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Volumn 316, Issue 2, 2004, Pages 533-539

Mammalian target of rapamycin regulates IRS-1 serine 307 phosphorylation

Author keywords

3T3 L1 adipocytes; c Jun NH2 terminal kinase; Cellular localization; Insulin; Okadaic acid; PP2A; Signal transduction

Indexed keywords

AMINO ACID; ANISOMYCIN; ENZYME INHIBITOR; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; OKADAIC ACID; PHOSPHATASE; PROTEIN KINASE B; RAPAMYCIN; SERINE; STRESS ACTIVATED PROTEIN KINASE; TARGET OF RAPAMYCIN KINASE; TUMOR NECROSIS FACTOR ALPHA;

EID: 1542616960     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.02.082     Document Type: Article
Times cited : (124)

References (33)
  • 1
    • 0031616132 scopus 로고    scopus 로고
    • The IRS-signaling system: A network of docking proteins that mediate insulin and cytokine action
    • White M.F. The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action. Recent Prog. Horm. Res. 53:1998;119-138.
    • (1998) Recent Prog. Horm. Res. , vol.53 , pp. 119-138
    • White, M.F.1
  • 3
    • 0033214461 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulated IRS-1 function
    • Paz K., Liu Y.-F., Shorer H., Hemi R., LeRoith D., Quan M., Kanety H., Seger R., Zick Y. Phosphorylation of insulin receptor substrate-1 (IRS-1) by protein kinase B positively regulated IRS-1 function. J. Biol. Chem. 274:1999;28816-28822.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28816-28822
    • Paz, K.1    Liu, Y.-F.2    Shorer, H.3    Hemi, R.4    Leroith, D.5    Quan, M.6    Kanety, H.7    Seger, R.8    Zick, Y.9
  • 4
    • 0037018924 scopus 로고    scopus 로고
    • Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation
    • Greene M.W., Garofalo R.S. Positive and negative regulatory role of insulin receptor substrate 1 and 2 (IRS-1 and IRS-2) serine/threonine phosphorylation. Biochemisty. 41:2002;7082-7091.
    • (2002) Biochemisty , vol.41 , pp. 7082-7091
    • Greene, M.W.1    Garofalo, R.S.2
  • 5
    • 0030669392 scopus 로고    scopus 로고
    • A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
    • Paz K., Hemi R., LeRoith D., Karasik A., Elhanany E., Kanety H., Zick Y. A molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation. J. Biol. Chem. 272:1997;29911-29918.
    • (1997) J. Biol. Chem. , vol.272 , pp. 29911-29918
    • Paz, K.1    Hemi, R.2    Leroith, D.3    Karasik, A.4    Elhanany, E.5    Kanety, H.6    Zick, Y.7
  • 6
    • 0028023002 scopus 로고
    • Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase
    • Tanti J.-F., Gremeaux T., Van Obberghen E., Marchand-Brustel Y.L. Insulin receptor substrate 1 is phosphorylated by the serine kinase activity of phosphatidylinositol 3-kinase. J. Biol. Chem. 269:1994;6051-6057.
    • (1994) J. Biol. Chem. , vol.269 , pp. 6051-6057
    • Tanti, J.-F.1    Gremeaux, T.2    Van Obberghen, E.3    Marchand-Brustel, Y.L.4
  • 7
    • 0034708832 scopus 로고    scopus 로고
    • The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307)
    • Aguire V., Uchida T., Yenush L., Davis R., White M.F. The c-Jun NH(2)-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of ser(307). J. Biol. Chem. 275:2000;9047-9054.
    • (2000) J. Biol. Chem. , vol.275 , pp. 9047-9054
    • Aguire, V.1    Uchida, T.2    Yenush, L.3    Davis, R.4    White, M.F.5
  • 8
    • 0037059330 scopus 로고    scopus 로고
    • Phosphorylation of ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action
    • Aguire V., Werner E.D., Giraud J., Lee Y.H., Shoelson S.E., White M.F. Phosphorylation of ser307 in insulin receptor substrate-1 blocks interactions with the insulin receptor and inhibits insulin action. J. Biol. Chem. 277:2002;1531-1537.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1531-1537
    • Aguire, V.1    Werner, E.D.2    Giraud, J.3    Lee, Y.H.4    Shoelson, S.E.5    White, M.F.6
  • 9
    • 0037424466 scopus 로고    scopus 로고
    • Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation
    • Greene M.W., Sakaue H., Wang L., Alessi D.R., Roth R.A. Modulation of insulin-stimulated degradation of human insulin receptor substrate-1 by serine 312 phosphorylation. J. Biol. Chem. 278:2003;8199-8211.
    • (2003) J. Biol. Chem. , vol.278 , pp. 8199-8211
    • Greene, M.W.1    Sakaue, H.2    Wang, L.3    Alessi, D.R.4    Roth, R.A.5
  • 10
    • 0038712570 scopus 로고    scopus 로고
    • Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes
    • Gual P., Gonzalez T., Gremeaux T., Barres T., Le Marchand-Brustel Y., Tanti J.F. Hyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytes. J. Biol. Chem. 278:2003;26550- 26557.
    • (2003) J. Biol. Chem. , vol.278 , pp. 26550-26557
    • Gual, P.1    Gonzalez, T.2    Gremeaux, T.3    Barres, T.4    Le Marchand-Brustel, Y.5    Tanti, J.F.6
  • 13
    • 0042591261 scopus 로고    scopus 로고
    • Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
    • Gao Z., Zuberi A., Quon M.J., Dong Z., Ye J. Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases. J. Biol. Chem. 278:2003;24944-24950.
    • (2003) J. Biol. Chem. , vol.278 , pp. 24944-24950
    • Gao, Z.1    Zuberi, A.2    Quon, M.J.3    Dong, Z.4    Ye, J.5
  • 14
    • 0037414811 scopus 로고    scopus 로고
    • Salicylic acid reverses phorbol 12-myristate- 13-acetate (PMA)- and tumor necrosis factor alpha (TNFα)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance inhuman embryonic kidney 293 (HEK293) cells
    • Jiang G., Dallas-Yang Q., Liu F., Moller D.E., Zhang B.B. Salicylic acid reverses phorbol 12-myristate- 13-acetate (PMA)- and tumor necrosis factor alpha (TNFα)-induced insulin receptor substrate 1 (IRS1) serine 307 phosphorylation and insulin resistance inhuman embryonic kidney 293 (HEK293) cells. J. Biol. Chem. 278:2003;180-186.
    • (2003) J. Biol. Chem. , vol.278 , pp. 180-186
    • Jiang, G.1    Dallas-Yang, Q.2    Liu, F.3    Moller, D.E.4    Zhang, B.B.5
  • 15
    • 0000085132 scopus 로고    scopus 로고
    • Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway
    • Sun X.J., Goldberg J.L., Qiao L.-Y., Mitchell J.J. Insulin-induced insulin receptor substrate-1 degradation is mediated by the proteasome degradation pathway. Diabetes. 48:1999;1359-1364.
    • (1999) Diabetes , vol.48 , pp. 1359-1364
    • Sun, X.J.1    Goldberg, J.L.2    Qiao, L.-Y.3    Mitchell, J.J.4
  • 16
    • 0035155272 scopus 로고    scopus 로고
    • Serine/threonine phosphorylation of IRS-1 triggers its degradation: Possible regulation by tyrosine phosphorylation
    • Pederson T.M., Kramer D.L., Rondinone C.M. Serine/threonine phosphorylation of IRS-1 triggers its degradation: possible regulation by tyrosine phosphorylation. Diabetes. 50:2001;24-31.
    • (2001) Diabetes , vol.50 , pp. 24-31
    • Pederson, T.M.1    Kramer, D.L.2    Rondinone, C.M.3
  • 17
    • 0036298262 scopus 로고    scopus 로고
    • Rapamycin partially prevents insulin resistance induced by chronic insulin treatment
    • Berg C.E., Lavan B.E., Rondinone C.M. Rapamycin partially prevents insulin resistance induced by chronic insulin treatment. Biochem. Biophys. Res. Commun. 293:2002;1021-1027.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 1021-1027
    • Berg, C.E.1    Lavan, B.E.2    Rondinone, C.M.3
  • 18
    • 0344686538 scopus 로고    scopus 로고
    • MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612, and 632
    • Gual P., Gremeaux T., Gonzalez T., Le Marchand-Brustel Y., Tanti J.-F. MAP kinases and mTOR mediate insulin-induced phosphorylation of insulin receptor substrate-1 on serine residues 307, 612, and 632. Diabetologia. 46:2003;1532-1542.
    • (2003) Diabetologia , vol.46 , pp. 1532-1542
    • Gual, P.1    Gremeaux, T.2    Gonzalez, T.3    Le Marchand-Brustel, Y.4    Tanti, J.-F.5
  • 19
    • 0034618364 scopus 로고    scopus 로고
    • Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    • Pham P.-T.T., Heydrick S.J., Fox H.L., Kimball S.R., Jefferson L.S. Jr., Lynch C.J. Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes. J. Cell. Biochem. 79:2000;427-441.
    • (2000) J. Cell. Biochem. , vol.79 , pp. 427-441
    • Pham, P.-T.T.1    Heydrick, S.J.2    Fox, H.L.3    Kimball, S.R.4    Jefferson, L.S.Jr.5    Lynch, C.J.6
  • 20
    • 0028850290 scopus 로고
    • Insulin regulation of membrane-associated insulin receptor substrate 1
    • Heller-Harrison R.A., Morin M., Czech M.P. Insulin regulation of membrane-associated insulin receptor substrate 1. J. Biol. Chem. 270:1995;24442-24450.
    • (1995) J. Biol. Chem. , vol.270 , pp. 24442-24450
    • Heller-Harrison, R.A.1    Morin, M.2    Czech, M.P.3
  • 22
    • 0032560521 scopus 로고    scopus 로고
    • Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway
    • Scott P.H., Brunn G.J., Kohn A.D., Roth R.A., Lawrence J.C. Jr. Evidence of insulin-stimulated phosphorylation and activation of the mammalian target of rapamycin mediated by a protein kinase B signaling pathway. Proc. Natl. Acad. Sci. USA. 95:1998;7772-7777.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7772-7777
    • Scott, P.H.1    Brunn, G.J.2    Kohn, A.D.3    Roth, R.A.4    Lawrence, J.C.Jr.5
  • 23
    • 0033429554 scopus 로고    scopus 로고
    • Mammalian target of rapamycin is a direct target for protein kinase b: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
    • Nave B.T., Ouwens D.M., Withers D.J., Alessi D.R., Shepherd P.R. Mammalian target of rapamycin is a direct target for protein kinase b: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem. J. 344:1999;427-431.
    • (1999) Biochem. J. , vol.344 , pp. 427-431
    • Nave, B.T.1    Ouwens, D.M.2    Withers, D.J.3    Alessi, D.R.4    Shepherd, P.R.5
  • 24
    • 0033551234 scopus 로고    scopus 로고
    • Protein phosphatase 2A interacts with the 70-kDa s6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein
    • Peterson R.T., Desai B.N., Hardwick J.S., Schreiber S.L. Protein phosphatase 2A interacts with the 70-kDa s6 kinase and is activated by inhibition of FKBP12-rapamycin associated protein. Proc. Natl. Acad. Sci. USA. 96:1999;4438-4442.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 4438-4442
    • Peterson, R.T.1    Desai, B.N.2    Hardwick, J.S.3    Schreiber, S.L.4
  • 25
    • 0034635408 scopus 로고    scopus 로고
    • Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance
    • Clark S.F., Molero J.-C., James D.E. Release of insulin receptor substrate proteins from an intracellular complex coincides with the development of insulin resistance. J. Biol. Chem. 275:2000;3819-3826.
    • (2000) J. Biol. Chem. , vol.275 , pp. 3819-3826
    • Clark, S.F.1    Molero, J.-C.2    James, D.E.3
  • 26
    • 0034947869 scopus 로고    scopus 로고
    • Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin
    • Takano A., Usui I., Haruta T., Kawahara J., Uno T., Iwata M., Kobayashi M. Mammalian target of rapamycin pathway regulates insulin signaling via subcellular redistribution of insulin receptor substrate 1 and integrates nutritional signals and metabolic signals of insulin. Mol. Cell. Biol. 21:2001;5050-5062.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 5050-5062
    • Takano, A.1    Usui, I.2    Haruta, T.3    Kawahara, J.4    Uno, T.5    Iwata, M.6    Kobayashi, M.7
  • 27
    • 0036837863 scopus 로고    scopus 로고
    • The rapamycin binding domain governs substrate selectivity by the mammalian target of rapamycin
    • McMahon L.P., Choi K.M., Lin T.-A., Abraham R.T., Lawrence J.C. Jr. The rapamycin binding domain governs substrate selectivity by the mammalian target of rapamycin. Mol. Cell. Biol. 22:2002;7428-7438.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 7428-7438
    • McMahon, L.P.1    Choi, K.M.2    Lin, T.-A.3    Abraham, R.T.4    Lawrence, J.C.Jr.5
  • 28
    • 0032928614 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase: Conservation of a three-kinase module from yeast to human
    • Widman C., Gibson S., Jarpe M.B., Johnson G.L. Mitogen-activated protein kinase: conservation of a three-kinase module from yeast to human. Phyiol. Rev. 79:1999;143-180.
    • (1999) Phyiol. Rev. , vol.79 , pp. 143-180
    • Widman, C.1    Gibson, S.2    Jarpe, M.B.3    Johnson, G.L.4
  • 29
    • 0037073679 scopus 로고    scopus 로고
    • Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex
    • Gao Z., Hwang D., Bataille F., Lefevre M., York D., Quon M.J., Ye J. Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa b kinase complex. J. Biol. Chem. 277:2002;48115-48121.
    • (2002) J. Biol. Chem. , vol.277 , pp. 48115-48121
    • Gao, Z.1    Hwang, D.2    Bataille, F.3    Lefevre, M.4    York, D.5    Quon, M.J.6    Ye, J.7
  • 30
    • 0037474274 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade
    • Lee Y.H., Giraud J., Davis R.J., White M.F. c-Jun N-terminal kinase (JNK) mediates feedback inhibition of the insulin signaling cascade. J. Biol. Chem. 278:2003;2896-2902.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2896-2902
    • Lee, Y.H.1    Giraud, J.2    Davis, R.J.3    White, M.F.4
  • 31
    • 0035836770 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1
    • Ozes O.N., Akca H., Mayo L.D., Gustin J.A., Maehama T., Dixon J.E., Donner D.B. A phosphatidylinositol 3-kinase/Akt/mTOR pathway mediates and PTEN antagonizes tumor necrosis factor inhibition of insulin signaling through insulin receptor substrate-1. Proc. Natl. Acad. Sci. USA. 98:2001;4640-4645.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4640-4645
    • Ozes, O.N.1    Akca, H.2    Mayo, L.D.3    Gustin, J.A.4    Maehama, T.5    Dixon, J.E.6    Donner, D.B.7
  • 32
    • 0036213626 scopus 로고    scopus 로고
    • Role of mTOR in the degradation of IRS-1: Regulation of PP2A activity
    • Hartley D., Cooper G.M. Role of mTOR in the degradation of IRS-1: regulation of PP2A activity. J. Cell. Biochem. 85:2002;304-314.
    • (2002) J. Cell. Biochem. , vol.85 , pp. 304-314
    • Hartley, D.1    Cooper, G.M.2
  • 33
    • 0036154215 scopus 로고    scopus 로고
    • Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes
    • Resjo S., Goransson O., Harndahl L., Zolnierowics S., Manganiello V., Degerman E. Protein phosphatase 2A is the main phosphatase involved in the regulation of protein kinase B in rat adipocytes. Cell. Signal. 14:2002;231-238.
    • (2002) Cell. Signal. , vol.14 , pp. 231-238
    • Resjo, S.1    Goransson, O.2    Harndahl, L.3    Zolnierowics, S.4    Manganiello, V.5    Degerman, E.6


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