Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Nature

Volumn 444, Issue 7119, 2006, Pages 638-642

  Di Micco, Raffaella ^a   Fumagalli, Marzia ^a   Cicalese, Angelo ^b   Piccinin, Sara ^c   Gasparini, Patrizia ^a   Luise, Chiara ^a   Schurra, Catherine ^d   Garré, Massimiliano ^a   Giovanni Nuciforo, Paolo ^a   Bensimon, Aaron ^e   Maestro, Roberta ^c   Giuseppe Pelicci, Pier ^b   D'Adda Di Fagagna, Fabrizio ^a  

^a FIRC INSTITUTE OF MOLECULAR ONCOLOGY   (Italy)

^b EUROPEAN INSTITUTE OF ONCOLOGY   (Italy)

^c CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^d INSTITUT PASTEUR   (France)

^e Genomic Vision   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ENERGY; CELLS; DNA SEQUENCES; GENETIC ENGINEERING; MOLECULAR DYNAMICS; PHYSIOLOGICAL MODELS;

CELL TRANSFORMATION; ONCOGENE ACTIVATION; ONCOGENE-INDUCED SENESCENCE (OIS); TUMORIGENESIS;

ONCOLOGY;

DNA; SMALL INTERFERING RNA;

DNA; GENE EXPRESSION; TUMOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOGENESIS; CELL AGING; CELL PROLIFERATION; CELL TRANSFORMATION; CHEMICAL LABELING; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; DNA RESPONSIVE ELEMENT; GENE ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE MICROSCOPY; MOUSE; NONHUMAN; ONCOGENE; ONCOGENE H RAS; PRIORITY JOURNAL; REPLICON; SENESCENCE;

EID: 33845269825     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature05327     Document Type: Article

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