메뉴 건너뛰기




Volumn 6, Issue 8, 2000, Pages 924-928

Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GLUCOSE TRANSPORTER; INSULIN; INSULIN RECEPTOR;

EID: 0033834248     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/78693     Document Type: Article
Times cited : (608)

References (25)
  • 1
    • 0030818166 scopus 로고    scopus 로고
    • Diabetes in midlife: Planting genetic time bombs
    • O'Rahilly, S. Diabetes in midlife: planting genetic time bombs. Nature Med. 3, 1080-1081 (1997).
    • (1997) Nature Med. , vol.3 , pp. 1080-1081
    • O'Rahilly, S.1
  • 3
    • 0030724591 scopus 로고    scopus 로고
    • Pathogenesis of type 2 diabetes: Metabolic and molecular implications for identifying diabetes genes
    • DeFronzo, R.A. Pathogenesis of type 2 diabetes: metabolic and molecular implications for identifying diabetes genes. Diabetes Rev. 5, 177-269 (1997).
    • (1997) Diabetes Rev. , vol.5 , pp. 177-269
    • DeFronzo, R.A.1
  • 4
    • 0033595120 scopus 로고    scopus 로고
    • Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes
    • Cline, G.W. et al. Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetes. N. Engl. J. Med. 341, 240-246 (1999).
    • (1999) N. Engl. J. Med. , vol.341 , pp. 240-246
    • Cline, G.W.1
  • 5
    • 0025355977 scopus 로고
    • Molecular biology of mammalian glucose transporters
    • Bell, G.I. et al. Molecular biology of mammalian glucose transporters. Diabetes Care 13, 198-208 (1990).
    • (1990) Diabetes Care , vol.13 , pp. 198-208
    • Bell, G.I.1
  • 6
    • 0030839435 scopus 로고    scopus 로고
    • GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes
    • Stenbit, A.E. et al. GLUT4 heterozygous knockout mice develop muscle insulin resistance and diabetes. Nature Med. 3, 1096-1101 (1997).
    • (1997) Nature Med. , vol.3 , pp. 1096-1101
    • Stenbit, A.E.1
  • 7
    • 0029148426 scopus 로고
    • Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
    • Katz, E.B., Stenbit, A.E., Hatton, K., DePinho, R. & Charron, M.J. Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4. Nature 377, 151-155 (1995).
    • (1995) Nature , vol.377 , pp. 151-155
    • Katz, E.B.1    Stenbit, A.E.2    Hatton, K.3    DePinho, R.4    Charron, M.J.5
  • 8
    • 0032214652 scopus 로고    scopus 로고
    • A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bruning, J.C. et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 2, 559-569 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1
  • 9
    • 0033393822 scopus 로고    scopus 로고
    • Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart
    • Abel, E.D. et al. Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart. J. Clin. Invest. 104, 1703-1714 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1703-1714
    • Abel, E.D.1
  • 10
    • 0025036574 scopus 로고
    • Facilitated diffusion of glucose
    • Carruthers, A. Facilitated diffusion of glucose. Physiol. Rev. 70, 1135-1176 (1990).
    • (1990) Physiol. Rev. , vol.70 , pp. 1135-1176
    • Carruthers, A.1
  • 11
    • 0025086964 scopus 로고
    • Cell surface labeling of glucose transporter isoform GLUT4 by bis- mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester
    • Holman, G.D. et al. Cell surface labeling of glucose transporter isoform GLUT4 by bis- mannose photolabel. Correlation with stimulation of glucose transport in rat adipose cells by insulin and phorbol ester. J. Biol. Chem 265, 18172-18179 (1990).
    • (1990) J. Biol. Chem , vol.265 , pp. 18172-18179
    • Holman, G.D.1
  • 12
    • 0031978984 scopus 로고    scopus 로고
    • Exercise, glucose transport, and insulin sensitivity
    • Goodyear, L.J. & Kahn, B.B. Exercise, glucose transport, and insulin sensitivity. Annu. Rev. Med. 49, 235-261 (1998).
    • (1998) Annu. Rev. Med. , vol.49 , pp. 235-261
    • Goodyear, L.J.1    Kahn, B.B.2
  • 13
    • 0021289044 scopus 로고
    • A [3H]2-deoxyglucose method for comparing rates of glucose metabolism and insulin responses among rat tissues in vivo. Validation of the model and the absence of an insulin effect on brain
    • Hom, F.C., Goodner, C.J. & Berrie, M.A. A [3H]2-deoxyglucose method for comparing rates of glucose metabolism and insulin responses among rat tissues in vivo. Validation of the model and the absence of an insulin effect on brain. Diabetes 33, 141-152 (1984).
    • (1984) Diabetes , vol.33 , pp. 141-152
    • Hom, F.C.1    Goodner, C.J.2    Berrie, M.A.3
  • 14
    • 0030611575 scopus 로고    scopus 로고
    • Incorporation of [3-3H]glucose and 2-[1-14C]deoxyglucose into glycogen in heart and skeletal muscle in vivo: Implications for the quantitation of tissue glucose up-take
    • Virkamaki, A., Rissanen, E., Hamalainen, S., Utriainen, T. & Yki-Jarvinen, H. Incorporation of [3-3H]glucose and 2-[1-14C]deoxyglucose into glycogen in heart and skeletal muscle in vivo: implications for the quantitation of tissue glucose up-take. Diabetes 46, 1106-1110 (1997).
    • (1997) Diabetes , vol.46 , pp. 1106-1110
    • Virkamaki, A.1    Rissanen, E.2    Hamalainen, S.3    Utriainen, T.4    Yki-Jarvinen, H.5
  • 15
    • 0021875841 scopus 로고
    • Incorporation of glucose into glycogen in primary cultures of rat hepatocytes
    • Parniak, M. & Kalant, N. Incorporation of glucose into glycogen in primary cultures of rat hepatocytes. Can. J. Biochem. Cell Biol. 63, 333-340 (1985).
    • (1985) Can. J. Biochem. Cell Biol. , vol.63 , pp. 333-340
    • Parniak, M.1    Kalant, N.2
  • 16
    • 0032697037 scopus 로고    scopus 로고
    • Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice
    • Wojtaszewski, J.F. et al. Exercise modulates postreceptor insulin signaling and glucose transport in muscle-specific insulin receptor knockout mice. J. Clin. Invest. 104, 1257-1264 (1999).
    • (1999) J. Clin. Invest. , vol.104 , pp. 1257-1264
    • Wojtaszewski, J.F.1
  • 17
    • 0025297082 scopus 로고
    • Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs
    • Trask, R.V. & Billadello, J.J. Tissue-specific distribution and developmental regulation of M and B creatine kinase mRNAs. Biochim. Biophys. Acta 1049, 182-188 (1990).
    • (1990) Biochim. Biophys. Acta , vol.1049 , pp. 182-188
    • Trask, R.V.1    Billadello, J.J.2
  • 18
    • 1842419225 scopus 로고
    • A glucose transport protein expressed predominately in insulin-responsive tissues
    • Charron, M.J., Brosius, F.C.d., Alper, S.L. & Lodish, H.F. A glucose transport protein expressed predominately in insulin-responsive tissues. Proc. Natl. Acad. Sci. USA 86, 2535-2539 (1989).
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 2535-2539
    • Charron, M.J.1    Brosius, F.C.D.2    Alper, S.L.3    Lodish, H.F.4
  • 19
    • 0026795125 scopus 로고
    • Insulin-responsive glucose transporter expression in renal microvessels and glomeruli
    • Brosius, F.C.d., Briggs, J.P., Marcus, R.G., Barac-Nieto, M. & Charron, M.J. Insulin-responsive glucose transporter expression in renal microvessels and glomeruli. Kidney Int. 42, 1086-1092 (1992).
    • (1992) Kidney Int. , vol.42 , pp. 1086-1092
    • Brosius, F.C.D.1    Briggs, J.P.2    Marcus, R.G.3    Barac-Nieto, M.4    Charron, M.J.5
  • 20
    • 0030012543 scopus 로고    scopus 로고
    • Discrete brain areas express the insulin-responsive glucose transporter GLUT4
    • Leloup, C. et al. Discrete brain areas express the insulin-responsive glucose transporter GLUT4. Brain Res. Mol. Brain Res. 38, 45-53 (1996).
    • (1996) Brain Res. Mol. Brain Res. , vol.38 , pp. 45-53
    • Leloup, C.1
  • 21
    • 0031057588 scopus 로고    scopus 로고
    • Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro
    • Young, M.E., Radda, G.K. & Leighton, B. Nitric oxide stimulates glucose transport and metabolism in rat skeletal muscle in vitro. Biochem. J. 322, 223-228 (1997).
    • (1997) Biochem. J. , vol.322 , pp. 223-228
    • Young, M.E.1    Radda, G.K.2    Leighton, B.3
  • 22
    • 15644372143 scopus 로고    scopus 로고
    • Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway
    • Etgen, G.J.Jr., Fryburg, D.A. & Gibbs, E.M. Nitric oxide stimulates skeletal muscle glucose transport through a calcium/contraction- and phosphatidylinositol-3-kinase-independent pathway. Diabetes 46, 1915-1919 (1997).
    • (1997) Diabetes , vol.46 , pp. 1915-1919
    • Etgen G.J., Jr.1    Fryburg, D.A.2    Gibbs, E.M.3
  • 23
    • 0033917321 scopus 로고    scopus 로고
    • Redistribution of substrates to adipose tissue in mice with selective insulin resistance in muscle promotes obesity
    • Kim, J.K. et al. Redistribution of substrates to adipose tissue in mice with selective insulin resistance in muscle promotes obesity. J. Clin Invest. 105, 1791-1797 (2000).
    • (2000) J. Clin Invest. , vol.105 , pp. 1791-1797
    • Kim, J.K.1
  • 24
    • 0029818934 scopus 로고    scopus 로고
    • Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: Expression, subcellular localization and tissue-specific regulation in insulin-resistant states
    • Frevert, E.U. & Kahn, B.B. Protein kinase C isoforms epsilon, eta, delta and zeta in murine adipocytes: expression, subcellular localization and tissue-specific regulation in insulin-resistant states. Biochem. J. 316, 865-871 (1996).
    • (1996) Biochem. J. , vol.316 , pp. 865-871
    • Frevert, E.U.1    Kahn, B.B.2
  • 25
    • 0031849916 scopus 로고    scopus 로고
    • Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport
    • Hayashi, T., Hirshman, M.F., Kurth, E.J., Winder, W.W. & Goodyear, L.J. Evidence for 5′ AMP-activated protein kinase mediation of the effect of muscle contraction on glucose transport. Diabetes 47, 1369-1373 (1998).
    • (1998) Diabetes , vol.47 , pp. 1369-1373
    • Hayashi, T.1    Hirshman, M.F.2    Kurth, E.J.3    Winder, W.W.4    Goodyear, L.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.