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Volumn 11, Issue 7, 2011, Pages 503-511

Pro-senescence therapy for cancer treatment

Author keywords

[No Author keywords available]

Indexed keywords

10058 F4; 7 HYDROXYSTAUROSPORINE; ANTINEOPLASTIC AGENT; APR 246; ARSENIC TRIOXIDE; BETA GALACTOSIDASE; ELLIPTICINE; FLAVOPIRIDOL; IMATINIB; IMETELSTAT; MLN 4924; MYC PROTEIN; N [5 (5 TERT BUTYL 2 OXAZOLYLMETHYLTHIO) 2 THIAZOLYL]ISONIPECOTAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; NUTLIN 3; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN INHIBITOR; PROTEIN P53; R 7112; RETINOIC ACID; ROSCOVITINE; S PHASE KINASE ASSOCIATED PROTEIN 2; TRASTUZUMAB; UNCLASSIFIED DRUG;

EID: 79959637828     PISSN: 1474175X     EISSN: 14741768     Source Type: Journal    
DOI: 10.1038/nrc3057     Document Type: Review
Times cited : (370)

References (104)
  • 1
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick, L. The limited in vitro lifetime of human diploid cell strains. Exp. Cell Res. 37, 614-636 (1965).
    • (1965) Exp. Cell Res. , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 2
    • 36048965126 scopus 로고    scopus 로고
    • Breaking news: high-speed race ends in arrest - how oncogenes induce senescence
    • DOI 10.1016/j.tcb.2007.07.012, PII S0962892407002383
    • Di Micco, R., Fumagalli, M. & d'Adda di Fagagna, F. Breaking news: high-speed race ends in arrest-how oncogenes induce senescence. Trends Cell Biol. 17, 529-536 (2007). (Pubitemid 350087662)
    • (2007) Trends in Cell Biology , vol.17 , Issue.11 , pp. 529-536
    • Di Micco, R.1    Fumagalli, M.2    D'Adda Di Fagagna, F.3
  • 5
    • 63249089044 scopus 로고    scopus 로고
    • Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation
    • Shamma, A. et al. Rb regulates DNA damage response and cellular senescence through E2F-dependent suppression of N-ras isoprenylation. Cancer Cell 15, 255-269 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 255-269
    • Shamma, A.1
  • 8
    • 15044351968 scopus 로고    scopus 로고
    • Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland
    • DOI 10.1128/MCB.25.7.2660-2672.2005
    • Lazzerini Denchi, E., Attwooll, C., Pasini, D. & Helin, K. Deregulated E2F activity induces hyperplasia and senescence-like features in the mouse pituitary gland. Mol. Cell Biol. 25, 2660-2672 (2005). (Pubitemid 40381630)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.7 , pp. 2660-2672
    • Denchi, E.L.1    Attwooll, C.2    Pasini, D.3    Helin, K.4
  • 11
    • 69949171557 scopus 로고    scopus 로고
    • P53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence
    • Fujita, K. et al. p53 isoforms Δ133p53 and p53β are endogenous regulators of replicative cellular senescence. Nature Cell Biol. 11, 1135-1142 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 1135-1142
    • Fujita, K.1
  • 13
    • 72949096792 scopus 로고    scopus 로고
    • Senescence in tumours: Evidence from mice and humans
    • Collado, M. & Serrano, M. Senescence in tumours: evidence from mice and humans. Nature Rev. Cancer 10, 51-57 (2010).
    • (2010) Nature Rev. Cancer , vol.10 , pp. 51-57
    • Collado, M.1    Serrano, M.2
  • 15
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C. B., Futcher, A. B. & Greider, C. W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990).
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 17
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri, H. & Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279-282 (1998). (Pubitemid 28111458)
    • (1998) Current Biology , vol.8 , Issue.5 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 18
    • 0033979731 scopus 로고    scopus 로고
    • Human keratinocytes that express hTERT and also bypass a p16(INK4a)- enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics
    • DOI 10.1128/MCB.20.4.1436-1447.2000
    • Dickson, M. A. et al. Human keratinocytes that express hTERT and also bypass a p16(INK4a)-enforced mechanism that limits life span become immortal yet retain normal growth and differentiation characteristics. Mol. Cell Biol. 20, 1436-1447 (2000). (Pubitemid 30069263)
    • (2000) Molecular and Cellular Biology , vol.20 , Issue.4 , pp. 1436-1447
    • Dickson, M.A.1    Hahn, W.C.2    Ino, Y.3    Ronfard, V.4    Wu, J.Y.5    Weinberg, R.A.6    Louis, D.N.7    Li, F.P.8    Rheinwald, J.G.9
  • 19
    • 0034666057 scopus 로고    scopus 로고
    • Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation
    • MacKenzie, K. L., Franco, S., May, C., Sadelain, M. & Moore, M. A. Mass cultured human fibroblasts overexpressing hTERT encounter a growth crisis following an extended period of proliferation. Exp. Cell Res. 259, 336-350 (2000).
    • (2000) Exp. Cell Res. , vol.259 , pp. 336-350
    • MacKenzie, K.L.1    Franco, S.2    May, C.3    Sadelain, M.4    Moore, M.A.5
  • 21
    • 0032487675 scopus 로고    scopus 로고
    • Both Rb/p16(INK4a) inactivation and telomerase activity are required to immortalize human epithelial cells
    • DOI 10.1038/23962
    • Kiyono, T. et al. Both Rb/p16INK4a inactivation and telomerase activity are required to immortalize human epithelial cells. Nature 396, 84-88 (1998). (Pubitemid 28520454)
    • (1998) Nature , vol.396 , Issue.6706 , pp. 84-88
    • Kiyono, T.1    Foster, S.A.2    Koop, J.I.3    McDougall, J.K.4    Galloway, D.A.5    Klingelhutz, A.J.6
  • 22
    • 0029154735 scopus 로고
    • Functional characterization and developmental regulation of mouse telomerase RNA
    • Blasco, M. A., Funk, W., Villeponteau, B. & Greider, C. W. Functional characterization and developmental regulation of mouse telomerase RNA. Science 269, 1267-1270 (1995).
    • (1995) Science , vol.269 , pp. 1267-1270
    • Blasco, M.A.1    Funk, W.2    Villeponteau, B.3    Greider, C.W.4
  • 24
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • Artandi, S. E. et al. Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice. Nature 406, 641-645 (2000).
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1
  • 25
    • 44349136891 scopus 로고    scopus 로고
    • Telomere dysfunction and tumour suppression: The senescence connection
    • DOI 10.1038/nrc2393, PII NRC2393
    • Deng, Y., Chan, S. S. & Chang, S. Telomere dysfunction and tumour suppression: the senescence connection. Nature Rev. Cancer 8, 450-458 (2008). (Pubitemid 351744962)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.6 , pp. 450-458
    • Deng, Y.1    Chan, S.S.2    Chang, S.3
  • 26
    • 0034003333 scopus 로고    scopus 로고
    • A critical role for telomeres in suppressing and facilitating carcinogenesis
    • DOI 10.1016/S0959-437X(99)00047-7
    • Artandi, S. E. & DePinho, R. A. A critical role for telomeres in suppressing and facilitating carcinogenesis. Curr. Opin. Genet. Dev. 10, 39-46 (2000). (Pubitemid 30113704)
    • (2000) Current Opinion in Genetics and Development , vol.10 , Issue.1 , pp. 39-46
    • Artandi, S.E.1    DePinho, R.A.2
  • 27
    • 0030944985 scopus 로고    scopus 로고
    • Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16(INK4a)
    • DOI 10.1016/S0092-8674(00)81902-9
    • Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D. & Lowe, S. W. Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a. Cell 88, 593-602 (1997). (Pubitemid 27152402)
    • (1997) Cell , vol.88 , Issue.5 , pp. 593-602
    • Serrano, M.1    Lin, A.W.2    McCurrach, M.E.3    Beach, D.4    Lowe, S.W.5
  • 29
    • 33745363911 scopus 로고    scopus 로고
    • DNA damage signaling and p53-dependent senescence after prolonged β-interferon stimulation
    • DOI 10.1091/mbc.E05-09-0858
    • Moiseeva, O., Mallette, F. A., Mukhopadhyay, U. K., Moores, A. & Ferbeyre, G. DNA damage signaling and p53-dependent senescence after prolonged beta-interferon stimulation. Mol. Biol. Cell 17, 1583-1592 (2006). (Pubitemid 44011578)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.4 , pp. 1583-1592
    • Moiseeva, O.1    Mallette, F.A.2    Mukhopadhyay, U.K.3    Moores, A.4    Ferbeyre, G.5
  • 30
    • 45849099050 scopus 로고    scopus 로고
    • Living on a break: Cellular senescence as a DNA-damage response
    • DOI 10.1038/nrc2440, PII NRC2440
    • d'Adda di Fagagna, F. Living on a break: cellular senescence as a DNA-damage response. Nature Rev. Cancer 8, 512-522 (2008). (Pubitemid 351881854)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.7 , pp. 512-522
    • D'Adda Di Fagagna, F.1
  • 32
    • 0034813364 scopus 로고    scopus 로고
    • ARF in replicative and induced senescence of human fibroblasts
    • DOI 10.1128/MCB.21.20.6748-6757.2001
    • Wei, W., Hemmer, R. M. & Sedivy, J. M. Role of p14ARF in replicative and induced senescence of human fibroblasts. Mol. Cell Biol. 21, 6748-6757 (2001). (Pubitemid 32911237)
    • (2001) Molecular and Cellular Biology , vol.21 , Issue.20 , pp. 6748-6757
    • Wei, W.1    Hemmer, R.M.2    Sedivy, J.M.3
  • 37
    • 33847201454 scopus 로고    scopus 로고
    • A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors
    • Dankort, D. et al. A new mouse model to explore the initiation, progression, and therapy of BRAFV600E-induced lung tumors. Genes Dev. 21, 379-384 (2007).
    • (2007) Genes Dev. , vol.21 , pp. 379-384
    • Dankort, D.1
  • 38
    • 63249105225 scopus 로고    scopus 로고
    • Oncogenic Braf induces melanocyte senescence and melanoma in mice
    • Dhomen, N. et al. Oncogenic Braf induces melanocyte senescence and melanoma in mice. Cancer Cell 15, 294-303 (2009).
    • (2009) Cancer Cell , vol.15 , pp. 294-303
    • Dhomen, N.1
  • 39
    • 77949737971 scopus 로고    scopus 로고
    • A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis
    • Alimonti, A. et al. A novel type of cellular senescence that can be enhanced in mouse models and human tumor xenografts to suppress prostate tumorigenesis. J. Clin. Invest. 120, 681-693.
    • J. Clin. Invest. , vol.120 , pp. 681-693
    • Alimonti, A.1
  • 40
    • 62349129015 scopus 로고    scopus 로고
    • Differential requirement of mTOR in postmitotic tissues and tumorigenesis
    • Nardella, C. et al. Differential requirement of mTOR in postmitotic tissues and tumorigenesis. Sci. Signal 2, ra2 (2009).
    • (2009) Sci. Signal , vol.2
    • Nardella, C.1
  • 41
    • 70350443240 scopus 로고    scopus 로고
    • Differential p53-independent outcomes of p19(Arf) loss in oncogenesis
    • Chen, Z. et al. Differential p53-independent outcomes of p19(Arf) loss in oncogenesis. Sci. Signal 2, ra44 (2009).
    • (2009) Sci. Signal , vol.2
    • Chen, Z.1
  • 42
    • 0032504784 scopus 로고    scopus 로고
    • P19(ARF) links the tumour suppressor p53 to Ras [6]
    • DOI 10.1038/25870
    • Palmero, I., Pantoja, C. & Serrano, M. p19ARF links the tumour suppressor p53 to Ras. Nature 395, 125-126 (1998). (Pubitemid 28425643)
    • (1998) Nature , vol.395 , Issue.6698 , pp. 125-126
    • Palmero, I.1    Pantoja, C.2    Serrano, M.3
  • 43
    • 78651482046 scopus 로고    scopus 로고
    • Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner
    • Song, M. S. et al. Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. Cell 144, 187-199 (2011).
    • (2011) Cell , vol.144 , pp. 187-199
    • Song, M.S.1
  • 44
    • 79951512852 scopus 로고    scopus 로고
    • SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression
    • Ding, Z. et al. SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression. Nature 470, 269-273 (2011).
    • (2011) Nature , vol.470 , pp. 269-273
    • Ding, Z.1
  • 45
    • 33646376411 scopus 로고    scopus 로고
    • Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells
    • DOI 10.1038/nature04703, PII NATURE04703
    • Yilmaz, O. H. et al. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature 441, 475-482 (2006). (Pubitemid 44050144)
    • (2006) Nature , vol.441 , Issue.7092 , pp. 475-482
    • Yilmaz, O.H.1    Valdez, R.2    Theisen, B.K.3    Guo, W.4    Ferguson, D.O.5    Wu, H.6    Morrison, S.J.7
  • 47
    • 79952268809 scopus 로고    scopus 로고
    • Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer
    • Di Micco, R. et al. Interplay between oncogene-induced DNA damage response and heterochromatin in senescence and cancer. Nature Cell Biol. 13, 292-302 (2011).
    • (2011) Nature Cell Biol. , vol.13 , pp. 292-302
    • Di Micco, R.1
  • 48
    • 23044514578 scopus 로고    scopus 로고
    • Multiple drug resistance in cancer revisited: The cancer stem cell hypothesis
    • DOI 10.1177/0091270005276905
    • Donnenberg, V. S. & Donnenberg, A. D. Multiple drug resistance in cancer revisited: the cancer stem cell hypothesis. J. Clin. Pharmacol. 45, 872-877 (2005). (Pubitemid 41060226)
    • (2005) Journal of Clinical Pharmacology , vol.45 , Issue.8 , pp. 872-877
    • Donnenberg, V.S.1    Donnenberg, A.D.2
  • 50
    • 34548771087 scopus 로고    scopus 로고
    • Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation
    • Wu, C. H. et al. Cellular senescence is an important mechanism of tumor regression upon c-Myc inactivation. Proc. Natl Acad. Sci. USA 104, 13028-13033 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , pp. 13028-13033
    • Wu, C.H.1
  • 51
    • 44849137232 scopus 로고    scopus 로고
    • Oncogene addiction versus oncogene amnesia: Perhaps more than just a bad habit?
    • Felsher, D. W. Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit? Cancer Res. 68, 3081-3086 (2008).
    • (2008) Cancer Res. , vol.68 , pp. 3081-3086
    • Felsher, D.W.1
  • 52
    • 0029033861 scopus 로고
    • The retinoblastoma protein and cell cycle control
    • Weinberg, R. A. The retinoblastoma protein and cell cycle control. Cell 81, 323-330 (1995).
    • (1995) Cell , vol.81 , pp. 323-330
    • Weinberg, R.A.1
  • 53
    • 71049169616 scopus 로고    scopus 로고
    • Cyclin-dependent kinases: A family portrait
    • Malumbres, M. et al. Cyclin-dependent kinases: a family portrait. Nature Cell Biol. 11, 1275-1276 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 1275-1276
    • Malumbres, M.1
  • 54
    • 77950486542 scopus 로고    scopus 로고
    • Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence
    • Chicas, A. et al. Dissecting the unique role of the retinoblastoma tumor suppressor during cellular senescence. Cancer Cell 17, 376-387 (2010).
    • (2010) Cancer Cell , vol.17 , pp. 376-387
    • Chicas, A.1
  • 55
    • 77949741498 scopus 로고    scopus 로고
    • Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence
    • Lin, H. K. et al. Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature 464, 374-379 (2010).
    • (2010) Nature , vol.464 , pp. 374-379
    • Lin, H.K.1
  • 56
    • 11144242211 scopus 로고    scopus 로고
    • Timeline: Chemotherapy and the war on cancer
    • Chabner, B. A. & Roberts, T. G. Jr. Timeline: Chemotherapy and the war on cancer. Nature Rev. Cancer 5, 65-72 (2005).
    • (2005) Nature Rev. Cancer , vol.5 , pp. 65-72
    • Chabner, B.A.1    Roberts Jr., T.G.2
  • 58
    • 0038277105 scopus 로고    scopus 로고
    • Tumor cell senescence in cancer treatment
    • Roninson, I. B. Tumor cell senescence in cancer treatment. Cancer Res. 63, 2705-2715 (2003). (Pubitemid 36667137)
    • (2003) Cancer Research , vol.63 , Issue.11 , pp. 2705-2715
    • Roninson, I.B.1
  • 59
    • 16844373387 scopus 로고    scopus 로고
    • Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers
    • DOI 10.1158/0008-5472.CAN-04-1270
    • Roberson, R. S., Kussick, S. J., Vallieres, E., Chen, S. Y. & Wu, D. Y. Escape from therapy-induced accelerated cellular senescence in p53-null lung cancer cells and in human lung cancers. Cancer Res. 65, 2795-2803 (2005). (Pubitemid 40490082)
    • (2005) Cancer Research , vol.65 , Issue.7 , pp. 2795-2803
    • Roberson, R.S.1    Kussick, S.J.2    Vallieres, E.3    Chen, S.-Y.J.4    Wu, D.Y.5
  • 60
    • 0037086268 scopus 로고    scopus 로고
    • DNA damage is able to induce senescence in tumor cells in vitro and in vivo
    • te Poele, R. H., Okorokov, A. L., Jardine, L., Cummings, J. & Joel, S. P. DNA damage is able to induce senescence in tumor cells in vitro and in vivo. Cancer Res. 62, 1876-1883 (2002).
    • (2002) Cancer Res. , vol.62 , pp. 1876-1883
    • Te Poele, R.H.1    Okorokov, A.L.2    Jardine, L.3    Cummings, J.4    Joel, S.P.5
  • 61
    • 78650713936 scopus 로고    scopus 로고
    • Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: An exploratory analysis
    • Sidi, R. et al. Induction of senescence markers after neo-adjuvant chemotherapy of malignant pleural mesothelioma and association with clinical outcome: an exploratory analysis. Eur. J. Cancer 47, 326-332 (2011).
    • (2011) Eur. J. Cancer , vol.47 , pp. 326-332
    • Sidi, R.1
  • 65
    • 51349164790 scopus 로고    scopus 로고
    • Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer
    • Carracedo, A. et al. Inhibition of mTORC1 leads to MAPK pathway activation through a PI3K-dependent feedback loop in human cancer. J. Clin. Invest. 118, 3065-3074 (2008).
    • (2008) J. Clin. Invest. , vol.118 , pp. 3065-3074
    • Carracedo, A.1
  • 66
    • 51849084360 scopus 로고    scopus 로고
    • The PTEN-PI3K pathway: Of feedbacks and cross-talks
    • Carracedo, A. & Pandolfi, P. P. The PTEN-PI3K pathway: of feedbacks and cross-talks. Oncogene 27, 5527-5541 (2008).
    • (2008) Oncogene , vol.27 , pp. 5527-5541
    • Carracedo, A.1    Pandolfi, P.P.2
  • 67
    • 66149091940 scopus 로고    scopus 로고
    • A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene
    • Luo, J. et al. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. Cell 137, 835-848 (2009).
    • (2009) Cell , vol.137 , pp. 835-848
    • Luo, J.1
  • 68
    • 77954279920 scopus 로고    scopus 로고
    • A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma
    • Puyol, M. et al. A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. Cancer Cell 18, 63-73 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 63-73
    • Puyol, M.1
  • 69
    • 77949730783 scopus 로고    scopus 로고
    • Cdk2 suppresses cellular senescence induced by the c-myc oncogene
    • Campaner, S. et al. Cdk2 suppresses cellular senescence induced by the c-myc oncogene. Nature Cell Biol. 12, 54-59 (2010).
    • (2010) Nature Cell Biol. , vol.12 , pp. 54-59
    • Campaner, S.1
  • 70
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G. P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl Acad. Sci. USA 92, 9363-9367 (1995).
    • (1995) Proc. Natl Acad. Sci. USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 71
    • 74949127989 scopus 로고    scopus 로고
    • Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo
    • Debacq-Chainiaux, F., Erusalimsky, J. D., Campisi, J. & Toussaint, O. Protocols to detect senescence-associated beta-galactosidase (SA-betagal) activity, a biomarker of senescent cells in culture and in vivo. Nature Protoc 4, 1798-1806 (2009).
    • (2009) Nature Protoc , vol.4 , pp. 1798-1806
    • Debacq-Chainiaux, F.1    Erusalimsky, J.D.2    Campisi, J.3    Toussaint, O.4
  • 73
    • 40749092119 scopus 로고    scopus 로고
    • Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo
    • Xu, M. et al. Beta-catenin expression results in p53-independent DNA damage and oncogene-induced senescence in prelymphomagenic thymocytes in vivo. Mol. Cell Biol. 28, 1713-1723 (2008).
    • (2008) Mol. Cell Biol. , vol.28 , pp. 1713-1723
    • Xu, M.1
  • 75
    • 1642328231 scopus 로고    scopus 로고
    • In vivo imaging of beta-galactosidase activity using far red fluorescent switch
    • Tung, C. H. et al. In vivo imaging of beta-galactosidase activity using far red fluorescent switch. Cancer Res. 64, 1579-1583 (2004).
    • (2004) Cancer Res. , vol.64 , pp. 1579-1583
    • Tung, C.H.1
  • 77
    • 84891713034 scopus 로고    scopus 로고
    • Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor
    • Coppe, J. P. et al. Senescence-associated secretory phenotypes reveal cell-nonautonomous functions of oncogenic RAS and the p53 tumor suppressor. PLoS Biol. 6, 2853-2868 (2008).
    • (2008) PLoS Biol. , vol.6 , pp. 2853-2868
    • Coppe, J.P.1
  • 78
    • 38849168162 scopus 로고    scopus 로고
    • Oncogenic BRAF Induces Senescence and Apoptosis through Pathways Mediated by the Secreted Protein IGFBP7
    • DOI 10.1016/j.cell.2007.12.032, PII S0092867408000536
    • Wajapeyee, N., Serra, R. W., Zhu, X., Mahalingam, M. & Green, M. R. Oncogenic BRAF induces senescence and apoptosis through pathways mediated by the secreted protein IGFBP7. Cell 132, 363-374 (2008). (Pubitemid 351191995)
    • (2008) Cell , vol.132 , Issue.3 , pp. 363-374
    • Wajapeyee, N.1    Serra, R.W.2    Zhu, X.3    Mahalingam, M.4    Green, M.R.5
  • 79
    • 58849154235 scopus 로고    scopus 로고
    • Senescence-messaging secretome: SMS-ing cellular stress
    • Kuilman, T. & Peeper, D. S. Senescence-messaging secretome: SMS-ing cellular stress. Nature Rev. Cancer 9, 81-94 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 81-94
    • Kuilman, T.1    Peeper, D.S.2
  • 80
    • 63049104211 scopus 로고    scopus 로고
    • Microenvironmental regulation of metastasis
    • Joyce, J. A. & Pollard, J. W. Microenvironmental regulation of metastasis. Nature Rev. Cancer 9, 239-252 (2009).
    • (2009) Nature Rev. Cancer , vol.9 , pp. 239-252
    • Joyce, J.A.1    Pollard, J.W.2
  • 81
    • 77949881221 scopus 로고    scopus 로고
    • The senescence-associated secretory phenotype: The dark side of tumor suppression
    • Coppe, J. P., Desprez, P. Y., Krtolica, A. & Campisi, J. The senescence-associated secretory phenotype: the dark side of tumor suppression. Annu. Rev. Pathol. 5, 99-118 (2010).
    • (2010) Annu. Rev. Pathol. , vol.5 , pp. 99-118
    • Coppe, J.P.1    Desprez, P.Y.2    Krtolica, A.3    Campisi, J.4
  • 82
    • 78249257291 scopus 로고    scopus 로고
    • CD4+ T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation
    • Rakhra, K. et al. CD4+ T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. Cancer Cell 18, 485-498 (2010).
    • (2010) Cancer Cell , vol.18 , pp. 485-498
    • Rakhra, K.1
  • 84
  • 85
    • 0035496607 scopus 로고    scopus 로고
    • Rescuing the function of mutant p53
    • Bullock, A. N. & Fersht, A. R. Rescuing the function of mutant p53. Nature Rev. Cancer 1, 68-76 (2001). (Pubitemid 33741882)
    • (2001) Nature Reviews Cancer , vol.1 , Issue.1 , pp. 68-76
    • Bullock, A.N.1    Fersht, A.R.2
  • 87
    • 0043170883 scopus 로고    scopus 로고
    • Rescue of mutant p53 transcription function by ellipticine
    • DOI 10.1038/sj.onc.1206777
    • Peng, Y., Li, C., Chen, L., Sebti, S. & Chen, J. Rescue of mutant p53 transcription function by ellipticine. Oncogene 22, 4478-4487 (2003). (Pubitemid 36920691)
    • (2003) Oncogene , vol.22 , Issue.29 , pp. 4478-4487
    • Peng, Y.1    Li, C.2    Chen, L.3    Sebti, S.4    Chen, J.5
  • 88
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • DOI 10.1038/nrm2233, PII NRM2233
    • Campisi, J. & d'Adda di Fagagna, F. Cellular senescence: when bad things happen to good cells. Nature Rev. Mol. Cell Biol. 8, 729-740 (2007). (Pubitemid 47312822)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.9 , pp. 729-740
    • Campisi, J.1    D'Adda Di Fagagna, F.2
  • 89
    • 0029670477 scopus 로고    scopus 로고
    • Translational control of p27Kip1 accumulation during the cell cycle
    • Hengst, L. & Reed, S. I. Translational control of p27Kip1 accumulation during the cell cycle. Science 271, 1861-1864 (1996).
    • (1996) Science , vol.271 , pp. 1861-1864
    • Hengst, L.1    Reed, S.I.2
  • 90
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: Prognostic potential and relevance to anticancer therapy
    • DOI 10.1038/nrc2347, PII NRC2347
    • Chu, I. M., Hengst, L. & Slingerland, J. M. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nature Rev. Cancer 8, 253-267 (2008). (Pubitemid 351430863)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.4 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3
  • 91
    • 1342335029 scopus 로고    scopus 로고
    • Novel small molecule cyclin-dependent kinases modulators in human clinical trials
    • Senderowicz, A. M. Novel small molecule cyclin-dependent kinases modulators in human clinical trials. Cancer Biol. Ther. 2, S84-95 (2003).
    • (2003) Cancer Biol. Ther. , vol.2
    • Senderowicz, A.M.1
  • 93
    • 0142057146 scopus 로고    scopus 로고
    • Low molecular weight inhibitors of Myc-Max interaction and function
    • DOI 10.1038/sj.onc.1206641
    • Yin, X., Giap, C., Lazo, J. S. & Prochownik, E. V. Low molecular weight inhibitors of Myc-Max interaction and function. Oncogene 22, 6151-6159 (2003). (Pubitemid 37281644)
    • (2003) Oncogene , vol.22 , Issue.40 , pp. 6151-6159
    • Yin, X.1    Giap, C.2    Lazo, J.S.3    Prochownik, E.V.4
  • 95
    • 33749635130 scopus 로고    scopus 로고
    • A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia
    • DOI 10.1016/j.exphem.2006.06.019, PII S0301472X06004280
    • Huang, M. J., Cheng, Y. C., Liu, C. R., Lin, S. & Liu, H. E. A small-molecule c-Myc inhibitor, 10058-F4, induces cell-cycle arrest, apoptosis, and myeloid differentiation of human acute myeloid leukemia. Exp. Hematol. 34, 1480-1489 (2006). (Pubitemid 44548118)
    • (2006) Experimental Hematology , vol.34 , Issue.11 , pp. 1480-1489
    • Huang, M.-J.1    Cheng, Y.-c.2    Liu, C.-R.3    Lin, S.4    Liu, H.E.5
  • 97
    • 4243110417 scopus 로고    scopus 로고
    • Pten dose dictates cancer progression in the prostate
    • Trotman, L. C. et al. Pten dose dictates cancer progression in the prostate. PLoS Biol. 1, E59 (2003).
    • (2003) PLoS Biol. , vol.1
    • Trotman, L.C.1
  • 98
    • 0028673260 scopus 로고
    • Telomerase, cell immortality, and cancer
    • Harley, C. B. et al. Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol. 59, 307-315 (1994).
    • (1994) Cold Spring Harb. Symp. Quant. Biol. , vol.59 , pp. 307-315
    • Harley, C.B.1
  • 99
    • 34548857357 scopus 로고    scopus 로고
    • Targeting the limitless replicative potential of cancer: The telomerase/telomere pathway
    • DOI 10.1158/1078-0432.CCR-07-0422
    • Kelland, L. Targeting the limitless replicative potential of cancer: the telomerase/telomere pathway. Clin. Cancer Res. 13, 4960-4963 (2007). (Pubitemid 47502059)
    • (2007) Clinical Cancer Research , vol.13 , Issue.17 , pp. 4960-4963
    • Kelland, L.1
  • 100
    • 39749163359 scopus 로고    scopus 로고
    • Telomerase and cancer therapeutics
    • DOI 10.1038/nrc2275, PII NRC2275
    • Harley, C. B. Telomerase and cancer therapeutics. Nature Rev. Cancer 8, 167-179 (2008). (Pubitemid 351305939)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.3 , pp. 167-179
    • Harley, C.B.1
  • 101
    • 57749108319 scopus 로고    scopus 로고
    • Clinical significance of p53 alterations in surgically treated prostate cancers
    • Schlomm, T. et al. Clinical significance of p53 alterations in surgically treated prostate cancers. Mod. Pathol. 21, 1371-1378 (2008).
    • (2008) Mod. Pathol. , vol.21 , pp. 1371-1378
    • Schlomm, T.1
  • 102
    • 77955374484 scopus 로고    scopus 로고
    • Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors
    • Efimova, E. V. et al. Poly(ADP-ribose) polymerase inhibitor induces accelerated senescence in irradiated breast cancer cells and tumors. Cancer Res. 70, 6277-6282 (2010).
    • (2010) Cancer Res. , vol.70 , pp. 6277-6282
    • Efimova, E.V.1
  • 103
    • 49749136970 scopus 로고    scopus 로고
    • The proto-oncogene LRF is under post-transcriptional control of MiR-20a: Implications for senescence
    • Poliseno, L. et al. The proto-oncogene LRF is under post-transcriptional control of MiR-20a: implications for senescence. PLoS One 3, e2542 (2008).
    • (2008) PLoS One , vol.3
    • Poliseno, L.1
  • 104
    • 67651148274 scopus 로고    scopus 로고
    • Evidence that inositol polyphosphate 4-phosphate type II is a tumor supressor that inhibits PI3K signalling
    • Gewinner, C. et al. Evidence that inositol polyphosphate 4-phosphate type II is a tumor supressor that inhibits PI3K signalling. Cancer Cell 16, 115-125 (2009).
    • (2009) Cancer Cell , vol.16 , pp. 115-125
    • Gewinner, C.1


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