-
1
-
-
33644894248
-
Developing a research agenda in biogerontology: Basic mechanisms
-
Warner HR. 2005. Developing a research agenda in biogerontology: basic mechanisms. Sci Aging Knowledge Environ 2005:pe33.
-
(2005)
Sci Aging Knowledge Environ 2005:pe33
-
-
Warner, H.R.1
-
2
-
-
11144324518
-
Open-minded scepticism: Inferring the causal mechanisms of human ageing from genetic perturbations
-
de Magalhaes JP. 2005. Open-minded scepticism: inferring the causal mechanisms of human ageing from genetic perturbations. Ageing Res Rev 4:1-22.
-
(2005)
Ageing Res Rev
, vol.4
, pp. 1-22
-
-
de Magalhaes, J.P.1
-
3
-
-
0034884345
-
Genes that prolong life: Relationships of growth hormone and growth to aging and life span
-
Bartke A, Coschigano K, Kopchick J, Chandrashekar V, Mattison J, et al. 2001. Genes that prolong life: relationships of growth hormone and growth to aging and life span. J. Gerontol A Biol Sci Med Sci 56:B340-B349.
-
(2001)
J. Gerontol A Biol Sci Med Sci
, vol.56
-
-
Bartke, A.1
Coschigano, K.2
Kopchick, J.3
Chandrashekar, V.4
Mattison, J.5
-
4
-
-
0037470542
-
Aging and genome maintenance: Lessons from the mouse?
-
Hasty P, Campisi J, Hoeijmakers J, van Steeg H, Vijg J. 2003. Aging and genome maintenance: lessons from the mouse? Science 299:1355-1359.
-
(2003)
Science
, vol.299
, pp. 1355-1359
-
-
Hasty, P.1
Campisi, J.2
Hoeijmakers, J.3
van Steeg, H.4
Vijg, J.5
-
5
-
-
0034626770
-
Lessons from human progeroid syndromes
-
Martin GM, Oshima J. 2000. Lessons from human progeroid syndromes. Nature 408:263-266.
-
(2000)
Nature
, vol.408
, pp. 263-266
-
-
Martin, G.M.1
Oshima, J.2
-
6
-
-
0037726549
-
Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology
-
Warner HR, Sierra F. 2003. Models of accelerated ageing can be informative about the molecular mechanisms of ageing and/or age-related pathology. Mech Ageing Dev 124:581-587.
-
(2003)
Mech Ageing Dev
, vol.124
, pp. 581-587
-
-
Warner, H.R.1
Sierra, F.2
-
7
-
-
4444281968
-
What can progeroid syndromes tell us about human aging?
-
Kipling D, Davis T, Ostler EL, Faragher RG. 2004. What can progeroid syndromes tell us about human aging? Science 305:1426-1431.
-
(2004)
Science
, vol.305
, pp. 1426-1431
-
-
Kipling, D.1
Davis, T.2
Ostler, E.L.3
Faragher, R.G.4
-
8
-
-
13744258936
-
The influence of genes on the aging process of mice: A statistical assessment of the genetics of aging
-
de Magalhaes JP, Cabral JA, Magalhaes D. 2005. The influence of genes on the aging process of mice: a statistical assessment of the genetics of aging. Genetics 169:265-274.
-
(2005)
Genetics
, vol.169
, pp. 265-274
-
-
de Magalhaes, J.P.1
Cabral, J.A.2
Magalhaes, D.3
-
10
-
-
0030025660
-
Replicative senescence: An old lives' tale?
-
Campisi J. 1996. Replicative senescence: an old lives' tale? Cell 84:497-500.
-
(1996)
Cell
, vol.84
, pp. 497-500
-
-
Campisi, J.1
-
11
-
-
0035989631
-
Historical claims and current interpretations of replicative aging
-
Wright WE, Shay JW. 2002. Historical claims and current interpretations of replicative aging. Nat Biotechnol 20:682-688.
-
(2002)
Nat Biotechnol
, vol.20
, pp. 682-688
-
-
Wright, W.E.1
Shay, J.W.2
-
12
-
-
4644250302
-
From cells to ageing: A review of models and mechanisms of cellular senescence and their impact on human ageing
-
de Magalhaes JP. 2004. From cells to ageing: a review of models and mechanisms of cellular senescence and their impact on human ageing. Exp Cell Res 300:1-10.
-
(2004)
Exp Cell Res
, vol.300
, pp. 1-10
-
-
de Magalhaes, J.P.1
-
13
-
-
24344438713
-
The thorny path linking cellular senescence to organismal aging
-
Patil CK, Mian IS, Campisi J. 2005. The thorny path linking cellular senescence to organismal aging. Mech Ageing Dev 126:1040-1045.
-
(2005)
Mech Ageing Dev
, vol.126
, pp. 1040-1045
-
-
Patil, C.K.1
Mian, I.S.2
Campisi, J.3
-
14
-
-
0032168373
-
Relationship between donor age and the replicative lifespan of human cells in culture: A reevaluation
-
Cristofalo VJ, Allen RG, Pignolo RJ, Martin BG, Beck JC. 1998. Relationship between donor age and the replicative lifespan of human cells in culture: a reevaluation. Proc Natl Acad Sci USA 95:10614-10619.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 10614-10619
-
-
Cristofalo, V.J.1
Allen, R.G.2
Pignolo, R.J.3
Martin, B.G.4
Beck, J.C.5
-
15
-
-
8444237425
-
Replicative senescence: A critical review
-
Cristofalo VJ, Lorenzini A, Allen RG, Torres C, Tresini M. 2004. Replicative senescence: a critical review. Mech Ageing Dev 125:827-848.
-
(2004)
Mech Ageing Dev
, vol.125
, pp. 827-848
-
-
Cristofalo, V.J.1
Lorenzini, A.2
Allen, R.G.3
Torres, C.4
Tresini, M.5
-
17
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, et al. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
Venkatachalam, S.2
Choi, J.3
Jones, S.4
Ghebranious, N.5
-
18
-
-
0037421896
-
Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing
-
Wong KK, Maser RS, Bachoo RM, Menon J, Carrasco DR, et al. 2003. Telomere dysfunction and Atm deficiency compromises organ homeostasis and accelerates ageing. Nature 421:643-648.
-
(2003)
Nature
, vol.421
, pp. 643-648
-
-
Wong, K.K.1
Maser, R.S.2
Bachoo, R.M.3
Menon, J.4
Carrasco, D.R.5
-
19
-
-
3543043128
-
Essential role of limiting telomeres in the pathogenesis of Werner syndrome
-
Chang S, Multani AS, Cabrera NG, Naylor ML, Laud P, et al. 2004. Essential role of limiting telomeres in the pathogenesis of Werner syndrome. Nat Genet 36:877-882.
-
(2004)
Nat Genet
, vol.36
, pp. 877-882
-
-
Chang, S.1
Multani, A.S.2
Cabrera, N.G.3
Naylor, M.L.4
Laud, P.5
-
20
-
-
0030931491
-
Telomere shortening and tumor formation by mouse cells lacking telomerase RNA
-
Blasco MA, Lee HW, Hande MP, Samper E, Lansdorp PM, et al. 1997. Telomere shortening and tumor formation by mouse cells lacking telomerase RNA. Cell 91:25-34.
-
(1997)
Cell
, vol.91
, pp. 25-34
-
-
Blasco, M.A.1
Lee, H.W.2
Hande, M.P.3
Samper, E.4
Lansdorp, P.M.5
-
21
-
-
33845892109
-
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation
-
Choudhury AR, Ju Z, Djojosubroto MW, Schienke A, Lechel A, et al. 2007. Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet 39:99-105.
-
(2007)
Nat Genet
, vol.39
, pp. 99-105
-
-
Choudhury, A.R.1
Ju, Z.2
Djojosubroto, M.W.3
Schienke, A.4
Lechel, A.5
-
22
-
-
0037439071
-
Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform
-
Cao L, Li W, Kim S, Brodie SG, Deng CX. 2003. Senescence, aging, and malignant transformation mediated by p53 in mice lacking the Brca1 full-length isoform. Genes Dev 17:201-213.
-
(2003)
Genes Dev
, vol.17
, pp. 201-213
-
-
Cao, L.1
Li, W.2
Kim, S.3
Brodie, S.G.4
Deng, C.X.5
-
23
-
-
33646757879
-
ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency
-
Cao L, Kim S, Xiao C, Wang RH, Coumoul X, et al. 2006. ATM-Chk2-p53 activation prevents tumorigenesis at an expense of organ homeostasis upon Brca1 deficiency. Embo J 25:2167-2177.
-
(2006)
Embo J
, vol.25
, pp. 2167-2177
-
-
Cao, L.1
Kim, S.2
Xiao, C.3
Wang, R.H.4
Coumoul, X.5
-
24
-
-
2442564700
-
Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
-
Sun LQ, Lee DW, Zhang Q, Xiao W, Raabe EH, et al. 2004. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev 18:1035-1046.
-
(2004)
Genes Dev
, vol.18
, pp. 1035-1046
-
-
Sun, L.Q.1
Lee, D.W.2
Zhang, Q.3
Xiao, W.4
Raabe, E.H.5
-
25
-
-
3042761646
-
BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice
-
Baker DJ, Jeganathan KB, Cameron JD, Thompson M, Juneja S, et al. 2004. BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice. Nat Genet 36:744-749.
-
(2004)
Nat Genet
, vol.36
, pp. 744-749
-
-
Baker, D.J.1
Jeganathan, K.B.2
Cameron, J.D.3
Thompson, M.4
Juneja, S.5
-
26
-
-
32644435114
-
Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice
-
Baker DJ, Jeganathan KB, Malureanu L, Perez-Terzic C, Terzic A, et al. 2006. Early aging-associated phenotypes in Bub3/Rae1 haploinsufficient mice. J. Cell Biol 172:529-540.
-
(2006)
J. Cell Biol
, vol.172
, pp. 529-540
-
-
Baker, D.J.1
Jeganathan, K.B.2
Malureanu, L.3
Perez-Terzic, C.4
Terzic, A.5
-
27
-
-
0029088143
-
The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH
-
Henning KA, Li L, Iyer N, McDaniel LD, Reagan MS, et al. 1995. The Cockayne syndrome group A gene encodes a WD repeat protein that interacts with CSB protein and a subunit of RNA polymerase II TFIIH. Cell 82:555-564.
-
(1995)
Cell
, vol.82
, pp. 555-564
-
-
Henning, K.A.1
Li, L.2
Iyer, N.3
McDaniel, L.D.4
Reagan, M.S.5
-
28
-
-
35648954068
-
From old organisms to new molecules: Integrative biology and therapeutic targets in accelerated human ageing
-
Cox LS, Faragher RG. 2007. From old organisms to new molecules: integrative biology and therapeutic targets in accelerated human ageing. Cell Mol Life Sci 64:2620-2641.
-
(2007)
Cell Mol Life Sci
, vol.64
, pp. 2620-2641
-
-
Cox, L.S.1
Faragher, R.G.2
-
29
-
-
0020531224
-
Genetic effects on the longevity of cultured human fibroblasts. II. DNA repair deficient syndromes
-
Thompson KV, Holliday R. 1983. Genetic effects on the longevity of cultured human fibroblasts. II. DNA repair deficient syndromes. Gerontology 29:83-88.
-
(1983)
Gerontology
, vol.29
, pp. 83-88
-
-
Thompson, K.V.1
Holliday, R.2
-
30
-
-
0027144126
-
The gene responsible for Werner syndrome may be a cell division "counting" gene
-
Faragher RG, Kill IR, Hunter JA, Pope FM, Tannock C, et al. 1993. The gene responsible for Werner syndrome may be a cell division "counting" gene. Proc Natl Acad Sci USA 90:12030-12034.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 12030-12034
-
-
Faragher, R.G.1
Kill, I.R.2
Hunter, J.A.3
Pope, F.M.4
Tannock, C.5
-
31
-
-
2342644879
-
Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis
-
Bridger JM, Kill IR. 2004. Aging of Hutchinson-Gilford progeria syndrome fibroblasts is characterised by hyperproliferation and increased apoptosis. Exp Gerontol 39:717-724.
-
(2004)
Exp Gerontol
, vol.39
, pp. 717-724
-
-
Bridger, J.M.1
Kill, I.R.2
-
32
-
-
34047113394
-
Progeria of stem cells: Stem cell exhaustion in Hutchinson-Gilford progeria syndrome
-
Halaschek-Wiener J, Brooks-Wilson A. 2007. Progeria of stem cells: stem cell exhaustion in Hutchinson-Gilford progeria syndrome. J. Gerontol A Biol Sci Med Sci 62:3-8.
-
(2007)
J. Gerontol A Biol Sci Med Sci
, vol.62
, pp. 3-8
-
-
Halaschek-Wiener, J.1
Brooks-Wilson, A.2
-
33
-
-
0141864666
-
Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks
-
Davalos AR, Campisi J. 2003. Bloom syndrome cells undergo p53-dependent apoptosis and delayed assembly of BRCA1 and NBS1 repair complexes at stalled replication forks. J. Cell Biol 162:1197-1209.
-
(2003)
J. Cell Biol
, vol.162
, pp. 1197-1209
-
-
Davalos, A.R.1
Campisi, J.2
-
35
-
-
0034455827
-
Assessment of growth parameters and life span of GHR/BP gene-disrupted mice
-
Coschigano KT, Clemmons D, Bellush LL, Kopchick JJ. 2000. Assessment of growth parameters and life span of GHR/BP gene-disrupted mice. Endocrinology 141:2608-2613.
-
(2000)
Endocrinology
, vol.141
, pp. 2608-2613
-
-
Coschigano, K.T.1
Clemmons, D.2
Bellush, L.L.3
Kopchick, J.J.4
-
36
-
-
0035811073
-
Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production
-
Flurkey K, Papaconstantinou J, Miller RA, Harrison DE. 2001. Lifespan extension and delayed immune and collagen aging in mutant mice with defects in growth hormone production. Proc Natl Acad Sci USA 98:6736-6741.
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6736-6741
-
-
Flurkey, K.1
Papaconstantinou, J.2
Miller, R.A.3
Harrison, D.E.4
-
37
-
-
0037470501
-
The endocrine regulation of aging by insulin-like signals
-
Tatar M, Bartke A, Antebi A. 2003. The endocrine regulation of aging by insulin-like signals. Science 299:1346-1351.
-
(2003)
Science
, vol.299
, pp. 1346-1351
-
-
Tatar, M.1
Bartke, A.2
Antebi, A.3
-
38
-
-
0242490056
-
Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice
-
Bartke A. 2003. Can growth hormone (GH) accelerate aging? Evidence from GH-transgenic mice. Neuroendocrinology 78:210-216.
-
(2003)
Neuroendocrinology
, vol.78
, pp. 210-216
-
-
Bartke, A.1
-
39
-
-
0027178438
-
Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: Lessons from transgenic animal models
-
Wolf E, Kahnt E, Ehrlein J, Hermanns W, Brem G, et al. 1993. Effects of long-term elevated serum levels of growth hormone on life expectancy of mice: lessons from transgenic animal models. Mech Ageing Dev 68:71-87.
-
(1993)
Mech Ageing Dev
, vol.68
, pp. 71-87
-
-
Wolf, E.1
Kahnt, E.2
Ehrlein, J.3
Hermanns, W.4
Brem, G.5
-
40
-
-
54249084483
-
Growth and aging: Why do big dogs die young?
-
Masoro EJ, Austad SN, editors, New York: Academic Press. p
-
Miller RA, Austad SN. 2006. Growth and aging: Why do big dogs die young?. In: Masoro EJ, Austad SN, editors. Handbook of the Biology of Aging. New York: Academic Press. p 512-533.
-
(2006)
Handbook of the Biology of Aging
, pp. 512-533
-
-
Miller, R.A.1
Austad, S.N.2
-
41
-
-
26944501617
-
Evolutionary conservation of the clk-1-dependent mechanism of longevity: Loss of mclk1 increases cellular fitness and lifespan in mice
-
Liu X, Jiang N, Hughes B, Bigras E, Shoubridge E, et al. 2005. Evolutionary conservation of the clk-1-dependent mechanism of longevity: loss of mclk1 increases cellular fitness and lifespan in mice. Genes Dev 19:2424-2434.
-
(2005)
Genes Dev
, vol.19
, pp. 2424-2434
-
-
Liu, X.1
Jiang, N.2
Hughes, B.3
Bigras, E.4
Shoubridge, E.5
-
42
-
-
0033581704
-
The p66shc adaptor protein controls oxidative stress response and life span in mammals
-
Migliaccio E, Giorgio M, Mele S, Pelicci G, Reboldi P, et al. 1999. The p66shc adaptor protein controls oxidative stress response and life span in mammals. Nature 402:309-313.
-
(1999)
Nature
, vol.402
, pp. 309-313
-
-
Migliaccio, E.1
Giorgio, M.2
Mele, S.3
Pelicci, G.4
Reboldi, P.5
-
43
-
-
0036671827
-
Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span
-
Mitsui A, Hamuro J, Nakamura H, Kondo N, Hirabayashi Y, et al. 2002. Overexpression of human thioredoxin in transgenic mice controls oxidative stress and life span. Antioxid Redox Signal 4:693-696.
-
(2002)
Antioxid Redox Signal
, vol.4
, pp. 693-696
-
-
Mitsui, A.1
Hamuro, J.2
Nakamura, H.3
Kondo, N.4
Hirabayashi, Y.5
-
44
-
-
0036798856
-
Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69
-
Haendeler J, Hoffmann J, Tischler V, Berk BC, Zeiher AM, et al. 2002. Redox regulatory and anti-apoptotic functions of thioredoxin depend on S-nitrosylation at cysteine 69. Nat Cell Biol 4:743-749.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 743-749
-
-
Haendeler, J.1
Hoffmann, J.2
Tischler, V.3
Berk, B.C.4
Zeiher, A.M.5
-
45
-
-
34447528668
-
Type 5 adenylyl cyclase disruption increases longevity and protects against stress
-
Yan L, Vatner DE, O'Connor JP, Ivessa A, Ge H, et al. 2007. Type 5 adenylyl cyclase disruption increases longevity and protects against stress. Cell 130:247-258.
-
(2007)
Cell
, vol.130
, pp. 247-258
-
-
Yan, L.1
Vatner, D.E.2
O'Connor, J.P.3
Ivessa, A.4
Ge, H.5
-
47
-
-
0025250262
-
Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse
-
Lok E, Scott FW, Mongeau R, Nera EA, Malcolm S, et al. 1990. Calorie restriction and cellular proliferation in various tissues of the female Swiss Webster mouse. Cancer Lett 51:67-73.
-
(1990)
Cancer Lett
, vol.51
, pp. 67-73
-
-
Lok, E.1
Scott, F.W.2
Mongeau, R.3
Nera, E.A.4
Malcolm, S.5
-
48
-
-
0031037294
-
Long-term caloric restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo
-
Li Y, Yan Q, Wolf NS. 1997. Long-term caloric restriction delays age-related decline in proliferation capacity of murine lens epithelial cells in vitro and in vivo. Invest Ophthalmol Vis Sci 38:100-107.
-
(1997)
Invest Ophthalmol Vis Sci
, vol.38
, pp. 100-107
-
-
Li, Y.1
Yan, Q.2
Wolf, N.S.3
-
49
-
-
0037362863
-
Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain
-
Shelke RR, Leeuwenburgh C. 2003. Lifelong caloric restriction increases expression of apoptosis repressor with a caspase recruitment domain (ARC) in the brain. Faseb J 17:494-496.
-
(2003)
Faseb J
, vol.17
, pp. 494-496
-
-
Shelke, R.R.1
Leeuwenburgh, C.2
-
50
-
-
0031967803
-
Upregulation of apoptosis with dietary restriction: Implications for carcinogenesis and aging
-
James SJ, Muskhelishvili L, Gaylor DW, Turturro A, Hart R. 1998. Upregulation of apoptosis with dietary restriction: implications for carcinogenesis and aging. Environ Health Perspect 106 (Suppl 1):307-312.
-
(1998)
Environ Health Perspect
, vol.106
, Issue.SUPPL. 1
, pp. 307-312
-
-
James, S.J.1
Muskhelishvili, L.2
Gaylor, D.W.3
Turturro, A.4
Hart, R.5
-
51
-
-
0033937640
-
Effects of reduced energy intake on the biology of aging: The primate model
-
Roth GS, Ingram DK, Black A, Lane MA. 2000. Effects of reduced energy intake on the biology of aging: the primate model. Eur J Clin Nutr 54 (Suppl 3):S15-S20.
-
(2000)
Eur J Clin Nutr
, vol.54
, Issue.SUPPL. 3
-
-
Roth, G.S.1
Ingram, D.K.2
Black, A.3
Lane, M.A.4
-
52
-
-
0036358167
-
Growth negatively impacts the life span of mammals
-
Rollo CD. 2002. Growth negatively impacts the life span of mammals. Evol Dev 4:55-61.
-
(2002)
Evol Dev
, vol.4
, pp. 55-61
-
-
Rollo, C.D.1
-
53
-
-
0037387682
-
Genotype and age influence the effect of caloric intake on mortality in mice
-
Forster MJ, Morris P, Sohal RS. 2003. Genotype and age influence the effect of caloric intake on mortality in mice. Faseb J 17:690-692.
-
(2003)
Faseb J
, vol.17
, pp. 690-692
-
-
Forster, M.J.1
Morris, P.2
Sohal, R.S.3
-
54
-
-
33751246228
-
Does caloric restriction extend life in wild mice?
-
Harper JM, Leathers CW, Austad SN. 2006. Does caloric restriction extend life in wild mice? Aging Cell 5:441-449.
-
(2006)
Aging Cell
, vol.5
, pp. 441-449
-
-
Harper, J.M.1
Leathers, C.W.2
Austad, S.N.3
-
55
-
-
0242580765
-
Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span
-
Mobbs CV, Bray GA, Atkinson RL, Bartke A, Finch CE, et al. 2001. Neuroendocrine and pharmacological manipulations to assess how caloric restriction increases life span. J. Gerontol A Biol Sci Med Sci 56 Spec No 1:34-44.
-
(2001)
J. Gerontol A Biol Sci Med Sci
, vol.56
, Issue.SPEC 1
, pp. 34-44
-
-
Mobbs, C.V.1
Bray, G.A.2
Atkinson, R.L.3
Bartke, A.4
Finch, C.E.5
-
56
-
-
33646731782
-
Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction
-
Bonkowski MS, Rocha JS, Masternak MM, Al Regaiey KA, Bartke A. 2006. Targeted disruption of growth hormone receptor interferes with the beneficial actions of calorie restriction. Proc Natl Acad Sci USA 103:7901-7905.
-
(2006)
Proc Natl Acad Sci USA
, vol.103
, pp. 7901-7905
-
-
Bonkowski, M.S.1
Rocha, J.S.2
Masternak, M.M.3
Al Regaiey, K.A.4
Bartke, A.5
-
57
-
-
0033450849
-
Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: Inferences from moderate caloric-restricted animals
-
Sonntag WE, Lynch CD, Cefalu WT, Ingram RL, Bennett SA, et al. 1999. Pleiotropic effects of growth hormone and insulin-like growth factor (IGF)-1 on biological aging: inferences from moderate caloric-restricted animals. J. Gerontol A Biol Sci Med Sci 54:B521-B538.
-
(1999)
J. Gerontol A Biol Sci Med Sci
, vol.54
-
-
Sonntag, W.E.1
Lynch, C.D.2
Cefalu, W.T.3
Ingram, R.L.4
Bennett, S.A.5
-
58
-
-
4444260309
-
Living and dying for sex. A. theory of aging based on the modulation of cell cycle signaling by reproductive hormones
-
Bowen RL, Atwood CS. 2004. Living and dying for sex. A. theory of aging based on the modulation of cell cycle signaling by reproductive hormones. Gerontology 50:265-290.
-
(2004)
Gerontology
, vol.50
, pp. 265-290
-
-
Bowen, R.L.1
Atwood, C.S.2
-
59
-
-
33750897379
-
Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice
-
Harper JM, Durkee SJ, Dysko RC, Austad SN, Miller RA. 2006. Genetic modulation of hormone levels and life span in hybrids between laboratory and wild-derived mice. J. Gerontol A Biol Sci Med Sci 61:1019-1029.
-
(2006)
J. Gerontol A Biol Sci Med Sci
, vol.61
, pp. 1019-1029
-
-
Harper, J.M.1
Durkee, S.J.2
Dysko, R.C.3
Austad, S.N.4
Miller, R.A.5
-
62
-
-
22144477243
-
Reduced insulin/IGF-1 signalling and human longevity
-
van Heemst D, Beekman M, Mooijaart SP, Heijmans BT, Brandt BW, et al. 2005. Reduced insulin/IGF-1 signalling and human longevity. Aging Cell 4:79-85.
-
(2005)
Aging Cell
, vol.4
, pp. 79-85
-
-
van Heemst, D.1
Beekman, M.2
Mooijaart, S.P.3
Heijmans, B.T.4
Brandt, B.W.5
-
63
-
-
0037318459
-
The association between body height and coronary heart disease among Finnish twins and singletons
-
Silventoinen K, Kaprio J, Koskenvuo M, Lahelma E. 2003. The association between body height and coronary heart disease among Finnish twins and singletons. Int J Epidemiol 32:78-82.
-
(2003)
Int J Epidemiol
, vol.32
, pp. 78-82
-
-
Silventoinen, K.1
Kaprio, J.2
Koskenvuo, M.3
Lahelma, E.4
-
64
-
-
0032573157
-
A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity
-
Lebel M, Leder P. 1998. A deletion within the murine Werner syndrome helicase induces sensitivity to inhibitors of topoisomerase and loss of cellular proliferative capacity. Proc Natl Acad Sci USA 95:13097-13102.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 13097-13102
-
-
Lebel, M.1
Leder, P.2
-
65
-
-
33645980992
-
Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice
-
Dolle ME, Busuttil RA, Garcia AM, Wijnhoven S, van Drunen E, et al. 2006. Increased genomic instability is not a prerequisite for shortened lifespan in DNA repair deficient mice. Mutat Res 596:22-35.
-
(2006)
Mutat Res
, vol.596
, pp. 22-35
-
-
Dolle, M.E.1
Busuttil, R.A.2
Garcia, A.M.3
Wijnhoven, S.4
van Drunen, E.5
-
67
-
-
34249885603
-
Deletion of the developmentally essential gene ATR in adult mice leads to premature aging phenotypes and stem cell loss
-
Ruzankina Y, Pinzon-Guzman C, Asare A, Ong T, Pontano L, et al. 2007. Deletion of the developmentally essential gene ATR in adult mice leads to premature aging phenotypes and stem cell loss. Cell Stem Cell 1:113-126.
-
(2007)
Cell Stem Cell
, vol.1
, pp. 113-126
-
-
Ruzankina, Y.1
Pinzon-Guzman, C.2
Asare, A.3
Ong, T.4
Pontano, L.5
-
68
-
-
0032493910
-
Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9
-
Kuida K, Haydar TF, Kuan CY, Gu Y, Taya C, et al. 1998. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 94:325-337.
-
(1998)
Cell
, vol.94
, pp. 325-337
-
-
Kuida, K.1
Haydar, T.F.2
Kuan, C.Y.3
Gu, Y.4
Taya, C.5
-
69
-
-
0034106125
-
Analysis of ku80-mutant mice and cells with deficient levels of p53
-
Lim DS, Vogel H, Willerford DM, Sands AT, Platt KA, et al. 2000. Analysis of ku80-mutant mice and cells with deficient levels of p53. Mol Cell Biol 20:3772-3780.
-
(2000)
Mol Cell Biol
, vol.20
, pp. 3772-3780
-
-
Lim, D.S.1
Vogel, H.2
Willerford, D.M.3
Sands, A.T.4
Platt, K.A.5
-
70
-
-
35148859307
-
Cancer resistance in transgenic mice expressing the SAC module of Par-4
-
Zhao Y, Burikhanov R, Qiu S, Lele SM, Jennings CD, et al. 2007. Cancer resistance in transgenic mice expressing the SAC module of Par-4. Cancer Res 67:9276-9285.
-
(2007)
Cancer Res
, vol.67
, pp. 9276-9285
-
-
Zhao, Y.1
Burikhanov, R.2
Qiu, S.3
Lele, S.M.4
Jennings, C.D.5
-
71
-
-
0033377627
-
The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: A review
-
Wolf NS, Pendergrass WR. 1999. The relationships of animal age and caloric intake to cellular replication in vivo and in vitro: a review. J. Gerontol A Biol Sci Med Sci 54:B502-B517.
-
(1999)
J. Gerontol A Biol Sci Med Sci
, vol.54
-
-
Wolf, N.S.1
Pendergrass, W.R.2
-
72
-
-
0041592698
-
Aging, progenitor cell exhaustion, and atherosclerosis
-
Rauscher FM, Goldschmidt-Clermont PJ, Davis BH, Wang T, Gregg D, et al. 2003. Aging, progenitor cell exhaustion, and atherosclerosis. Circulation 108:457-463.
-
(2003)
Circulation
, vol.108
, pp. 457-463
-
-
Rauscher, F.M.1
Goldschmidt-Clermont, P.J.2
Davis, B.H.3
Wang, T.4
Gregg, D.5
-
73
-
-
13944283022
-
Longevity and lineages: Toward the integrative biology of degenerative diseases in heart, muscle, and bone
-
Chien KR, Karsenty G. 2005. Longevity and lineages: toward the integrative biology of degenerative diseases in heart, muscle, and bone. Cell 120:533-544.
-
(2005)
Cell
, vol.120
, pp. 533-544
-
-
Chien, K.R.1
Karsenty, G.2
-
74
-
-
0032990977
-
Early growth determines longevity in male rats and may be related to telomere shortening in the kidney
-
Jennings BJ, Ozanne SE, Dorling MW, Hales CN. 1999. Early growth determines longevity in male rats and may be related to telomere shortening in the kidney. FEBS Lett 448:4-8.
-
(1999)
FEBS Lett
, vol.448
, pp. 4-8
-
-
Jennings, B.J.1
Ozanne, S.E.2
Dorling, M.W.3
Hales, C.N.4
-
77
-
-
29344467120
-
A developmental timing microRNA and its target regulate life span in C. elegans
-
Boehm M, Slack F. 2005. A developmental timing microRNA and its target regulate life span in C. elegans. Science 310:1954-1957.
-
(2005)
Science
, vol.310
, pp. 1954-1957
-
-
Boehm, M.1
Slack, F.2
-
78
-
-
29144521716
-
Counting human somatic cell replications: Methylation mirrors endometrial stem cell divisions
-
Kim JY, Tavare S, Shibata D. 2005. Counting human somatic cell replications: methylation mirrors endometrial stem cell divisions. Proc Natl Acad Sci USA 102:17739-17744.
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 17739-17744
-
-
Kim, J.Y.1
Tavare, S.2
Shibata, D.3
-
79
-
-
3042648746
-
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
-
Kapahi P, Zid BM, Harper T, Koslover D, Sapin V, et al. 2004. Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway. Curr Biol 14:885-890.
-
(2004)
Curr Biol
, vol.14
, pp. 885-890
-
-
Kapahi, P.1
Zid, B.M.2
Harper, T.3
Koslover, D.4
Sapin, V.5
-
80
-
-
33846119369
-
The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer
-
Martin GM. 2007. The genetics and epigenetics of altered proliferative homeostasis in ageing and cancer. Mech Ageing Dev 128:9-12.
-
(2007)
Mech Ageing Dev
, vol.128
, pp. 9-12
-
-
Martin, G.M.1
-
81
-
-
33749167092
-
Ageing: Balancing regeneration and cancer
-
Beausejour CM, Campisi J. 2006. Ageing: balancing regeneration and cancer. Nature 443:404-405.
-
(2006)
Nature
, vol.443
, pp. 404-405
-
-
Beausejour, C.M.1
Campisi, J.2
-
82
-
-
34548153747
-
How stem cells age and why this makes us grow old
-
Sharpless NE, Depinho RA. 2007. How stem cells age and why this makes us grow old. Nat Rev Mol Cell Biol 8:703-713.
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 703-713
-
-
Sharpless, N.E.1
Depinho, R.A.2
-
83
-
-
34250007142
-
Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age
-
Rossi DJ, Bryder D, Seita J, Nussenzweig A, Hoeijmakers J, et al. 2007. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447:725-729.
-
(2007)
Nature
, vol.447
, pp. 725-729
-
-
Rossi, D.J.1
Bryder, D.2
Seita, J.3
Nussenzweig, A.4
Hoeijmakers, J.5
-
84
-
-
0344827208
-
Notch-mediated restoration of regenerative potential to aged muscle
-
Conboy IM, Conboy MJ, Smythe GM, Rando TA. 2003. Notch-mediated restoration of regenerative potential to aged muscle. Science 302:1575-1577.
-
(2003)
Science
, vol.302
, pp. 1575-1577
-
-
Conboy, I.M.1
Conboy, M.J.2
Smythe, G.M.3
Rando, T.A.4
-
85
-
-
43049162965
-
Age-related intrinsic changes in human bone marrow-derived mesenchymal stem cells and their differentiation to osteoblasts
-
in press
-
Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, et al. in press. Age-related intrinsic changes in human bone marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell.
-
Aging Cell
-
-
Zhou, S.1
Greenberger, J.S.2
Epperly, M.W.3
Goff, J.P.4
Adler, C.5
-
86
-
-
0041666387
-
The role of stem cells in aging
-
Van Zant G, Liang Y. 2003. The role of stem cells in aging. Exp Hematol 31:659-672.
-
(2003)
Exp Hematol
, vol.31
, pp. 659-672
-
-
Van Zant, G.1
Liang, Y.2
-
87
-
-
0033039097
-
Revisiting the role of fat mass in the life extension induced by caloric restriction
-
discussion B97-88
-
Barzilai N, Gupta G. 1999. Revisiting the role of fat mass in the life extension induced by caloric restriction. J. Gerontol A Biol Sci Med Sci 54:B89-B96: discussion B97-88.
-
(1999)
J. Gerontol A Biol Sci Med Sci
, vol.54
-
-
Barzilai, N.1
Gupta, G.2
-
88
-
-
13944260728
-
Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
-
Parrinello S, Coppe JP, Krtolica A, Campisi J. 2005. Stromal-epithelial interactions in aging and cancer: senescent fibroblasts alter epithelial cell differentiation. J. Cell Sci 118:485-496.
-
(2005)
J. Cell Sci
, vol.118
, pp. 485-496
-
-
Parrinello, S.1
Coppe, J.P.2
Krtolica, A.3
Campisi, J.4
-
89
-
-
0035916357
-
An evolutionary conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control
-
Brogiolo W, Stocker H, Ikeya T, Rintelen F, Fernandez R, et al. 2001. An evolutionary conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control. Curr Biol 11:213-221.
-
(2001)
Curr Biol
, vol.11
, pp. 213-221
-
-
Brogiolo, W.1
Stocker, H.2
Ikeya, T.3
Rintelen, F.4
Fernandez, R.5
-
90
-
-
18344391645
-
Cell-cycle control in Caenorhabditis elegans: How the worm moves from G1 to S
-
Koreth J, van den Heuvel S. 2005. Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S. Oncogene 24:2756-2764.
-
(2005)
Oncogene
, vol.24
, pp. 2756-2764
-
-
Koreth, J.1
van den Heuvel, S.2
-
91
-
-
84900969225
-
Ink4a/Arf expression is a biomarker of aging
-
Krishnamurthy J, Torrice C, Ramsey MR, Kovalev GI, Al-Regaiey K, et al. 2004. Ink4a/Arf expression is a biomarker of aging. J. Clin Invest 114: 1299-1307.
-
(2004)
J. Clin Invest
, vol.114
, pp. 1299-1307
-
-
Krishnamurthy, J.1
Torrice, C.2
Ramsey, M.R.3
Kovalev, G.I.4
Al-Regaiey, K.5
-
92
-
-
33644692330
-
Cellular senescence in aging primates
-
Herbig U, Ferreira M, Condel L, Carey D, Sedivy JM. 2006. Cellular senescence in aging primates. Science 311:1257.
-
(2006)
Science
, vol.311
, pp. 1257
-
-
Herbig, U.1
Ferreira, M.2
Condel, L.3
Carey, D.4
Sedivy, J.M.5
-
93
-
-
0029094755
-
Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C
-
Zhou X, Benson KF, Ashar HR, Chada K. 1995. Mutation responsible for the mouse pygmy phenotype in the developmentally regulated factor HMGI-C. Nature 376:771-774.
-
(1995)
Nature
, vol.376
, pp. 771-774
-
-
Zhou, X.1
Benson, K.F.2
Ashar, H.R.3
Chada, K.4
-
94
-
-
0035680580
-
Maximum life spans in mice are extended by wild strain alleles
-
Klebanov S, Astle CM, Roderick TH, Flurkey K, Archer JR, et al. 2001. Maximum life spans in mice are extended by wild strain alleles. Exp Biol Med (Maywood) 226:854-859.
-
(2001)
Exp Biol Med (Maywood)
, vol.226
, pp. 854-859
-
-
Klebanov, S.1
Astle, C.M.2
Roderick, T.H.3
Flurkey, K.4
Archer, J.R.5
-
95
-
-
34748830310
-
A common variant of HMGA2 is associated with adult and childhood height in the general population
-
Weedon MN, Lettre G, Freathy RM, Lindgren CM, Voight BF, et al. 2007. A common variant of HMGA2 is associated with adult and childhood height in the general population. Nat Genet 39:1245-1250.
-
(2007)
Nat Genet
, vol.39
, pp. 1245-1250
-
-
Weedon, M.N.1
Lettre, G.2
Freathy, R.M.3
Lindgren, C.M.4
Voight, B.F.5
-
96
-
-
15844415946
-
Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1)
-
Kiyokawa H, Kineman RD, Manova-Todorova KO, Soares VC, Hoffman ES, et al. 1996. Enhanced growth of mice lacking the cyclin-dependent kinase inhibitor function of p27(Kip1). Cell 85:721-732.
-
(1996)
Cell
, vol.85
, pp. 721-732
-
-
Kiyokawa, H.1
Kineman, R.D.2
Manova-Todorova, K.O.3
Soares, V.C.4
Hoffman, E.S.5
-
97
-
-
13944261231
-
Rejuvenation of aged progenitor cells by exposure to a young systemic environment
-
Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, et al. 2005. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433:760-764.
-
(2005)
Nature
, vol.433
, pp. 760-764
-
-
Conboy, I.M.1
Conboy, M.J.2
Wagers, A.J.3
Girma, E.R.4
Weissman, I.L.5
-
98
-
-
33846604728
-
Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes
-
Wang L, Yang L, Debidda M, Witte D, Zheng Y. 2007. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc Natl Acad Sci USA 104:1248-1253.
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 1248-1253
-
-
Wang, L.1
Yang, L.2
Debidda, M.3
Witte, D.4
Zheng, Y.5
-
99
-
-
33845914051
-
A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis
-
Niedernhofer LJ, Garinis GA, Raams A, Lalai AS, Robinson AR, et al. 2006. A new progeroid syndrome reveals that genotoxic stress suppresses the somatotroph axis. Nature 444:1038-1043.
-
(2006)
Nature
, vol.444
, pp. 1038-1043
-
-
Niedernhofer, L.J.1
Garinis, G.A.2
Raams, A.3
Lalai, A.S.4
Robinson, A.R.5
-
100
-
-
2642580016
-
Premature ageing in mice expressing defective mitochondrial DNA polymerase
-
Trifunovic A, Wredenberg A, Falkenberg M, Spelbrink JN, Rovio AT, et al. 2004. Premature ageing in mice expressing defective mitochondrial DNA polymerase. Nature 429:417-423.
-
(2004)
Nature
, vol.429
, pp. 417-423
-
-
Trifunovic, A.1
Wredenberg, A.2
Falkenberg, M.3
Spelbrink, J.N.4
Rovio, A.T.5
-
101
-
-
31044445366
-
Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cel
-
Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, et al. 2006. Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cel. 124:315-329.
-
(2006)
, vol.124
, pp. 315-329
-
-
Mostoslavsky, R.1
Chua, K.F.2
Lombard, D.B.3
Pang, W.W.4
Fischer, M.R.5
-
102
-
-
0037123638
-
Premature aging in mice deficient in DNA repair and transcription
-
de Boer J, Andressoo JO, de Wit J, Huijmans J, Beems RB, et al. 2002. Premature aging in mice deficient in DNA repair and transcription. Science 296:1276-1279.
-
(2002)
Science
, vol.296
, pp. 1276-1279
-
-
de Boer, J.1
Andressoo, J.O.2
de Wit, J.3
Huijmans, J.4
Beems, R.B.5
-
103
-
-
15844409553
-
Positional cloning of the Werner's syndrome gene
-
Yu CE, Oshima J, Fu YH, Wijsman EM, Hisama F, et al. 1996. Positional cloning of the Werner's syndrome gene. Science 272:258-262.
-
(1996)
Science
, vol.272
, pp. 258-262
-
-
Yu, C.E.1
Oshima, J.2
Fu, Y.H.3
Wijsman, E.M.4
Hisama, F.5
-
104
-
-
0037673950
-
Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome
-
Eriksson M, Brown WT, Gordon LB, Glynn MW, Singer J, et al. 2003. Recurrent de novo point mutations in lamin A cause Hutchinson-Gilford progeria syndrome. Nature 423:293-298.
-
(2003)
Nature
, vol.423
, pp. 293-298
-
-
Eriksson, M.1
Brown, W.T.2
Gordon, L.B.3
Glynn, M.W.4
Singer, J.5
|