Induction of p16INK4a transcription and of cellular senescence by aclacinomycin-derivatives and cardiac glycosides

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 4, 2002, Pages 461-465

  Egawa, Kiyoshi ^a   Kurihara, Yosuke ^a   Ito, Tatsuya ^b   Matsumoto, Masahiko ^b   Nose, Kiyoshi ^a  

^a SHOWA UNIVERSITY   (Japan)

^b CHUGAI PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cinerubin B; Luciferase; p16; Periplocin; Senescence

Indexed keywords

ACLACINOMYCIN; ANTINEOPLASTIC AGENT; BETA GALACTOSIDASE; CARDIAC GLYCOSIDE; CENERUBIN B; PERIPLOCIN; PLANT EXTRACT; PROTEIN P16; PROTEIN P16INK4A; UNCLASSIFIED DRUG; ACLACINOMYCINS; ACLARUBICIN; DRUG DERIVATIVE;

ACTINOBACTERIA; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL AGING; CELL GROWTH; CONTROLLED STUDY; ENZYME ACTIVITY; FIBROBLAST; GROWTH INHIBITION; HUMAN; HUMAN CELL; TRANSCRIPTION INITIATION; TRANSCRIPTION REGULATION; CELL CULTURE; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; PHYSIOLOGY; TUMOR SUPPRESSOR GENE;

ACLARUBICIN; CARDIAC GLYCOSIDES; CELL AGING; CELLS, CULTURED; GENE EXPRESSION REGULATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, P16; HUMANS; TRANSCRIPTION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0036545595     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.461     Document Type: Article

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