메뉴 건너뛰기




Volumn 17, Issue 7, 2011, Pages 2616-2643

Senescence; An endogenous anticancer mechanism

Author keywords

Cancer; Chemotherapy; DNA damage; Epigenetics; Evolution; Premature senescence; Replicative senescence; Review; Telomere erosion

Indexed keywords


EID: 84860273010     PISSN: 27686701     EISSN: 27686698     Source Type: Journal    
DOI: 10.2741/4074     Document Type: Article
Times cited : (27)

References (266)
  • 1
    • 0033539169 scopus 로고    scopus 로고
    • Microarray analysis of replicative senescence
    • DOI 10.1016/S0960-9822(99)80420-5
    • D N Shelton, E Chang, P S Whittier, D Choi, W D Funk: Microarray analysis of replicative senescence. Curr Biol 9, 939-945 (1999) (Pubitemid 29442477)
    • (1999) Current Biology , vol.9 , Issue.17 , pp. 939-945
    • Shelton, D.N.1    Chang, E.2    Whittier, P.S.3    Choi, D.4    Funk, W.D.5
  • 2
    • 0034788516 scopus 로고    scopus 로고
    • Senescence and cytoskeleton: Overproduction of vimentin induces senescent-like morphology in human fibroblasts
    • DOI 10.1007/s004180100325
    • K Nishio, A Inoue, S Qiao, H Kondo, A Mimura: Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts. Histochem Cell Biol 116, 321-327 (2001) (Pubitemid 32972326)
    • (2001) Histochemistry and Cell Biology , vol.116 , Issue.4 , pp. 321-327
    • Nishio, K.1    Inoue, A.2    Qiao, S.3    Kondo, H.4    Mimura, A.5
  • 3
    • 0033730616 scopus 로고    scopus 로고
    • Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells
    • D J Kurz, S Decary, Y Hong, J D Erusalimsky: Senescence-associated (beta)-galactosidase reflects an increase in lysosomal mass during replicative ageing of human endothelial cells. J Cell Sci 113, 3613-3622 (2000)
    • (2000) J Cell Sci , vol.113 , pp. 3613-3622
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Erusalimsky, J.D.4
  • 4
    • 33947236204 scopus 로고    scopus 로고
    • Molecular dissection of formation of senescence-associated heterochromatin foci
    • DOI 10.1128/MCB.02019-06
    • R Zhang, W Chen, P D Adams: Molecular dissection of formation of senescence-associated heterochromatin foci. Mol Cell Biol 27, 2343-2358 (2007) (Pubitemid 46418486)
    • (2007) Molecular and Cellular Biology , vol.27 , Issue.6 , pp. 2343-2358
    • Zhang, R.1    Chen, W.2    Adams, P.D.3
  • 5
    • 34147182401 scopus 로고    scopus 로고
    • Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging
    • DOI 10.1016/j.gene.2007.04.020, PII S0378111907001904
    • P D Adams: Remodeling of chromatin structure in senescent cells and its potential impact on tumor suppression and aging. Gene 397, 84-93 (2007) (Pubitemid 46992697)
    • (2007) Gene , vol.397 , Issue.1-2 , pp. 84-93
    • Adams, P.D.1
  • 6
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • LHayflick: The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 37, 614-36 (1965)
    • (1965) Exp Cell Res , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 7
    • 0035253719 scopus 로고    scopus 로고
    • Cellular senescence as a tumor-protection mechanism: The essential role of counting
    • DOI 10.1016/S0959-437X(00)00163-5
    • W E Wright, J W Shay: Cellular senescence as a tumorprotection mechanism: the essential role of counting. Curr Opin Genet Dev 11, 98-103 (2001) (Pubitemid 32119285)
    • (2001) Current Opinion in Genetics and Development , vol.11 , Issue.1 , pp. 98-103
    • Wright, W.E.1    Shay, J.W.2
  • 8
    • 19844382620 scopus 로고    scopus 로고
    • Senescence and immortalization: Role of telomeres and telomerase
    • DOI 10.1093/carcin/bgh296
    • J W Shay, W E Wright: Senescence and immortalization: role of telomeres and telomerase. Carcinogenesis 26, 867-874 (2005) (Pubitemid 41214314)
    • (2005) Carcinogenesis , vol.26 , Issue.5 , pp. 867-874
    • Shay, J.W.1    Wright, W.E.2
  • 9
    • 4143070586 scopus 로고    scopus 로고
    • Non-neutral role of replicative senescence in tissue homeostasis and tumorigenesis
    • DOI 10.1016/j.jtbi.2004.05.011, PII S0022519304002590
    • J F Poyatos, A Carnero: Non-neutral role of replicative senescence in tissue homeostasis and tumorigenesis. J Theor Biol 230, 333-341 (2004) (Pubitemid 39092336)
    • (2004) Journal of Theoretical Biology , vol.230 , Issue.3 , pp. 333-341
    • Poyatos, J.F.1    Carnero, A.2
  • 10
    • 0038049143 scopus 로고    scopus 로고
    • Cancer and ageing: Rival demons?
    • DOI 10.1038/nrc1073
    • J Campisi: Cancer and ageing: rival demons? Nat Rev Cancer 3, 339-349 (2003) (Pubitemid 37328854)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.5 , pp. 339-349
    • Campisi, J.1
  • 11
    • 45549101782 scopus 로고    scopus 로고
    • Cell divisions and mammalian aging: Integrative biology insights from genes that regulate longevity
    • DOI 10.1002/bies.20760
    • J P de Magalhaes, R G Faragher: Cell divisions and mammalian aging: integrative biology insights from genes that regulate longevity. Bioessays 30, 567-578 (2008) (Pubitemid 351859413)
    • (2008) BioEssays , vol.30 , Issue.6 , pp. 567-578
    • De Magalhaes, J.P.1    Faragher, R.G.A.2
  • 12
    • 0034666057 scopus 로고    scopus 로고
    • Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation
    • K L MacKenzie, S Franco, C May, M Sadelain, M A Moore: Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation. Exp Cell Res 259, 336-350 (2000)
    • (2000) Exp Cell Res , vol.259 , pp. 336-350
    • MacKenzie, K.L.1    Franco, S.2    May, C.3    Sadelain, M.4    Moore, M.A.5
  • 13
    • 0031043998 scopus 로고    scopus 로고
    • Telomerase in the early detection of cancer
    • J W Shay, A F Gazdar: Telomerase in the early detection of cancer. J Clin Pathol 50, 106-109 (1997) (Pubitemid 27093024)
    • (1997) Journal of Clinical Pathology , vol.50 , Issue.2 , pp. 106-109
    • Shay, J.W.1    Gazdar, A.F.2
  • 15
    • 74049111326 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer
    • S E Artandi, R A DePinho: Telomeres and telomerase in cancer. Carcinogenesis 31, 9-18 (2010)
    • (2010) Carcinogenesis , vol.31 , pp. 9-18
    • Artandi, S.E.1    Depinho, R.A.2
  • 16
    • 78649629320 scopus 로고    scopus 로고
    • Oncogene-induced senescence: The bright and dark side of the response
    • V G Gorgoulis, T D Halazonetis: Oncogene-induced senescence: the bright and dark side of the response. Curr Opin Cell Biol 22, 816-827 (2010)
    • (2010) Curr Opin Cell Biol , vol.22 , pp. 816-827
    • Gorgoulis, V.G.1    Halazonetis, T.D.2
  • 17
    • 75449097024 scopus 로고    scopus 로고
    • Oncogene-induced cellular senescence
    • C Chandeck, W J Mooi: Oncogene-induced cellular senescence. Adv Anat Pathol 17, 42-48 (2010)
    • (2010) Adv Anat Pathol , vol.17 , pp. 42-48
    • Chandeck, C.1    Mooi, W.J.2
  • 18
    • 77953190969 scopus 로고    scopus 로고
    • Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells
    • S S Moumtzi, M L Roberts, T Joyce, M Evangelidou, L Probert, S Frillingos, T Fotsis, A Pintzas: Gene expression profile associated with oncogenic ras-induced senescence, cell death, and transforming properties in human cells. Cancer Invest 28, 563-587 (2010)
    • (2010) Cancer Invest , vol.28 , pp. 563-587
    • Moumtzi, S.S.1    Roberts, M.L.2    Joyce, T.3    Evangelidou, M.4    Probert, L.5    Frillingos, S.6    Fotsis, T.7    Pintzas, A.8
  • 19
    • 34247897276 scopus 로고    scopus 로고
    • Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis
    • DOI 10.1038/ncb1567, PII NCB1567
    • C J Sarkisian, B A Keister, D B Stairs, R B Boxer, S E Moody, L A Chodosh: Dose-dependent oncogene-induced senescence in vivo and its evasion during mammary tumorigenesis. Nat Cell Biol 9, 493-505 (2007) (Pubitemid 46696530)
    • (2007) Nature Cell Biology , vol.9 , Issue.5 , pp. 493-505
    • Sarkisian, C.J.1    Keister, B.A.2    Stairs, D.B.3    Boxer, R.B.4    Moody, S.E.5    Chodosh, L.A.6
  • 22
    • 33846334501 scopus 로고    scopus 로고
    • Oncogene-Induced Senescence Pathways Weave an Intricate Tapestry
    • DOI 10.1016/j.cell.2007.01.005, PII S0092867407000578
    • P Yaswen, J Campisi: Oncogene-induced senescence pathways weave an intricate tapestry. Cell 128, 233-234 (2007) (Pubitemid 46123519)
    • (2007) Cell , vol.128 , Issue.2 , pp. 233-234
    • Yaswen, P.1    Campisi, J.2
  • 28
    • 78651482046 scopus 로고    scopus 로고
    • Nuclear PTEN regulates the APCCDH1 tumor-suppressive complex in a phosphataseindependent manner
    • M S Song, A Carracedo, L Salmena, S J Song, A Egia, M Malumbres, P P Pandolfi: Nuclear PTEN regulates the APCCDH1 tumor-suppressive complex in a phosphataseindependent manner. Cell 144, 187-199 (2011)
    • (2011) Cell , vol.144 , pp. 187-199
    • Song, M.S.1    Carracedo, A.2    Salmena, L.3    Song, S.J.4    Egia, A.5    Malumbres, M.6    Pandolfi, P.P.7
  • 29
    • 33847649218 scopus 로고    scopus 로고
    • Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: A potential mechanism of apoptosis resistance
    • P Y Lin, S P Fosmire, S H Park, J Y Park, S Baksh, J F Modiano, R H Weiss: Attenuation of PTEN increases p21 stability and cytosolic localization in kidney cancer cells: a potential mechanism of apoptosis resistance. Mol Cancer 6, 16 (2007)
    • (2007) Mol Cancer , vol.6 , pp. 16
    • Lin, P.Y.1    Fosmire, S.P.2    Park, S.H.3    Park, J.Y.4    Baksh, S.5    Modiano, J.F.6    Weiss, R.H.7
  • 30
    • 1342281227 scopus 로고    scopus 로고
    • Contribution of environmental factors to cancer risk
    • DOI 10.1093/bmp/ldg023
    • P Boffetta, F Nyberg: Contribution of environmental factors to cancer risk. Br Med Bull, 68, 71-94 (2003) (Pubitemid 38258221)
    • (2003) British Medical Bulletin , vol.68 , pp. 71-94
    • Boffetta, P.1    Nyberg, F.2
  • 31
    • 4344716728 scopus 로고    scopus 로고
    • Cell cycle checkpoint control mechanisms that can be disrupted in cancer
    • B C Dash, W S El-Deiry: Cell cycle checkpoint control mechanisms that can be disrupted in cancer. Methods Mol Biol 280, 99-161 (2004)
    • (2004) Methods Mol Biol , vol.280 , pp. 99-161
    • Dash, B.C.1    El-Deiry, W.S.2
  • 32
    • 0034455671 scopus 로고    scopus 로고
    • Cell cycle control and cancer
    • C J Sherr: Cell cycle control and cancer. Harvey Lect 96, 73-92 (2000)
    • (2000) Harvey Lect , vol.96 , pp. 73-92
    • Sherr, C.J.1
  • 33
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • C J Sherr, R A DePinho: Cellular senescence: mitotic clock or culture shock? Cell 102, 407-410 (2000)
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    Depinho, R.A.2
  • 35
    • 0942301175 scopus 로고    scopus 로고
    • Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence
    • DOI 10.1038/sj.onc.1206886
    • F A Mallette, S Goumard, M F Gaumont-Leclerc, O Moieeva, G Ferbeyre: Human fibroblasts require the Rb family of tumor suppressors, but not p53, for PML-induced senescence. Oncogene 23, 91-99 (2004) . (Pubitemid 38142243)
    • (2004) Oncogene , vol.23 , Issue.1 , pp. 91-99
    • Mallette, F.A.1    Goumard, S.2    Gaumont-Leclerc, M.-F.3    Moiseeva, O.4    Ferbeyre, G.5
  • 36
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • D Hanahan, R A Weinberg: Hallmarks of cancer: the next generation. Cell 144, 646-674 (2011)
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 37
    • 0036545595 scopus 로고    scopus 로고
    • INK4a transcription and of cellular senescence by aclacinomycin-derivatives and cardiac glycosides
    • DOI 10.1248/bpb.25.461
    • K Egawa, Y Kurihara, T Ito, M Matsumoto, K Nose: Induction of p16INK4a transcription and of cellular senescence by aclacinomycin-derivatives and cardiac glycosides. Biol Pharm Bull 25, 461-465 (2002) (Pubitemid 40036736)
    • (2002) Biological and Pharmaceutical Bulletin , vol.25 , Issue.4 , pp. 461-465
    • Egawa, K.1    Kurihara, Y.2    Ito, T.3    Matsumoto, M.4    Nose, K.5
  • 38
    • 41649108818 scopus 로고    scopus 로고
    • Drug-induced senescence bystander proliferation in prostate cancer cells in vitro and in vivo
    • DOI 10.1038/sj.bjc.6604288, PII 6604288
    • J Ewald, J Desotelle, N Almassi, D Jarrard: Druginduced senescence bystander proliferation in prostate cancer cells in vitro and in vivo. Br J Cancer 98, 1244-1249 (2008) (Pubitemid 351481674)
    • (2008) British Journal of Cancer , vol.98 , Issue.7 , pp. 1244-1249
    • Ewald, J.A.1    Desotelle, J.A.2    Almassi, N.3    Jarrard, D.F.4
  • 41
    • 33846128155 scopus 로고    scopus 로고
    • The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence
    • DOI 10.1101/gad.1487307
    • F A Mallette, M F Gaumont-Leclerc, G Ferbeyre: The DNA damage signaling pathway is a critical mediator of oncogene-induced senescence. Genes Dev 21, 43-48 (2007) (Pubitemid 46089705)
    • (2007) Genes and Development , vol.21 , Issue.1 , pp. 43-48
    • Mallette, F.A.1    Gaumont-Leclerc, M.-F.2    Ferbeyre, G.3
  • 42
    • 0037148342 scopus 로고    scopus 로고
    • Telomeres, aging and cancer: In search of a happy ending
    • DOI 10.1038/sj/onc/1205077
    • S H Kim Sh, P Kaminker, J Campisi: Telomeres, aging and cancer: in search of a happy ending. Oncogene 21, 503-511 (2002) (Pubitemid 34146250)
    • (2002) Oncogene , vol.21 , pp. 503-511
    • Kim, S.-H.1    Kaminker, P.2    Campisi, J.3
  • 43
    • 0037148270 scopus 로고    scopus 로고
    • New ways not to make ends meet: Telomerase, DNA damage proteins and heterochromatin
    • DOI 10.1038/sj/onc/1205082
    • S W Chan, E H Blackburn: New ways not to make ends meet: telomerase, DNA damage proteins and heterochromatin. Oncogene 21, 553-563 (2002) (Pubitemid 34146255)
    • (2002) Oncogene , vol.21 , pp. 553-563
    • Chan, S.W.-L.1    Blackburn, E.H.2
  • 45
    • 59649109187 scopus 로고    scopus 로고
    • Cellular senescence, telomere recombination and maintenance
    • Q Yang: Cellular senescence, telomere recombination and maintenance. Cytogenet Genome Res 122, 211-218 (2008)
    • (2008) Cytogenet Genome Res , vol.122 , pp. 211-218
    • Yang, Q.1
  • 48
    • 79955872483 scopus 로고    scopus 로고
    • Walking the walk from genes through telomere maintenance to cancer risk
    • E H Blackburn: Walking the walk from genes through telomere maintenance to cancer risk. Cancer Prev Res 4, 473-475 (2011)
    • (2011) Cancer Prev Res , vol.4 , pp. 473-475
    • Blackburn, E.H.1
  • 49
    • 33646831821 scopus 로고    scopus 로고
    • Telomeres, chromosome instability and cancer
    • DOI 10.1093/nar/gkl303
    • S M Bailey, J P Murnane: Telomeres, chromosome instability and cancer. Nucleic Acids Res 34, 2408-2417 (2006) (Pubitemid 43985678)
    • (2006) Nucleic Acids Research , vol.34 , Issue.8 , pp. 2408-2417
    • Bailey, S.M.1    Murnane, J.P.2
  • 50
    • 0041704526 scopus 로고    scopus 로고
    • Telomere maintenance and DNA replication: How closely are these two connected?
    • DOI 10.1016/S0168-9525(03)00135-5
    • M Chakhparonian, R J Wellinger: Telomere maintenance and DNA replication: how closely are these two connected? Trends Genet 19, 439-446 (2003) (Pubitemid 36930027)
    • (2003) Trends in Genetics , vol.19 , Issue.8 , pp. 439-446
    • Chakhparonian, M.1    Wellinger, R.J.2
  • 54
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: The senescence connection
    • DOI 10.1038/nrc2393, PII NRC2393
    • Y Deng, S S Chan, S Chang: Telomere dysfunction and tumour suppression: the senescence connection. Nat Rev Cancer 8, 450-458 (2008) (Pubitemid 351744962)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 55
    • 0034003333 scopus 로고    scopus 로고
    • A critical role for telomeres in suppressing and facilitating carcinogenesis
    • DOI 10.1016/S0959-437X(99)00047-7
    • S E Artandi, R A DePinho: A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr Opin Genet Dev 10, 39-46 (2000) (Pubitemid 30113704)
    • (2000) Current Opinion in Genetics and Development , vol.10 , Issue.1 , pp. 39-46
    • Artandi, S.E.1    DePinho, R.A.2
  • 56
    • 65349126392 scopus 로고    scopus 로고
    • Cellular senescence: Its role in tumor suppression and aging
    • N Ohtani, D J Mann, E Hara: Cellular senescence: its role in tumor suppression and aging. Cancer Sci 100, 792-797 (2009)
    • (2009) Cancer Sci , vol.100 , pp. 792-797
    • Ohtani, N.1    Mann, D.J.2    Hara, E.3
  • 58
    • 69449099710 scopus 로고    scopus 로고
    • HTERT promotes the invasion of telomerase negative tumor cells in vitro
    • S T Yu, L Chen, H J Wang, X D Tang, D C Fang, S M Yang: hTERT promotes the invasion of telomerase negative tumor cells in vitro. Int J Oncol 35, 329-336 (2009)
    • (2009) Int J Oncol , vol.35 , pp. 329-336
    • Yu, S.T.1    Chen, L.2    Wang, H.J.3    Tang, X.D.4    Fang, D.C.5    Yang, S.M.6
  • 59
    • 79957668093 scopus 로고    scopus 로고
    • The potential utility of telomere-related markers for cancer diagnosis
    • C M Heaphy, A K Meeker: The potential utility of telomere-related markers for cancer diagnosis. J Cell Mol Med 15, 1227-1238 (2011)
    • (2011) J Cell Mol Med , vol.15 , pp. 1227-1238
    • Heaphy, C.M.1    Meeker, A.K.2
  • 60
    • 78349270933 scopus 로고    scopus 로고
    • Role of shelterin in cancer and aging
    • P Martinez, M A Blasco: Role of shelterin in cancer and aging. Aging Cell 9, 653-666 (2010)
    • (2010) Aging Cell , vol.9 , pp. 653-666
    • Martinez, P.1    Blasco, M.A.2
  • 61
    • 34247581288 scopus 로고    scopus 로고
    • Short telomeres limit tumor progression in vivo by inducing senescence
    • DOI 10.1016/j.ccr.2007.02.026, PII S1535610807000876
    • D M Feldser, C W Greider: Short telomeres limit tumor progression in vivo by inducing senescence. Cancer Cell 11, 461-469 (2007) (Pubitemid 46670077)
    • (2007) Cancer Cell , vol.11 , Issue.5 , pp. 461-469
    • Feldser, D.M.1    Greider, C.W.2
  • 62
    • 34247860915 scopus 로고    scopus 로고
    • Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence
    • DOI 10.1038/sj.embor.7400937, PII 7400937
    • W Cosme-Blanco, M F Shen, A J Lazar, S Pathak, G Lozano, A S Multani, S Chang: Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep 8, 497-503 (2007) (Pubitemid 46696521)
    • (2007) EMBO Reports , vol.8 , Issue.5 , pp. 497-503
    • Cosme-Blanco, W.1    Shen, M.-F.2    Lazar, A.J.F.3    Pathak, S.4    Lozano, G.5    Multani, A.S.6    Chang, S.7
  • 63
    • 74049111326 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer
    • S E Artandi, R A DePinho: Telomeres and telomerase in cancer. Carcinogenesis 31, 9-18 (2010)
    • (2010) Carcinogenesis , vol.31 , pp. 9-18
    • Artandi, S.E.1    Depinho, R.A.2
  • 65
    • 66149123737 scopus 로고    scopus 로고
    • Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma
    • U Svenson, B Ljungberg, G Roos: Telomere length in peripheral blood predicts survival in clear cell renal cell carcinoma. Cancer Res 69, 2896-2901 (2009)
    • (2009) Cancer Res , vol.69 , pp. 2896-2901
    • Svenson, U.1    Ljungberg, B.2    Roos, G.3
  • 69
    • 70349661733 scopus 로고    scopus 로고
    • Consecutive formation of G-quadruplexes in human telomeric-overhang DNA: A protective capping structure for telomere ends
    • Y Xu, T Ishizuka, K Kurabayashi, M Komiyama: Consecutive formation of G-quadruplexes in human telomeric-overhang DNA: a protective capping structure for telomere ends. Angew Chem Int Ed Engl 48, 7833-7836 (2009)
    • (2009) Angew Chem Int Ed Engl , vol.48 , pp. 7833-7836
    • Xu, Y.1    Ishizuka, T.2    Kurabayashi, K.3    Komiyama, M.4
  • 70
    • 0033553455 scopus 로고    scopus 로고
    • Telomeres do D-loop-T-loop
    • DOI 10.1016/S0092-8674(00)80750-3
    • C W Greider: Telomeres do D-loop-T-loop. Cell 97, 419-422 (1999) (Pubitemid 29231163)
    • (1999) Cell , vol.97 , Issue.4 , pp. 419-422
    • Greider, C.W.1
  • 73
    • 0027240171 scopus 로고
    • 4) in solution
    • F W Smith, J Feigon: Strand orientation in the DNA quadruplex formed from the Oxytricha telomere repeat oligonucleotide d(G4T4G4) in solution. Biochemistry 32, 8682-8692 (1993) (Pubitemid 23270456)
    • (1993) Biochemistry , vol.32 , Issue.33 , pp. 8682-8692
    • Smith, F.W.1    Feigon, J.2
  • 74
    • 77949310670 scopus 로고    scopus 로고
    • Telomere and telomerase as targets for cancer therapy
    • X Tian, B Chen, X Liu: Telomere and telomerase as targets for cancer therapy. Appl Biochem Biotechnol 160, 1460-1472 (2010)
    • (2010) Appl Biochem Biotechnol , vol.160 , pp. 1460-1472
    • Tian, X.1    Chen, B.2    Liu, X.3
  • 76
    • 12844254472 scopus 로고    scopus 로고
    • POT1 and TRF2 cooperate to maintain telomeric integrity
    • DOI 10.1128/MCB.25.3.1070-1080.2005
    • Q Yang, Y L Zheng, C C Harris: POT1 and TRF2 cooperate to maintain telomeric integrity. Mol Cell Biol 25, 1070-1080 (2005) (Pubitemid 40165813)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.3 , pp. 1070-1080
    • Yang, Q.1    Zheng, Y.-L.2    Harris, C.C.3
  • 77
    • 33845433298 scopus 로고    scopus 로고
    • Telomeres rather than telomerase a key target for anti-cancer therapy?
    • DOI 10.1111/j.1600-0625.2006.00517.x
    • P Boukamp, N Mirancea: Telomeres rather than telomerase a key target for anti-cancer therapy? Exp Dermatol 16, 71-79 (2007) (Pubitemid 44890358)
    • (2007) Experimental Dermatology , vol.16 , Issue.1 , pp. 71-79
    • Boukamp, P.1    Mirancea, N.2
  • 79
    • 39449092745 scopus 로고    scopus 로고
    • Targeting telomerase for cancer therapeutics
    • DOI 10.1038/sj.bjc.6604209, PII 6604209
    • J W Shay, W N Keith: Targeting telomerase for cancer therapeutics. Br J Cancer 98, 677-683 (2008) (Pubitemid 351272604)
    • (2008) British Journal of Cancer , vol.98 , Issue.4 , pp. 677-683
    • Shay, J.W.1    Keith, W.N.2
  • 80
    • 34548857357 scopus 로고    scopus 로고
    • Targeting the limitless replicative potential of cancer: The telomerase/telomere pathway
    • DOI 10.1158/1078-0432.CCR-07-0422
    • L Kelland: Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway. Clin Cancer Res 13, 4960-4963 (2007) (Pubitemid 47502059)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 4960-4963
    • Kelland, L.1
  • 83
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • DOI 10.1038/nrc2275, PII NRC2275
    • C B Harley: Telomerase and cancer therapeutics. Nat Rev Cancer 8, 167-179 (2008) (Pubitemid 351305939)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.3 , pp. 167-179
    • Harley, C.B.1
  • 87
    • 30944442508 scopus 로고    scopus 로고
    • Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma
    • DOI 10.1002/hep.20822
    • M W Djojosubroto, A C Chin, N Go, S Schaetzlein, M P Manns, S Gryaznov, C B Harley, K L Rudolph: Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology 42, 1127-1136 (2005) (Pubitemid 43112680)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1127-1136
    • Djojosubroto, M.W.1    Chin, A.C.2    Go, N.3    Schaetzlein, S.4    Manns, M.P.5    Gryaznov, S.6    Harley, C.B.7    Rudolph, K.L.8
  • 88
  • 90
    • 77958584577 scopus 로고    scopus 로고
    • Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms
    • S K Brennan, Q Wang, R Tressler, C Harley, N Go, E Bassett, C A Huff, R J Jones, W Matsui: Telomerase inhibition targets clonogenic multiple myeloma cells through telomere length-dependent and independent mechanisms. PLoS One 5, e12487 (2010)
    • (2010) PLoS One , vol.5
    • Brennan, S.K.1    Wang, Q.2    Tressler, R.3    Harley, C.4    Go, N.5    Bassett, E.6    Huff, C.A.7    Jones, R.J.8    Matsui, W.9
  • 91
    • 16844368698 scopus 로고    scopus 로고
    • Tumour stem cells and drug resistance
    • DOI 10.1038/nrc1590
    • M Dean, T Fojo, S Bates: Tumour stem cells and drug resistance. Nat Rev Cancer 5, 275-284 (2005) (Pubitemid 40488633)
    • (2005) Nature Reviews Cancer , vol.5 , Issue.4 , pp. 275-284
    • Dean, M.1    Fojo, T.2    Bates, S.3
  • 92
    • 77951637673 scopus 로고    scopus 로고
    • Telomerase-based therapies emerging slowly
    • V Brower: Telomerase-based therapies emerging slowly. J Natl Cancer Inst 102, 520-521 (2010)
    • (2010) J Natl Cancer Inst , vol.102 , pp. 520-521
    • Brower, V.1
  • 93
    • 0026341239 scopus 로고
    • Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide
    • P E Nielsen, M Egholm, R H Berg, O Buchardt: Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500 (1991) (Pubitemid 21917487)
    • (1991) Science , vol.254 , Issue.5037 , pp. 1497-1500
    • Nielsen, P.E.1    Egholm, M.2    Berg, R.H.3    Buchardt, O.4
  • 95
    • 0033524004 scopus 로고    scopus 로고
    • Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells
    • M A Shammas, C G Simmons, D R Corey, R J Shmookler Reis: Telomerase inhibition by peptide nucleic acids reverses 'immortality' of transformed human cells. Oncogene 18, 6191-6200 (1999)
    • (1999) Oncogene , vol.18 , pp. 6191-6200
    • Shammas, M.A.1    Simmons, C.G.2    Corey, D.R.3    Shmookler Reis, R.J.4
  • 96
    • 0033150534 scopus 로고    scopus 로고
    • Cellular delivery of peptide nucleic acids and inhibition of human telomerase
    • DOI 10.1016/S1074-5521(99)80046-5
    • S E Hamilton, C G Simmons, I S Kathiriya, D R Corey: Cellular delivery of peptide nucleic acids and inhibition of human telomerase. Chem Biol 6, 343-351 (1999) (Pubitemid 29363167)
    • (1999) Chemistry and Biology , vol.6 , Issue.6 , pp. 343-351
    • Hamilton, S.E.1    Simmons, C.G.2    Kathiriya, I.S.3    Corey, D.R.4
  • 97
    • 36749079827 scopus 로고    scopus 로고
    • Pharmacological intervention strategies for affecting telomerase activity: Future prospects to treat cancer and degenerative disease
    • DOI 10.1016/j.biochi.2007.09.002, PII S0300908407002441, Telomeres and Telomerase: from Basic Research to Clinical Applications
    • I Tarkanyi, J Aradi: Pharmacological intervention strategies for affecting telomerase activity: future prospects to treat cancer and degenerative disease. Biochimie 90, 156-172 (2008) (Pubitemid 350216216)
    • (2008) Biochimie , vol.90 , Issue.1 , pp. 156-172
    • Tarkanyi, I.1    Aradi, J.2
  • 100
    • 0041353443 scopus 로고    scopus 로고
    • Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: Involvement of ATM-dependent DNA damage response pathways
    • DOI 10.1038/sj.onc.1206833
    • T Tauchi, K Shin-Ya, G Sashida, M Sumi, A Nakajima, T Shimamoto, J H Ohyashiki, K Ohyashiki: Activity of a novel G-quadruplex-interactive telomerase inhibitor, telomestatin (SOT-095), against human leukemia cells: involvement of ATM-dependent DNA damage response pathways. Oncogene 22, 5338-5347 (2003) (Pubitemid 37056096)
    • (2003) Oncogene , vol.22 , Issue.34 , pp. 5338-5347
    • Tauchi, T.1    Shin-Ya, K.2    Sashida, G.3    Sumi, M.4    Nakajima, A.5    Shimamoto, T.6    Ohyashiki, J.H.7    Ohyashiki, K.8
  • 101
    • 7444237059 scopus 로고    scopus 로고
    • A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells
    • C M Incles, C M Schultes, H Kempski, H Koehler, L R Kelland, S Neidle: A G-quadruplex telomere targeting agent produces p16-associated senescence and chromosomal fusions in human prostate cancer cells. Mol Cancer Ther 3, 1201-1206 (2004) (Pubitemid 39440164)
    • (2004) Molecular Cancer Therapeutics , vol.3 , Issue.10 , pp. 1201-1206
    • Incles, C.M.1    Schultes, C.M.2    Kempski, H.3    Koehler, H.4    Kelland, L.R.5    Neidle, S.6
  • 102
    • 6944239985 scopus 로고    scopus 로고
    • Biological activity of the G-quadruplex ligand RHPS4 (3, 11-difluoro-6,8,13-trimethyl-8H-quino[4,3,2-kl]acridinium methosulfate) is associated with telomere capping alteration
    • DOI 10.1124/mol.104.001537
    • C Leonetti, S Amodei, C D'Angelo, A Rizzo, B Benassi, A Antonelli, R Elli, M F Stevens, M D'Incalci, G Zupi, A Biroccio: Biological activity of the G-quadruplex ligand RHPS4 (3, 11-difluoro-6, 8, 13-trimethyl-8H-quino[4, 3, 2-kl]acridinium methosulfate) is associated with telomere capping alteration. Mol Pharmacol 66, 1138-1146 (2004) (Pubitemid 39411054)
    • (2004) Molecular Pharmacology , vol.66 , Issue.5 , pp. 1138-1146
    • Leonetti, C.1    Amodei, S.2    D'Angelo, C.3    Rizzo, A.4    Benassi, B.5    Antonelli, A.6    Elli, R.7    Stevens, M.F.G.8    D'Incalci, M.9    Zupi, G.10    Biroccio, A.11
  • 103
    • 70349084987 scopus 로고    scopus 로고
    • The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplexforming oligonucleotides and uncaps telomeres in ALT cells
    • N Temime-Smaali, L Guittat, A Sidibe, K Shin-ya, C Trentesaux, J F Riou: The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIalpha to G-quadruplexforming oligonucleotides and uncaps telomeres in ALT cells. PLoS One 4, e6919 (2009)
    • (2009) PLoS One , vol.4
    • Temime-Smaali, N.1    Guittat, L.2    Sidibe, A.3    Shin-Ya, K.4    Trentesaux, C.5    Riou, J.F.6
  • 105
    • 0036241599 scopus 로고    scopus 로고
    • A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity
    • DOI 10.1124/mol.61.5.1154
    • S M Gowan, J R Harrison, L Patterson, M Valenti, M A Read, S Neidle, L R Kelland: A G-quadruplex-interactive potent small-molecule inhibitor of telomerase exhibiting in vitro and in vivo antitumor activity. Mol Pharmacol 61, 1154-1162 (2002) (Pubitemid 34441781)
    • (2002) Molecular Pharmacology , vol.61 , Issue.5 , pp. 1154-1162
    • Gowan, S.M.1    Harrison, J.R.2    Patterson, L.3    Valenti, M.4    Read, M.A.5    Neidle, S.6    Kelland, L.R.7
  • 106
    • 33645280314 scopus 로고    scopus 로고
    • G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells
    • H Tahara, K Shin-Ya, H Seimiya, H Yamada, T Tsuruo, T Ide: G-Quadruplex stabilization by telomestatin induces TRF2 protein dissociation from telomeres and anaphase bridge formation accompanied by loss of the 3' telomeric overhang in cancer cells. Oncogene 25, 1955-1966 (2006)
    • (2006) Oncogene , vol.25 , pp. 1955-1966
    • Tahara, H.1    Shin-Ya, K.2    Seimiya, H.3    Yamada, H.4    Tsuruo, T.5    Ide, T.6
  • 107
    • 3142657601 scopus 로고    scopus 로고
    • Inhibition on telomerase activity and cytotoxic effects by cisplatin in cultured human choroidal melanoma cells
    • H Cheng, Z Wu, J Zheng, G Lu, J Yan, M Liu, D Huang, J Lin: Inhibition on telomerase activity and cytotoxic effects by cisplatin in cultured human choroidal melanoma cells. Yan Ke Xue Bao 19, 54-59 (2003)
    • (2003) Yan Ke Xue Bao , vol.19 , pp. 54-59
    • Cheng, H.1    Wu, Z.2    Zheng, J.3    Lu, G.4    Yan, J.5    Liu, M.6    Huang, D.7    Lin, J.8
  • 108
    • 34347251957 scopus 로고    scopus 로고
    • The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells
    • DOI 10.1016/j.bbrc.2007.06.030, PII S0006291X07012752
    • D Sadava, E Whitlock, S E Kane: The green tea polyphenol, epigallocatechin-3-gallate inhibits telomerase and induces apoptosis in drug-resistant lung cancer cells. Biochem Biophys Res Commun 360, 233-237 (2007) (Pubitemid 46994711)
    • (2007) Biochemical and Biophysical Research Communications , vol.360 , Issue.1 , pp. 233-237
    • Sadava, D.1    Whitlock, E.2    Kane, S.E.3
  • 110
    • 39949085055 scopus 로고    scopus 로고
    • Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast
    • Q Meng, C N Velalar, R Ruan: Effects of epigallocatechin-3-gallate on mitochondrial integrity and antioxidative enzyme activity in the aging process of human fibroblast. Free Radic Biol Med 44, 1032-1041 (2008)
    • (2008) Free Radic Biol Med , vol.44 , pp. 1032-1041
    • Meng, Q.1    Velalar, C.N.2    Ruan, R.3
  • 111
    • 85047689866 scopus 로고    scopus 로고
    • Telomeres, stem cells, senescence, and cancer
    • DOI 10.1172/JCI200420761
    • N E Sharpless, R A DePinho: Telomeres, stem cells, senescence, and cancer. J Clin Invest 113, 160-168 (2004) (Pubitemid 38544198)
    • (2004) Journal of Clinical Investigation , vol.113 , Issue.2 , pp. 160-168
    • Sharpless, N.E.1    DePinho, R.A.2
  • 115
    • 38749107524 scopus 로고    scopus 로고
    • Long-term effects of short hairpin RNA-targeted human telomerase reverse transcriptase on suppression of SGC-7901 cell proliferation by inhibition of telomerase activity
    • X Qian, J Cheng, A Chen, Y Wang, Y Tao, J Cao, Z Feng: Long-term effects of short hairpin RNA-targeted human telomerase reverse transcriptase on suppression of SGC-7901 cell proliferation by inhibition of telomerase activity. Oncol Rep 19, 575-581 (2008) (Pubitemid 351176123)
    • (2008) Oncology Reports , vol.19 , Issue.2 , pp. 575-581
    • Qian, X.1    Cheng, J.2    Chen, A.3    Wang, Y.4    Tao, Y.5    Cao, J.6    Feng, Z.7
  • 116
    • 26844458316 scopus 로고    scopus 로고
    • Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: Mechanism and therapeutic potential
    • A Shammas, H Koley, R B Batchu, R C Bertheau, A Protopopov, N C Munshi, R K Goyal: Telomerase inhibition by siRNA causes senescence and apoptosis in Barrett's adenocarcinoma cells: mechanism and therapeutic potential. Mol Cancer 4, 24 (2005)
    • (2005) Mol Cancer , vol.4 , pp. 24
    • Shammas, A.1    Koley, H.2    Batchu, R.B.3    Bertheau, R.C.4    Protopopov, A.5    Munshi, N.C.6    Goyal, R.K.7
  • 117
    • 32444445166 scopus 로고    scopus 로고
    • RNAi-hTERT inhibition hepatocellular carcinoma cell proliferation via decreasing telomerase activity
    • DOI 10.1016/j.jss.2005.09.017, PII S0022480405005007
    • P H Zhang, L Zou, Z G Tu: RNAi-hTERT inhibition hepatocellular carcinoma cell proliferation via decreasing telomerase activity. J Surg Res 131, 143-149 (2006) (Pubitemid 43227598)
    • (2006) Journal of Surgical Research , vol.131 , Issue.1 , pp. 143-149
    • Zhang, P.-H.1    Zou, L.2    Tu, Z.-G.3
  • 118
    • 67649764432 scopus 로고    scopus 로고
    • SiRNA inhibition of telomerase enhances the anticancer effect of doxorubicin in breast cancer cells
    • X Dong, A Liu, C Zer, J Feng, Z Zhen, M Yang, L Zhong: siRNA inhibition of telomerase enhances the anticancer effect of doxorubicin in breast cancer cells. BMC Cancer 9, 133 (2009)
    • (2009) BMC Cancer , vol.9 , pp. 133
    • Dong, X.1    Liu, A.2    Zer, C.3    Feng, J.4    Zhen, Z.5    Yang, M.6    Zhong, L.7
  • 119
    • 33644844096 scopus 로고    scopus 로고
    • ShRNA-targeted hTERT suppress cell proliferation of bladder cancer by inhibiting telomerase activity
    • L Zou, P Zhang, C Luo, Z Tu: shRNA-targeted hTERT suppress cell proliferation of bladder cancer by inhibiting telomerase activity. Cancer Chemother Pharmacol 57, 328-334 (2006)
    • (2006) Cancer Chemother Pharmacol , vol.57 , pp. 328-334
    • Zou, L.1    Zhang, P.2    Luo, C.3    Tu, Z.4
  • 120
    • 79957582182 scopus 로고    scopus 로고
    • Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo
    • X Liu, H Huang, J Wang, C Wang, M Wang, B Zhang, C Pan: Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo. Biochem Pharmacol 82, 17-23 (2011)
    • (2011) Biochem Pharmacol , vol.82 , pp. 17-23
    • Liu, X.1    Huang, H.2    Wang, J.3    Wang, C.4    Wang, M.5    Zhang, B.6    Pan, C.7
  • 123
    • 33645293178 scopus 로고    scopus 로고
    • TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons
    • P Zhang, K Furukawa, P L Opresko, X Xu, V A Bohr, M P Mattson: TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons. J Neurochem 97, 567-581 (2006)
    • (2006) J Neurochem , vol.97 , pp. 567-581
    • Zhang, P.1    Furukawa, K.2    Opresko, P.L.3    Xu, X.4    Bohr, V.A.5    Mattson, M.P.6
  • 125
    • 13944272246 scopus 로고    scopus 로고
    • The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function
    • DOI 10.1158/0008-5472.CAN-04-2910
    • A M Burger, F Dai, C M Schultes, A P Reszka, M J Moore, J A Double, S Neidle: The G-quadruplex-interactive molecule BRACO-19 inhibits tumor growth, consistent with telomere targeting and interference with telomerase function. Cancer Res 65, 1489-1496 (2005) (Pubitemid 40270178)
    • (2005) Cancer Research , vol.65 , Issue.4 , pp. 1489-1496
    • Burger, A.M.1    Dai, F.2    Schultes, C.M.3    Reszka, A.P.4    Moore, M.J.5    Double, J.A.6    Neidle, S.7
  • 126
    • 34247208639 scopus 로고    scopus 로고
    • Telomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism
    • DOI 10.1038/sj.bjc.6603691, PII 6603691
    • P Phatak, J C Cookson, F Dai, V Smith, R B Gartenhaus, M F Stevens, A M Burger: Telomere uncapping by the Gquadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism. Br J Cancer 96, 1223-1233 (2007) (Pubitemid 46625068)
    • (2007) British Journal of Cancer , vol.96 , Issue.8 , pp. 1223-1233
    • Phatak, P.1    Cookson, J.C.2    Dai, F.3    Smith, V.4    Gartenhaus, R.B.5    Stevens, M.F.G.6    Burger, A.M.7
  • 127
    • 73149108422 scopus 로고    scopus 로고
    • G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells
    • W J Zhou, R Deng, X Y Zhang, G K Feng, L Q Gu, X F Zhu: G-quadruplex ligand SYUIQ-5 induces autophagy by telomere damage and TRF2 delocalization in cancer cells. Mol Cancer Ther 8, 3203-3213 (2009)
    • (2009) Mol Cancer Ther , vol.8 , pp. 3203-3213
    • Zhou, W.J.1    Deng, R.2    Zhang, X.Y.3    Feng, G.K.4    Gu, L.Q.5    Zhu, X.F.6
  • 130
    • 30944442508 scopus 로고    scopus 로고
    • Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma
    • DOI 10.1002/hep.20822
    • W Djojosubroto, A C Chin, N Go, S Schaetzlein, M P Manns, S Gryaznov, C B Harley, K L Rudolph: Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology 42, 1127-1136 (2005) (Pubitemid 43112680)
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1127-1136
    • Djojosubroto, M.W.1    Chin, A.C.2    Go, N.3    Schaetzlein, S.4    Manns, M.P.5    Gryaznov, S.6    Harley, C.B.7    Rudolph, K.L.8
  • 132
    • 33644829061 scopus 로고    scopus 로고
    • Inhibition of human telomerase reverse transcriptase in hep-2 cells using short hairpin RNA expression vectors
    • DOI 10.1001/archotol.132.2.200
    • S M Chen, Z Z Tao, Q Q Hua, D Liu, H M Chi, Q Cai: Inhibition of human telomerase reverse transcriptase in hep-2 cells using short hairpin RNA expression vectors. Arch Otolaryngol Head Neck Surg 132, 200-205 (2006) (Pubitemid 43356259)
    • (2006) Archives of Otolaryngology - Head and Neck Surgery , vol.132 , Issue.2 , pp. 200-205
    • Chen, S.-M.1    Tao, Z.-Z.2    Hua, Q.-Q.3    Liu, D.4    Chi, H.-M.5    Cai, Q.6
  • 134
    • 65949091352 scopus 로고    scopus 로고
    • Telomerase-targeting antisense oligonucleotides carried by polycation liposomes enhance the growth inhibition effect on tumor cells
    • L Chen, Y Hu, W P Shuai, H L Chen, W Q Liang, J Q Gao: Telomerase-targeting antisense oligonucleotides carried by polycation liposomes enhance the growth inhibition effect on tumor cells. J Biomed Mater Res B Appl Biomater 89B, 362-368 (2009)
    • (2009) J Biomed Mater Res B Appl Biomater 89B , pp. 362-368
    • Chen, L.1    Hu, Y.2    Shuai, W.P.3    Chen, H.L.4    Liang, W.Q.5    Gao, J.Q.6
  • 135
    • 9644254229 scopus 로고    scopus 로고
    • The peptide nucleic acids (PNAs): A new generation of probes for genetic and cytogenetic analyses
    • DOI 10.1016/j.anngen.2004.07.001, PII S0003399504000565
    • P Paulasova, F Pellestor: The peptide nucleic acids (PNAs): a new generation of probes for genetic and cytogenetic analyses. Ann Genet 47, 349-358 (2004) (Pubitemid 39575613)
    • (2004) Annales de Genetique , vol.47 , Issue.4 , pp. 349-358
    • Paulasova, P.1    Pellestor, F.2
  • 136
    • 0034006777 scopus 로고    scopus 로고
    • Role of telomerase in cell senescence and oncogenesis
    • DOI 10.1146/annurev.med.51.1.65
    • V Urquidi, D Tarin, S Goodison: Role of telomerase in cell senescence and oncogenesis. Annu Rev Med 51, 65-79 (2000) (Pubitemid 30216026)
    • (2000) Annual Review of Medicine , vol.51 , pp. 65-79
    • Urquidi, V.1    Tarin, D.2    Goodison, S.3
  • 137
    • 0037148281 scopus 로고    scopus 로고
    • Alternative lengthening of telomeres in mammalian cells
    • DOI 10.1038/sj/onc/1205058
    • J D Henson, A A Neumann, T R Yeager, R R Reddel: Alternative lengthening of telomeres in mammalian cells. Oncogene 21, 598-610 (2002) (Pubitemid 34146260)
    • (2002) Oncogene , vol.21 , pp. 598-610
    • Henson, J.D.1    Neumann, A.A.2    Yeager, T.R.3    Reddel, R.R.4
  • 138
    • 79955034796 scopus 로고    scopus 로고
    • Heterochromatin and the DNA damage response: The need to relax
    • K L Cann, G Dellaire: Heterochromatin and the DNA damage response: the need to relax. Biochem Cell Biol 89, 45-60 (2011)
    • (2011) Biochem Cell Biol , vol.89 , pp. 45-60
    • Cann, K.L.1    Dellaire, G.2
  • 139
    • 73949118293 scopus 로고    scopus 로고
    • Genomic instability and the selection of treatments for cancer
    • S A Martin, M Hewish, C J Lord, A Ashworth: Genomic instability and the selection of treatments for cancer. J Pathol 220, 281-289 (2010)
    • (2010) J Pathol , vol.220 , pp. 281-289
    • Martin, S.A.1    Hewish, M.2    Lord, C.J.3    Ashworth, A.4
  • 140
  • 142
    • 77953021493 scopus 로고    scopus 로고
    • Oxidatively generated base damage to cellular DNA
    • J Cadet, T Douki, J L Ravanat: Oxidatively generated base damage to cellular DNA Free Radic Biol Med 49, 9-21 (2010)
    • (2010) Free Radic Biol Med , vol.49 , pp. 9-21
    • Cadet, J.1    Douki, T.2    Ravanat, J.L.3
  • 143
    • 78149468904 scopus 로고    scopus 로고
    • Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy
    • A Guainazzi, O D Scharer: Using synthetic DNA interstrand crosslinks to elucidate repair pathways and identify new therapeutic targets for cancer chemotherapy. Cell Mol Life Sci 67, 3683-3697 (2010)
    • (2010) Cell Mol Life Sci , vol.67 , pp. 3683-3697
    • Guainazzi, A.1    Scharer, O.D.2
  • 144
    • 79956191022 scopus 로고    scopus 로고
    • Role of oxidative stress and DNA damage in human carcinogenesis
    • T B Kryston, A B Georgiev, P Pissis, A G Georgakilas: Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711, 193-201 (2011)
    • (2011) Mutat Res , vol.711 , pp. 193-201
    • Kryston, T.B.1    Georgiev, A.B.2    Pissis, P.3    Georgakilas, A.G.4
  • 145
    • 79952260454 scopus 로고    scopus 로고
    • The DNA damage response: Balancing the scale between cancer and ageing
    • E G Seviour, S Y Lin: The DNA damage response: Balancing the scale between cancer and ageing. Aging 2, 900-907 (2010)
    • (2010) Aging , vol.2 , pp. 900-907
    • Seviour, E.G.1    Lin, S.Y.2
  • 146
    • 0032542364 scopus 로고    scopus 로고
    • Genetic instabilities in human cancers
    • DOI 10.1038/25292
    • C Lengauer, K W Kinzler, B Vogelstein: Genetic instabilities in human cancers. Nature 396, 643-649 (1998) (Pubitemid 29003936)
    • (1998) Nature , vol.396 , Issue.6712 , pp. 643-649
    • Lengauer, C.1    Kinzler, K.W.2    Vogelstein, B.3
  • 147
    • 8844224076 scopus 로고    scopus 로고
    • Chromosome rearrangements resulting from telomere dysfunction and their role in cancer
    • DOI 10.1002/bies.20125
    • J P Murnane, L Sabatier: Chromosome rearrangements resulting from telomere dysfunction and their role in cancer. Bioessays 26, 1164-1174 (2004) (Pubitemid 39536612)
    • (2004) BioEssays , vol.26 , Issue.11 , pp. 1164-1174
    • Murnane, J.P.1    Sabatier, L.2
  • 148
    • 44349092536 scopus 로고    scopus 로고
    • Is NHEJ a tumor suppressor or an aging suppressor?
    • P Hasty: Is NHEJ a tumor suppressor or an aging suppressor? Cell Cycle 7, 1139-1145 (2008) (Pubitemid 351749263)
    • (2008) Cell Cycle , vol.7 , Issue.9 , pp. 1139-1145
    • Hasty, P.1
  • 149
    • 78650215702 scopus 로고    scopus 로고
    • Harnessing the complexity of DNAdamage response pathways to improve cancer treatment outcomes
    • F Al-Ejeh, R Kumar, A Wiegmans, S R Lakhani, M P Brown, K K Khanna: Harnessing the complexity of DNAdamage response pathways to improve cancer treatment outcomes. Oncogene 29, 6085-6098 (2010)
    • (2010) Oncogene , vol.29 , pp. 6085-6098
    • Al-Ejeh, F.1    Kumar, R.2    Wiegmans, A.3    Lakhani, S.R.4    Brown, M.P.5    Khanna, K.K.6
  • 150
    • 36749022214 scopus 로고    scopus 로고
    • The DNA damage response: Ten years after
    • DOI 10.1016/j.molcel.2007.11.015, PII S1097276507007836
    • J W Harper, S J Elledge: The DNA damage response: ten years after. Mol Cell 28, 739-745 (2007) (Pubitemid 350217064)
    • (2007) Molecular Cell , vol.28 , Issue.5 , pp. 739-745
    • Harper, J.W.1    Elledge, S.J.2
  • 151
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • DOI 10.1016/j.cell.2005.02.003
    • J Campisi: Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120, 513-522 (2005) (Pubitemid 40269765)
    • (2005) Cell , vol.120 , Issue.4 , pp. 513-522
    • Campisi, J.1
  • 152
    • 34547676756 scopus 로고    scopus 로고
    • Soothing the watchman: Telomerase reduces the p53-dependent cellular stress response
    • A Beliveau, P Yaswen: Soothing the watchman: telomerase reduces the p53-dependent cellular stress response. Cell Cycle 6, 1284-1287 (2007) (Pubitemid 47327957)
    • (2007) Cell Cycle , vol.6 , Issue.11 , pp. 1284-1287
    • Beliveau, A.1    Yaswen, P.2
  • 153
    • 0031266691 scopus 로고    scopus 로고
    • Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review
    • H Vaziri: Critical telomere shortening regulated by the ataxia-telangiectasia gene acts as a DNA damage signal leading to activation of p53 protein and limited life-span of human diploid fibroblasts. A review. Biochemistry, 62, 1306-1310 (1997) (Pubitemid 127665920)
    • (1997) Biochemistry (Moscow) , vol.62 , Issue.11 , pp. 1306-1310
    • Vaziri, H.1
  • 154
    • 34548317418 scopus 로고    scopus 로고
    • Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1
    • DOI 10.1038/nature06065, PII NATURE06065
    • E L Denchi, T de Lange: Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1. Nature 448, 1068-1071 (2007) (Pubitemid 47345583)
    • (2007) Nature , vol.448 , Issue.7157 , pp. 1068-1071
    • Denchi, E.L.1    De Lange, T.2
  • 155
    • 33745685066 scopus 로고    scopus 로고
    • Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres
    • D Hockemeyer, J P Daniels, H Takai, T de Lange: Recent expansion of the telomeric complex in rodents: Two distinct POT1 proteins protect mouse telomeres. Cell 126, 63-77 (2006)
    • (2006) Cell , vol.126 , pp. 63-77
    • Hockemeyer, D.1    Daniels, J.P.2    Takai, H.3    De Lange, T.4
  • 157
    • 0037178761 scopus 로고    scopus 로고
    • Connecting chromosomes, crisis, and cancer
    • S Maser, R A DePinho: Connecting chromosomes, crisis, and cancer. Science 297, 565-569 (2002)
    • (2002) Science , vol.297 , pp. 565-569
    • Maser, S.1    Depinho, R.A.2
  • 158
    • 77950932096 scopus 로고    scopus 로고
    • Persistent telomere damage induces bypass of mitosis and tetraploidy
    • T Davoli, E L Denchi, T de Lange: Persistent telomere damage induces bypass of mitosis and tetraploidy. Cell 141, 81-93 (2010)
    • (2010) Cell , vol.141 , pp. 81-93
    • Davoli, T.1    Denchi, E.L.2    De Lange, T.3
  • 160
    • 52949152429 scopus 로고    scopus 로고
    • Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation
    • D A Gewirtz, S E Holt, L W Elmore: Accelerated senescence: an emerging role in tumor cell response to chemotherapy and radiation. Biochem Pharmacol 76, 947-957 (2008)
    • (2008) Biochem Pharmacol , vol.76 , pp. 947-957
    • Gewirtz, D.A.1    Holt, S.E.2    Elmore, L.W.3
  • 161
    • 19444371245 scopus 로고    scopus 로고
    • 2-M cell arrest in p53-mutated human non-small cell lung cancer cells
    • DOI 10.1016/j.canlet.2004.10.049, PII S0304383504008560
    • C C Chiu, C H Li, M W Ung, T S Fuh, W L Chen, K Fang: Etoposide (VP-16) elicits apoptosis following prolonged G2-M cell arrest in p53-mutated human non small cell lung cancer cells. Cancer Lett 223, 249-258 (2005) (Pubitemid 40723603)
    • (2005) Cancer Letters , vol.223 , Issue.2 , pp. 249-258
    • Chiu, C.-C.1    Li, C.-H.2    Ung, M.-W.3    Fuh, T.-S.4    Chen, W.-L.5    Fang, K.6
  • 163
    • 16844373387 scopus 로고    scopus 로고
    • Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
    • DOI 10.1158/0008-5472.CAN-04-1270
    • R S Roberson, S J Kussick, E Vallieres, S Y Chen, D Y Wu: Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res 65, 2795-2803 (2005) (Pubitemid 40490082)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2795-2803
    • Roberson, R.S.1    Kussick, S.J.2    Vallieres, E.3    Chen, S.-Y.J.4    Wu, D.Y.5
  • 164
    • 11144290236 scopus 로고    scopus 로고
    • Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts
    • DOI 10.1038/sj.cr.7290203, PII 7290203
    • W Zhao, Z X Lin, Z Q Zhang: Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts. Cell Res 14, 60-66 (2004) (Pubitemid 43231831)
    • (2004) Cell Research , vol.14 , Issue.1 , pp. 60-66
    • Zhao, W.1    Lin, Z.X.2    Zhang, Z.Q.3
  • 168
    • 79952113981 scopus 로고    scopus 로고
    • Cytokines shape chemotherapy-induced and 'bystander' senescence
    • Z Hodny, S Hubackova, J Bartek: Cytokines shape chemotherapy-induced and 'bystander' senescence. Aging, 2, 375-376 (2010)
    • (2010) Aging , vol.2 , pp. 375-376
    • Hodny, Z.1    Hubackova, S.2    Bartek, J.3
  • 170
    • 58849131828 scopus 로고    scopus 로고
    • Cancer and the tumor microenvironment: A review of an essential relationship
    • F Mbeunkui, D J Johann, Jr.: Cancer and the tumor microenvironment: a review of an essential relationship. Cancer Chemother Pharmacol 63, 571-582 (2009)
    • (2009) Cancer Chemother Pharmacol , vol.63 , pp. 571-582
    • Mbeunkui, F.1    Johann Jr., D.J.2
  • 171
    • 0004334206 scopus 로고
    • 1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration
    • DOI 10.1073/pnas.82.6.1810
    • J B Konopka, S M Watanabe, J W Singer, S J Collins, O N Witte: Cell lines and clinical isolates derived from Ph1-positive chronic myelogenous leukemia patients express c-abl proteins with a common structural alteration. Proc Natl Acad Sci U S A 82, 1810-1814 (1985) (Pubitemid 15085267)
    • (1985) Proceedings of the National Academy of Sciences of the United States of America , vol.82 , Issue.6 , pp. 1810-1814
    • Konopka, J.B.1    Watanabe, S.M.2    Singer, J.W.3
  • 172
    • 38749114995 scopus 로고    scopus 로고
    • Oncogenes and cancer
    • DOI 10.1056/NEJMra072367
    • C M Croce: Oncogenes and cancer. N Engl J Med 358, 502-511 (2008) (Pubitemid 351185806)
    • (2008) New England Journal of Medicine , vol.358 , Issue.5 , pp. 502-511
    • Croce, C.M.1
  • 173
    • 0022379447 scopus 로고
    • The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining
    • Y Tsujimoto, J Gorham, J Cossman, E Jaffe, C M Croce: The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science 229, 1390-1393 (1985) (Pubitemid 16222379)
    • (1985) Science , vol.229 , Issue.4720 , pp. 1390-1393
    • Tsujimoto, Y.1    Gorham, J.2    Cossman, J.3
  • 174
    • 0022972786 scopus 로고
    • A common mechanism of chromosomal translocation in T- and B-cell neoplasia
    • L R Finger, R C Harvey, R C Moore, L C Showe, C M Croce: A common mechanism of chromosomal translocation in T-and B-cell neoplasia. Science 234, 982-985 (1986) (Pubitemid 17193020)
    • (1986) Science , vol.234 , Issue.4779 , pp. 982-985
    • Finger, L.R.1    Harvey, R.C.2    Moore, R.C.A.3
  • 175
    • 0020521611 scopus 로고
    • Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene
    • R F Newbold, R W Overell: Fibroblast immortality is a prerequisite for transformation by EJ c-Ha-ras oncogene. Nature 304, 648-651 (1983) (Pubitemid 13035507)
    • (1983) Nature , vol.304 , Issue.5927 , pp. 648-651
    • Newbold, R.F.1    Overell, R.W.2
  • 176
    • 79953306808 scopus 로고    scopus 로고
    • Oncogenic ras-induced expression of Noxa and Beclin-1 rootes autophagic cell death and limits clonogenic survival
    • M Elgendy, C Sheridan, G Brumatti, S J Martin: Oncogenic ras-induced expression of Noxa and Beclin-1 rootes autophagic cell death and limits clonogenic survival. Mol Cell 42, 23-35 (2011)
    • (2011) Mol Cell , vol.42 , pp. 23-35
    • Elgendy, M.1    Sheridan, C.2    Brumatti, G.3    Martin, S.J.4
  • 177
    • 11244334166 scopus 로고    scopus 로고
    • Molecular signature of oncogenic ras-induced senescence
    • DOI 10.1038/sj.onc.1208172
    • D X Mason, T J Jackson, A W Lin: Molecular signature of oncogenic ras-induced senescence. Oncogene 23, 9238-9246 (2004) (Pubitemid 40069694)
    • (2004) Oncogene , vol.23 , Issue.57 , pp. 9238-9246
    • Mason, D.X.1    Jackson, T.J.2    Lin, A.W.3
  • 183
    • 4644362834 scopus 로고    scopus 로고
    • Akt-induced cellular senescence: Implication for human disease
    • T. Minamino, H Miyauchi, K Tateno, T Kunieda, I Komuro: Akt-induced cellular senescence: implication for human disease. Cell Cycle 3, 449-451 (2004) (Pubitemid 40278235)
    • (2004) Cell Cycle , vol.3 , Issue.4 , pp. 449-451
    • Minamino, T.1    Miyauchi, H.2    Tateno, K.3    Kunieda, T.4    Komuro, I.5
  • 184
    • 78650631129 scopus 로고    scopus 로고
    • Forced activation of Stat5 subjects mammary epithelial cells to DNA damage and preferential induction of the cellular response mechanism during proliferation
    • T Eilon, I Barash: Forced activation of Stat5 subjects mammary epithelial cells to DNA damage and preferential induction of the cellular response mechanism during proliferation. J Cell Physiol 226, 616-26 (2011)
    • (2011) J Cell Physiol , vol.226 , pp. 616-626
    • Eilon, T.1    Barash, I.2
  • 185
    • 0033989829 scopus 로고    scopus 로고
    • Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor
    • G P Dimri, K Itahana, M Acosta, J Campisi: Regulation of a senescence checkpoint response by the E2F1 transcription factor and p14(ARF) tumor suppressor. Mol Cell Biol 20, 273-285 (2000) (Pubitemid 30002569)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.1 , pp. 273-285
    • Dimri, G.P.1    Itahana, K.2    Acosta, M.3    Campisi, J.4
  • 186
    • 15044351968 scopus 로고    scopus 로고
    • Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
    • DOI 10.1128/MCB.25.7.2660-2672.2005
    • E Lazzerini Denchi, C Attwooll, D Pasini, K Helin: Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol Cell Biol 25, 2660-2672 (2005) (Pubitemid 40381630)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.7 , pp. 2660-2672
    • Denchi, E.L.1    Attwooll, C.2    Pasini, D.3    Helin, K.4
  • 187
    • 48849117698 scopus 로고    scopus 로고
    • Oncogene-induced senescence: An essential role for Runx
    • A Kilbey, A Terry, E R Cameron, J C Neil: Oncogene-induced senescence: an essential role for Runx. Cell Cycle 7, 2333-2340 (2008)
    • (2008) Cell Cycle , vol.7 , pp. 2333-2340
    • Kilbey, A.1    Terry, A.2    Cameron, E.R.3    Neil, J.C.4
  • 188
    • 40549130342 scopus 로고    scopus 로고
    • CDC6: From DNA replication to cell cycle checkpoints and oncogenesis
    • DOI 10.1093/carcin/bgm268
    • L R Borlado, J Mendez: CDC6: from DNA replication to cell cycle checkpoints and oncogenesis. Carcinogenesis 29, 237-243 (2008) (Pubitemid 351359661)
    • (2008) Carcinogenesis , vol.29 , Issue.2 , pp. 237-243
    • Borlado, L.R.1    Mendez, J.2
  • 190
    • 34248157632 scopus 로고    scopus 로고
    • Irreversibility of cellular senescence: Dual roles of p16INK4a/Rb-pathway in cell cycle control
    • A Takahashi, N Ohtani, E Hara: Irreversibility of cellular senescence: dual roles of p16INK4a/Rb-pathway in cell cycle control. Cell Div 2, 10 (2007)
    • (2007) Cell Div , vol.2 , pp. 10
    • Takahashi, A.1    Ohtani, N.2    Hara, E.3
  • 191
    • 63249089044 scopus 로고    scopus 로고
    • Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation
    • A Shamma, Y Takegami, T Miki, S Kitajima, M Noda, T Obara, T Okamoto and C Takahashi: Rb Regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell 15, 255-269 (2009)
    • (2009) Cancer Cell , vol.15 , pp. 255-269
    • Shamma, A.1    Takegami, Y.2    Miki, T.3    Kitajima, S.4    Noda, M.5    Obara, T.6    Okamoto, T.7    Takahashi, C.8
  • 192
    • 0037013154 scopus 로고    scopus 로고
    • INK4a contributes to the outcome of cancer therapy
    • DOI 10.1016/S0092-8674(02)00734-1
    • A Schmitt, J S Fridman, M Yang, S Lee, E Baranov, R M Hoffman, S W Lowe: A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109, 335-346 (2002) (Pubitemid 34606876)
    • (2002) Cell , vol.109 , Issue.3 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3    Lee, S.4    Baranov, E.5    Hoffman, R.M.6    Lowe, S.W.7
  • 193
    • 62349129614 scopus 로고    scopus 로고
    • Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes
    • K Vijayachandra, W Higgins, J Lee, A Glick: Induction of p16ink4a and p19ARF by TGFbeta1 contributes to growth arrest and senescence response in mouse keratinocytes. Mol Carcinog 48, 181-186 (2009)
    • (2009) Mol Carcinog , vol.48 , pp. 181-186
    • Vijayachandra, K.1    Higgins, W.2    Lee, J.3    Glick, A.4
  • 194
    • 0032850895 scopus 로고    scopus 로고
    • Overexpression of the p21(sdi1) gene induces senescence-like state in human cancer cells: Implication for senescence-directed molecular therapy for cancer
    • S Kagawa, T Fujiwara, Y Kadowaki, T Fukazawa, R Sok-Joo, J A Roth, N Tanaka: Overexpression of the p21 sdi1 gene induces senescence-like state in human cancer cells: implication for senescence-directed molecular therapy for cancer. Cell Death Differ 6, 765-772 (1999) (Pubitemid 29425387)
    • (1999) Cell Death and Differentiation , vol.6 , Issue.8 , pp. 765-772
    • Kagawa, S.1    Fujiwara, T.2    Kadowaki, Y.3    Fukazawa, T.4    Sok-Joo, R.5    Roth, J.A.6    Tanaka, N.7
  • 195
    • 72949100316 scopus 로고    scopus 로고
    • The p53-p21(Cip1/WAF1) pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells
    • J Y Kang, J J Kim, S Y Jang, Y S Bae: The p53-p21(Cip1/WAF1) pathway is necessary for cellular senescence induced by the inhibition of protein kinase CKII in human colon cancer cells. Mol Cells 28, 489-494 (2009)
    • (2009) Mol Cells , vol.28 , pp. 489-494
    • Kang, J.Y.1    Kim, J.J.2    Jang, S.Y.3    Bae, Y.S.4
  • 196
    • 0342656549 scopus 로고    scopus 로고
    • Adenovirus-mediated overexpression of p15(INK4B) inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16(INK4A)
    • J Fuxe, G Akusjarvi, H M Goike, G Roos, V P Collins, R F Pettersson: Adenovirus-mediated overexpression of p15INK4B inhibits human glioma cell growth, induces replicative senescence, and inhibits telomerase activity similarly to p16INK4A Cell Growth Differ 11, 373-384 (2000) (Pubitemid 30619565)
    • (2000) Cell Growth and Differentiation , vol.11 , Issue.7 , pp. 373-384
    • Fuxe, J.1    Akusjarvi, G.2    Goike, H.M.3    Roos, G.4    Collins, V.P.5    Pettersson, R.F.6
  • 198
    • 1242272929 scopus 로고    scopus 로고
    • PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells
    • DOI 10.1038/sj.onc.1207162
    • H Zhao, J Dupont, S Yakar, M Karas, D LeRoith: PTEN inhibits cell proliferation and induces apoptosis by downregulating cell surface IGF-IR expression in prostate cancer cells. Oncogene 23, 786-794 (2004) (Pubitemid 38241279)
    • (2004) Oncogene , vol.23 , Issue.3 , pp. 786-794
    • Zhao, H.1    Dupont, J.2    Yakar, S.3    Karas, M.4    LeRoith, D.5
  • 199
    • 0035901937 scopus 로고    scopus 로고
    • Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth
    • DOI 10.1038/sj.onc.1204397
    • M Baba, S Hirai, S Kawakami, T Kishida, N Sakai, S Kaneko, M Yao, T Shuin, Y Kubota, M Hosaka, S Ohno: Tumor suppressor protein VHL is induced at high cell density and mediates contact inhibition of cell growth. Oncogene 20, 2727-2736 (2001) (Pubitemid 32549830)
    • (2001) Oncogene , vol.20 , Issue.22 , pp. 2727-2736
    • Baba, M.1    Hirai, S.-I.2    Kawakami, S.3    Kishida, T.4    Sakai, N.5    Kaneko, S.6    Yao, M.7    Shuin, T.8    Kubota, Y.9    Hosaka, M.10    Ohno, S.11
  • 200
    • 0034491067 scopus 로고    scopus 로고
    • Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features
    • C Bastian, P E LeBoit, D Pinkel: Mutations and copy number increase of HRAS in Spitz nevi with distinctive histopathological features. Am J Pathol 157, 967-972 (2000) (Pubitemid 32109388)
    • (2000) American Journal of Pathology , vol.157 , Issue.3 , pp. 967-972
    • Bastian, B.C.1    LeBoit, P.E.2    Pinkel, D.3
  • 202
    • 0033819340 scopus 로고    scopus 로고
    • Epigenetic PTEN silencing in malignant melanomas without PTEN mutation
    • X P Zhou, O Gimm, H Hampel, T Niemann, M J Walker, C Eng: Epigenetic PTEN silencing in malignant melanomas without PTEN mutation. Am J Pathol 157, 1123-1128 (2000)
    • (2000) Am J Pathol , vol.157 , pp. 1123-1128
    • Zhou, X.P.1    Gimm, O.2    Hampel, H.3    Niemann, T.4    Walker, M.J.5    Eng, C.6
  • 203
    • 42949129074 scopus 로고    scopus 로고
    • Many roads lead to oncogene-induced senescence
    • DOI 10.1038/sj.onc.1210950, PII 1210950
    • S Courtois-Cox, S L Jones, K Cichowski: Many roads lead to oncogene-induced senescence. Oncogene 27, 2801-2809 (2008) (Pubitemid 351620451)
    • (2008) Oncogene , vol.27 , Issue.20 , pp. 2801-2809
    • Courtois-Cox, S.1    Jones, S.L.2    Cichowski, K.3
  • 204
    • 7044249212 scopus 로고    scopus 로고
    • PTEN regulatory functions in tumor suppression and cell biology
    • E C Chu, A S Tarnawski: PTEN regulatory functions in tumor suppression and cell biology. Med Sci Monit 10, RA235-RA241 (2004) (Pubitemid 39424480)
    • (2004) Medical Science Monitor , vol.10 , Issue.10
    • Chu, E.C.1    Tarnawski, A.S.2
  • 205
    • 33846153618 scopus 로고    scopus 로고
    • Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts
    • DOI 10.1089/hum.2006.17.975
    • S Anai, S Goodison, K Shiverick, K Iczkowski, M Tanaka, C J Rosser: Combination of PTEN gene therapy and radiation inhibits the growth of human prostate cancer xenografts. Hum Gene Ther 17, 975-984 (2006) (Pubitemid 46076739)
    • (2006) Human Gene Therapy , vol.17 , Issue.10 , pp. 975-984
    • Anai, S.1    Goodison, S.2    Shiverick, K.3    Iczkowski, K.4    Tanaka, M.5    Rosser, C.J.6
  • 208
    • 79551542888 scopus 로고    scopus 로고
    • PTEN level in tumor suppression: How much is too little?
    • A Carracedo, A Alimonti, P P Pandolfi: PTEN level in tumor suppression: how much is too little? Cancer Res 71, 629-633 (2011)
    • (2011) Cancer Res , vol.71 , pp. 629-633
    • Carracedo, A.1    Alimonti, A.2    Pandolfi, P.P.3
  • 209
    • 0034616627 scopus 로고    scopus 로고
    • Gatekeeper for endometrium: The PTEN tumor suppressor gene
    • I U Ali: Gatekeeper for endometrium: the PTEN tumor suppressor gene. J Natl Cancer Inst 92, 861-863 (2000) (Pubitemid 30429187)
    • (2000) Journal of the National Cancer Institute , vol.92 , Issue.11 , pp. 861-863
    • Ali, I.U.1
  • 212
    • 79251536870 scopus 로고    scopus 로고
    • PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer
    • T A Bismar, M Yoshimoto, R T Vollmer, Q Duan, M Firszt, J Corcos, J A Squire: PTEN genomic deletion is an early event associated with ERG gene rearrangements in prostate cancer. BJU Int 107, 477-485 (2011)
    • (2011) BJU Int , vol.107 , pp. 477-485
    • Bismar, T.A.1    Yoshimoto, M.2    Vollmer, R.T.3    Duan, Q.4    Firszt, M.5    Corcos, J.6    Squire, J.A.7
  • 213
    • 77952975814 scopus 로고    scopus 로고
    • Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway
    • Y G Wen, Q Wang, C Z Zhou, G Q Qiu, Z H Peng, H M Tang: Mutation analysis of tumor suppressor gene PTEN in patients with gastric carcinomas and its impact on PI3K/AKT pathway. Oncol Rep 24, 89-95 (2010)
    • (2010) Oncol Rep , vol.24 , pp. 89-95
    • Wen, Y.G.1    Wang, Q.2    Zhou, C.Z.3    Qiu, G.Q.4    Peng, Z.H.5    Tang, H.M.6
  • 214
    • 0037325853 scopus 로고    scopus 로고
    • Deregulated degradation of the cdk inhibitor p27 and malignant transformation
    • DOI 10.1016/S1044-579X(02)00098-6, PII S1044579X02000986
    • J. Bloom, M Pagano: Deregulated degradation of the cdk inhibitor p27 and malignant transformation. Semin Cancer Biol 13, 41-47 (2003) (Pubitemid 36269179)
    • (2003) Seminars in Cancer Biology , vol.13 , Issue.1 , pp. 41-47
    • Bloom, J.1    Pagano, M.2
  • 215
    • 17044370346 scopus 로고    scopus 로고
    • Regulation of the cell cycle by SCF-type ubiquitin ligases
    • K I Nakayama, K Nakayama: Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol 16, 323-333 (2005)
    • (2005) Semin Cell Dev Biol , vol.16 , pp. 323-333
    • Nakayama, K.I.1    Nakayama, K.2
  • 217
    • 71649103633 scopus 로고    scopus 로고
    • DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging
    • C Kim, S Friso, S W Choi: DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging. J Nutr Biochem 20, 917-926 (2009)
    • (2009) J Nutr Biochem , vol.20 , pp. 917-926
    • Kim, C.1    Friso, S.2    Choi, S.W.3
  • 218
    • 70849124305 scopus 로고    scopus 로고
    • Ageing and cancer as diseases of epigenesis
    • S F Gilbert: Ageing and cancer as diseases of epigenesis. J Biosci 34, 601-604 (2009)
    • (2009) J Biosci , vol.34 , pp. 601-604
    • Gilbert, S.F.1
  • 219
    • 33847304584 scopus 로고    scopus 로고
    • Biology of polycomb and trithorax group proteins
    • DOI 10.1016/S0074-7696(07)58002-2, PII S0074769607580022, A Survey of Cell Biology
    • A Breiling, L Sessa, V Orlando: Biology of polycomb and trithorax group proteins. Int Rev Cytol 258, 83-136 (2007) (Pubitemid 46330484)
    • (2007) International Review of Cytology , vol.258 , pp. 83-136
    • Breiling, A.1    Sessa, L.2    Orlando, V.3
  • 221
    • 34447625911 scopus 로고    scopus 로고
    • Epigenetics and aging: The targets and the marks
    • DOI 10.1016/j.tig.2007.05.008, PII S0168952507001862
    • M F Fraga, M Esteller: Epigenetics and aging: the targets and the marks. Trends Genet 23, 413-418 (2007) (Pubitemid 47088010)
    • (2007) Trends in Genetics , vol.23 , Issue.8 , pp. 413-418
    • Fraga, M.F.1    Esteller, M.2
  • 222
    • 77953625822 scopus 로고    scopus 로고
    • The central role of chromatin maintenance in aging
    • G Pegoraro, T Misteli: The central role of chromatin maintenance in aging. Aging 1, 1017-1022 (2009)
    • (2009) Aging , vol.1 , pp. 1017-1022
    • Pegoraro, G.1    Misteli, T.2
  • 223
    • 73749085370 scopus 로고    scopus 로고
    • Epigenetic factors in aging and longevity
    • S Gravina, J Vijg: Epigenetic factors in aging and longevity. Pflugers Arch 459, 247-258 (2010)
    • (2010) Pflugers Arch , vol.459 , pp. 247-258
    • Gravina, S.1    Vijg, J.2
  • 224
    • 55849115277 scopus 로고    scopus 로고
    • Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons
    • R Satta, E Maloku, A Zhubi, F Pibiri, M Hajos, E Costa, A Guidotti: Nicotine decreases DNA methyltransferase 1 expression and glutamic acid decarboxylase 67 promoter methylation in GABAergic interneurons. Proc Natl Acad Sci U S A 105, 16356-16361 (2008)
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 16356-16361
    • Satta, R.1    Maloku, E.2    Zhubi, A.3    Pibiri, F.4    Hajos, M.5    Costa, E.6    Guidotti, A.7
  • 226
    • 33847703331 scopus 로고    scopus 로고
    • Cellular senescence and chromatin organization
    • M Narita: Cellular senescence and chromatin organization. Br J Cancer 96, 686-691 (2007)
    • (2007) Br J Cancer , vol.96 , pp. 686-691
    • Narita, M.1
  • 227
    • 33846111256 scopus 로고    scopus 로고
    • Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer
    • R K Lin, H S Hsu, J W Chang, C Y Chen, J T Chen, Y C Wang: Alteration of DNA methyltransferases contributes to 5'CpG methylation and poor prognosis in lung cancer. Lung Cancer 55, 205-213 (2007)
    • (2007) Lung Cancer , vol.55 , pp. 205-213
    • Lin, R.K.1    Hsu, H.S.2    Chang, J.W.3    Chen, C.Y.4    Chen, J.T.5    Wang, Y.C.6
  • 228
    • 33646027860 scopus 로고    scopus 로고
    • Chromatin modification and senescence: Linkage by tumor suppressors?
    • X Han, P Berardi, K Riabowol: Chromatin modification and senescence: linkage by tumor suppressors? Rejuvenation Res 9, 69-76 (2006)
    • (2006) Rejuvenation Res , vol.9 , pp. 69-76
    • Han, X.1    Berardi, P.2    Riabowol, K.3
  • 229
    • 28344440823 scopus 로고    scopus 로고
    • MicroRNA function: Multiple mechanisms for a tiny RNA?
    • DOI 10.1261/rna.2248605
    • R S Pillai: MicroRNA function: multiple mechanisms for a tiny RNA? RNA, 11(12), 1753-61 (2005) (Pubitemid 41720024)
    • (2005) RNA , vol.11 , Issue.12 , pp. 1753-1761
    • Pillai, R.S.1
  • 230
    • 34247204196 scopus 로고    scopus 로고
    • MicroRNA function in animal development
    • K Inoue: MicroRNA function in animal development. Tanpakushitsu Kakusan Koso 52, 197-204 (2007)
    • (2007) Tanpakushitsu Kakusan Koso , vol.52 , pp. 197-204
    • Inoue, K.1
  • 232
    • 64549137199 scopus 로고    scopus 로고
    • Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms
    • K Lafferty-Whyte, C J Cairney, N B Jamieson, K A Oien, W N Keith: Pathway analysis of senescence-associated miRNA targets reveals common processes to different senescence induction mechanisms. Biochim Biophys Acta 1792, 341-352 (2009)
    • (2009) Biochim Biophys Acta , vol.1792 , pp. 341-352
    • Lafferty-Whyte, K.1    Cairney, C.J.2    Jamieson, N.B.3    Oien, K.A.4    Keith, W.N.5
  • 239
    • 78650658030 scopus 로고    scopus 로고
    • Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells
    • X Zhong, N Li, S Liang, Q Huang, G Coukos and L Zhang: Identification of microRNAs regulating reprogramming factor LIN28 in embryonic stem cells and cancer cells. J Biol Chem 285, 41961-41971 (2010)
    • (2010) J Biol Chem , vol.285 , pp. 41961-41971
    • Zhong, X.1    Li, N.2    Liang, S.3    Huang, Q.4    Coukos, G.5    Zhang, L.6
  • 240
    • 70350111289 scopus 로고    scopus 로고
    • MiR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A
    • X Yang, M Feng, X Jiang, Z Wu, Z Li, M Aau, Q Yu: miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A Genes Dev 23, 2388-23893 (2009)
    • (2009) Genes Dev , vol.23 , pp. 2388-23893
    • Yang, X.1    Feng, M.2    Jiang, X.3    Wu, Z.4    Li, Z.5    Aau, M.6    Yu, Q.7
  • 243
    • 74249123570 scopus 로고    scopus 로고
    • The miR-34 family in cancer and apoptosis
    • H Hermeking: The miR-34 family in cancer and apoptosis. Cell Death Differ 17, 193-199 (2009)
    • (2009) Cell Death Differ , vol.17 , pp. 193-199
    • Hermeking, H.1
  • 246
    • 38049103266 scopus 로고    scopus 로고
    • MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression
    • D Y Lee, Z Deng, C H Wang, B B Yang: MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expression. Proc Natl Acad Sci U S A 104, 20350-20355 (2007)
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 20350-20355
    • Lee, D.Y.1    Deng, Z.2    Wang, C.H.3    Yang, B.B.4
  • 247
    • 77955294582 scopus 로고    scopus 로고
    • MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence
    • S Venkataraman, I Alimova, R Fan, P Harris, N Foreman, R Vibhakar: MicroRNA 128a increases intracellular ROS level by targeting Bmi-1 and inhibits medulloblastoma cancer cell growth by promoting senescence. PLoS One 5, e10748 (2010)
    • (2010) PLoS One , vol.5
    • Venkataraman, S.1    Alimova, I.2    Fan, R.3    Harris, P.4    Foreman, N.5    Vibhakar, R.6
  • 251
    • 77049133320 scopus 로고
    • UNSOLVED problem of biology
    • P. Medawar: UNSOLVED problem of biology. Med J Aust 1, 854-855 (1953)
    • (1953) Med J Aust , vol.1 , pp. 854-855
    • Medawar, P.1
  • 252
    • 77951601845 scopus 로고    scopus 로고
    • Mutation and the evolution of ageing: From biometrics to system genetics
    • K A Hughes: Mutation and the evolution of ageing: from biometrics to system genetics. Philos Trans R Soc Lond B Biol Sci 365, 1273-1279 (2010)
    • (2010) Philos Trans R Soc Lond B Biol Sci , vol.365 , pp. 1273-1279
    • Hughes, K.A.1
  • 253
    • 0042697664 scopus 로고    scopus 로고
    • Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence
    • P D Williams, T Day: Antagonistic pleiotropy, mortality source interactions, and the evolutionary theory of senescence. Evolution 57, 1478-1488 (2003) (Pubitemid 36953637)
    • (2003) Evolution , vol.57 , Issue.7 , pp. 1478-1488
    • Williams, P.D.1    Day, T.2
  • 255
    • 0345272134 scopus 로고    scopus 로고
    • Observation and theory
    • Ed: W Newton-Smith M A Malden. Blackwell Publishing Ltd
    • P Achinstein. Observation and theory. In: A Companion to the Philosophy of Science. Ed: W Newton-Smith, M A Malden. Blackwell Publishing Ltd (2000)
    • (2000) A Companion to the Philosophy of Science
    • Achinstein, P.1
  • 257
    • 34247580184 scopus 로고    scopus 로고
    • Telomeres limit cancer growth by inducing senescence: Long-sought in vivo evidence obtained
    • DOI 10.1016/j.ccr.2007.04.014, PII S1535610807001201
    • J M Sedivy: Telomeres limit cancer growth by inducing senescence: long-sought in vivo evidence obtained. Cancer Cell 11, 389-391 (2007) (Pubitemid 46670082)
    • (2007) Cancer Cell , vol.11 , Issue.5 , pp. 389-391
    • Sedivy, J.M.1
  • 258
    • 78951475020 scopus 로고    scopus 로고
    • P53 and its mutants in tumor cell migration and invasion
    • P A Muller, K H Vousden, J C Norman: p53 and its mutants in tumor cell migration and invasion. J Cell Biol 192, 209-218 (2011)
    • (2011) J Cell Biol , vol.192 , pp. 209-218
    • Muller, P.A.1    Vousden, K.H.2    Norman, J.C.3
  • 260
    • 34248578816 scopus 로고    scopus 로고
    • Telomerase activity is maintained throughout the lifespan of long-lived birds
    • DOI 10.1016/j.exger.2007.03.004, PII S0531556507000587
    • M F Haussmann, D W Winkler, C E Huntington, I C Nisbet, C M Vleck: Telomerase activity is maintained throughout the lifespan of long-lived birds. Exp Gerontol 42, 610-618 (2007) (Pubitemid 46756106)
    • (2007) Experimental Gerontology , vol.42 , Issue.7 , pp. 610-618
    • Haussmann, M.F.1    Winkler, D.W.2    Huntington, C.E.3    Nisbet, I.C.T.4    Vleck, C.M.5
  • 261
    • 58149341744 scopus 로고    scopus 로고
    • Coevolution of telomerase activity and body mass in mammals: From mice to beavers
    • V Gorbunova, A Seluanov: Coevolution of telomerase activity and body mass in mammals: from mice to beavers. Mech Ageing Dev 130, 3-9 (2009)
    • (2009) Mech Ageing Dev , vol.130 , pp. 3-9
    • Gorbunova, V.1    Seluanov, A.2
  • 264
    • 16244399543 scopus 로고    scopus 로고
    • Asymmetry and the origins of ageing
    • DOI 10.1016/j.mad.2005.02.001
    • T B Kirkwood: Asymmetry and the origins of ageing. Mech Ageing Dev 126, 533-534 (2005) (Pubitemid 40461952)
    • (2005) Mechanisms of Ageing and Development , vol.126 , Issue.5 , pp. 533-534
    • Kirkwood, T.B.L.1
  • 265
    • 0035195557 scopus 로고    scopus 로고
    • The evolution of diverse biological responses to DNA damage: Insights from yeast and p53
    • DOI 10.1038/ncb1201-e277
    • G M Wahl, A M Carr: The evolution of diverse biological responses to DNA damage: insights from yeast and p53. Nat Cell Biol 3, E277-E286 (2001) (Pubitemid 33130452)
    • (2001) Nature Cell Biology , vol.3 , Issue.12
    • Wahl, G.M.1    Carr, A.M.2
  • 266
    • 34447108090 scopus 로고    scopus 로고
    • Genomic instability: On the birth and death of cancer
    • M Murga, O Fernandez-Capetillo: Genomic instability: on the birth and death of cancer. Clin Transl Oncol 9, 216-220 (2007)
    • (2007) Clin Transl Oncol , vol.9 , pp. 216-220
    • Murga, M.1    Fernandez-Capetillo, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.