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Volumn 17, Issue 2, 2010, Pages 193-199

The miR-34 family in cancer and apoptosis

Author keywords

MicroRNA; MiR 34; MiR 34a; MiR 34b c; SIRT1

Indexed keywords

MICRORNA; MICRORNA 34; PROTEIN P53; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

EID: 74249123570     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2009.56     Document Type: Review
Times cited : (1084)

References (67)
  • 2
    • 34047216406 scopus 로고    scopus 로고
    • P53 alterations in human cancer: More questions than answers
    • Soussi T. p53 alterations in human cancer: more questions than answers. Oncogene 2007; 26: 2145-2156.
    • (2007) Oncogene , vol.26 , pp. 2145-2156
    • Soussi, T.1
  • 4
    • 0038075338 scopus 로고    scopus 로고
    • Decision making by p53: Life, death and cancer
    • Oren M. Decision making by p53: life, death and cancer. Cell Death Differ 2003; 10: 431-442.
    • (2003) Cell Death Differ , vol.10 , pp. 431-442
    • Oren, M.1
  • 5
    • 33947534030 scopus 로고    scopus 로고
    • And Lane DP. p53 in health and disease
    • Vousden KH and Lane DP. p53 in health and disease. Nat Rev Mol Cell Biol 2007; 8: 275-283.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 275-283
    • Vousden, K.H.1
  • 7
    • 34547935761 scopus 로고    scopus 로고
    • Living with p53, dying of p53
    • Aylon Y and Oren M. Living with p53, dying of p53. Cell 2007; 130: 597-600.
    • (2007) Cell , vol.130 , pp. 597-600
    • Aylon, Y.1    Oren, M.2
  • 9
    • 0035265823 scopus 로고    scopus 로고
    • PUMA induces the rapid apoptosis of colorectal cancer cells
    • Yu J, Zhang L, Hwang PM, Kinzler KW and Vogelstein B. PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell 2001; 7: 673-682.
    • (2001) Mol Cell , vol.7 , pp. 673-682
    • Yu, J.1    Zhang, L.2    Hwang, P.M.3    Kinzler, K.W.4    Vogelstein, B.5
  • 11
    • 33748752327 scopus 로고    scopus 로고
    • Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression
    • Spurgers KB, Gold DL, Coombes KR, Bohnenstiehl NL, Mullins B and Meyn RE et al. Identification of cell cycle regulatory genes as principal targets of p53-mediated transcriptional repression. J Biol Chem 2006; 281: 25134-25142.
    • (2006) J Biol Chem , vol.281 , pp. 25134-25142
    • Spurgers, K.B.1    Gold, D.L.2    Coombes, K.R.3    Bohnenstiehl, N.L.4    Mullins, B.5    Meyn, R.E.6
  • 12
    • 0038751837 scopus 로고    scopus 로고
    • Transcriptional repression mediated by the p53 tumour suppressor
    • Ho J and Benchimol S. Transcriptional repression mediated by the p53 tumour suppressor. Cell Death Differ 2003; 10: 404-408.
    • (2003) Cell Death Differ , vol.10 , pp. 404-408
    • Ho, J.1    Benchimol, S.2
  • 13
    • 0041857759 scopus 로고    scopus 로고
    • P21/CDKN1A mediates negative regulation of transcription by p53
    • Lohr K, Moritz C, Contente A and Dobbelstein M. p21/CDKN1A mediates negative regulation of transcription by p53. J Biol Chem 2003; 278: 32507-32516.
    • (2003) J Biol Chem , vol.278 , pp. 32507-32516
    • Lohr, K.1    Moritz, C.2    Contente, A.3    Dobbelstein, M.4
  • 14
    • 0033591217 scopus 로고    scopus 로고
    • And Latchman DS. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor
    • Budhram-Mahadeo V, Morris PJ, Smith MD, Midgley CA, Boxer LM and Latchman DS. p53 suppresses the activation of the Bcl-2 promoter by the Brn-3a POU family transcription factor. J Biol Chem 1999; 274: 15237-15244.
    • (1999) J Biol Chem , vol.274 , pp. 15237-15244
    • Budhram-Mahadeo, V.1    Morris, P.J.2    Smith, M.D.3    Midgley, C.A.4    Boxer, L.M.5
  • 15
    • 33644768174 scopus 로고    scopus 로고
    • Control of translation and mRNA degradation by miRNAs and siRNAs
    • Valencia-Sanchez MA, Liu J, Hannon GJ and Parker R. Control of translation and mRNA degradation by miRNAs and siRNAs. Genes Dev 2006; 20: 515-524.
    • (2006) Genes Dev , vol.20 , pp. 515-524
    • Valencia-Sanchez, M.A.1    Liu, J.2    Hannon, G.J.3    Parker, R.4
  • 16
    • 34249810892 scopus 로고    scopus 로고
    • Argonaute proteins: Mediators of RNA silencing
    • Peters L and Meister G. Argonaute proteins: mediators of RNA silencing. Mol Cell 2007; 26: 611-623.
    • (2007) Mol Cell , vol.26 , pp. 611-623
    • Peters, L.1    Meister, G.2
  • 17
    • 33846283385 scopus 로고    scopus 로고
    • The evolution of gene regulation by transcription factors and microRNAs
    • Chen K and Rajewsky N. The evolution of gene regulation by transcription factors and microRNAs. Nat Rev Genet 2007; 8: 93-103.
    • (2007) Nat Rev Genet , vol.8 , pp. 93-103
    • Chen, K.1    Rajewsky, N.2
  • 18
    • 33748928159 scopus 로고    scopus 로고
    • The diverse functions of microRNAs in animal development and disease
    • Kloosterman WP and Plasterk RH. The diverse functions of microRNAs in animal development and disease. Dev Cell 2006; 11: 441-450.
    • (2006) Dev Cell , vol.11 , pp. 441-450
    • Kloosterman, W.P.1    Plasterk, R.H.2
  • 19
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • Bartel DP. MicroRNAs: target recognition and regulatory functions. Cell 2009; 136: 215-233.
    • (2009) Cell , vol.136 , pp. 215-233
    • Bartel, D.P.1
  • 20
    • 4644223259 scopus 로고    scopus 로고
    • Mechanisms of gene silencing by double-stranded RNA
    • Meister G and Tuschl T. Mechanisms of gene silencing by double-stranded RNA. Nature 2004; 431: 343-349.
    • (2004) Nature , vol.431 , pp. 343-349
    • Meister, G.1    Tuschl, T.2
  • 21
    • 33846277696 scopus 로고    scopus 로고
    • Repression of protein synthesis by miRNAs: How many mechanisms?
    • Pillai RS, Bhattacharyya SN and Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms? Trends Cell Biol 2007; 17: 118-126.
    • (2007) Trends Cell Biol , vol.17 , pp. 118-126
    • Pillai, R.S.1    Bhattacharyya, S.N.2    Filipowicz, W.3
  • 22
    • 13944282215 scopus 로고    scopus 로고
    • Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs
    • Lim LP, Lau NC, Garrett-Engele P, Grimson A, Schelter JM and Castle J et al. Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature 2005; 433: 769-773.
    • (2005) Nature , vol.433 , pp. 769-773
    • Lim, L.P.1    Lau, N.C.2    Garrett-Engele, P.3    Grimson, A.4    Schelter, J.M.5    Castle, J.6
  • 24
    • 33749519036 scopus 로고    scopus 로고
    • Implications of micro-RNA profiling for cancer diagnosis
    • Cummins JM and Velculescu VE. Implications of micro-RNA profiling for cancer diagnosis. Oncogene 2006; 25: 6220-6227.
    • (2006) Oncogene , vol.25 , pp. 6220-6227
    • Cummins, J.M.1    Velculescu, V.E.2
  • 25
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs-microRNAs with a role in cancer
    • Esquela-Kerscher A and Slack FJ. Oncomirs-microRNAs with a role in cancer. Nat Rev Cancer 2006; 6: 259-269.
    • (2006) Nat Rev Cancer , vol.6 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 26
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin GA and Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006; 6: 857-866.
    • (2006) Nat Rev Cancer , vol.6 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 27
    • 66149138833 scopus 로고    scopus 로고
    • MicroRNAs in cancer
    • Lee YS and Dutta A. MicroRNAs in cancer. Annu Rev Pathol 2009; 4: 199-227.
    • (2009) Annu Rev Pathol , vol.4 , pp. 199-227
    • Lee, Y.S.1    Dutta, A.2
  • 29
    • 33947431322 scopus 로고    scopus 로고
    • Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation
    • Mayr C, Hemann MT and Bartel DP. Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformation. Science 2007; 315: 1576-1579.
    • (2007) Science , vol.315 , pp. 1576-1579
    • Mayr, C.1    Hemann, M.T.2    Bartel, D.P.3
  • 30
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E, Seike M, Kumamoto K and Yi M et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006; 9: 189-198.
    • (2006) Cancer Cell , vol.9 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3    Seike, M.4    Kumamoto, K.5    Yi, M.6
  • 31
    • 34249817549 scopus 로고    scopus 로고
    • Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis
    • Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M and Lee KH et al. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell 2007; 26: 745-752.
    • (2007) Mol Cell , vol.26 , pp. 745-752
    • Chang, T.C.1    Wentzel, E.A.2    Kent, O.A.3    Ramachandran, K.4    Mullendore, M.5    Lee, K.H.6
  • 32
    • 34250851115 scopus 로고    scopus 로고
    • A microRNA component of the p53 tumour suppressor network
    • He L, He X, Lim LP, de Stanchina E, Xuan Z and Liang Y et al. A microRNA component of the p53 tumour suppressor network. Nature 2007; 447: 1130-1134.
    • (2007) Nature , vol.447 , pp. 1130-1134
    • He, L.1    He, X.2    Lim, L.P.3    De Stanchina, E.4    Xuan, Z.5    Liang, Y.6
  • 34
    • 34250868124 scopus 로고    scopus 로고
    • Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: MiR-34a is a p53 target that induces apoptosis and G1-arrest
    • Tarasov V, Jung P, Verdoodt B, Lodygin D, Epanchintsev A and Menssen A et al. Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrest. Cell Cycle 2007; 6: 1586-1593.
    • (2007) Cell Cycle , vol.6 , pp. 1586-1593
    • Tarasov, V.1    Jung, P.2    Verdoodt, B.3    Lodygin, D.4    Epanchintsev, A.5    Menssen, A.6
  • 35
    • 34547458550 scopus 로고    scopus 로고
    • And Love RE et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes
    • Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R and Love RE et al. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol 2007; 17: 1298-1307.
    • (2007) Curr Biol , vol.17 , pp. 1298-1307
    • Bommer, G.T.1    Gerin, I.2    Feng, Y.3    Kaczorowski, A.J.4    Kuick, R.5
  • 36
    • 34548803950 scopus 로고    scopus 로고
    • MicroRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth
    • Corney DC, Flesken-Nikitin A, Godwin AK, Wang W and Nikitin AY. MicroRNA-34b and microRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res 2007; 67: 8433-8438.
    • (2007) Cancer Res , vol.67 , pp. 8433-8438
    • Corney, D.C.1    Flesken-Nikitin, A.2    Godwin, A.K.3    Wang, W.4    Nikitin, A.Y.5
  • 37
    • 35748961986 scopus 로고    scopus 로고
    • P53 enters the microRNA world
    • Hermeking H. p53 enters the microRNA world. Cancer Cell 2007; 12: 414-418.
    • (2007) Cancer Cell , vol.12 , pp. 414-418
    • Hermeking, H.1
  • 39
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M, Blasco MA and Serrano M. Cellular senescence in cancer and aging. Cell 2007; 130: 223-233.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 40
    • 34249812122 scopus 로고    scopus 로고
    • MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells
    • Welch C, Chen Y and Stallings RL. MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cells. Oncogene 2007; 26: 5017-5022.
    • (2007) Oncogene , vol.26 , pp. 5017-5022
    • Welch, C.1    Chen, Y.2    Stallings, R.L.3
  • 43
    • 53949090314 scopus 로고    scopus 로고
    • Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
    • Ji Q, Hao X, Meng Y, Zhang M, Desano J and Fan D et al. Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres. BMC Cancer 2008; 8: 266.
    • (2008) BMC Cancer , vol.8 , pp. 266
    • Ji, Q.1    Hao, X.2    Meng, Y.3    Zhang, M.4    Desano, J.5    Fan, D.6
  • 44
    • 42049092138 scopus 로고    scopus 로고
    • Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest
    • Sun F, Fu H, Liu Q, Tie Y, Zhu J and Xing R et al. Downregulation of CCND1 and CDK6 by miR-34a induces cell cycle arrest. FEBS Lett 2008; 582: 1564-1568.
    • (2008) FEBS Lett , vol.582 , pp. 1564-1568
    • Sun, F.1    Fu, H.2    Liu, Q.3    Tie, Y.4    Zhu, J.5    Xing, R.6
  • 45
    • 49249121155 scopus 로고    scopus 로고
    • Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer
    • Toyota M, Suzuki H, Sasaki Y, Maruyama R, Imai K and Shinomura Y et al. Epigenetic silencing of microRNA-34b/c and B-cell translocation gene 4 is associated with CpG island methylation in colorectal cancer. Cancer Res 2008; 68: 4123-4132.
    • (2008) Cancer Res , vol.68 , pp. 4123-4132
    • Toyota, M.1    Suzuki, H.2    Sasaki, Y.3    Maruyama, R.4    Imai, K.5    Shinomura, Y.6
  • 47
    • 65549124181 scopus 로고    scopus 로고
    • MiR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia
    • Pigazzi M, Manara E, Baron E and Basso G. miR-34b targets cyclic AMP-responsive element binding protein in acute myeloid leukemia. Cancer Res 2009; 69: 2471-2478.
    • (2009) Cancer Res , vol.69 , pp. 2471-2478
    • Pigazzi, M.1    Manara, E.2    Baron, E.3    Basso, G.4
  • 49
    • 34848868157 scopus 로고    scopus 로고
    • Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells
    • Tazawa H, Tsuchiya N, Izumiya M and Nakagama H. Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cells. Proc Natl Acad Sci USA 2007; 104: 15472-15477.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 15472-15477
    • Tazawa, H.1    Tsuchiya, N.2    Izumiya, M.3    Nakagama, H.4
  • 50
    • 58549114916 scopus 로고    scopus 로고
    • MiR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells
    • Li N, Fu H, Tie Y, Hu Z, Kong W and Wu Y et al. miR-34a inhibits migration and invasion by down-regulation of c-Met expression in human hepatocellular carcinoma cells. Cancer Lett 2009; 275: 44-53.
    • (2009) Cancer Lett , vol.275 , pp. 44-53
    • Li, N.1    Fu, H.2    Tie, Y.3    Hu, Z.4    Kong, W.5    Wu, Y.6
  • 51
    • 64049119151 scopus 로고    scopus 로고
    • MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met
    • Yan D, Zhou X, Chen X, Hu DN, Dong XD and Wang J et al. MicroRNA-34a inhibits uveal melanoma cell proliferation and migration through downregulation of c-Met. Invest Ophthalmol Vis Sci 2009; 50: 1559-1565.
    • (2009) Invest Ophthalmol Vis Sci , vol.50 , pp. 1559-1565
    • Yan, D.1    Zhou, X.2    Chen, X.3    Hu, D.N.4    Dong, X.D.5    Wang, J.6
  • 53
    • 57149097456 scopus 로고    scopus 로고
    • MYC translocation-negative classical Burkitt lymphoma cases: An alternative pathogenetic mechanism involving miRNA deregulation
    • Leucci E, Cocco M, Onnis A, De Falco G, van Cleef P and Bellan C et al. MYC translocation-negative classical Burkitt lymphoma cases: an alternative pathogenetic mechanism involving miRNA deregulation. J Pathol 2008; 216: 440-450.
    • (2008) J Pathol , vol.216 , pp. 440-450
    • Leucci, E.1    Cocco, M.2    Onnis, A.3    De Falco, G.4    Van Cleef, P.5    Bellan, C.6
  • 54
    • 48249119199 scopus 로고    scopus 로고
    • The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene
    • Kong YW, Cannell IG, de Moor CH, Hill K, Garside PG and Hamilton TL et al. The mechanism of micro-RNA-mediated translation repression is determined by the promoter of the target gene. Proc Natl Acad Sci USA 2008; 105: 8866-8871.
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 8866-8871
    • Kong, Y.W.1    Cannell, I.G.2    De Moor, C.H.3    Hill, K.4    Garside, P.G.5    Hamilton, T.L.6
  • 57
    • 56149095484 scopus 로고    scopus 로고
    • Full-length hdmX transcripts decrease following genotoxic stress
    • Markey M and Berberich SJ. Full-length hdmX transcripts decrease following genotoxic stress. Oncogene 2008; 27: 6657-6666.
    • (2008) Oncogene , vol.27 , pp. 6657-6666
    • Markey, M.1    Berberich, S.J.2
  • 58
    • 34547938506 scopus 로고    scopus 로고
    • MicroRNAs: A safeguard against turmoil?
    • Leung AK and Sharp PA. microRNAs: a safeguard against turmoil? Cell 2007; 130: 581-585.
    • (2007) Cell , vol.130 , pp. 581-585
    • Leung, A.K.1    Sharp, P.A.2
  • 59
    • 33751073710 scopus 로고    scopus 로고
    • Denoising feedback loops by thresholding\-a new role for microRNAs
    • Cohen SM, Brennecke J and Stark A. Denoising feedback loops by thresholding\-a new role for microRNAs. Genes Dev 2006; 20: 2769-2772.
    • (2006) Genes Dev , vol.20 , pp. 2769-2772
    • Cohen, S.M.1    Brennecke, J.2    Stark, A.3
  • 60
    • 42049104107 scopus 로고    scopus 로고
    • Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer
    • Kozaki K, Imoto I, Mogi S, Omura K and Inazawa J. Exploration of tumor-suppressive microRNAs silenced by DNA hypermethylation in oral cancer. Cancer Res 2008; 68: 2094-2105.
    • (2008) Cancer Res , vol.68 , pp. 2094-2105
    • Kozaki, K.1    Imoto, I.2    Mogi, S.3    Omura, K.4    Inazawa, J.5
  • 61
    • 65749109370 scopus 로고    scopus 로고
    • Down-regulation of the microRNAs miR-34a miR-127 and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet
    • [E-pub ahead of print] doi: 10.1002/mc.20484
    • Tryndyak VP, Ross SA, Beland FA and Pogribny IP. Down-regulation of the microRNAs miR-34a, miR-127, and miR-200b in rat liver during hepatocarcinogenesis induced by a methyl-deficient diet. Mol Carcinog 2008; [E-pub ahead of print]. doi: 10.1002/mc.20484.
    • (2008) Mol Carcinog
    • Tryndyak, V.P.1    Ross, S.A.2    Beland, F.A.3    Pogribny, I.P.4
  • 62
    • 58849158388 scopus 로고    scopus 로고
    • How does SIRT1 affect metabolism, senescence and cancer?
    • Brooks CL and Gu W. How does SIRT1 affect metabolism, senescence and cancer? Nat Rev Cancer 2009; 9: 123-128.
    • (2009) Nat Rev Cancer , vol.9 , pp. 123-128
    • Brooks, C.L.1    Gu, W.2
  • 64
    • 65549110908 scopus 로고    scopus 로고
    • MiR-34a as part of the chemotherapy resistance network in chronic lymphocytic leukemia
    • Zenz T, Mohr J, Eldering E, Kater AP, Buhler A and Kienle D et al. MiR-34a as part of the chemotherapy resistance network in chronic lymphocytic leukemia. Blood 2009; 113: 3801-3808.
    • (2009) Blood , vol.113 , pp. 3801-3808
    • Zenz, T.1    Mohr, J.2    Eldering, E.3    Kater, A.P.4    Buhler, A.5    Kienle, D.6
  • 65
    • 67349191499 scopus 로고    scopus 로고
    • MiR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities
    • [E-pub ahead of print]. doi: 10.1038
    • Mraz M, Malinova K, Kotaskova J, Pavlova S, Tichy B and Malcikova J et al. miR-34a, miR-29c and miR-17-5p are downregulated in CLL patients with TP53 abnormalities. Leukemia 2009; [E-pub ahead of print]. doi: 10.1038.
    • (2009) Leukemia
    • Mraz, M.1    Malinova, K.2    Kotaskova, J.3    Pavlova, S.4    Tichy, B.5    Malcikova, J.6
  • 66
    • 44849091255 scopus 로고    scopus 로고
    • Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence
    • Kumamoto K, Spillare EA, Fujita K, Horikawa I, Yamashita T and Appella E et al. Nutlin-3a activates p53 to both down-regulate inhibitor of growth 2 and up-regulate mir-34a, mir-34b, and mir-34c expression, and induce senescence. Cancer Res 2008; 68: 3193-3203.
    • (2008) Cancer Res , vol.68 , pp. 3193-3203
    • Kumamoto, K.1    Spillare, E.A.2    Fujita, K.3    Horikawa, I.4    Yamashita, T.5    Appella, E.6


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