The G-quadruplex ligand telomestatin impairs binding of topoisomerase IIIα to G-quadruplex-forming oligonucleotides and uncaps telomeres in ALT cells

PLoS ONE

Volumn 4, Issue 9, 2009, Pages

  Temime Smaali, Nassima ^a   Guittat, Lionel ^b   Sidibe, Assitan ^b   Shin Ya, Kazuo ^c   Trentesaux, Chantal ^a,b   Riou, Jean François ^a,b  

^a UNIVERSITÉ DE REIMS CHAMPAGNE ARDENNE   (France)

^b MUSÉUM NATIONAL D'HISTOIRE NATURELLE   (France)

^c NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

DNA TOPOISOMERASE; DNA TOPOISOMERASE III ALPHA; TELOMESTATIN; UNCLASSIFIED DRUG; GUANINE QUADRUPLEX; LIGAND; OLIGONUCLEOTIDE; OXAZOLE DERIVATIVE; TOPOISOMERASE IIIALPHA;

ARTICLE; CELL STRAIN; CELL STRAIN ALT; CONTROLLED STUDY; DNA DAMAGE; GENE DISRUPTION; GENE REPLICATION; GENE SEGREGATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; PROTEIN BINDING; PROTEIN DEPLETION; PROTEIN STRUCTURE; TELOMERE; BIOLOGICAL MODEL; CELL CULTURE; CELL NUCLEUS; CELL SEPARATION; CHEMISTRY; FLOW CYTOMETRY; GENETIC RECOMBINATION; METABOLISM; PROTEIN TERTIARY STRUCTURE; ULTRASTRUCTURE;

CELL NUCLEUS; CELL SEPARATION; CELLS, CULTURED; DNA TOPOISOMERASES, TYPE I; FLOW CYTOMETRY; G-QUADRUPLEXES; HUMANS; LIGANDS; MODELS, BIOLOGICAL; OLIGONUCLEOTIDES; OXAZOLES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINATION, GENETIC; TELOMERE;

EID: 70349084987     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0006919     Document Type: Article

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