Specific telomere dysfunction induced by GRN163L increases radiation sensitivity in breast cancer cells

International Journal of Radiation Oncology Biology Physics

Volumn 67, Issue 3, 2007, Pages 897-905

  Gomez Millan, Jaime ^a   Goldblatt, Erin M ^a   Gryaznov, Sergei M ^c   Mendonca, Marc S ^a,b   Herbert, Brittney Shea ^a,b  

^a INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c GERON CORPORATION   (United States)

Author keywords

Breast cancer; Irradiation; Telomerase inhibitors; Thio phosphoramidates

Indexed keywords

BREAST CANCER; CLONOGENIC ASSAYS; RADIATION SENSITIVITY; TELOMERASE INHIBITORS; THIO-PHOSPHORAMIDATES;

CELLS; DNA; ENZYME KINETICS; IRRADIATION; TUMORS;

RADIOTHERAPY;

GRN163L ENZYME; TELOMERASE; TELOMERASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BREAST CANCER; CANCER ADJUVANT THERAPY; CANCER CELL; CANCER CENTER; CELL SURVIVAL; CELL THERAPY; CLONOGENIC ASSAY; DRUG EXPOSURE; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HYPOTHESIS; IN VIVO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RADIOSENSITIVITY; STATISTICAL SIGNIFICANCE; TELOMERE; TUMOR GROWTH; XENOGRAFT;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; MICE; MICE, NUDE; OLIGOPEPTIDES; RADIATION TOLERANCE; TELOMERASE; TELOMERE; TUMOR CELLS, CULTURED;

EID: 33846799020     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2006.09.038     Document Type: Article

References (32)

1. Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
2. Cong Y., Wright W., and Shay J. Human telomerase and its regulation. Microbiol Mol Biol Rev 66 (2002) 407-425 table of contents
3. Feng J., Funk W.D., Wang S.S., et al. The RNA component of human telomerase. Science 269 (1995) 1236-1241
4. Harrington L., Zhou W., McPhail T., et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev 11 (1997) 3109-3115
5. Shay J.W., and Bacchetti S. A survey of telomerase activity in human cancer. Eur J Cancer 33 (1997) 787-791
6. Kelland L.R. Overcoming the immortality of tumour cells by telomere and telomerase based cancer therapeutics-Current status and future prospects. Eur J Cancer 41 (2005) 971-979
7. Dikmen Z.G., Gellert G.C., Jackson S., et al. In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor. Cancer Res 65 (2005) 7866-7873
8. Herbert B.S., Gellert G.C., Hochreiter A., et al. Lipid modification of GRN163, an N3′->P5′ thio-phosphoramidate oligonucleotide, enhances the potency of telomerase inhibition. Oncogene 24 (2005) 5262-5268
9. Djojosubroto M.W., Chin A.C., Go N., et al. Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology 42 (2005) 1127-1136
10. Gellert G.C., Dikmen Z.G., Wright W.E., et al. Effects of a novel telomerase inhibitor, GRN163L, in human breast cancer. Breast Cancer Res Treat 96 (2006) 73-81
11. Hochreiter A.E., Xiao H., Goldblatt E.M., et al. Telomerase template antagonist GRN163L disrupts telomere maintenance, tumor growth, and metastasis of breast cancer. Clin Cancer Res 12 (2006) 3184-3192
12. Bernier J., Hall E.J., and Giaccia A. Radiation oncology: A century of achievements. Nat Rev Cancer 4 (2004) 737-747
13. Sharma G.G., Gupta A., Wang H., et al. hTERT associates with human telomeres and enhances genomic stability and DNA repair. Oncogene 22 (2003) 131-146
14. Mendonca M.S., Desmond L.A., Temples T.M., et al. Loss of chromosome 14 increases the radiosensitivity of CGL1 human hybrid cells but lowers their susceptibility to radiation-induced neoplastic transformation. Mutagenesis 15 (2000) 187-193
15. Mendonca M.S., Antoniono R., Latham K., et al. Characterization of intestinal alkaline phosphatase expression and the tumorigenic potential of gamma-irradiated HeLa x fibroblast cell hybrids. Cancer Res 51 (1991) 4455-4462
16. Wright W.E., Shay J.W., and Piatyszek M.A. Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res 23 (1995) 3794-3795
17. Ouellette M.M., Liao M., Herbert B.S., et al. Subsenescent telomere lengths in fibroblasts immortalized by limiting amounts of telomerase. J Biol Chem 275 (2000) 10072-10076
18. Asai A., Oshima Y., Yamamoto Y., et al. A novel telomerase template antagonist (GRN163) as a potential anticancer agent. Cancer Res 63 (2003) 3931-3939
19. Malaise E.P., Fertil B., Chavaudra N., et al. Distribution of radiation sensitivities for human tumor cells of specific histological types: Comparison of in vitro to in vivo data. Int J Radiat Oncol Biol Phys 12 (1986) 617-624
20. Jones K.R., Gewirtz D.A., Yannone S.M., et al. Radiosensitization of MDA-MB-231 breast tumor cells by adenovirus-mediated overexpression of a fragment of the XRCC4 protein. Mol Cancer Ther 4 (2005) 1541-1547
21. Elkind M.M., and Sutton H. Radiation response of mammalian cells grown in culture. 1. Repair of X-ray damage in surviving Chinese hamster cells. Radiat Res 13 (1960) 556-593
22. Hahn W.C., Stewart S.A., Brooks M.W., et al. Inhibition of telomerase limits the growth of human cancer cells. Nat Med 5 (1999) 1164-1170
23. Zhang X., Mar V., Zhou W., et al. Telomere shortening and apoptosis in telomerase-inhibited human tumor cells. Genes Dev 13 (1999) 2388-2399
24. Herbert B., Pitts A.E., Baker S.I., et al. Inhibition of human telomerase in immortal human cells leads to progressive telomere shortening and cell death. Proc Natl Acad Sci U S A 96 (1999) 14276-14281
25. Hemann M.T., Strong M.A., Hao L.Y., et al. The shortest telomere, not average telomere length, is critical for cell viability and chromosome stability. Cell 107 (2001) 67-77
26. Shin K.H., Kang M.K., Dicterow E., et al. Introduction of human telomerase reverse transcriptase to normal human fibroblasts enhances DNA repair capacity. Clin Cancer Res 10 (2004) 2551-2560
27. Masutomi K., Possemato R., Wong J.M., et al. The telomerase reverse transcriptase regulates chromatin state and DNA damage responses. Proc Natl Acad Sci U S A 102 (2005) 8222-8227
28. Goytisolo F.A., Samper E., Martin-Caballero J., et al. Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals. J Exp Med 192 (2000) 1625-1636
29. Wong K.K., Chang S., Weiler S.R., et al. Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation. Nat Genet 26 (2000) 85-88
30. Nakamura M., Masutomi K., Kyo S., et al. Efficient inhibition of human telomerase reverse transcriptase expression by RNA interference sensitizes cancer cells to ionizing radiation and chemotherapy. Hum Gene Ther 16 (2005) 859-868
31. Overgaard M., Hansen P.S., Overgaard J., et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. Danish Breast Cancer Cooperative Group 82b Trial. N Engl J Med 337 (1997) 949-955
32. Bentzen S.M., and Thames H.D. Clinical evidence for tumor clonogen regeneration: Interpretations of the data. Radiother Oncol 22 (1991) 161-166