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Volumn 33, Issue 4, 2003, Pages 492-496

Erosion of the telomeric single-strand overhang at replicative senescence

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; RETINOBLASTOMA PROTEIN; TELOMERASE;

EID: 0037382414     PISSN: 10614036     EISSN: None     Source Type: Journal    
DOI: 10.1038/ng1127     Document Type: Article
Times cited : (284)

References (28)
  • 1
    • 0035989630 scopus 로고    scopus 로고
    • The disparity between human cell senescence in vitro and lifelong replication in vivo
    • Rubin, H. The disparity between human cell senescence in vitro and lifelong replication in vivo. Nat. Biotechnol. 20, 675-681 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 675-681
    • Rubin, H.1
  • 2
    • 0015859824 scopus 로고
    • The biology of human aging
    • Hayflick, L. The biology of human aging. Am. J. Med. Sci. 265, 432-445 (1973).
    • (1973) Am. J. Med. Sci. , vol.265 , pp. 432-445
    • Hayflick, L.1
  • 3
    • 0028673260 scopus 로고
    • Telomerase, cell immortality, and cancer
    • Harley, C.B. et al. Telomerase, cell immortality, and cancer. Cold Spring Harb. Symp. Quant. Biol. 59, 307-315 (1994).
    • (1994) Cold Spring Harb. Symp. Quant. Biol. , vol.59 , pp. 307-315
    • Harley, C.B.1
  • 4
    • 0035989631 scopus 로고    scopus 로고
    • Historical claims and current interpretations of replicative aging
    • Wright, W.E. & Shay, J.W. Historical claims and current interpretations of replicative aging. Nat. Biotechnol. 20, 682-688 (2002).
    • (2002) Nat. Biotechnol. , vol.20 , pp. 682-688
    • Wright, W.E.1    Shay, J.W.2
  • 5
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley, C.B., Futcher, A.B. & Greider, C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345, 458-460 (1990).
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 6
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar, A.G. et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279, 349-352 (1998).
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1
  • 7
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri, H. & Benchimol, S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr. Biol. 8, 279-282 (1998).
    • (1998) Curr. Biol. , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 8
    • 0029145379 scopus 로고
    • Evidence for a critical telomere length in senescent human fibroblasts
    • Allsopp, R.C. & Harley, C.B. Evidence for a critical telomere length in senescent human fibroblasts. Exp. Cell Res. 219, 130-136 (1995).
    • (1995) Exp. Cell Res. , vol.219 , pp. 130-136
    • Allsopp, R.C.1    Harley, C.B.2
  • 9
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu, J., Wang, H., Bishop, J.M. & Blackburn, E.H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc. Natl. Acad. Sci. USA 96, 3723-3728 (1999).
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4
  • 10
    • 0034616215 scopus 로고    scopus 로고
    • Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase
    • Ouellette, M.M. et al. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J. Biol. Chem. 275, 10072-10076 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 10072-10076
    • Ouellette, M.M.1
  • 11
    • 0034597794 scopus 로고    scopus 로고
    • Telomere states and cell fates
    • Blackburn, E.H. Telomere states and cell fates. Nature 408, 53-56 (2000).
    • (2000) Nature , vol.408 , pp. 53-56
    • Blackburn, E.H.1
  • 12
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • Karlseder, J., Smogorzewska, A. & de Lange, T. Senescence induced by altered telomere state, not telomere loss. Science 295, 2446-2449 (2002).
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    De Lange, T.3
  • 13
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright, W.E., Tesmer, V.M., Huffman, K.E., Levene, S.D. & Shay, J.W. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev. 11, 2801-2809 (1997).
    • (1997) Genes Dev. , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 14
    • 0031000884 scopus 로고    scopus 로고
    • Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening
    • Makarov, V.L., Hirose, Y. & Langmore, J.P. Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening. Cell 88, 657-666 (1997).
    • (1997) Cell , vol.88 , pp. 657-666
    • Makarov, V.L.1    Hirose, Y.2    Langmore, J.P.3
  • 15
    • 0030982721 scopus 로고    scopus 로고
    • The terminal DNA structure of mammalian chromosomes
    • McElligott, R. & Wellinger, R.J. The terminal DNA structure of mammalian chromosomes. EMBO J. 16, 370S-3714 (1997).
    • (1997) EMBO J. , vol.16
    • McElligott, R.1    Wellinger, R.J.2
  • 16
    • 0034733606 scopus 로고    scopus 로고
    • Telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang
    • Huffman, K.E., Levene, S.D., Tesmer, V.M., Shay, J.W. & Wright, W.E. Telomere shortening is proportional to the size of the G-rich telomeric 3′-overhang. J. Biol. Chem. 275, 19719-19722 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 19719-19722
    • Huffman, K.E.1    Levene, S.D.2    Tesmer, V.M.3    Shay, J.W.4    Wright, W.E.5
  • 17
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn, E.H. Switching and signaling at the telomere. Cell 106, 661-673 (2001).
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 18
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith, J.D. et al. Mammalian telomeres end in a large duplex loop. Cell 97, 503-514 (1999).
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1
  • 19
    • 0024573115 scopus 로고
    • An overhanging 3′ terminus is a conserved feature of telomeres
    • Henderson, E.R. & Blackburn, E.H. An overhanging 3′ terminus is a conserved feature of telomeres. Mol. Cell. Biol. 9, 345-348 (1989).
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 345-348
    • Henderson, E.R.1    Blackburn, E.H.2
  • 20
    • 0035315819 scopus 로고    scopus 로고
    • The length of telomeric G-rich strand 3′-overhang measured by oligonucleotide ligation assay
    • Cimino-Reale, G. et al. The length of telomeric G-rich strand 3′-overhang measured by oligonucleotide ligation assay. Nucleic Acids Res. 29, E3S (2001).
    • (2001) Nucleic Acids Res. , vol.29
    • Cimino-Reale, G.1
  • 21
    • 0035476710 scopus 로고    scopus 로고
    • T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang
    • Stansel, R.M., de Lange, T. & Griffith, J.D. T-loop assembly in vitro involves binding of TRF2 near the 3′ telomeric overhang. EMBO J. 20, 5532-5540 (2001).
    • (2001) EMBO J. , vol.20 , pp. 5532-5540
    • Stansel, R.M.1    De Lange, T.2    Griffith, J.D.3
  • 22
    • 0029156035 scopus 로고
    • Telomere shortening is associated with cell division in vitro and in vivo
    • Allsopp, R.C. et al. Telomere shortening is associated with cell division in vitro and in vivo. Exp. Cell Res. 220, 194-200 (1995).
    • (1995) Exp. Cell Res. , vol.220 , pp. 194-200
    • Allsopp, R.C.1
  • 23
    • 0029128798 scopus 로고
    • Telomerase and DNA end replication: No longer a lagging strand problem?
    • Lingner, J., Cooper, J.P. & Cech, T.R. Telomerase and DNA end replication: no longer a lagging strand problem? Science 269, 1533-1534 (1995).
    • (1995) Science , vol.269 , pp. 1533-1534
    • Lingner, J.1    Cooper, J.P.2    Cech, T.R.3
  • 24
    • 0026054961 scopus 로고
    • A role for both RB and p 53 in the regulation of human cellular senescence
    • Shay, J.W., Pereira-Smith, O.M. & Wright, W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp. Cell Res. 196, 33-39 (1991).
    • (1991) Exp. Cell Res. , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 25
    • 0031821009 scopus 로고    scopus 로고
    • Preferential accumulation of single-stranded regions in telomeres of human fibroblasts
    • Petersen, S., Saretzki, G. & von Zglinicki, T. Preferential accumulation of single-stranded regions in telomeres of human fibroblasts. Exp. Cell Res. 239, 152-160 (1998).
    • (1998) Exp. Cell Res. , vol.239 , pp. 152-160
    • Petersen, S.1    Saretzki, G.2    Von Zglinicki, T.3
  • 26
    • 0033614998 scopus 로고    scopus 로고
    • Creation of human tumour cells with defined genetic elements
    • Hahn, W.C. et al. Creation of human tumour cells with defined genetic elements. Nature 400, 464-468 (1999).
    • (1999) Nature , vol.400 , pp. 464-468
    • Hahn, W.C.1
  • 27
    • 0029047362 scopus 로고
    • A biomarker that identifies senescent human cells in culture and in aging skin in vivo
    • Dimri, G.P. et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 92, 9363-9367 (1995).
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 9363-9367
    • Dimri, G.P.1
  • 28
    • 77649173768 scopus 로고
    • Longitudinal data analysis using generalized linear models
    • Liang, K. & Zeger, S. Longitudinal data analysis using generalized linear models. Biometrika 73, 13-22 (1986).
    • (1986) Biometrika , vol.73 , pp. 13-22
    • Liang, K.1    Zeger, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.