In Vitro Phosphorylation of Insulin Receptor Substrate 1 by Protein Kinase C-ζ: Functional Analysis and Identification of Novel Phosphorylation Sites

Biochemistry

Volumn 43, Issue 19, 2004, Pages 5888-5901

  Sommerfeld, Mark R ^a   Metzger, Sabine ^b   Stosik, Magdalene ^a   Tennagels, Norbert ^c   Eckel, Jürgen ^a  

^a LEIBNIZ CENTER FOR DIABETES RESEARCH AT HEINRICH HEINE UNIVERSITY DÜSSELDORF   (Germany)

^b HEINRICH HEINE UNIVERSITY   (Germany)

^c SANOFI AVENTIS DEUTSCHLAND GMBH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL MODIFICATION; ENZYME INHIBITION; ENZYMES; FEEDBACK CONTROL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INSULIN; MASS SPECTROMETRY; SURFACE PLASMON RESONANCE;

INSULIN RECEPTOR SUBSTRATES; ISOFORMS; PHOSPHORYLATION;

BIOCHEMISTRY;

ANTISERUM; INSULIN; INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; PEPTIDE FRAGMENT; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHOPEPTIDE; PROTEIN KINASE C ZETA; PROTEIN P85ALPHA; PROTEIN SUBUNIT; RECOMBINANT PROTEIN; TYROSINE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; ENZYME MECHANISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOBLOTTING; IN VITRO STUDY; MASS SPECTROMETRY; MUTANT; NEGATIVE FEEDBACK; PEPTIDE MAPPING; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SURFACE PLASMON RESONANCE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; AMINO ACID SEQUENCE; ANIMALS; HUMANS; INSULIN; INSULIN ANTAGONISTS; ISOENZYMES; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN STRUCTURE, TERTIARY; PROTEIN SUBUNITS; RATS; RECEPTOR, INSULIN; SERINE; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY; TYROSINE;

EID: 2442544855     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049640v     Document Type: Article

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