메뉴 건너뛰기




Volumn 20, Issue 12, 2009, Pages 917-926

DNA methylation, an epigenetic mechanism connecting folate to healthy embryonic development and aging

Author keywords

Aging; Carcinogenesis; DNA methylation; Embryonic development; Folate

Indexed keywords

DNA METHYLTRANSFERASE; FOLIC ACID; GENOMIC DNA;

EID: 71649103633     PISSN: 09552863     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jnutbio.2009.06.008     Document Type: Review
Times cited : (166)

References (137)
  • 1
    • 0022621648 scopus 로고
    • Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales
    • Barker D.J., and Osmond C. Infant mortality, childhood nutrition, and ischaemic heart disease in England and Wales. Lancet 1 (1986) 1077-1081
    • (1986) Lancet , vol.1 , pp. 1077-1081
    • Barker, D.J.1    Osmond, C.2
  • 2
    • 32944472635 scopus 로고    scopus 로고
    • Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen
    • Kensara O.A., Wootton S.A., Phillips D.I., Patel M., Jackson A.A., and Elia M. Fetal programming of body composition: relation between birth weight and body composition measured with dual-energy X-ray absorptiometry and anthropometric methods in older Englishmen. Am J Clin Nutr 82 (2005) 980-987
    • (2005) Am J Clin Nutr , vol.82 , pp. 980-987
    • Kensara, O.A.1    Wootton, S.A.2    Phillips, D.I.3    Patel, M.4    Jackson, A.A.5    Elia, M.6
  • 3
    • 0027484614 scopus 로고
    • Early growth and death from cardiovascular disease in women
    • Osmond C., Barker D.J., Winter P.D., Fall C.H., and Simmonds S.J. Early growth and death from cardiovascular disease in women. BMJ 307 (1993) 1519-1524
    • (1993) BMJ , vol.307 , pp. 1519-1524
    • Osmond, C.1    Barker, D.J.2    Winter, P.D.3    Fall, C.H.4    Simmonds, S.J.5
  • 4
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
    • Hales C.N., and Barker D.J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia 35 (1992) 595-601
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barker, D.J.2
  • 6
    • 18744399851 scopus 로고    scopus 로고
    • Longitudinal study of birth weight and adult body mass index in predicting risk of coronary heart disease and stroke in women
    • Rich-Edwards J.W., Kleinman K., Michels K.B., et al. Longitudinal study of birth weight and adult body mass index in predicting risk of coronary heart disease and stroke in women. BMJ 330 (2005) 1115
    • (2005) BMJ , vol.330 , pp. 1115
    • Rich-Edwards, J.W.1    Kleinman, K.2    Michels, K.B.3
  • 7
    • 46449087037 scopus 로고    scopus 로고
    • Effect of in utero and early-life conditions on adult health and disease
    • Gluckman P.D., Hanson M.A., Cooper C., and Thornburg K.L. Effect of in utero and early-life conditions on adult health and disease. N Engl J Med 359 (2008) 61-73
    • (2008) N Engl J Med , vol.359 , pp. 61-73
    • Gluckman, P.D.1    Hanson, M.A.2    Cooper, C.3    Thornburg, K.L.4
  • 8
    • 33847317873 scopus 로고    scopus 로고
    • DNA methylation in health, disease, and cancer
    • Shames D.S., Minna J.D., and Gazdar A.F. DNA methylation in health, disease, and cancer. Curr Mol Med 7 (2007) 85-102
    • (2007) Curr Mol Med , vol.7 , pp. 85-102
    • Shames, D.S.1    Minna, J.D.2    Gazdar, A.F.3
  • 10
    • 0347123629 scopus 로고    scopus 로고
    • Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases
    • Waterland R.A., and Jirtle R.L. Early nutrition, epigenetic changes at transposons and imprinted genes, and enhanced susceptibility to adult chronic diseases. Nutrition 20 (2004) 63-68
    • (2004) Nutrition , vol.20 , pp. 63-68
    • Waterland, R.A.1    Jirtle, R.L.2
  • 11
    • 23044514669 scopus 로고    scopus 로고
    • Epigenetic differences arise during the lifetime of monozygotic twins
    • Fraga M.F., Ballestar E., Paz M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc Natl Acad Sci U S A 102 (2005) 10604-10609
    • (2005) Proc Natl Acad Sci U S A , vol.102 , pp. 10604-10609
    • Fraga, M.F.1    Ballestar, E.2    Paz, M.F.3
  • 12
    • 0035839126 scopus 로고    scopus 로고
    • Epigenetic reprogramming in mammalian development
    • Reik W., Dean W., and Walter J. Epigenetic reprogramming in mammalian development. Sciences (New York, NY) 293 (2001) 1089-1093
    • (2001) Sciences (New York, NY) , vol.293 , pp. 1089-1093
    • Reik, W.1    Dean, W.2    Walter, J.3
  • 13
    • 34548757364 scopus 로고    scopus 로고
    • Epigenetic reprogramming and imprinting in origins of disease
    • Tang W.Y., and Ho S.M. Epigenetic reprogramming and imprinting in origins of disease. Rev Endocr Metab Disord 8 (2007) 173-182
    • (2007) Rev Endocr Metab Disord , vol.8 , pp. 173-182
    • Tang, W.Y.1    Ho, S.M.2
  • 15
    • 0036733675 scopus 로고    scopus 로고
    • Chromatin modification and epigenetic reprogramming in mammalian development
    • Li E. Chromatin modification and epigenetic reprogramming in mammalian development. Nat Rev Genet 3 (2002) 662-673
    • (2002) Nat Rev Genet , vol.3 , pp. 662-673
    • Li, E.1
  • 16
    • 34247549297 scopus 로고    scopus 로고
    • Metastable epialleles, imprinting, and the fetal origins of adult diseases
    • Dolinoy D.C., Das R., Weidman J.R., and Jirtle R.L. Metastable epialleles, imprinting, and the fetal origins of adult diseases. Pediatr Res 61 (2007) 30R-37R
    • (2007) Pediatr Res , vol.61
    • Dolinoy, D.C.1    Das, R.2    Weidman, J.R.3    Jirtle, R.L.4
  • 17
    • 0038118635 scopus 로고    scopus 로고
    • Imprinting evolution and the price of silence
    • Murphy S.K., and Jirtle R.L. Imprinting evolution and the price of silence. Bioessays 25 (2003) 577-588
    • (2003) Bioessays , vol.25 , pp. 577-588
    • Murphy, S.K.1    Jirtle, R.L.2
  • 18
    • 1042278765 scopus 로고    scopus 로고
    • The history of cancer epigenetics
    • Feinberg A.P., and Tycko B. The history of cancer epigenetics. Nat Rev Cancer 4 (2004) 143-153
    • (2004) Nat Rev Cancer , vol.4 , pp. 143-153
    • Feinberg, A.P.1    Tycko, B.2
  • 19
    • 5444255150 scopus 로고    scopus 로고
    • The epigenetics of cancer etiology
    • Feinberg A.P. The epigenetics of cancer etiology. Semin Cancer Biol 14 (2004) 427-432
    • (2004) Semin Cancer Biol , vol.14 , pp. 427-432
    • Feinberg, A.P.1
  • 21
    • 45349108598 scopus 로고    scopus 로고
    • Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development
    • Hirasawa R., Chiba H., Kaneda M., et al. Maternal and zygotic Dnmt1 are necessary and sufficient for the maintenance of DNA methylation imprints during preimplantation development. Genes Dev 22 (2008) 1607-1616
    • (2008) Genes Dev , vol.22 , pp. 1607-1616
    • Hirasawa, R.1    Chiba, H.2    Kaneda, M.3
  • 22
    • 0014069458 scopus 로고
    • Studies in the mode of action of royal jelly in honeybee development. VII. The free amino acids in the haemolymph of developing larvae
    • Lue P.F., and Dizon S.E. Studies in the mode of action of royal jelly in honeybee development. VII. The free amino acids in the haemolymph of developing larvae. Can J Zool 45 (1967) 205-214
    • (1967) Can J Zool , vol.45 , pp. 205-214
    • Lue, P.F.1    Dizon, S.E.2
  • 23
    • 36249013591 scopus 로고    scopus 로고
    • Genome-wide analysis reveals differences in brain gene expression patterns associated with caste and reproductive status in honey bees (Apis mellifera)
    • Grozinger C.M., Fan Y., Hoover S.E., and Winston M.L. Genome-wide analysis reveals differences in brain gene expression patterns associated with caste and reproductive status in honey bees (Apis mellifera). Mol Ecol 16 (2007) 4837-4848
    • (2007) Mol Ecol , vol.16 , pp. 4837-4848
    • Grozinger, C.M.1    Fan, Y.2    Hoover, S.E.3    Winston, M.L.4
  • 25
    • 0035228002 scopus 로고    scopus 로고
    • Expression profiles during honeybee caste determination
    • RESEARCH0001
    • Evans J.D., and Wheeler D.E. Expression profiles during honeybee caste determination. Genome Biol 2 (2001) RESEARCH0001
    • (2001) Genome Biol , vol.2
    • Evans, J.D.1    Wheeler, D.E.2
  • 26
    • 0033545923 scopus 로고    scopus 로고
    • Differential gene expression between developing queens and workers in the honey bee, Apis mellifera
    • Evans J.D., and Wheeler D.E. Differential gene expression between developing queens and workers in the honey bee, Apis mellifera. Proc Natl Acad Sci U S A 96 (1999) 5575-5580
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 5575-5580
    • Evans, J.D.1    Wheeler, D.E.2
  • 27
    • 41349085806 scopus 로고    scopus 로고
    • Nutritional control of reproductive status in honeybees via DNA methylation
    • Kucharski R., Maleszka J., Foret S., and Maleszka R. Nutritional control of reproductive status in honeybees via DNA methylation. Sciences (New York, NY) 319 (2008) 1827-1830
    • (2008) Sciences (New York, NY) , vol.319 , pp. 1827-1830
    • Kucharski, R.1    Maleszka, J.2    Foret, S.3    Maleszka, R.4
  • 28
    • 33750486851 scopus 로고    scopus 로고
    • Functional CpG methylation system in a social insect
    • Wang Y., Jorda M., Jones P.L., et al. Functional CpG methylation system in a social insect. Sciences (New York, NY) 314 (2006) 645-647
    • (2006) Sciences (New York, NY) , vol.314 , pp. 645-647
    • Wang, Y.1    Jorda, M.2    Jones, P.L.3
  • 29
    • 33847767127 scopus 로고    scopus 로고
    • DNA methylation with a sting: an active DNA methylation system in the honeybee
    • Schaefer M., and Lyko F. DNA methylation with a sting: an active DNA methylation system in the honeybee. Bioessays 29 (2007) 208-211
    • (2007) Bioessays , vol.29 , pp. 208-211
    • Schaefer, M.1    Lyko, F.2
  • 30
  • 32
    • 84882900279 scopus 로고    scopus 로고
    • Do maternal methyl supplements in mice affect DNA methylation of offspring?
    • author reply 239
    • Waterland R.A. Do maternal methyl supplements in mice affect DNA methylation of offspring?. J Nutr 133 (2003) 238 author reply 239
    • (2003) J Nutr , vol.133 , pp. 238
    • Waterland, R.A.1
  • 33
    • 0031873353 scopus 로고    scopus 로고
    • Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice
    • Wolff G.L., Kodell R.L., Moore S.R., and Cooney C.A. Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. Faseb J 12 (1998) 949-957
    • (1998) Faseb J , vol.12 , pp. 949-957
    • Wolff, G.L.1    Kodell, R.L.2    Moore, S.R.3    Cooney, C.A.4
  • 34
    • 0036322831 scopus 로고    scopus 로고
    • Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring
    • Cooney C.A., Dave A.A., and Wolff G.L. Maternal methyl supplements in mice affect epigenetic variation and DNA methylation of offspring. J Nutr 132 (2002) 2393S-2400S
    • (2002) J Nutr , vol.132
    • Cooney, C.A.1    Dave, A.A.2    Wolff, G.L.3
  • 35
    • 0043093697 scopus 로고    scopus 로고
    • Transposable elements: targets for early nutritional effects on epigenetic gene regulation
    • Waterland R.A., and Jirtle R.L. Transposable elements: targets for early nutritional effects on epigenetic gene regulation. Mol Cell Biol 23 (2003) 5293-5300
    • (2003) Mol Cell Biol , vol.23 , pp. 5293-5300
    • Waterland, R.A.1    Jirtle, R.L.2
  • 36
    • 34548715144 scopus 로고    scopus 로고
    • Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development
    • Dolinoy D.C., Huang D., and Jirtle R.L. Maternal nutrient supplementation counteracts bisphenol A-induced DNA hypomethylation in early development. Proc Natl Acad Sci U S A 104 (2007) 13056-13061
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 13056-13061
    • Dolinoy, D.C.1    Huang, D.2    Jirtle, R.L.3
  • 37
    • 53149087398 scopus 로고    scopus 로고
    • Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A
    • Yaoi T., Itoh K., Nakamura K., Ogi H., Fujiwara Y., and Fushiki S. Genome-wide analysis of epigenomic alterations in fetal mouse forebrain after exposure to low doses of bisphenol A. Biochem Biophys Res Commun 376 (2008) 563-567
    • (2008) Biochem Biophys Res Commun , vol.376 , pp. 563-567
    • Yaoi, T.1    Itoh, K.2    Nakamura, K.3    Ogi, H.4    Fujiwara, Y.5    Fushiki, S.6
  • 38
    • 0030803587 scopus 로고    scopus 로고
    • Expression of intracisternal A-particle retrotransposons in primary tumors of oncogene-expressing transgenic mice
    • Dupressoir A., and Heidmann T. Expression of intracisternal A-particle retrotransposons in primary tumors of oncogene-expressing transgenic mice. Oncogene 14 (1997) 2951-2958
    • (1997) Oncogene , vol.14 , pp. 2951-2958
    • Dupressoir, A.1    Heidmann, T.2
  • 39
    • 33645633542 scopus 로고    scopus 로고
    • Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome
    • Dolinoy D.C., Weidman J.R., Waterland R.A., and Jirtle R.L. Maternal genistein alters coat color and protects Avy mouse offspring from obesity by modifying the fetal epigenome. Environ Health Perspect 114 (2006) 567-572
    • (2006) Environ Health Perspect , vol.114 , pp. 567-572
    • Dolinoy, D.C.1    Weidman, J.R.2    Waterland, R.A.3    Jirtle, R.L.4
  • 40
  • 41
    • 0037418193 scopus 로고    scopus 로고
    • Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission
    • Rakyan V.K., Chong S., Champ M.E., et al. Transgenerational inheritance of epigenetic states at the murine Axin(Fu) allele occurs after maternal and paternal transmission. Proc Natl Acad Sci U S A 100 (2003) 2538-2543
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 2538-2543
    • Rakyan, V.K.1    Chong, S.2    Champ, M.E.3
  • 42
    • 33751242483 scopus 로고    scopus 로고
    • Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation
    • Cropley J.E., Suter C.M., Beckman K.B., and Martin D.I. Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation. Proc Natl Acad Sci U S A 103 (2006) 17308-17312
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17308-17312
    • Cropley, J.E.1    Suter, C.M.2    Beckman, K.B.3    Martin, D.I.4
  • 43
    • 33751251702 scopus 로고    scopus 로고
    • Germ cells carry the epigenetic benefits of grandmother's diet
    • Cooney C.A. Germ cells carry the epigenetic benefits of grandmother's diet. Proc Natl Acad Sci U S A 103 (2006) 17071-17072
    • (2006) Proc Natl Acad Sci U S A , vol.103 , pp. 17071-17072
    • Cooney, C.A.1
  • 44
    • 35248840160 scopus 로고    scopus 로고
    • Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female
    • Waterland R.A., Travisano M., and Tahiliani K.G. Diet-induced hypermethylation at agouti viable yellow is not inherited transgenerationally through the female. Faseb J 21 (2007) 3380-3385
    • (2007) Faseb J , vol.21 , pp. 3380-3385
    • Waterland, R.A.1    Travisano, M.2    Tahiliani, K.G.3
  • 45
    • 33846878956 scopus 로고    scopus 로고
    • In utero physiology: role of folic acid in nutrient delivery and fetal development
    • Antony A.C. In utero physiology: role of folic acid in nutrient delivery and fetal development. Am J Clin Nutr 85 (2007) 598S-603S
    • (2007) Am J Clin Nutr , vol.85
    • Antony, A.C.1
  • 46
    • 0033664062 scopus 로고    scopus 로고
    • Folate and intrauterine growth retardation
    • Rondo P.H., and Tomkins A.M. Folate and intrauterine growth retardation. Ann Trop Paediatr 20 (2000) 253-258
    • (2000) Ann Trop Paediatr , vol.20 , pp. 253-258
    • Rondo, P.H.1    Tomkins, A.M.2
  • 47
    • 34547104382 scopus 로고    scopus 로고
    • Induction and prevention of cleft lip, alveolus and palate and neural tube defects with special consideration of B vitamins and the methylation cycle
    • Weingartner J., Lotz K., Fanghanel J., Gedrange T., Bienengraber V., and Proff P. Induction and prevention of cleft lip, alveolus and palate and neural tube defects with special consideration of B vitamins and the methylation cycle. J Orofac Orthop 68 (2007) 266-277
    • (2007) J Orofac Orthop , vol.68 , pp. 266-277
    • Weingartner, J.1    Lotz, K.2    Fanghanel, J.3    Gedrange, T.4    Bienengraber, V.5    Proff, P.6
  • 48
    • 34548804586 scopus 로고    scopus 로고
    • Folate and homocysteine levels during pregnancy affect DNA methylation in human placenta
    • Park B.H., Kim Y.J., Park J.S., et al. Folate and homocysteine levels during pregnancy affect DNA methylation in human placenta. J Prev Med Public Health 38 (2005) 437-442
    • (2005) J Prev Med Public Health , vol.38 , pp. 437-442
    • Park, B.H.1    Kim, Y.J.2    Park, J.S.3
  • 49
    • 58749107929 scopus 로고    scopus 로고
    • Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats
    • Kim J.M., Hong K., Lee J.H., Lee S., and Chang N. Effect of folate deficiency on placental DNA methylation in hyperhomocysteinemic rats. J Nutr Biochem 20 (2009) 172-176
    • (2009) J Nutr Biochem , vol.20 , pp. 172-176
    • Kim, J.M.1    Hong, K.2    Lee, J.H.3    Lee, S.4    Chang, N.5
  • 50
    • 42149090406 scopus 로고    scopus 로고
    • Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring
    • Watkins A.J., Wilkins A., Cunningham C., et al. Low protein diet fed exclusively during mouse oocyte maturation leads to behavioural and cardiovascular abnormalities in offspring. J Physiol 586 (2008) 2231-2244
    • (2008) J Physiol , vol.586 , pp. 2231-2244
    • Watkins, A.J.1    Wilkins, A.2    Cunningham, C.3
  • 51
    • 17844382124 scopus 로고    scopus 로고
    • Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways
    • Kappen C. Folate supplementation in three genetic models: implications for understanding folate-dependent developmental pathways. Am J Med Genet C Semin Med Genet 135C (2005) 24-30
    • (2005) Am J Med Genet C Semin Med Genet , vol.135 C , pp. 24-30
    • Kappen, C.1
  • 52
    • 20444411948 scopus 로고    scopus 로고
    • Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring
    • Lillycrop K.A., Phillips E.S., Jackson A.A., Hanson M.A., and Burdge G.C. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr 135 (2005) 1382-1386
    • (2005) J Nutr , vol.135 , pp. 1382-1386
    • Lillycrop, K.A.1    Phillips, E.S.2    Jackson, A.A.3    Hanson, M.A.4    Burdge, G.C.5
  • 53
    • 34247514180 scopus 로고    scopus 로고
    • Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications
    • Lillycrop K.A., Slater-Jefferies J.L., Hanson M.A., Godfrey K.M., Jackson A.A., and Burdge G.C. Induction of altered epigenetic regulation of the hepatic glucocorticoid receptor in the offspring of rats fed a protein-restricted diet during pregnancy suggests that reduced DNA methyltransferase-1 expression is involved in impaired DNA methylation and changes in histone modifications. Br J Nutr 97 (2007) 1064-1073
    • (2007) Br J Nutr , vol.97 , pp. 1064-1073
    • Lillycrop, K.A.1    Slater-Jefferies, J.L.2    Hanson, M.A.3    Godfrey, K.M.4    Jackson, A.A.5    Burdge, G.C.6
  • 54
    • 37649011327 scopus 로고    scopus 로고
    • DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status
    • Sinclair K.D., Allegrucci C., Singh R., et al. DNA methylation, insulin resistance, and blood pressure in offspring determined by maternal periconceptional B vitamin and methionine status. Proc Natl Acad Sci U S A 104 (2007) 19351-19356
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 19351-19356
    • Sinclair, K.D.1    Allegrucci, C.2    Singh, R.3
  • 55
    • 35548941189 scopus 로고    scopus 로고
    • Epigenetic epidemiology of the developmental origins hypothesis
    • Waterland R.A., and Michels K.B. Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27 (2007) 363-388
    • (2007) Annu Rev Nutr , vol.27 , pp. 363-388
    • Waterland, R.A.1    Michels, K.B.2
  • 56
    • 10644297327 scopus 로고    scopus 로고
    • Folate and DNA methylation during in utero development and aging
    • McKay J.A., Williams E.A., and Mathers J.C. Folate and DNA methylation during in utero development and aging. Biochem Soc Trans 32 (2004) 1006-1007
    • (2004) Biochem Soc Trans , vol.32 , pp. 1006-1007
    • McKay, J.A.1    Williams, E.A.2    Mathers, J.C.3
  • 57
    • 5444231261 scopus 로고    scopus 로고
    • Age-associated alteration of gene expression patterns in mouse oocytes
    • Hamatani T., Falco G., Carter M.G., et al. Age-associated alteration of gene expression patterns in mouse oocytes. Hum Mol Genet 13 (2004) 2263-2278
    • (2004) Hum Mol Genet , vol.13 , pp. 2263-2278
    • Hamatani, T.1    Falco, G.2    Carter, M.G.3
  • 58
    • 0024546311 scopus 로고
    • Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice
    • Ono T., Takahashi N., and Okada S. Age-associated changes in DNA methylation and mRNA level of the c-myc gene in spleen and liver of mice. Mutat Res 219 (1989) 39-50
    • (1989) Mutat Res , vol.219 , pp. 39-50
    • Ono, T.1    Takahashi, N.2    Okada, S.3
  • 59
    • 26844554974 scopus 로고    scopus 로고
    • Age-related changes in Usp9x protein expression and DNA methylation in mouse brain
    • Xu J. Age-related changes in Usp9x protein expression and DNA methylation in mouse brain. Brain Res 140 (2005) 17-24
    • (2005) Brain Res , vol.140 , pp. 17-24
    • Xu, J.1
  • 60
    • 0036328026 scopus 로고    scopus 로고
    • Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer
    • Richardson B.C. Role of DNA methylation in the regulation of cell function: autoimmunity, aging and cancer. J Nutr 132 (2002) 2401S-2405S
    • (2002) J Nutr , vol.132
    • Richardson, B.C.1
  • 61
    • 0020638422 scopus 로고
    • DNA methylation decreases in aging but not in immortal cells
    • Wilson V.L., and Jones P.A. DNA methylation decreases in aging but not in immortal cells. Sciences (New York, NY) 220 (1983) 1055-1057
    • (1983) Sciences (New York, NY) , vol.220 , pp. 1055-1057
    • Wilson, V.L.1    Jones, P.A.2
  • 62
    • 0344321897 scopus 로고    scopus 로고
    • Impact of aging on DNA methylation
    • Richardson B. Impact of aging on DNA methylation. Ageing Res Rev 2 (2003) 245-261
    • (2003) Ageing Res Rev , vol.2 , pp. 245-261
    • Richardson, B.1
  • 63
    • 0024988560 scopus 로고
    • Quantitative changes in T cell DNA methylation occur during differentiation and ageing
    • Golbus J., Palella T.D., and Richardson B.C. Quantitative changes in T cell DNA methylation occur during differentiation and ageing. Eur J Immunol 20 (1990) 1869-1872
    • (1990) Eur J Immunol , vol.20 , pp. 1869-1872
    • Golbus, J.1    Palella, T.D.2    Richardson, B.C.3
  • 64
    • 45849127657 scopus 로고    scopus 로고
    • Intra-individual change over time in DNA methylation with familial clustering
    • Bjornsson H.T., Sigurdsson M.I., Fallin M.D., et al. Intra-individual change over time in DNA methylation with familial clustering. Jama 299 (2008) 2877-2883
    • (2008) Jama , vol.299 , pp. 2877-2883
    • Bjornsson, H.T.1    Sigurdsson, M.I.2    Fallin, M.D.3
  • 65
    • 0028001087 scopus 로고
    • Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon
    • Issa J.P., Ottaviano Y.L., Celano P., Hamilton S.R., Davidson N.E., and Baylin S.B. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7 (1994) 536-540
    • (1994) Nat Genet , vol.7 , pp. 536-540
    • Issa, J.P.1    Ottaviano, Y.L.2    Celano, P.3    Hamilton, S.R.4    Davidson, N.E.5    Baylin, S.B.6
  • 66
    • 0032831285 scopus 로고    scopus 로고
    • Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system
    • Post W.S., Goldschmidt-Clermont P.J., Wilhide C.C., et al. Methylation of the estrogen receptor gene is associated with aging and atherosclerosis in the cardiovascular system. Cardiovasc Res 43 (1999) 985-991
    • (1999) Cardiovasc Res , vol.43 , pp. 985-991
    • Post, W.S.1    Goldschmidt-Clermont, P.J.2    Wilhide, C.C.3
  • 67
    • 33845647686 scopus 로고    scopus 로고
    • Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence
    • Kim J., Kim J.Y., Song K.S., et al. Epigenetic changes in estrogen receptor beta gene in atherosclerotic cardiovascular tissues and in-vitro vascular senescence. Biochim Biophys Acta 1772 (2007) 72-80
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 72-80
    • Kim, J.1    Kim, J.Y.2    Song, K.S.3
  • 68
    • 0032401895 scopus 로고    scopus 로고
    • Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen-induced mammary tumorigenesis in the rat
    • Yenbutr P., Hilakivi-Clarke L., and Passaniti A. Hypomethylation of an exon I estrogen receptor CpG island in spontaneous and carcinogen-induced mammary tumorigenesis in the rat. Mech Ageing Dev 106 (1998) 93-102
    • (1998) Mech Ageing Dev , vol.106 , pp. 93-102
    • Yenbutr, P.1    Hilakivi-Clarke, L.2    Passaniti, A.3
  • 69
    • 34447128753 scopus 로고    scopus 로고
    • Age-related DNA methylation changes in normal human prostate tissues
    • Kwabi-Addo B., Chung W., Shen L., et al. Age-related DNA methylation changes in normal human prostate tissues. Clin Cancer Res 13 (2007) 3796-3802
    • (2007) Clin Cancer Res , vol.13 , pp. 3796-3802
    • Kwabi-Addo, B.1    Chung, W.2    Shen, L.3
  • 70
    • 3242756641 scopus 로고    scopus 로고
    • Age-dependent methylation of ESR1 gene in prostate cancer
    • Li L.C., Shiina H., Deguchi M., et al. Age-dependent methylation of ESR1 gene in prostate cancer. Biochem Biophys Res Commun 321 (2004) 455-461
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 455-461
    • Li, L.C.1    Shiina, H.2    Deguchi, M.3
  • 71
    • 0029976873 scopus 로고    scopus 로고
    • Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis
    • Issa J.P., Vertino P.M., Boehm C.D., Newsham I.F., and Baylin S.B. Switch from monoallelic to biallelic human IGF2 promoter methylation during aging and carcinogenesis. Proc Natl Acad Sci U S A 93 (1996) 11757-11762
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 11757-11762
    • Issa, J.P.1    Vertino, P.M.2    Boehm, C.D.3    Newsham, I.F.4    Baylin, S.B.5
  • 72
  • 73
    • 0028080422 scopus 로고
    • Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts
    • Vertino P.M., Issa J.P., Pereira-Smith O.M., and Baylin S.B. Stabilization of DNA methyltransferase levels and CpG island hypermethylation precede SV40-induced immortalization of human fibroblasts. Cell Growth Differ 5 (1994) 1395-1402
    • (1994) Cell Growth Differ , vol.5 , pp. 1395-1402
    • Vertino, P.M.1    Issa, J.P.2    Pereira-Smith, O.M.3    Baylin, S.B.4
  • 74
    • 34447114447 scopus 로고    scopus 로고
    • Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon
    • Keyes M.K., Jang H., Mason J.B., et al. Older age and dietary folate are determinants of genomic and p16-specific DNA methylation in mouse colon. J Nutr 137 (2007) 1713-1717
    • (2007) J Nutr , vol.137 , pp. 1713-1717
    • Keyes, M.K.1    Jang, H.2    Mason, J.B.3
  • 75
    • 40949161396 scopus 로고    scopus 로고
    • Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma
    • Nishida N., Nagasaka T., Nishimura T., Ikai I., Boland C.R., and Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 47 (2008) 908-918
    • (2008) Hepatology , vol.47 , pp. 908-918
    • Nishida, N.1    Nagasaka, T.2    Nishimura, T.3    Ikai, I.4    Boland, C.R.5    Goel, A.6
  • 76
    • 33748939095 scopus 로고    scopus 로고
    • Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia
    • So K., Tamura G., Honda T., et al. Multiple tumor suppressor genes are increasingly methylated with age in non-neoplastic gastric epithelia. Cancer Sci 97 (2006) 1155-1158
    • (2006) Cancer Sci , vol.97 , pp. 1155-1158
    • So, K.1    Tamura, G.2    Honda, T.3
  • 78
    • 44849107824 scopus 로고    scopus 로고
    • Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease
    • Silva P.N., Gigek C.O., Leal M.F., et al. Promoter methylation analysis of SIRT3, SMARCA5, HTERT and CDH1 genes in aging and Alzheimer's disease. J Alzheimers Dis 13 (2008) 173-176
    • (2008) J Alzheimers Dis , vol.13 , pp. 173-176
    • Silva, P.N.1    Gigek, C.O.2    Leal, M.F.3
  • 79
    • 38348998901 scopus 로고    scopus 로고
    • Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney
    • Akintola A.D., Crislip Z.L., Catania J.M., et al. Promoter methylation is associated with the age-dependent loss of N-cadherin in the rat kidney. Am J Physiol 294 (2008) F170-F176
    • (2008) Am J Physiol , vol.294
    • Akintola, A.D.1    Crislip, Z.L.2    Catania, J.M.3
  • 80
    • 0034854116 scopus 로고    scopus 로고
    • Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals
    • Bornman D.M., Mathew S., Alsruhe J., Herman J.G., and Gabrielson E. Methylation of the E-cadherin gene in bladder neoplasia and in normal urothelial epithelium from elderly individuals. Am J Pathol 159 (2001) 831-835
    • (2001) Am J Pathol , vol.159 , pp. 831-835
    • Bornman, D.M.1    Mathew, S.2    Alsruhe, J.3    Herman, J.G.4    Gabrielson, E.5
  • 81
    • 0141537154 scopus 로고    scopus 로고
    • Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation
    • Kang G.H., Lee H.J., Hwang K.S., Lee S., Kim J.H., and Kim J.S. Aberrant CpG island hypermethylation of chronic gastritis, in relation to aging, gender, intestinal metaplasia, and chronic inflammation. Am J Pathol 163 (2003) 1551-1556
    • (2003) Am J Pathol , vol.163 , pp. 1551-1556
    • Kang, G.H.1    Lee, H.J.2    Hwang, K.S.3    Lee, S.4    Kim, J.H.5    Kim, J.S.6
  • 82
    • 33744828510 scopus 로고    scopus 로고
    • Hypermethylation of CpGs in the promoter of the COL1A1 gene in the aged periodontal ligament
    • Ohi T., Uehara Y., Takatsu M., Watanabe M., and Ono T. Hypermethylation of CpGs in the promoter of the COL1A1 gene in the aged periodontal ligament. J Dental Res 85 (2006) 245-250
    • (2006) J Dental Res , vol.85 , pp. 245-250
    • Ohi, T.1    Uehara, Y.2    Takatsu, M.3    Watanabe, M.4    Ono, T.5
  • 83
    • 0032824713 scopus 로고    scopus 로고
    • Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament
    • Takatsu M., Uyeno S., Komura J., Watanabe M., and Ono T. Age-dependent alterations in mRNA level and promoter methylation of collagen alpha1(I) gene in human periodontal ligament. Mech Ageing Dev 110 (1999) 37-48
    • (1999) Mech Ageing Dev , vol.110 , pp. 37-48
    • Takatsu, M.1    Uyeno, S.2    Komura, J.3    Watanabe, M.4    Ono, T.5
  • 84
    • 0030570416 scopus 로고    scopus 로고
    • Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver
    • Choi E.K., Uyeno S., Nishida N., et al. Alterations of c-fos gene methylation in the processes of aging and tumorigenesis in human liver. Mutat Res 354 (1996) 123-128
    • (1996) Mutat Res , vol.354 , pp. 123-128
    • Choi, E.K.1    Uyeno, S.2    Nishida, N.3
  • 85
    • 38849185903 scopus 로고    scopus 로고
    • Adiposity and age are statistically related to enhanced RASSF1A tumor suppressor gene promoter methylation in normal autopsy kidney tissue
    • Peters I., Vaske B., Albrecht K., Kuczyk M.A., Jonas U., and Serth J. Adiposity and age are statistically related to enhanced RASSF1A tumor suppressor gene promoter methylation in normal autopsy kidney tissue. Cancer Epidemiol Biomarkers Prev 16 (2007) 2526-2532
    • (2007) Cancer Epidemiol Biomarkers Prev , vol.16 , pp. 2526-2532
    • Peters, I.1    Vaske, B.2    Albrecht, K.3    Kuczyk, M.A.4    Jonas, U.5    Serth, J.6
  • 86
    • 52649102557 scopus 로고    scopus 로고
    • DNA methylation in benign breast epithelium in relation to age and breast cancer risk
    • Euhus D.M., Bu D., Milchgrub S., et al. DNA methylation in benign breast epithelium in relation to age and breast cancer risk. Cancer Epidemiol Biomarkers Prev 17 (2008) 1051-1059
    • (2008) Cancer Epidemiol Biomarkers Prev , vol.17 , pp. 1051-1059
    • Euhus, D.M.1    Bu, D.2    Milchgrub, S.3
  • 87
    • 0038418287 scopus 로고    scopus 로고
    • Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer
    • Kim D.H., Kim J.S., Ji Y.I., et al. Hypermethylation of RASSF1A promoter is associated with the age at starting smoking and a poor prognosis in primary non-small cell lung cancer. Cancer Res 63 (2003) 3743-3746
    • (2003) Cancer Res , vol.63 , pp. 3743-3746
    • Kim, D.H.1    Kim, J.S.2    Ji, Y.I.3
  • 88
    • 7944239285 scopus 로고    scopus 로고
    • Aging: gene silencing or gene activation?
    • Burzynski S.R. Aging: gene silencing or gene activation?. Med Hypotheses 64 (2005) 201-208
    • (2005) Med Hypotheses , vol.64 , pp. 201-208
    • Burzynski, S.R.1
  • 89
    • 0037375733 scopus 로고    scopus 로고
    • Gene silencing-a new theory of aging
    • Burzynski S.R. Gene silencing-a new theory of aging. Med Hypotheses 60 (2003) 578-583
    • (2003) Med Hypotheses , vol.60 , pp. 578-583
    • Burzynski, S.R.1
  • 90
    • 34249683635 scopus 로고    scopus 로고
    • Cross-talk between aging and cancer: the epigenetic language
    • Fraga M.F., Agrelo R., and Esteller M. Cross-talk between aging and cancer: the epigenetic language. Ann N Y Acad Sci 1100 (2007) 60-74
    • (2007) Ann N Y Acad Sci , vol.1100 , pp. 60-74
    • Fraga, M.F.1    Agrelo, R.2    Esteller, M.3
  • 91
    • 0035116352 scopus 로고    scopus 로고
    • Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort
    • Jacques P.F., Bostom A.G., Wilson P.W., Rich S., Rosenberg I.H., and Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr 73 (2001) 613-621
    • (2001) Am J Clin Nutr , vol.73 , pp. 613-621
    • Jacques, P.F.1    Bostom, A.G.2    Wilson, P.W.3    Rich, S.4    Rosenberg, I.H.5    Selhub, J.6
  • 92
    • 0034703084 scopus 로고    scopus 로고
    • Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation
    • [In Process Citation]
    • Yi P., Melnyk S., Pogribna M., Pogribny I.P., Hine R.J., and James S.J. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. [In Process Citation]. J Biol Chem 275 (2000) 29318-29323
    • (2000) J Biol Chem , vol.275 , pp. 29318-29323
    • Yi, P.1    Melnyk, S.2    Pogribna, M.3    Pogribny, I.P.4    Hine, R.J.5    James, S.J.6
  • 93
    • 33947543307 scopus 로고    scopus 로고
    • Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women
    • Friso S., Lamon-Fava S., Jang H., Schaefer E.J., Corrocher R., and Choi S.W. Oestrogen replacement therapy reduces total plasma homocysteine and enhances genomic DNA methylation in postmenopausal women. Br J Nutr 97 (2007) 617-621
    • (2007) Br J Nutr , vol.97 , pp. 617-621
    • Friso, S.1    Lamon-Fava, S.2    Jang, H.3    Schaefer, E.J.4    Corrocher, R.5    Choi, S.W.6
  • 94
    • 0033970043 scopus 로고    scopus 로고
    • Folate and carcinogenesis: an integrated scheme
    • Choi S.W., and Mason J.B. Folate and carcinogenesis: an integrated scheme. J Nutr 130 (2000) 129-132
    • (2000) J Nutr , vol.130 , pp. 129-132
    • Choi, S.W.1    Mason, J.B.2
  • 95
    • 0033805888 scopus 로고    scopus 로고
    • Genomic DNA methylation decreases in response to moderate folate depletion in elderly women
    • [see comments]
    • Rampersaud G.C., Kauwell G.P., Hutson A.D., Cerda J.J., and Bailey L.B. Genomic DNA methylation decreases in response to moderate folate depletion in elderly women. [see comments]. Am J Clin Nutr 72 (2000) 998-1003
    • (2000) Am J Clin Nutr , vol.72 , pp. 998-1003
    • Rampersaud, G.C.1    Kauwell, G.P.2    Hutson, A.D.3    Cerda, J.J.4    Bailey, L.B.5
  • 96
    • 0031816123 scopus 로고    scopus 로고
    • Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women
    • Jacob R.A., Gretz D.M., Taylor P.C., et al. Moderate folate depletion increases plasma homocysteine and decreases lymphocyte DNA methylation in postmenopausal women. J Nutr 128 (1998) 1204-1212
    • (1998) J Nutr , vol.128 , pp. 1204-1212
    • Jacob, R.A.1    Gretz, D.M.2    Taylor, P.C.3
  • 98
    • 33646819033 scopus 로고    scopus 로고
    • A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats
    • Ghoshal K., Li X., Datta J., et al. A folate- and methyl-deficient diet alters the expression of DNA methyltransferases and methyl CpG binding proteins involved in epigenetic gene silencing in livers of F344 rats. J Nutr 136 (2006) 1522-1527
    • (2006) J Nutr , vol.136 , pp. 1522-1527
    • Ghoshal, K.1    Li, X.2    Datta, J.3
  • 99
    • 0034994336 scopus 로고    scopus 로고
    • Dietary selenium and arsenic affect DNA methylation
    • Cooney C.A. Dietary selenium and arsenic affect DNA methylation. J Nutr 131 (2001) 1871-1872
    • (2001) J Nutr , vol.131 , pp. 1871-1872
    • Cooney, C.A.1
  • 100
    • 0035679346 scopus 로고    scopus 로고
    • Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts
    • Lopatina N., Haskell J.F., Andrews L.G., Poole J.C., Saldanha S., and Tollefsbol T. Differential maintenance and de novo methylating activity by three DNA methyltransferases in aging and immortalized fibroblasts. J Cell Biochem 84 (2002) 324-334
    • (2002) J Cell Biochem , vol.84 , pp. 324-334
    • Lopatina, N.1    Haskell, J.F.2    Andrews, L.G.3    Poole, J.C.4    Saldanha, S.5    Tollefsbol, T.6
  • 101
    • 33845755946 scopus 로고    scopus 로고
    • Heterochromatin revisited
    • Grewal S.I., and Jia S. Heterochromatin revisited. Nat Rev Genet 8 (2007) 35-46
    • (2007) Nat Rev Genet , vol.8 , pp. 35-46
    • Grewal, S.I.1    Jia, S.2
  • 102
    • 12544259900 scopus 로고    scopus 로고
    • DNA methyltransferase gene dDnmt2 and longevity of Drosophila
    • Lin M.J., Tang L.Y., Reddy M.N., and Shen C.K. DNA methyltransferase gene dDnmt2 and longevity of Drosophila. J Biol Chem 280 (2005) 861-864
    • (2005) J Biol Chem , vol.280 , pp. 861-864
    • Lin, M.J.1    Tang, L.Y.2    Reddy, M.N.3    Shen, C.K.4
  • 103
    • 0034234784 scopus 로고    scopus 로고
    • The putative Drosophila methyltransferase gene dDnmt2 is contained in a transposon-like element and is expressed specifically in ovaries
    • Lyko F., Whittaker A.J., Orr-Weaver T.L., and Jaenisch R. The putative Drosophila methyltransferase gene dDnmt2 is contained in a transposon-like element and is expressed specifically in ovaries. Mech Dev 95 (2000) 215-217
    • (2000) Mech Dev , vol.95 , pp. 215-217
    • Lyko, F.1    Whittaker, A.J.2    Orr-Weaver, T.L.3    Jaenisch, R.4
  • 104
    • 22844433327 scopus 로고    scopus 로고
    • Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG
    • Sun L.Q., and Arceci R.J. Altered epigenetic patterning leading to replicative senescence and reduced longevity. A role of a novel SNF2 factor, PASG. Cell Cycle 4 (2005) 3-5
    • (2005) Cell Cycle , vol.4 , pp. 3-5
    • Sun, L.Q.1    Arceci, R.J.2
  • 105
    • 2442564700 scopus 로고    scopus 로고
    • Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG
    • Sun L.Q., Lee D.W., Zhang Q., et al. Growth retardation and premature aging phenotypes in mice with disruption of the SNF2-like gene, PASG. Genes Dev 18 (2004) 1035-1046
    • (2004) Genes Dev , vol.18 , pp. 1035-1046
    • Sun, L.Q.1    Lee, D.W.2    Zhang, Q.3
  • 106
    • 0034322263 scopus 로고    scopus 로고
    • Telomere length maintenance in aging and carcinogenesis
    • Aragona M., Maisano R., Panetta S., et al. Telomere length maintenance in aging and carcinogenesis. Int J Oncol 17 (2000) 981-989
    • (2000) Int J Oncol , vol.17 , pp. 981-989
    • Aragona, M.1    Maisano, R.2    Panetta, S.3
  • 107
    • 34547949573 scopus 로고    scopus 로고
    • A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway
    • Fingerman I.M., Li H.C., and Briggs S.D. A charge-based interaction between histone H4 and Dot1 is required for H3K79 methylation and telomere silencing: identification of a new trans-histone pathway. Genes Dev 21 (2007) 2018-2029
    • (2007) Genes Dev , vol.21 , pp. 2018-2029
    • Fingerman, I.M.1    Li, H.C.2    Briggs, S.D.3
  • 108
    • 0347988045 scopus 로고    scopus 로고
    • Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases
    • Garcia-Cao M., O'Sullivan R., Peters A.H., Jenuwein T., and Blasco M.A. Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases. Nat Genet 36 (2004) 94-99
    • (2004) Nat Genet , vol.36 , pp. 94-99
    • Garcia-Cao, M.1    O'Sullivan, R.2    Peters, A.H.3    Jenuwein, T.4    Blasco, M.A.5
  • 109
    • 34249914820 scopus 로고    scopus 로고
    • Histone methylation controls telomerase-independent telomere lengthening in cells undergoing dedifferentiation
    • Grafi G., Ben-Meir H., Avivi Y., Moshe M., Dahan Y., and Zemach A. Histone methylation controls telomerase-independent telomere lengthening in cells undergoing dedifferentiation. Dev Biol 306 (2007) 838-846
    • (2007) Dev Biol , vol.306 , pp. 838-846
    • Grafi, G.1    Ben-Meir, H.2    Avivi, Y.3    Moshe, M.4    Dahan, Y.5    Zemach, A.6
  • 110
    • 33645702660 scopus 로고    scopus 로고
    • DNA methyltransferases control telomere length and telomere recombination in mammalian cells
    • Gonzalo S., Jaco I., Fraga M.F., et al. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol 8 (2006) 416-424
    • (2006) Nat Cell Biol , vol.8 , pp. 416-424
    • Gonzalo, S.1    Jaco, I.2    Fraga, M.F.3
  • 111
    • 33646101264 scopus 로고    scopus 로고
    • Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells
    • Zhu J.H., Chen J.Z., Wang X.X., Xie X.D., Sun J., and Zhang F.R. Homocysteine accelerates senescence and reduces proliferation of endothelial progenitor cells. J Mol Cell Cardiol 40 (2006) 648-652
    • (2006) J Mol Cell Cardiol , vol.40 , pp. 648-652
    • Zhu, J.H.1    Chen, J.Z.2    Wang, X.X.3    Xie, X.D.4    Sun, J.5    Zhang, F.R.6
  • 112
    • 52049086861 scopus 로고    scopus 로고
    • Homocysteine levels and leukocyte telomere length
    • Richards J.B., Valdes A.M., Gardner J.P., et al. Homocysteine levels and leukocyte telomere length. Atherosclerosis 200 (2008) 271-277
    • (2008) Atherosclerosis , vol.200 , pp. 271-277
    • Richards, J.B.1    Valdes, A.M.2    Gardner, J.P.3
  • 113
    • 42149093769 scopus 로고    scopus 로고
    • Genome-health nutrigenomics and nutrigenetics: nutritional requirements or 'nutriomes' for chromosomal stability and telomere maintenance at the individual level
    • Bull C., and Fenech M. Genome-health nutrigenomics and nutrigenetics: nutritional requirements or 'nutriomes' for chromosomal stability and telomere maintenance at the individual level. Proc Nutr Soc 67 (2008) 146-156
    • (2008) Proc Nutr Soc , vol.67 , pp. 146-156
    • Bull, C.1    Fenech, M.2
  • 114
    • 13844316472 scopus 로고    scopus 로고
    • Limited TTP supply affects telomere length regulation in a telomerase-independent fashion
    • Toussaint M., Dionne I., and Wellinger R.J. Limited TTP supply affects telomere length regulation in a telomerase-independent fashion. Nucleic Acids Res 33 (2005) 704-713
    • (2005) Nucleic Acids Res , vol.33 , pp. 704-713
    • Toussaint, M.1    Dionne, I.2    Wellinger, R.J.3
  • 115
    • 0344196937 scopus 로고    scopus 로고
    • Aging, cancer and nutrition: the DNA methylation connection
    • Liu L., Wylie R.C., Andrews L.G., and Tollefsbol T.O. Aging, cancer and nutrition: the DNA methylation connection. Mech Ageing Dev 124 (2003) 989-998
    • (2003) Mech Ageing Dev , vol.124 , pp. 989-998
    • Liu, L.1    Wylie, R.C.2    Andrews, L.G.3    Tollefsbol, T.O.4
  • 117
    • 0034015438 scopus 로고    scopus 로고
    • CpG-island methylation in aging and cancer
    • Issa J.P. CpG-island methylation in aging and cancer. Curr Top Microbiol Immunol 249 (2000) 101-118
    • (2000) Curr Top Microbiol Immunol , vol.249 , pp. 101-118
    • Issa, J.P.1
  • 118
    • 0033959282 scopus 로고    scopus 로고
    • The role of DNA hypermethylation in human neoplasia
    • Toyota M., and Issa J.P. The role of DNA hypermethylation in human neoplasia. Electrophoresis 21 (2000) 329-333
    • (2000) Electrophoresis , vol.21 , pp. 329-333
    • Toyota, M.1    Issa, J.P.2
  • 119
    • 0242584454 scopus 로고    scopus 로고
    • Chromosomal instability and tumors promoted by DNA hypomethylation
    • Eden A., Gaudet F., Waghmare A., and Jaenisch R. Chromosomal instability and tumors promoted by DNA hypomethylation. Sciences (New York, NY) 300 (2003) 455
    • (2003) Sciences (New York, NY) , vol.300 , pp. 455
    • Eden, A.1    Gaudet, F.2    Waghmare, A.3    Jaenisch, R.4
  • 120
    • 0242584449 scopus 로고    scopus 로고
    • Induction of tumors in mice by genomic hypomethylation
    • Gaudet F., Hodgson J.G., Eden A., et al. Induction of tumors in mice by genomic hypomethylation. Sciences (New York, NY) 300 (2003) 489-492
    • (2003) Sciences (New York, NY) , vol.300 , pp. 489-492
    • Gaudet, F.1    Hodgson, J.G.2    Eden, A.3
  • 122
    • 0031662164 scopus 로고    scopus 로고
    • Transcription of IAP endogenous retroviruses is constrained by cytosine methylation
    • Walsh C.P., Chaillet J.R., and Bestor T.H. Transcription of IAP endogenous retroviruses is constrained by cytosine methylation. Nat Genet 20 (1998) 116-117
    • (1998) Nat Genet , vol.20 , pp. 116-117
    • Walsh, C.P.1    Chaillet, J.R.2    Bestor, T.H.3
  • 123
    • 0034046665 scopus 로고    scopus 로고
    • Folate and carcinogenesis: developing a unifying hypothesis
    • Mason J.B., and Choi S.W. Folate and carcinogenesis: developing a unifying hypothesis. Adv Enzyme Regul 40 (2000) 127-141
    • (2000) Adv Enzyme Regul , vol.40 , pp. 127-141
    • Mason, J.B.1    Choi, S.W.2
  • 124
    • 0030979178 scopus 로고    scopus 로고
    • Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage
    • Blount B.C., Mack M.M., Wehr C.M., et al. Folate deficiency causes uracil misincorporation into human DNA and chromosome breakage: implications for cancer and neuronal damage. Proc Natl Acad Sci U S A 94 (1997) 3290-3295
    • (1997) Proc Natl Acad Sci U S A , vol.94 , pp. 3290-3295
    • Blount, B.C.1    Mack, M.M.2    Wehr, C.M.3
  • 125
    • 0037384611 scopus 로고    scopus 로고
    • Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific
    • Choi S.W., Friso S., Dolnikowski G.G., et al. Biochemical and molecular aberrations in the rat colon due to folate depletion are age-specific. J Nutr 133 (2003) 1206-1212
    • (2003) J Nutr , vol.133 , pp. 1206-1212
    • Choi, S.W.1    Friso, S.2    Dolnikowski, G.G.3
  • 126
    • 0026673471 scopus 로고
    • New evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging
    • Shay J.W., and Werbin H. New evidence for the insertion of mitochondrial DNA into the human genome: significance for cancer and aging. Mutat Res 275 (1992) 227-235
    • (1992) Mutat Res , vol.275 , pp. 227-235
    • Shay, J.W.1    Werbin, H.2
  • 127
    • 1842583930 scopus 로고    scopus 로고
    • Large-scale mitochondrial DNA deletion mutations and nuclear genome instability in human breast cancer
    • Zhu W., Qin W., and Sauter E.R. Large-scale mitochondrial DNA deletion mutations and nuclear genome instability in human breast cancer. Cancer Detect Prev 28 (2004) 119-126
    • (2004) Cancer Detect Prev , vol.28 , pp. 119-126
    • Zhu, W.1    Qin, W.2    Sauter, E.R.3
  • 128
    • 13144260676 scopus 로고    scopus 로고
    • Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats
    • Crott J.W., Choi S.W., Branda R.F., and Mason J.B. Accumulation of mitochondrial DNA deletions is age, tissue and folate-dependent in rats. Mutat Res 570 (2005) 63-70
    • (2005) Mutat Res , vol.570 , pp. 63-70
    • Crott, J.W.1    Choi, S.W.2    Branda, R.F.3    Mason, J.B.4
  • 129
    • 14144251552 scopus 로고    scopus 로고
    • Folate supplementation increases genomic DNA methylation in the liver of elder rats
    • Choi S.W., Friso S., Keyes M.K., and Mason J.B. Folate supplementation increases genomic DNA methylation in the liver of elder rats. Br J Nutr 93 (2005) 31-35
    • (2005) Br J Nutr , vol.93 , pp. 31-35
    • Choi, S.W.1    Friso, S.2    Keyes, M.K.3    Mason, J.B.4
  • 130
    • 0032739329 scopus 로고    scopus 로고
    • CpG island methylator phenotypes in aging and cancer
    • Toyota M., and Issa J.P. CpG island methylator phenotypes in aging and cancer. Semin Cancer Biol 9 (1999) 349-357
    • (1999) Semin Cancer Biol , vol.9 , pp. 349-357
    • Toyota, M.1    Issa, J.P.2
  • 131
    • 36749025213 scopus 로고    scopus 로고
    • Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer
    • Shen L., Toyota M., Kondo Y., et al. Integrated genetic and epigenetic analysis identifies three different subclasses of colon cancer. Proc Natl Acad Sci U S A 104 (2007) 18654-18659
    • (2007) Proc Natl Acad Sci U S A , vol.104 , pp. 18654-18659
    • Shen, L.1    Toyota, M.2    Kondo, Y.3
  • 132
    • 55949124994 scopus 로고    scopus 로고
    • DNA methylation, epimutations and cancer predisposition
    • Dobrovic A., and Kristensen L.S. DNA methylation, epimutations and cancer predisposition. Int J Biochem Cell Biol 41 (2009) 34-39
    • (2009) Int J Biochem Cell Biol , vol.41 , pp. 34-39
    • Dobrovic, A.1    Kristensen, L.S.2
  • 134
    • 33748103002 scopus 로고    scopus 로고
    • Genetic variants in epigenetic genes and breast cancer risk
    • Cebrian A., Pharoah P.D., Ahmed S., et al. Genetic variants in epigenetic genes and breast cancer risk. Carcinogenesis 27 (2006) 1661-1669
    • (2006) Carcinogenesis , vol.27 , pp. 1661-1669
    • Cebrian, A.1    Pharoah, P.D.2    Ahmed, S.3
  • 135
    • 33846018546 scopus 로고    scopus 로고
    • Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer
    • Koushik A., Kraft P., Fuchs C.S., et al. Nonsynonymous polymorphisms in genes in the one-carbon metabolism pathway and associations with colorectal cancer. Cancer Epidemiol Biomarkers Prev 15 (2006) 2408-2417
    • (2006) Cancer Epidemiol Biomarkers Prev , vol.15 , pp. 2408-2417
    • Koushik, A.1    Kraft, P.2    Fuchs, C.S.3
  • 136
    • 34547850403 scopus 로고    scopus 로고
    • The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway
    • Siva A., De Lange M., Clayton D., Monteith S., Spector T., and Brown M.J. The heritability of plasma homocysteine, and the influence of genetic variation in the homocysteine methylation pathway. QJM 100 (2007) 495-499
    • (2007) QJM , vol.100 , pp. 495-499
    • Siva, A.1    De Lange, M.2    Clayton, D.3    Monteith, S.4    Spector, T.5    Brown, M.J.6
  • 137
    • 34548734299 scopus 로고    scopus 로고
    • Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing
    • Taylor K.H., Kramer R.S., Davis J.W., et al. Ultradeep bisulfite sequencing analysis of DNA methylation patterns in multiple gene promoters by 454 sequencing. Cancer Res 67 (2007) 8511-8518
    • (2007) Cancer Res , vol.67 , pp. 8511-8518
    • Taylor, K.H.1    Kramer, R.S.2    Davis, J.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.