Cellular delivery of peptide nucleic acids and inhibition of human telomerase

Chemistry and Biology

Volumn 6, Issue 6, 1999, Pages 343-351

  Hamilton, Susan E ^a   Simmons, Carla G ^a   Kathiriya, Irfan S ^b   Corey, David R ^a  

^a HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

Cationic lipid; Peptide nucleic acid; RNA; Telomerase

Indexed keywords

ENZYME INHIBITION; OLIGONUCLEOTIDE; TELOMERASE;

EUKARYOTA;

EID: 0033150534     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(99)80046-5     Document Type: Article

References (36)

1. Nielsen, P.G., Egholm, M., Berg, R.H. & Buchardt, O. (1991). Sequence-selective recognition of DNA by strand displacement with a thymine-substituted polyamide. Science 254, 1497-1500.
2. Smulevitch, S.V., Simmons, C.G., Norton, J.C., Wise, T.W. & Corey, D.R. (1996). Enhancement of strand invasion by oligonucleotides through manipulation of backbone charge. Nat. Biotechnol. 14, 1700-1705.
3. Egholm, M. et al., & Nielsen, P.E. (1993). PNA hybridizes to complementary oligonucleotides obeying the Watson-Crick hydrogen-bonding rules. Nature 365, 566-568.
4. Demidov, V.V., et al., & Nielsen, P.E. (1994). Stability of peptide nucleic acids in human serum and cellular extracts. Biochem. Pharmacol. 48, 1310-1313.
5. Hamilton, S.E., Iyer, M., Norton, J.C. & Corey, D.R. (1996). Specific and nonspecific inhibition of transcription by DNA, PNA and phosphorothioate promotor analog duplexes. Bioorg. Med. Chem. Lett. 6, 2897-2900.
6. Demidov, V.V., Yavnilovich, M.V., Belotserkovskii, B.P., Frank-Kamenetskii, M.D. & Nielsen, P.E. (1995). Kinetics and mechanism of polyamide ("peptide") nucleic acid binding to duplex DNA. Proc. Natl Acad Sci. USA 92, 2637-2641.
7. Bukanov, N.O., Demidov, V.V., Nielsen, P.E. & Frank-Kamenetskii, M.D. (1998). P-D loop: A complex of duplex DNA with an oligonucleotide. Proc. Natl Acad. Sci. USA 95, 5516-5520.
8. Iyer, M., Norton, J.C. & Corey, D.R. (1995). Accelerated hybridization of oligonucleotides to duplex DNA. J. Biol. Chem. 270, 14712-14717.
9. Ishihara T. & Corey D.R. (1999). Rules for strand invasion by chemically modified oligomers. J. Am. Chem. Soc. 121, 2012-2020.
10. Boffa, L.C., Carpaneto, E.M. & Allfrey, V.G. (1995). Isolation of genes containing CAG repeats by DNA strand invasion by a peptide nucleic acid. Proc. Natl Acad. Sci. USA 92, 1901-1905.
11. Morin, G.B. (1991). Recognition of a chromosome truncation site associated with α-thalassaemia by human telomerase. Nature 353, 454-456.
12. Feng, J., et al., & Villeponteau, B. (1995). The RNA component of human telomerase. Science 269, 1236-1241.
13. Autexier, C., Pruzan, R., Funk, W.D. & Greider, C.W. (1996). Reconstitution of human telomerase activity and identification of a minimal functional region of the human telomerase RNA. EMBO J. 15, 5928-5935.
14. Beattie, T.L., Zhou, W., Robinson, M.O. & Harrington, L. (1998). Reconstitution of human telomerase activity in vitro. Curr. Biol. 8, 177-180.
15. Weinrich, S.L, et al., & Morin, G.B. (1997). Reconstitution of human telomerase with the template RNA component hTR and the catalytic protein subunit hTRT. Nat. Genet. 23, 498-502.
16. Counter, C.M., Hirte, H.W., Bachetti, S. & Harley, C.B. (1994). Telomerase activity in human ovarian carcinoma. Proc. Natl Acad. Sci. USA 91, 2900-2904.
17. Kim, N.W., et al., & Shay, J.W. (1994). Specific association of human telomerase activity with immortal cells and cancer. Science 266, 2011-2015.
18. Holt, S.E., Shay, J.W. & Wright, W.E. (1996). Refining the telomeretelomerase hypothesis of aging and cancer. Nat. Biotech. 14, 836-839.
19. Hamilton, S.E. & Corey, D.R. (1996). Telomerase: Anti-cancer target or just a fascinating enzyme? Chem. Biol. 3, 863-867.
20. Akhtar, S. & Agrawal, S. (1997). In vivo studies with antisense oligonucleotides. Trends Pharmacol. Sci. 18, 12-18.
21. Hamilton, S.E., et al., & Corey, D.R. (1997). Identification of determinants for inhibitor binding within the RNA active site of human telomerase using PNA scanning. Biochemistry 36, 11873-11880.
22. Norton, J.C., Piatyszek, M.A., Wright, W.E., Shay, J.W. & Corey, D.R. (1996). Inhibition of human telomerase activity by peptide nucleic acids. Nat. Biotech. 14, 615-620.
23. Holt, S.E., Norton, J.C., Wright, W.E. & Shay, J.W. (1996). Comparison of the telomeric repeat amplification protocol (TRAP) to the new TRAP-eze telomerase detcation kit. Methods Cell. Sci. 18, 237-248.
24. Yi, X., Tesmer, V.M., Savre-Train, I., Shay, J.W. & Wright, W.E. (1999). Both transcriptional and post-transcriptional mechanisms regulate human telomerase template RNA (hTR) levels. Mol. Cell. Biol., in press.
25. Faruqi, A.F., Egholm, M. & Glazer, P.M. (1997). Peptide nucleic acid-targeted mutagenesis of a chromosomal gene in mouse cells. Proc. Natl Acad. Sci. USA 95, 1398-1403.
26. Simmons, C.G., Pitts, A.E., Mayfield, L.D., Shay, J.W. & Corey, D.R. (1997). Synthesis and membrane permeability of PNA-peptide conjugates. Bioorg. Med. Chem. Lett. 7, 3001-3007.
27. Basu, S. & Wickstrom, E. (1997). Synthesis and characterization of a peptide nucleic acid conjugated to a D-peptide analog of insulin-like growth factor 1 for increased cellular uptake. Bioconj. Chem. 8, 481-488.
28. Pooga, M., et al., & Langel, U. (1998). Cell penetrating PNA constructs regulate galanin receptor levels and modify pain transmission in vivo. Nat. Biotechnol. 16, 857-861.
29. Zelphati, O. & Szoka, F.C. (1996). Mechanism of oligonucleotide release from cationic liposomes. Proc. Natl Acad. Sci. USA 93, 11493-11498.
30. Pitts, A.E. & Corey, D.R. (1998). Inhibition of human telomerase by 2′-O-methyl-RNA. Proc. Natl Acad. Sci USA 95, 1151-1154.
31. Koltover I., Salditt, T., Radler, J.O. & Safinya, C.R. (1998). An inverted hexagonal phase of cationic liposome-DNA complexes related to DNA release and delivery. Science 281, 78-81.
32. Corey, D.R. (1997). Peptide nucleic acids: Expanding the scope of nucleic acid recognition. Trends Biotechnol. 15, 221-229.
33. Dickinson, L.A., et al., & Dervan, P.B. (1998). Inhibition of RNA polymerase II transcription in human cells by synthetic DNA-binding ligands. Proc. Natl Acad. Sci. USA 95, 12890-12895.
34. Denison, C. & Kodadek, T. (1998). Small-molecule-based strategies for controlling gene expression. Chem. Biol. 5, 129-145.
35. Mayfield, L.D. & Corey, D.R. (1999). Automated synthesis of peptide nucleic acid (PNAs) and peptide nucleic acid-peptide conjugates Anal. Biochem. 268, 401-404.
36. Norton, J.C., Waggenspack, J.H., Varnum, E. & Corey, D.R. (1995). Targeting peptide nucleic acid-protein conjugates to structural features within duplex DNA. Bioorg. Med. Chem. 3, 437-445.