메뉴 건너뛰기




Volumn 7, Issue 9, 2008, Pages 1139-1145

Is NHEJ a tumor suppressor or an aging suppressor?

Author keywords

Apoptosis; Cellular senescence; Chromosomal rearrangements; Ku70; Ku80; NHEJ; p53

Indexed keywords

PROTEIN P53;

EID: 44349092536     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.7.9.5807     Document Type: Review
Times cited : (17)

References (115)
  • 3
    • 36248930421 scopus 로고    scopus 로고
    • The sources and potential hazards of mutagens in complex environmental matrices-Part II
    • White PA. The sources and potential hazards of mutagens in complex environmental matrices-Part II. Mutat Res 2007.
    • (2007) Mutat Res
    • White, P.A.1
  • 4
    • 0030932869 scopus 로고    scopus 로고
    • Gatekeepers and caretakers
    • Kinzler KW, Vogelstein B. Gatekeepers and caretakers. Nature 1997; 386:761-3.
    • (1997) Nature , vol.386 , pp. 761-763
    • Kinzler, K.W.1    Vogelstein, B.2
  • 5
    • 34548186667 scopus 로고    scopus 로고
    • Cellular senescence: When bad things happen to good cells
    • Campisi J, d'Adda di Fagagna F. Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 2007; 8:729-40.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 729-740
    • Campisi, J.1    d'Adda di Fagagna, F.2
  • 6
    • 50549218525 scopus 로고
    • The limited in vitro lifetime of human diploid cell strains
    • Hayflick L. The limited in vitro lifetime of human diploid cell strains. Experimental Cell Research 1965; 37:614-36.
    • (1965) Experimental Cell Research , vol.37 , pp. 614-636
    • Hayflick, L.1
  • 7
    • 0033026714 scopus 로고    scopus 로고
    • Mechanisms of apoptosis avoidance in cancer
    • Reed JC. Mechanisms of apoptosis avoidance in cancer. Curr Opin Oncol 1999; 11:68-75.
    • (1999) Curr Opin Oncol , vol.11 , pp. 68-75
    • Reed, J.C.1
  • 9
    • 34548153747 scopus 로고    scopus 로고
    • How stem cells age and why this makes us grow old
    • Sharpless NE, DePinho RA. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 2007; 8:703-13.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 703-713
    • Sharpless, N.E.1    DePinho, R.A.2
  • 10
    • 34447543913 scopus 로고    scopus 로고
    • Cellular senescence in cancer and aging
    • Collado M, Blasco MA, Serrano M. Cellular senescence in cancer and aging. Cell 2007; 130:223-33.
    • (2007) Cell , vol.130 , pp. 223-233
    • Collado, M.1    Blasco, M.A.2    Serrano, M.3
  • 11
    • 23644449752 scopus 로고    scopus 로고
    • Cancer: Crime and punishment
    • Sharpless NE, DePinho RA. Cancer: crime and punishment. Nature 2005; 436:636-7.
    • (2005) Nature , vol.436 , pp. 636-637
    • Sharpless, N.E.1    DePinho, R.A.2
  • 12
    • 33745712849 scopus 로고    scopus 로고
    • The power and the promise of oncogene-induced senescence markers
    • Collado M, Serrano M. The power and the promise of oncogene-induced senescence markers. Nat Rev Cancer 2006; 6:472-6.
    • (2006) Nat Rev Cancer , vol.6 , pp. 472-476
    • Collado, M.1    Serrano, M.2
  • 13
    • 2942570699 scopus 로고    scopus 로고
    • Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture
    • Busuttil RA, Rubio M, Dolle ME, Campisi J, Vijg J. Oxygen accelerates the accumulation of mutations during the senescence and immortalization of murine cells in culture. Aging Cell 2003; 2:287-94.
    • (2003) Aging Cell , vol.2 , pp. 287-294
    • Busuttil, R.A.1    Rubio, M.2    Dolle, M.E.3    Campisi, J.4    Vijg, J.5
  • 17
    • 0030887851 scopus 로고    scopus 로고
    • Aging and cancer: The double-edged sword of replicative senescence
    • Campisi J. Aging and cancer: the double-edged sword of replicative senescence. J Am Geriatr Soc 1997; 45:482-8.
    • (1997) J Am Geriatr Soc , vol.45 , pp. 482-488
    • Campisi, J.1
  • 18
    • 0034069237 scopus 로고    scopus 로고
    • Cancer, aging and cellular senescence
    • Campisi J. Cancer, aging and cellular senescence. In Vivo 2000; 14:183-8.
    • (2000) In Vivo , vol.14 , pp. 183-188
    • Campisi, J.1
  • 19
    • 1542781658 scopus 로고    scopus 로고
    • Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence?
    • Pelicci PG. Do tumor-suppressive mechanisms contribute to organism aging by inducing stem cell senescence? J Clin Invest 2004; 113:4-7.
    • (2004) J Clin Invest , vol.113 , pp. 4-7
    • Pelicci, P.G.1
  • 23
    • 10944251591 scopus 로고    scopus 로고
    • Repair and genetic consequences of endogenous DNA base damage in mammalian cells
    • Barnes DE, Lindahl T. Repair and genetic consequences of endogenous DNA base damage in mammalian cells. Annu Rev Genet 2004; 38:445-76.
    • (2004) Annu Rev Genet , vol.38 , pp. 445-476
    • Barnes, D.E.1    Lindahl, T.2
  • 24
    • 34247599335 scopus 로고    scopus 로고
    • A unified view of base excision repair: Lesion-dependent protein complexes regulated by post-translational modification
    • Almeida KH, Sobol RW. A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification. DNA Repair (Amst) 2007; 6:695-711.
    • (2007) DNA Repair (Amst) , vol.6 , pp. 695-711
    • Almeida, K.H.1    Sobol, R.W.2
  • 25
    • 0034054019 scopus 로고    scopus 로고
    • Nucleotide excision repair and human syndromes
    • de Boer J, Hoeijmakers JH. Nucleotide excision repair and human syndromes. Carcinogenesis 2000; 21:453-60.
    • (2000) Carcinogenesis , vol.21 , pp. 453-460
    • de Boer, J.1    Hoeijmakers, J.H.2
  • 27
    • 0034733599 scopus 로고    scopus 로고
    • Recombination factors of Saccharomyces cerevisiae
    • Sung P, Trujillo KM, Van Komen S. Recombination factors of Saccharomyces cerevisiae. Mutat Res 2000; 451:257-75.
    • (2000) Mutat Res , vol.451 , pp. 257-275
    • Sung, P.1    Trujillo, K.M.2    Van Komen, S.3
  • 28
    • 0038700698 scopus 로고    scopus 로고
    • Molecular views of recombination proteins and their control
    • West SC. Molecular views of recombination proteins and their control. Nat Rev Mol Cell Biol 2003; 4:435-45.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 435-445
    • West, S.C.1
  • 29
    • 0042839614 scopus 로고    scopus 로고
    • Mechanism and regulation of human nonhomologous DNA end-joining
    • Lieber MR, Ma Y, Pannicke U, Schwarz K. Mechanism and regulation of human nonhomologous DNA end-joining. Nat Rev Mol Cell Biol 2003; 4:712-20.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 712-720
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 30
    • 0033950791 scopus 로고    scopus 로고
    • Chromosome breaks and genomic instability
    • Jasin M. Chromosome breaks and genomic instability. Cancer Invest 2000; 18:78-86.
    • (2000) Cancer Invest , vol.18 , pp. 78-86
    • Jasin, M.1
  • 31
    • 3242881897 scopus 로고    scopus 로고
    • An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome
    • O'Driscoll M, Gennery AR, Seidel J, Concannon P, Jeggo PA. An overview of three new disorders associated with genetic instability: LIG4 syndrome, RS-SCID and ATR-Seckel syndrome. DNA Repair (Amst) 2004; 3:1227-35.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1227-1235
    • O'Driscoll, M.1    Gennery, A.R.2    Seidel, J.3    Concannon, P.4    Jeggo, P.A.5
  • 32
    • 0035902108 scopus 로고    scopus 로고
    • Genome maintenance mechanisms for preventing cancer
    • Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 2001; 411:366-74.
    • (2001) Nature , vol.411 , pp. 366-374
    • Hoeijmakers, J.H.1
  • 33
    • 36448996703 scopus 로고    scopus 로고
    • Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations
    • Fackenthal JD, Olopade OI. Breast cancer risk associated with BRCA1 and BRCA2 in diverse populations. Nat Rev Cancer 2007; 7:937-48.
    • (2007) Nat Rev Cancer , vol.7 , pp. 937-948
    • Fackenthal, J.D.1    Olopade, O.I.2
  • 34
    • 34548321123 scopus 로고    scopus 로고
    • Molecular genetics of RecQ helicase disorders
    • Hanada K, Hickson ID. Molecular genetics of RecQ helicase disorders. Cell Mol Life Sci 2007; 64:2306-22.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 2306-2322
    • Hanada, K.1    Hickson, I.D.2
  • 35
    • 36949021811 scopus 로고    scopus 로고
    • The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome
    • Demuth I, Digweed M. The clinical manifestation of a defective response to DNA double-strand breaks as exemplified by Nijmegen breakage syndrome. Oncogene 2007; 26:7792-8.
    • (2007) Oncogene , vol.26 , pp. 7792-7798
    • Demuth, I.1    Digweed, M.2
  • 37
    • 3242879122 scopus 로고    scopus 로고
    • The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination
    • Lieber MR, Ma Y, Pannicke U, Schwarz K. The mechanism of vertebrate nonhomologous DNA end joining and its role in V(D)J recombination. DNA Repair (Amst) 2004; 3:817-26.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 817-826
    • Lieber, M.R.1    Ma, Y.2    Pannicke, U.3    Schwarz, K.4
  • 38
    • 0035833552 scopus 로고    scopus 로고
    • Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair
    • Walker JR, Corpina RA, Goldberg J. Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair. Nature 2001; 412:607-14.
    • (2001) Nature , vol.412 , pp. 607-614
    • Walker, J.R.1    Corpina, R.A.2    Goldberg, J.3
  • 40
    • 31044432090 scopus 로고    scopus 로고
    • XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining
    • Ahnesorg P, Smith P, Jackson SP. XLF Interacts with the XRCC4-DNA Ligase IV Complex to Promote DNA Nonhomologous End-Joining. Cell 2006; 124:301-13.
    • (2006) Cell , vol.124 , pp. 301-313
    • Ahnesorg, P.1    Smith, P.2    Jackson, S.P.3
  • 41
    • 0030576534 scopus 로고    scopus 로고
    • Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates
    • Zhu C, Bogue MA, Lim DS, Hasty P, Roth DB. Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 1996; 86:379-89.
    • (1996) Cell , vol.86 , pp. 379-389
    • Zhu, C.1    Bogue, M.A.2    Lim, D.S.3    Hasty, P.4    Roth, D.B.5
  • 43
    • 0031471226 scopus 로고    scopus 로고
    • Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: The effects of ionizing radiation on growth, survival, and development
    • Nussenzweig A, Sokol K, Burgman P, Li L, Li GC. Hypersensitivity of Ku80-deficient cell lines and mice to DNA damage: the effects of ionizing radiation on growth, survival, and development. Proc Natl Acad Sci USA 1997; 94:13588-93.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 13588-13593
    • Nussenzweig, A.1    Sokol, K.2    Burgman, P.3    Li, L.4    Li, G.C.5
  • 44
    • 0030858967 scopus 로고    scopus 로고
    • Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination
    • Gu Y, Jin S, Gao Y, Weaver DT, Alt FW. Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination. Proc Natl Acad Sci USA 1997; 94:8076-81.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8076-8081
    • Gu, Y.1    Jin, S.2    Gao, Y.3    Weaver, D.T.4    Alt, F.W.5
  • 48
    • 0033576687 scopus 로고    scopus 로고
    • The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts
    • Karanjawala ZE, Grawunder U, Hsieh CL, Lieber MR. The nonhomologous DNA end joining pathway is important for chromosome stability in primary fibroblasts. Curr Biol 1999; 9:1501-4.
    • (1999) Curr Biol , vol.9 , pp. 1501-1504
    • Karanjawala, Z.E.1    Grawunder, U.2    Hsieh, C.L.3    Lieber, M.R.4
  • 51
    • 0034612308 scopus 로고    scopus 로고
    • The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations
    • Ferguson DO, Sekiguchi JM, Chang S, Frank KM, Gao Y, DePinho RA, Alt FW. The nonhomologous end-joining pathway of DNA repair is required for genomic stability and the suppression of translocations. Proc Natl Acad Sci USA 2000; 97:6630-3.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 6630-6633
    • Ferguson, D.O.1    Sekiguchi, J.M.2    Chang, S.3    Frank, K.M.4    Gao, Y.5    DePinho, R.A.6    Alt, F.W.7
  • 52
    • 36849088515 scopus 로고    scopus 로고
    • Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer
    • Li H, Vogel H, Holcomb VB, Gu Y, Hasty P. Deletion of Ku70, Ku80, or Both Causes Early Aging without Substantially Increased Cancer. Mol Cell Biol 2007; 27:8205-14.
    • (2007) Mol Cell Biol , vol.27 , pp. 8205-8214
    • Li, H.1    Vogel, H.2    Holcomb, V.B.3    Gu, Y.4    Hasty, P.5
  • 55
    • 0037027853 scopus 로고    scopus 로고
    • The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: Implications for unifying the heterogeneous phenotypes of NHEJ mutants
    • Karanjawala ZE, Adachi N, Irvine RA, Oh EK, Shibata D, Schwarz K, Hsieh CL, Lieber MR. The embryonic lethality in DNA ligase IV-deficient mice is rescued by deletion of Ku: implications for unifying the heterogeneous phenotypes of NHEJ mutants. DNA Repair (Amst) 2002; 1:1017-26.
    • (2002) DNA Repair (Amst) , vol.1 , pp. 1017-1026
    • Karanjawala, Z.E.1    Adachi, N.2    Irvine, R.A.3    Oh, E.K.4    Shibata, D.5    Schwarz, K.6    Hsieh, C.L.7    Lieber, M.R.8
  • 57
    • 37349074760 scopus 로고    scopus 로고
    • Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs
    • Holcomb VB, Vogel H, Hasty P. Deletion of Ku80 causes early aging independent of chronic inflammation and Rag-1-induced DSBs. Mech Ageing Dev 2007.
    • (2007) Mech Ageing Dev
    • Holcomb, V.B.1    Vogel, H.2    Hasty, P.3
  • 58
    • 33745752959 scopus 로고    scopus 로고
    • Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression
    • Chao C, Herr D, Chun J, Xu Y. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. Embo J 2006; 25:2615-22.
    • (2006) Embo J , vol.25 , pp. 2615-2622
    • Chao, C.1    Herr, D.2    Chun, J.3    Xu, Y.4
  • 62
    • 0141518531 scopus 로고    scopus 로고
    • Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction
    • Um JH, Kim SJ, Kim DW, Ha MY, Jang JH, Kim DW, Chung BS, Kang CD, Kim SH. Tissue-specific changes of DNA repair protein Ku and mtHSP70 in aging rats and their retardation by caloric restriction. Mech Ageing Dev 2003; 124:967-75.
    • (2003) Mech Ageing Dev , vol.124 , pp. 967-975
    • Um, J.H.1    Kim, S.J.2    Kim, D.W.3    Ha, M.Y.4    Jang, J.H.5    Kim, D.W.6    Chung, B.S.7    Kang, C.D.8    Kim, S.H.9
  • 66
    • 35748930210 scopus 로고    scopus 로고
    • Changes in the level and distribution of Ku proteins during cellular senescence
    • Amst
    • Seluanov A, Danek J, Hause N, Gorbunova V. Changes in the level and distribution of Ku proteins during cellular senescence. DNA Repair (Amst) 2007.
    • (2007) DNA Repair
    • Seluanov, A.1    Danek, J.2    Hause, N.3    Gorbunova, V.4
  • 67
    • 0036326014 scopus 로고    scopus 로고
    • Non-homologous DNA end joining in the mature rat brain
    • Ren K, de Ortiz SP. Non-homologous DNA end joining in the mature rat brain. J Neurochem 2002; 80:949-59.
    • (2002) J Neurochem , vol.80 , pp. 949-959
    • Ren, K.1    de Ortiz, S.P.2
  • 68
    • 28444474288 scopus 로고    scopus 로고
    • DNA double strand break repair in brain: Reduced NHEJ activity in aging rat neurons
    • Vyjayanti VN, Rao KS. DNA double strand break repair in brain: reduced NHEJ activity in aging rat neurons. Neurosci Lett 2006; 393:18-22.
    • (2006) Neurosci Lett , vol.393 , pp. 18-22
    • Vyjayanti, V.N.1    Rao, K.S.2
  • 69
    • 33344463678 scopus 로고    scopus 로고
    • DNA end joining activity is reduced in Alzheimer's disease
    • Shackelford DA. DNA end joining activity is reduced in Alzheimer's disease. Neurobiol Aging 2006; 27:596-605.
    • (2006) Neurobiol Aging , vol.27 , pp. 596-605
    • Shackelford, D.A.1
  • 72
    • 0036894745 scopus 로고    scopus 로고
    • Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation
    • Tong WM, Cortes U, Hande MP, Ohgaki H, Cavalli LR, Lansdorp PM, Haddad BR, Wang ZQ. Synergistic role of Ku80 and poly(ADP-ribose) polymerase in suppressing chromosomal aberrations and liver cancer formation. Cancer Res 2002; 62:6990-6.
    • (2002) Cancer Res , vol.62 , pp. 6990-6996
    • Tong, W.M.1    Cortes, U.2    Hande, M.P.3    Ohgaki, H.4    Cavalli, L.R.5    Lansdorp, P.M.6    Haddad, B.R.7    Wang, Z.Q.8
  • 73
    • 3242883729 scopus 로고    scopus 로고
    • The p53 response to DNA damage
    • Meek DW. The p53 response to DNA damage. DNA Repair (Amst) 2004; 3:1049-56.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 1049-1056
    • Meek, D.W.1
  • 77
    • 0037188898 scopus 로고    scopus 로고
    • Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations
    • Zhu C, Mills KD, Ferguson DO, Lee C, Manis J, Fleming J, Gao Y, Morton CC, Alt FW. Unrepaired DNA breaks in p53-deficient cells lead to oncogenic gene amplification subsequent to translocations. Cell 2002; 109:811-21.
    • (2002) Cell , vol.109 , pp. 811-821
    • Zhu, C.1    Mills, K.D.2    Ferguson, D.O.3    Lee, C.4    Manis, J.5    Fleming, J.6    Gao, Y.7    Morton, C.C.8    Alt, F.W.9
  • 78
    • 33751116534 scopus 로고    scopus 로고
    • Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs
    • Holcomb VB, Vogel H, Marple T, Kornegay RW, Hasty P. Ku80 and p53 suppress medulloblastoma that arise independent of Rag-1-induced DSBs. Oncogene 2006; 25:7159-65.
    • (2006) Oncogene , vol.25 , pp. 7159-7165
    • Holcomb, V.B.1    Vogel, H.2    Marple, T.3    Kornegay, R.W.4    Hasty, P.5
  • 79
    • 0037112505 scopus 로고    scopus 로고
    • DNA ligase IV suppresses medulloblastoma formation
    • Lee Y, McKinnon PJ. DNA ligase IV suppresses medulloblastoma formation. Cancer Res 2002; 62:6395-9.
    • (2002) Cancer Res , vol.62 , pp. 6395-6399
    • Lee, Y.1    McKinnon, P.J.2
  • 81
    • 0034690173 scopus 로고    scopus 로고
    • New guardians of the genome
    • Roth DB, Gellert M. New guardians of the genome. Nature 2000; 404:823-5.
    • (2000) Nature , vol.404 , pp. 823-825
    • Roth, D.B.1    Gellert, M.2
  • 82
    • 33747889722 scopus 로고    scopus 로고
    • Role of non-homologous end joining (NHEJ) in maintaining genomic integrity
    • Burma S, Chen BP, Chen DJ. Role of non-homologous end joining (NHEJ) in maintaining genomic integrity. DNA Repair (Amst) 2006; 5:1042-8.
    • (2006) DNA Repair (Amst) , vol.5 , pp. 1042-1048
    • Burma, S.1    Chen, B.P.2    Chen, D.J.3
  • 86
    • 37849023839 scopus 로고    scopus 로고
    • Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells
    • Windhofer F, Krause S, Hader C, Schulz WA, Florl AR. Distinctive differences in DNA double-strand break repair between normal urothelial and urothelial carcinoma cells. Mutat Res 2008; 638:56-65.
    • (2008) Mutat Res , vol.638 , pp. 56-65
    • Windhofer, F.1    Krause, S.2    Hader, C.3    Schulz, W.A.4    Florl, A.R.5
  • 88
    • 34548084240 scopus 로고    scopus 로고
    • DNA double-strand break repair capacity and risk of breast cancer
    • Bau DT, Mau YC, Ding SL, Wu PE, Shen CY. DNA double-strand break repair capacity and risk of breast cancer. Carcinogenesis 2007; 28:1726-30.
    • (2007) Carcinogenesis , vol.28 , pp. 1726-1730
    • Bau, D.T.1    Mau, Y.C.2    Ding, S.L.3    Wu, P.E.4    Shen, C.Y.5
  • 91
    • 33845467396 scopus 로고    scopus 로고
    • Epstein-Barr virus selectively deregulates DNA damage responses in normal B cells but has no detectable effect on regulation of the tumor suppressor p53
    • O'Nions J, Turner A, Craig R, Allday MJ. Epstein-Barr virus selectively deregulates DNA damage responses in normal B cells but has no detectable effect on regulation of the tumor suppressor p53. J Virol 2006; 80:12408-13.
    • (2006) J Virol , vol.80 , pp. 12408-12413
    • O'Nions, J.1    Turner, A.2    Craig, R.3    Allday, M.J.4
  • 93
    • 0037198009 scopus 로고    scopus 로고
    • Large genome rearrangements as a primary cause of aging
    • Vijg J, Dolle ME. Large genome rearrangements as a primary cause of aging. Mech Ageing Dev 2002; 123:907-15.
    • (2002) Mech Ageing Dev , vol.123 , pp. 907-915
    • Vijg, J.1    Dolle, M.E.2
  • 95
    • 34250315824 scopus 로고    scopus 로고
    • DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: A mouse model
    • Van Nguyen T, Puebla-Osorio N, Pang H, Dujka ME, Zhu C. DNA damage-induced cellular senescence is sufficient to suppress tumorigenesis: a mouse model. J Exp Med 2007; 204:1453-61.
    • (2007) J Exp Med , vol.204 , pp. 1453-1461
    • Van Nguyen, T.1    Puebla-Osorio, N.2    Pang, H.3    Dujka, M.E.4    Zhu, C.5
  • 96
    • 10944256695 scopus 로고    scopus 로고
    • The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: Observations in humans and mice
    • Hasty P. The impact of DNA damage, genetic mutation and cellular responses on cancer prevention, longevity and aging: observations in humans and mice. Mech Ageing Dev 2005; 126:71-7.
    • (2005) Mech Ageing Dev , vol.126 , pp. 71-77
    • Hasty, P.1
  • 97
    • 33645781346 scopus 로고    scopus 로고
    • Making ends meet: Repairing breaks in bacterial DNA by nonhomologous end-joining
    • Bowater R, Doherty AJ. Making ends meet: repairing breaks in bacterial DNA by nonhomologous end-joining. PLoS Genet 2006; 2:8.
    • (2006) PLoS Genet , vol.2 , pp. 8
    • Bowater, R.1    Doherty, A.J.2
  • 98
    • 7944231563 scopus 로고    scopus 로고
    • Non-homologous end-joining factors of Saccharomyces cerevisiae
    • Dudasova Z, Dudas A, Chovanec M. Non-homologous end-joining factors of Saccharomyces cerevisiae. FEMS Microbiol Rev 2004; 28:581-601.
    • (2004) FEMS Microbiol Rev , vol.28 , pp. 581-601
    • Dudasova, Z.1    Dudas, A.2    Chovanec, M.3
  • 99
    • 28544436537 scopus 로고    scopus 로고
    • Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11
    • Di Virgilio M, Gautier J. Repair of double-strand breaks by nonhomologous end joining in the absence of Mre11. J Cell Biol 2005; 171:765-71.
    • (2005) J Cell Biol , vol.171 , pp. 765-771
    • Di Virgilio, M.1    Gautier, J.2
  • 100
    • 0346249708 scopus 로고    scopus 로고
    • Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining
    • Dore AS, Drake AC, Brewerton SC, Blundell TL. Identification of DNA-PK in the arthropods. Evidence for the ancient ancestry of vertebrate non-homologous end-joining. DNA Repair (Amst) 2004; 3:33-41.
    • (2004) DNA Repair (Amst) , vol.3 , pp. 33-41
    • Dore, A.S.1    Drake, A.C.2    Brewerton, S.C.3    Blundell, T.L.4
  • 102
    • 34447509272 scopus 로고    scopus 로고
    • Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis
    • Bladen CL, Navarre S, Dynan WS, Kozlowski DJ. Expression of the Ku70 subunit (XRCC6) and protection from low dose ionizing radiation during zebrafish embryogenesis. Neurosci Lett 2007; 422:97-102.
    • (2007) Neurosci Lett , vol.422 , pp. 97-102
    • Bladen, C.L.1    Navarre, S.2    Dynan, W.S.3    Kozlowski, D.J.4
  • 103
    • 0032934980 scopus 로고    scopus 로고
    • Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts
    • Labhart P. Ku-dependent nonhomologous DNA end joining in Xenopus egg extracts. Mol Cell Biol 1999; 19:2585-93.
    • (1999) Mol Cell Biol , vol.19 , pp. 2585-2593
    • Labhart, P.1
  • 104
    • 0032530658 scopus 로고    scopus 로고
    • Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells
    • Takata M, Sasaki MS, Sonoda E, Morrison C, Hashimoto M, Utsumi H, Yamaguchi-Iwai Y, Shinohara A, Takeda S. Homologous recombination and non-homologous end-joining pathways of DNA double-strand break repair have overlapping roles in the maintenance of chromosomal integrity in vertebrate cells. Embo J 1998; 17:5497-508.
    • (1998) Embo J , vol.17 , pp. 5497-5508
    • Takata, M.1    Sasaki, M.S.2    Sonoda, E.3    Morrison, C.4    Hashimoto, M.5    Utsumi, H.6    Yamaguchi-Iwai, Y.7    Shinohara, A.8    Takeda, S.9
  • 105
    • 33646789152 scopus 로고    scopus 로고
    • Lessons from p53 in non-mammalian models
    • Lu WJ, Abrams JM. Lessons from p53 in non-mammalian models. Cell Death Differ 2006; 13:909-12.
    • (2006) Cell Death Differ , vol.13 , pp. 909-912
    • Lu, W.J.1    Abrams, J.M.2
  • 107
    • 0030473888 scopus 로고    scopus 로고
    • A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis
    • de Nooij JC, Letendre MA, Hariharan IK. A cyclin-dependent kinase inhibitor, Dacapo, is necessary for timely exit from the cell cycle during Drosophila embryogenesis. Cell 1996; 87:1237-47.
    • (1996) Cell , vol.87 , pp. 1237-1247
    • de Nooij, J.C.1    Letendre, M.A.2    Hariharan, I.K.3
  • 109
    • 0030886015 scopus 로고    scopus 로고
    • Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53
    • Sugrue MM, Shin DY, Lee SW, Aaronson SA. Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci USA 1997; 94:9648-53.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 9648-9653
    • Sugrue, M.M.1    Shin, D.Y.2    Lee, S.W.3    Aaronson, S.A.4
  • 112
    • 0037015397 scopus 로고    scopus 로고
    • DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53
    • Courtois S, Verhaegh G, North S, Luciani MG, Lassus P, Hibner U, Oren M, Hainaut P. DeltaN-p53, a natural isoform of p53 lacking the first transactivation domain, counteracts growth suppression by wild-type p53. Oncogene 2002; 21:6722-8.
    • (2002) Oncogene , vol.21 , pp. 6722-6728
    • Courtois, S.1    Verhaegh, G.2    North, S.3    Luciani, M.G.4    Lassus, P.5    Hibner, U.6    Oren, M.7    Hainaut, P.8
  • 113
    • 0036307307 scopus 로고    scopus 로고
    • p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products
    • Yin Y, Stephen CW, Luciani MG, Fahraeus R. p53 Stability and activity is regulated by Mdm2-mediated induction of alternative p53 translation products. Nat Cell Biol 2002; 4:462-7.
    • (2002) Nat Cell Biol , vol.4 , pp. 462-467
    • Yin, Y.1    Stephen, C.W.2    Luciani, M.G.3    Fahraeus, R.4
  • 114
    • 28444434535 scopus 로고    scopus 로고
    • Loss of function of def selectively upregulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish
    • Chen J, Ruan H, Ng SM, Gao C, Soo HM, Wu W, Zhang Z, Wen Z, Lane DP, Peng J. Loss of function of def selectively upregulates Delta113p53 expression to arrest expansion growth of digestive organs in zebrafish. Genes Dev 2005; 19:2900-11.
    • (2005) Genes Dev , vol.19 , pp. 2900-2911
    • Chen, J.1    Ruan, H.2    Ng, S.M.3    Gao, C.4    Soo, H.M.5    Wu, W.6    Zhang, Z.7    Wen, Z.8    Lane, D.P.9    Peng, J.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.