Epigenetic PTEN silencing in malignant melanomas without PTEN mutation

American Journal of Pathology

Volumn 157, Issue 4, 2000, Pages 1123-1128

  Zhou, Xiao Ping ^a,b   Gimm, Oliver ^a,b   Hampel, Heather ^a,b   Niemann, Theodore ^b   Walker, Michael J ^b   Eng, Charis ^a,b,c  

^a OHIO STATE UNIVERSITY   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALLELE; ARTICLE; CHROMOSOME 10Q; GENE DELETION; GENE EXPRESSION; GENE INACTIVATION; GENE STRUCTURE; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MELANOMA; PRIORITY JOURNAL; TUMOR SUPPRESSOR GENE;

EID: 0033819340     PISSN: 00029440     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9440(10)64627-5     Document Type: Article

References (41)

1. PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer
2. Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers
3. TEP1, encoded by a candidate tumor suppressor locus, is a novel protein tyrosine phosphatase regulated by transforming growth factor beta
4. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
5. The phosphoinositol phosphatase activity of PTEN mediates a serum-sensitive G1 growth arrest in glioma cells
6. The lipid phosphatase activity of PTEN is critical for its tumor supressor function
7. PTEN is inversely correlated with the cell survival factor Akt/PKB and is inactivated via multiple mechanisms in haematological malignancies
8. Inhibition of cell migration, spreading, and focal adhesions by tumor suppressor PTEN
9. Shc and FAK differentially regulate cell motility and directionality modulated by PTEN
10. PTEN/MMAC1/TEP1 suppresses the tumorigenicity and induces G1 cell cycle arrest in human glioblastoma cells
11. PTEN suppresses breast cancer cell growth by phosphatase activity-dependent G1 arrest followed by cell death
12. Germline mutations of the PTEN gene in Cowden disease, an inherited breast and thyroid cancer syndrome
13. Germline mutations in PTEN are present in Bannayan-Zonana syndrome
14. Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation
15. PTEN mutation spectrum and genotype-phenotype correlations in Bannayan-Riley-Ruvalcaba syndrome suggest a single entity with Cowden syndrome
16. Germline and germline mosaic PTEN mutations associated with a Proteus-like syndrome of hemihypertrophy, lower limb asymmetry, arterio-venous malformations and lipomatosis
17. Somatic mutations of PTEN in glioblastoma multiforme
18. PTEN gene mutations are seen in high-grade but not in low-grade gliomas
19. PTEN mutations in gliomas and glioneuronal tumors
20. Mutations in PTEN are frequent in endometrial carcinoma but rare in other common gynecological malignancies
21. Frequent inactivation of PTEN/MMAC1 in primary prostate cancer
22. Molecular mechanisms controlling human melanoma progression and metastasis
23. Malignant melanoma
24. Loss of heterozygosity for 10q22-10qter in malignant melanoma progression
25. Prognostic significance of allelic losses in primary melanoma
26. Disruption of the MMAC1/PTEN gene by deletion or mutation is a frequent event in malignant melanoma
27. MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines
28. Identification of PTEN/MMAC1 alterations in uncultured melanomas and melanoma cell lines
29. In vitro loss of heterozygosity targets the PTEN/MMAC1 gene in melanoma
30. The PTEN tumour suppressor gene and malignant melanoma
31. PTEN and MX11 allelic loss on chromosome 10q is rare in melanoma in vivo
32. Mutation and allelic loss of the PTEN/MMAC1 gene in primary and metastatic melanoma biopsies
33. Immunohistochemical evidence of loss of PTEN expression in primary ductal adenocarcinomas of the breast
34. Differential nuclear and cytoplasmic expression of PTEN in normal thyroid tissue, and benign and malignant epithelial thyroid tumors
35. Somatic deletions and mutations in the Cowden disease gene, PTEN, in sporadic thyroid tumors
36. Exclusion of PTEN and 10q22-24 as the susceptibility locus for juvenile polyposis syndrome
37. Inactivation of the tumor suppressor PTEN/MMAC1 in advanced human prostate cancer through loss of expression
38. Mutation analysis of the putative tumor suppressor gene PTEN/MMAC1 in primary breast carcinomas
39. Sporadic breast cancers exhibit loss of heterozygosity on chromosome segment 10q23 close to the Cowden disease locus
40. Analysis of the 10q23 chromosomal region and the PTEN gene in human sporadic breast carcinoma
41. Differential loss of heterozygosity in the region of the Cowden locus within 10q22-23 in follicular thyroid adenomas and carcinomas