-
1
-
-
0031616132
-
The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
-
White M.F. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog. Horm. Res. 53:1998;119-138.
-
(1998)
Recent Prog. Horm. Res.
, vol.53
, pp. 119-138
-
-
White, M.F.1
-
2
-
-
0025813375
-
Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein
-
Sun X.J., Rothenberg P., Kahn C.R., Backer J.M., Araki E., Wilden P.A., Cahill D.A., Goldstein B.J., White M.F. Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein. Nature. 352:1991;73-77.
-
(1991)
Nature
, vol.352
, pp. 73-77
-
-
Sun, X.J.1
Rothenberg, P.2
Kahn, C.R.3
Backer, J.M.4
Araki, E.5
Wilden, P.A.6
Cahill, D.A.7
Goldstein, B.J.8
White, M.F.9
-
3
-
-
0033214461
-
Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulated IRS-1 function
-
Paz K., Liu Y.-F., Shorer H., Hemi R., LeRoith D., Quan M., Kanety H., Seger R., Zick Y. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulated IRS-1 function. J. Biol. Chem. 274:1999;28816-28822.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28816-28822
-
-
Paz, K.1
Liu, Y.-F.2
Shorer, H.3
Hemi, R.4
Leroith, D.5
Quan, M.6
Kanety, H.7
Seger, R.8
Zick, Y.9
-
4
-
-
0037018924
-
Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation
-
Greene M.W., Garofalo R.S. Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation. Biochemisty. 41:2002;7082-7091.
-
(2002)
Biochemisty
, vol.41
, pp. 7082-7091
-
-
Greene, M.W.1
Garofalo, R.S.2
-
5
-
-
0030669392
-
A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
-
Paz K., Hemi R., LeRoith D., Karasik A., Elhanany E., Kanety H., Zick Y. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J. Biol. Chem. 272:1997;29911-29918.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 29911-29918
-
-
Paz, K.1
Hemi, R.2
Leroith, D.3
Karasik, A.4
Elhanany, E.5
Kanety, H.6
Zick, Y.7
-
6
-
-
0028023002
-
Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase
-
Tanti J.-F., Gremeaux T., Van Obberghen E., Marchand-Brustel Y.L. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. J. Biol. Chem. 269:1994;6051-6057.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 6051-6057
-
-
Tanti, J.-F.1
Gremeaux, T.2
Van Obberghen, E.3
Marchand-Brustel, Y.L.4
-
7
-
-
0034708832
-
The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307)
-
Aguire V., Uchida T., Yenush L., Davis R., White M.F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307). J. Biol. Chem. 275:2000;9047-9054.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 9047-9054
-
-
Aguire, V.1
Uchida, T.2
Yenush, L.3
Davis, R.4
White, M.F.5
-
8
-
-
0037059330
-
Phosphorylation of ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
-
Aguire V., Werner E.D., Giraud J., Lee Y.H., Shoelson S.E., White M.F. Phosphorylation of ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277:2002;1531-1537.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 1531-1537
-
-
Aguire, V.1
Werner, E.D.2
Giraud, J.3
Lee, Y.H.4
Shoelson, S.E.5
White, M.F.6
-
9
-
-
0037424466
-
Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation
-
Greene M.W., Sakaue H., Wang L., Alessi D.R., Roth R.A. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation. J. Biol. Chem. 278:2003;8199-8211.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 8199-8211
-
-
Greene, M.W.1
Sakaue, H.2
Wang, L.3
Alessi, D.R.4
Roth, R.A.5
-
10
-
-
0038712570
-
Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes
-
Gual P., Gonzalez T., Gremeaux T., Barres T., Le Marchand-Brustel Y., Tanti J.F. Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes. J. Biol. Chem. 278:2003;26550- 26557.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 26550-26557
-
-
Gual, P.1
Gonzalez, T.2
Gremeaux, T.3
Barres, T.4
Le Marchand-Brustel, Y.5
Tanti, J.F.6
-
11
-
-
0035144307
-
Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory ser307 via distinct pathways
-
Rui L., Agguire V., Kim J.K., Shulman G.I., Lee A., Corbould A., Dunaif A., White M.F. Insulin/IGF-1 and TNF-α stimulate phosphorylation of IRS-1 at inhibitory ser307 via distinct pathways. J. Clin. Invest. 107:2001;181-189.
-
(2001)
J. Clin. Invest.
, vol.107
, pp. 181-189
-
-
Rui, L.1
Agguire, V.2
Kim, J.K.3
Shulman, G.I.4
Lee, A.5
Corbould, A.6
Dunaif, A.7
White, M.F.8
-
12
-
-
0037184925
-
Mechanism by which fatty acid inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
-
Yu C., Chen Y., Zong H., Wang Y., Bergeron R., Kim J.K., Cline G.W., Cushman S.W., Clooney G.J., Atcheson B., White M.F., Kraegan E.W., Shulman G.I. Mechanism by which fatty acid inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277:2002;50230-50236.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 50230-50236
-
-
Yu, C.1
Chen, Y.2
Zong, H.3
Wang, Y.4
Bergeron, R.5
Kim, J.K.6
Cline, G.W.7
Cushman, S.W.8
Clooney, G.J.9
Atcheson, B.10
White, M.F.11
Kraegan, E.W.12
Shulman, G.I.13
-
13
-
-
0042591261
-
Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
-
Gao Z., Zuberi A., Quon M.J., Dong Z., Ye J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J. Biol. Chem. 278:2003;24944-24950.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 24944-24950
-
-
Gao, Z.1
Zuberi, A.2
Quon, M.J.3
Dong, Z.4
Ye, J.5
-
14
-
-
0037414811
-
Salicylic acid reverses phorbol 12-myristate- 13-acetate (PMA)- and tumor necrosis factor alpha (TNFα)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance inhuman embryonic kidney 293 (HEK293) cells
-
Jiang G., Dallas-Yang Q., Liu F., Moller D.E., Zhang B.B. Salicylic acid reverses phorbol 12-myristate- 13-acetate (PMA)- and tumor necrosis factor alpha (TNFα)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance inhuman embryonic kidney 293 (HEK293) cells. J. Biol. Chem. 278:2003;180-186.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 180-186
-
-
Jiang, G.1
Dallas-Yang, Q.2
Liu, F.3
Moller, D.E.4
Zhang, B.B.5
-
15
-
-
0000085132
-
Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway
-
Sun X.J., Goldberg J.L., Qiao L.-Y., Mitchell J.J. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes. 48:1999;1359-1364.
-
(1999)
Diabetes
, vol.48
, pp. 1359-1364
-
-
Sun, X.J.1
Goldberg, J.L.2
Qiao, L.-Y.3
Mitchell, J.J.4
-
16
-
-
0035155272
-
Serine/threonine phosphorylation of IRS-1 triggers its degradation: Possible regulation by tyrosine phosphorylation
-
Pederson T.M., Kramer D.L., Rondinone C.M. Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation. Diabetes. 50:2001;24-31.
-
(2001)
Diabetes
, vol.50
, pp. 24-31
-
-
Pederson, T.M.1
Kramer, D.L.2
Rondinone, C.M.3
-
17
-
-
0036298262
-
Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
-
Berg C.E., Lavan B.E., Rondinone C.M. Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. Biochem. Biophys. Res. Commun. 293:2002;1021-1027.
-
(2002)
Biochem. Biophys. Res. Commun.
, vol.293
, pp. 1021-1027
-
-
Berg, C.E.1
Lavan, B.E.2
Rondinone, C.M.3
-
18
-
-
0344686538
-
MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612, and 632
-
Gual P., Gremeaux T., Gonzalez T., Le Marchand-Brustel Y., Tanti J.-F. MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612, and 632. Diabetologia. 46:2003;1532-1542.
-
(2003)
Diabetologia
, vol.46
, pp. 1532-1542
-
-
Gual, P.1
Gremeaux, T.2
Gonzalez, T.3
Le Marchand-Brustel, Y.4
Tanti, J.-F.5
-
19
-
-
0034618364
-
Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
-
Pham P.-T.T., Heydrick S.J., Fox H.L., Kimball S.R., Jefferson L.S. Jr., Lynch C.J. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J. Cell. Biochem. 79:2000;427-441.
-
(2000)
J. Cell. Biochem.
, vol.79
, pp. 427-441
-
-
Pham, P.-T.T.1
Heydrick, S.J.2
Fox, H.L.3
Kimball, S.R.4
Jefferson, L.S.Jr.5
Lynch, C.J.6
-
20
-
-
0028850290
-
Insulin regulation of membrane-associated insulin receptor substrate 1
-
Heller-Harrison R.A., Morin M., Czech M.P. Insulin regulation of membrane-associated insulin receptor substrate 1. J. Biol. Chem. 270:1995;24442-24450.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 24442-24450
-
-
Heller-Harrison, R.A.1
Morin, M.2
Czech, M.P.3
-
21
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1
-
Burnett P.E., Barrow R.K., Cohen N.A., Snyder S.H., Sabatini D.M. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1. Proc. Natl. Acad. Sci. USA. 95:1998;1432-1437.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
22
-
-
0032560521
-
Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
-
Scott P.H., Brunn G.J., Kohn A.D., Roth R.A., Lawrence J.C. Jr. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA. 95:1998;7772-7777.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 7772-7777
-
-
Scott, P.H.1
Brunn, G.J.2
Kohn, A.D.3
Roth, R.A.4
Lawrence, J.C.Jr.5
-
23
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase b: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave B.T., Ouwens D.M., Withers D.J., Alessi D.R., Shepherd P.R. Mammalian target of rapamycin is a direct target for protein kinase b: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 344:1999;427-431.
-
(1999)
Biochem. J.
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, D.M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
24
-
-
0033551234
-
Protein phosphatase 2A interacts with the 70-kDa s6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein
-
Peterson R.T., Desai B.N., Hardwick J.S., Schreiber S.L. Protein phosphatase 2A interacts with the 70-kDa s6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein. Proc. Natl. Acad. Sci. USA. 96:1999;4438-4442.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 4438-4442
-
-
Peterson, R.T.1
Desai, B.N.2
Hardwick, J.S.3
Schreiber, S.L.4
-
25
-
-
0034635408
-
Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance
-
Clark S.F., Molero J.-C., James D.E. Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. J. Biol. Chem. 275:2000;3819-3826.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3819-3826
-
-
Clark, S.F.1
Molero, J.-C.2
James, D.E.3
-
26
-
-
0034947869
-
Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
-
Takano A., Usui I., Haruta T., Kawahara J., Uno T., Iwata M., Kobayashi M. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol. Cell. Biol. 21:2001;5050-5062.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 5050-5062
-
-
Takano, A.1
Usui, I.2
Haruta, T.3
Kawahara, J.4
Uno, T.5
Iwata, M.6
Kobayashi, M.7
-
27
-
-
0036837863
-
The rapamycin binding domain governs substrate selectivity by the mammalian target of rapamycin
-
McMahon L.P., Choi K.M., Lin T.-A., Abraham R.T., Lawrence J.C. Jr. The rapamycin binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol. Cell. Biol. 22:2002;7428-7438.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 7428-7438
-
-
McMahon, L.P.1
Choi, K.M.2
Lin, T.-A.3
Abraham, R.T.4
Lawrence, J.C.Jr.5
-
28
-
-
0032928614
-
Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
-
Widman C., Gibson S., Jarpe M.B., Johnson G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Phyiol. Rev. 79:1999;143-180.
-
(1999)
Phyiol. Rev.
, vol.79
, pp. 143-180
-
-
Widman, C.1
Gibson, S.2
Jarpe, M.B.3
Johnson, G.L.4
-
29
-
-
0037073679
-
Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex
-
Gao Z., Hwang D., Bataille F., Lefevre M., York D., Quon M.J., Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex. J. Biol. Chem. 277:2002;48115-48121.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 48115-48121
-
-
Gao, Z.1
Hwang, D.2
Bataille, F.3
Lefevre, M.4
York, D.5
Quon, M.J.6
Ye, J.7
-
30
-
-
0037474274
-
C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
-
Lee Y.H., Giraud J., Davis R.J., White M.F. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278:2003;2896-2902.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2896-2902
-
-
Lee, Y.H.1
Giraud, J.2
Davis, R.J.3
White, M.F.4
-
31
-
-
0035836770
-
A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
-
Ozes O.N., Akca H., Mayo L.D., Gustin J.A., Maehama T., Dixon J.E., Donner D.B. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl. Acad. Sci. USA. 98:2001;4640-4645.
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 4640-4645
-
-
Ozes, O.N.1
Akca, H.2
Mayo, L.D.3
Gustin, J.A.4
Maehama, T.5
Dixon, J.E.6
Donner, D.B.7
-
32
-
-
0036213626
-
Role of mTOR in the degradation of IRS-1: Regulation of PP2A activity
-
Hartley D., Cooper G.M. Role of mTOR in the degradation of IRS-1: regulation of PP2A activity. J. Cell. Biochem. 85:2002;304-314.
-
(2002)
J. Cell. Biochem.
, vol.85
, pp. 304-314
-
-
Hartley, D.1
Cooper, G.M.2
-
33
-
-
0036154215
-
Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
-
Resjo S., Goransson O., Harndahl L., Zolnierowics S., Manganiello V., Degerman E. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell. Signal. 14:2002;231-238.
-
(2002)
Cell. Signal.
, vol.14
, pp. 231-238
-
-
Resjo, S.1
Goransson, O.2
Harndahl, L.3
Zolnierowics, S.4
Manganiello, V.5
Degerman, E.6
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