Angiotensin II impairs the insulin signaling pathway promoting production of nitric oxide by inducing phosphorylation of insulin receptor substrate-1 on Ser12 and Ser616 in human umbilical vein endothelial cells

Circulation Research

Volumn 94, Issue 9, 2004, Pages 1211-1218

  Andreozzi, Francesco ^a   Laratta, Emanuela ^a   Sciacqua, Angela ^a   Perticone, Francesco ^a,b   Sesti, Giorgio ^a  

^a UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^b Dipto di Medicina Sperimentale   (Italy)

Author keywords

Angiotensin II; Endothelium; Insulin; Nitric oxide

Indexed keywords

ANGIOTENSIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LOSARTAN; MITOGEN ACTIVATED PROTEIN KINASE 1; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN P85; PROTEIN SUBUNIT; SERINE DERIVATIVE; STRESS ACTIVATED PROTEIN KINASE; TYROSINE;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVATION; ENZYME ACTIVITY; HORMONE ACTION; HUMAN; HUMAN CELL; HYPOTHESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; UMBILICAL VEIN; VASODILATATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANGIOTENSIN II; CELLS, CULTURED; CODON; CULTURE MEDIA, SERUM-FREE; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; GLUCOSE; HUMANS; INSULIN; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LOSARTAN; MAP KINASE KINASE 4; MAP KINASE SIGNALING SYSTEM; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, BIOLOGICAL; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE III; PHOSPHOPROTEINS; PHOSPHORYLATION; PHOSPHOSERINE; PHOSPHOTYROSINE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, ANGIOTENSIN, TYPE 1; SIGNAL TRANSDUCTION; UMBILICAL VEINS;

EID: 2442691522     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000126501.34994.96     Document Type: Article

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