Accelerated senescence: An emerging role in tumor cell response to chemotherapy and radiation

Biochemical Pharmacology

Volumn 76, Issue 8, 2008, Pages 947-957

  Gewirtz, David A ^a,b   Holt, Shawn E ^a,b   Elmore, Lynne W ^a,b  

^a VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

Accelerated senescence; cdc2; Chemotherapy; p21; p53; Radiation; Replicative senescence; Telomerase; Telomere

Indexed keywords

ANTINEOPLASTIC AGENT; ATM PROTEIN; BETA GALACTOSIDASE; BLEOMYCIN; CAMPTOTHECIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CISPLATIN; CYCLIN DEPENDENT KINASE 1; CYCLIN DEPENDENT KINASE INHIBITOR 1; DAUNORUBICIN; DISCOMERDOLIDE; DNA; DOXORUBICIN; ETOPOSIDE; IRINOTECAN; JG 03 14; MELPHALAN; METHOTREXATE; PACLITAXEL; PROTEIN P16; PROTEIN P53; PYRROLE DERIVATIVE; RETINOBLASTOMA PROTEIN; STRESS ACTIVATED PROTEIN KINASE; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CHEMOTHERAPY; CANCER RADIOTHERAPY; CELL KILLING; CELL RENEWAL; CULTURE MEDIUM; DNA DAMAGE; DRUG RESPONSE; GENE EXPRESSION; HUMAN; IONIZING RADIATION; LEUKEMIA; LYMPHOMA; MITOGENESIS; MITOSIS; ONCOGENE; PRIORITY JOURNAL; RADIATION RESPONSE; RADIOSENSITIVITY; SENESCENCE; SIGNAL TRANSDUCTION; SOLID TUMOR; TUMOR CELL; TUMOR CELL CULTURE; TUMOR CELL DESTRUCTION;

EID: 52949152429     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2008.06.024     Document Type: Note

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