Physiol 41:565-573, 1976
    • (1976) J Appl Physiol , vol.41 , pp. 565-573
    • McGuire, E.A.1    Helderman, J.H.2    Tobin, J.D.3    Andres, R.4    Berman, M.5
  • 30
    • 0018520840 scopus 로고
    • Glucose clamp technique: A method for quantifying insulin secretion and resistance
    • DeFronzo RA, Tobin JD, Andres R: Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am J Physiol (Endocrinol Metab) 237:E214-E223, 1979
    • (1979) Am J Physiol (Endocrinol Metab) , vol.237
    • Defronzo, R.A.1    Tobin, J.D.2    Andres, R.3
  • 31
    • 0025089269 scopus 로고
    • On the determination of basal glucose production rate in patients with type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glucose infusion
    • Hother-Nielsen O, Beck-Nielsen H: On the determination of basal glucose production rate in patients with type 2 (non-insulin-dependent) diabetes mellitus using primed-continuous 3-3H-glucose infusion. Diabetologia 33: 603-610, 1990
    • (1990) Diabetologia , vol.33 , pp. 603-610
    • Hother-Nielsen, O.1    Beck-Nielsen, H.2
  • 33
    • 0023930822 scopus 로고
    • The theoretical bases of indirect calorimetry: A review
    • Ferrannini E: The theoretical bases of indirect calorimetry: a review. Metabolism 37:287-301, 1988
    • (1988) Metabolism , vol.37 , pp. 287-301
    • Ferrannini, E.1
  • 34
    • 0020576146 scopus 로고
    • Calculation of substrate oxidation rates in vivo from gaseous exchange
    • Frayn KN: Calculation of substrate oxidation rates in vivo from gaseous exchange. J Appl Physiol 55:628-634, 1983
    • (1983) J Appl Physiol , vol.55 , pp. 628-634
    • Frayn, K.N.1
  • 35
    • 14444276528 scopus 로고    scopus 로고
    • Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects
    • Krook A, Whitehead JP, Dobson SP, Griffiths MR, Ouwens M, Baker C, Hayward AC, Sen SK, Maassen JA, Siddle K, Tavare JM, O'Rahilly S: Two naturally occurring insulin receptor tyrosine kinase domain mutants provide evidence that phosphoinositide 3-kinase activation alone is not sufficient for the mediation of insulin's metabolic and mitogenic effects. J Biol Chem 272:30208-30214, 1997
    • (1997) J Biol Chem , vol.272 , pp. 30208-30214
    • Krook, A.1    Whitehead, J.P.2    Dobson, S.P.3    Griffiths, M.R.4    Ouwens, M.5    Baker, C.6    Hayward, A.C.7    Sen, S.K.8    Maassen, J.A.9    Siddle, K.10    Tavare, J.M.11    O'Rahilly, S.12
  • 36
    • 0000648085 scopus 로고
    • Influence of glucose loading and of injected insulin on hepatic glucose output
    • Steele R: Influence of glucose loading and of injected insulin on hepatic glucose output. Ann N Y Acad Sci 82:420-430, 1959
    • (1959) Ann N Y Acad Sci , vol.82 , pp. 420-430
    • Steele, R.1
  • 37
    • 0029160069 scopus 로고
    • Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction
    • Burgering BM, Coffer PJ: Protein kinase B (c-Akt) in phosphatidylinositol-3-OH kinase signal transduction. Nature 376:599-602, 1995
    • (1995) Nature , vol.376 , pp. 599-602
    • Burgering, B.M.1    Coffer, P.J.2
  • 38
    • 0030265564 scopus 로고    scopus 로고
    • Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase
    • Didichenko SA, Tilton B, Hemmings BA, Ballmer-Hofer K, Thelen M: Constitutive activation of protein kinase B and phosphorylation of p47phox by a membrane-targeted phosphoinositide 3-kinase. Curr Biol 6:1271-1278, 1996
    • (1996) Curr Biol , vol.6 , pp. 1271-1278
    • Didichenko, S.A.1    Tilton, B.2    Hemmings, B.A.3    Ballmer-Hofer, K.4    Thelen, M.5
  • 39
  • 40
    • 0029043394 scopus 로고
    • Peripheral and hepatic insulin sensitivity in subjects with impaired glucose tolerance
    • Berrish TS, Hetherington CS, Alberti KG, Walker M: Peripheral and hepatic insulin sensitivity in subjects with impaired glucose tolerance. Diabetologia 38:699-704, 1995
    • (1995) Diabetologia , vol.38 , pp. 699-704
    • Berrish, T.S.1    Hetherington, C.S.2    Alberti, K.G.3    Walker, M.4
  • 41
    • 0026611962 scopus 로고
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: Evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus
    • 31P nuclear magnetic resonance measurements of muscle glucose-6-phosphate: evidence for reduced insulin-dependent muscle glucose transport or phosphorylation activity in non-insulin-dependent diabetes mellitus. J Clin Invest 89:1069-1075, 1992
    • (1992) J Clin Invest , vol.89 , pp. 1069-1075
    • Rothman, D.L.1    Shulman, R.G.2    Shulman, G.I.3
  • 42
    • 0343091465 scopus 로고    scopus 로고
    • Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity
    • Krutzfeldt J, Kausch C, Volk A, Klein HH, Rett K, Haring HU, Stumvoll M: Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity. Diabetes 49:992-998, 2000
    • (2000) Diabetes , vol.49 , pp. 992-998
    • Krutzfeldt, J.1    Kausch, C.2    Volk, A.3    Klein, H.H.4    Rett, K.5    Haring, H.U.6    Stumvoll, M.7
  • 43
    • 0033938499 scopus 로고    scopus 로고
    • Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families
    • Jackson S, Bagstaff SM, Lynn S, Yeaman SJ, Turnbull DM, Walker M: Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families. Diabetes 49:1169-1177, 2000
    • (2000) Diabetes , vol.49 , pp. 1169-1177
    • Jackson, S.1    Bagstaff, S.M.2    Lynn, S.3    Yeaman, S.J.4    Turnbull, D.M.5    Walker, M.6
  • 44
    • 0028147131 scopus 로고
    • Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man
    • Del Prato S, Leonetti F, Simonson DC, Sheehan P, Matsuda M, DeFronzo RA: Effect of sustained physiologic hyperinsulinaemia and hyperglycaemia on insulin secretion and insulin sensitivity in man. Diabetologia 37:1025-1035, 1994
    • (1994) Diabetologia , vol.37 , pp. 1025-1035
    • Del Prato, S.1    Leonetti, F.2    Simonson, D.C.3    Sheehan, P.4    Matsuda, M.5    DeFronzo, R.A.6
  • 45
    • 0032587240 scopus 로고    scopus 로고
    • The role of TNFa and TNF receptors in obesity and insulin resistance
    • Hotamisligil GS: The role of TNFa and TNF receptors in obesity and insulin resistance. J Intern Med 245:621-625, 1999
    • (1999) J Intern Med , vol.245 , pp. 621-625
    • Hotamisligil, G.S.1
  • 47
    • 0030024814 scopus 로고    scopus 로고
    • Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites
    • Pillay TS, Xiao S, Olefsky JM: Glucose-induced phosphorylation of the insulin receptor. Functional effects and characterization of phosphorylation sites. J Clin Invest 97:613-620, 1996
    • (1996) J Clin Invest , vol.97 , pp. 613-620
    • Pillay, T.S.1    Xiao, S.2    Olefsky, J.M.3
  • 48
    • 0034617286 scopus 로고    scopus 로고
    • Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells
    • Nakajima K, Yamauchi K, Shigematsu S, Ikeo S, Komatsu M, Aizawa T, Hashizume K: Selective attenuation of metabolic branch of insulin receptor down-signaling by high glucose in a hepatoma cell line, HepG2 cells. J Biol Chem 275:20880-20886, 2000
    • (2000) J Biol Chem , vol.275 , pp. 20880-20886
    • Nakajima, K.1    Yamauchi, K.2    Shigematsu, S.3    Ikeo, S.4    Komatsu, M.5    Aizawa, T.6    Hashizume, K.7
  • 49
    • 0027309410 scopus 로고
    • Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus
    • Handberg A, Vaag A, Vinten J, Beck-Nielsen H: Decreased tyrosine kinase activity in partially purified insulin receptors from muscle of young, non-obese first degree relatives of patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia 36:668-674, 1993
    • (1993) Diabetologia , vol.36 , pp. 668-674
    • Handberg, A.1    Vaag, A.2    Vinten, J.3    Beck-Nielsen, H.4


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