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Volumn 3, Issue 12, 2001, Pages

The evolution of diverse biological responses to DNA damage: Insights from yeast and p53

Author keywords

[No Author keywords available]

Indexed keywords

DNA; PROTEIN P53;

EID: 0035195557     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1201-e277     Document Type: Review
Times cited : (328)

References (162)
  • 3
    • 0028198383 scopus 로고
    • Identification and characterisation of new elements involved in checkpoints and feedback controls in fission yeast
    • (1994) Mol. Biol. Cell , vol.5 , pp. 147-160
    • Al-Khodairy, F.1
  • 6
    • 0032004942 scopus 로고    scopus 로고
    • S-phase-specific activation of Cds1 kinase defines a subpathway of the checkpoint response in Schizosaccharomyces pombe
    • (1998) Genes Dev. , vol.12 , pp. 382-395
    • Lindsay, H.D.1
  • 7
    • 0032535157 scopus 로고    scopus 로고
    • Analysis of Rad3 and Chk1 protein kinases defines different checkpoint responses
    • (1998) EMBO J. , vol.17 , pp. 7239-7249
    • Martinho, R.G.1
  • 8
    • 0030664297 scopus 로고    scopus 로고
    • Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae
    • (1997) Genes Dev. , vol.11 , pp. 3032-3045
    • Sidorova, J.M.1    Breeden, L.L.2
  • 9
    • 0033527787 scopus 로고    scopus 로고
    • Control of the DNA damage checkpoint by chk1 and rad53 protein kinases through distinct mechanisms
    • (1999) Science , vol.286 , pp. 1166-1171
    • Sanchez, Y.1
  • 10
    • 0014416872 scopus 로고
    • Delayed initiation of DNA synthesis in irradiated human diploid cells
    • (1968) Nature , vol.146 , pp. 1064-1065
    • Little, J.B.1
  • 13
    • 0025345637 scopus 로고
    • Sensitivity of human diploid fibroblast cell strains from various genetic disorders to acute and protracted radiation exposure
    • (1990) Radiat. Res. , vol.123 , pp. 87-92
    • Little, J.B.1    Nove, J.2
  • 21
    • 0027258466 scopus 로고
    • Thymocyte apoptosis induced by p53-dependent and independent pathways
    • (1993) Nature , vol.362 , pp. 849-852
    • Clarke, A.R.1
  • 32
    • 0034664733 scopus 로고    scopus 로고
    • p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser46-phosphorylated p53
    • (2000) Cell , vol.102 , pp. 849-862
    • Oda, K.1
  • 33
    • 0034654623 scopus 로고    scopus 로고
    • PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family
    • (2000) Genes Dev. , vol.14 , pp. 704-718
    • Attardi, L.D.1
  • 37
    • 0033821977 scopus 로고    scopus 로고
    • A transactivation-deficient mouse model provides insights into Trp53 regulation and function
    • (2000) Nature Genet. , vol.26 , pp. 37-43
    • Jimenez, G.S.1
  • 38
    • 0034665461 scopus 로고    scopus 로고
    • p53 transcriptional activity is essential for p53-dependent apoptosis following DNA damage
    • (2000) EMBO J. , vol.19 , pp. 4967-4975
    • Chao, C.1
  • 39
    • 0027359827 scopus 로고
    • WAF1, a potential mediator of p53 tumor suppression
    • (1993) Cell , vol.75 , pp. 817-825
    • El-Deiry, W.S.1
  • 41
    • 0031310665 scopus 로고    scopus 로고
    • 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression
    • (1997) Mol. Cell , vol.1 , pp. 3-11
    • Hermeking, H.1
  • 43
    • 0034656243 scopus 로고    scopus 로고
    • Analysis of p53-regulated gene expression patterns using oligonucleotide arrays
    • (2000) Genes Dev. , vol.14 , pp. 981-993
    • Zhao, R.1
  • 44
    • 0033215387 scopus 로고    scopus 로고
    • Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
    • (1999) Genes Dev. , vol.13 , pp. 2490-2501
    • Murphy, M.1
  • 46
    • 0035252883 scopus 로고    scopus 로고
    • Structural and functional involvement of p53 in BER in vitro and in vivo
    • (2001) Oncogene , vol.20 , pp. 581-589
    • Offer, H.1
  • 48
    • 0034039040 scopus 로고    scopus 로고
    • Dial 9-1-1 for p53: Mechanisms of p53 activation by cellular stress
    • (2000) Neoplasia , vol.2 , pp. 208-225
    • Ljungman, M.1
  • 49
    • 0033579412 scopus 로고    scopus 로고
    • Regulation of the p53 tumor suppressor protein
    • (1999) J. Biol. Chem. , vol.274 , pp. 36031-36034
    • Oren, M.1
  • 51
    • 0030797585 scopus 로고    scopus 로고
    • Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain
    • (1997) Cell , vol.90 , pp. 595-606
    • Gu, W.1    Roeder, R.G.2
  • 52
    • 0034881964 scopus 로고    scopus 로고
    • Transcriptional regulation by p53 through intrinsic DNA/chromatin binding and site-directed cofactor recruitment
    • (2001) Mol. Cell , vol.8 , pp. 57-69
    • Espinosa, J.M.1    Emerson, B.M.2
  • 55
    • 0033559256 scopus 로고    scopus 로고
    • A leucine-rich nuclear export signal in the p53 tetramerization domain: Regulation of subcellular localization and p53 activity by NES masking
    • (1999) EMBO J. , vol.18 , pp. 1660-1672
    • Stommel, J.M.1
  • 59
    • 0034624678 scopus 로고    scopus 로고
    • Activity of MDM2, a ubiquitin ligase, toward p53 or itself is dependent on the RING finger domain of the ligase
    • (2000) Oncogene , vol.19 , pp. 1473-1476
    • Honda, R.1    Yasuda, H.2
  • 65
    • 0030575937 scopus 로고    scopus 로고
    • Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain
    • (1996) Science , vol.274 , pp. 948-953
    • Kussie, P.H.1
  • 66
    • 0027325132 scopus 로고
    • Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53
    • (1993) Nature , vol.362 , pp. 857-860
    • Oliner, J.D.1
  • 69
    • 0032169459 scopus 로고    scopus 로고
    • JNK targets p53 ubiquitination and degradation in nonstressed cells
    • (1998) Genes Dev. , vol.12 , pp. 2658-2663
    • Fuchs, S.Y.1
  • 71
    • 0033523015 scopus 로고    scopus 로고
    • Oligomerization is required for p53 to be efficiently ubiquitinated by MDM2
    • (1999) J. Biol. Chem. , vol.274 , pp. 16531-16535
    • Maki, C.G.1
  • 76
    • 0032238342 scopus 로고    scopus 로고
    • The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily
    • (1998) Mol. Cell , vol.2 , pp. 869-875
    • Vassilev, A.1
  • 77
    • 0032906633 scopus 로고    scopus 로고
    • p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 1202-1209
    • Liu, L.1
  • 79
    • 0035903157 scopus 로고    scopus 로고
    • Human mdm2 Mediates Multiple Mono-ubiquitination of p53 by a Mechanism Requiring Enzyme Isomerization
    • (2001) J. Biol. Chem. , vol.276 , pp. 31357-31367
    • Lai, Z.1
  • 83
    • 0034863683 scopus 로고    scopus 로고
    • Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
    • (2001) Nature Genet , vol.29 , pp. 92-95
    • Parant, J.1
  • 84
    • 0032185124 scopus 로고    scopus 로고
    • p300/MDM2 complexes participate in MDM2-mediated p53 degradation
    • (1998) Mol. Cell , vol.2 , pp. 405-415
    • Grossman, S.R.1
  • 88
    • 0035339357 scopus 로고    scopus 로고
    • ATM-dependent phosphorylation of Mdm2 on serine 395: Role in p53 activation by DNA damage
    • (2001) Genes Dev. , vol.15 , pp. 1067-1077
    • Maya, R.1
  • 92
    • 0033521621 scopus 로고    scopus 로고
    • Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53
    • (1999) EMBO J. , vol.18 , pp. 22-27
    • Honda, R.1    Yasuda, H.2
  • 93
    • 0035266308 scopus 로고    scopus 로고
    • Increased oxidative stress in ataxia telangiectasia evidenced by alterations in redox state of brains from Atm-deficient mice
    • (2001) Cancer Res. , vol.61 , pp. 1849-1854
    • Kamsler, A.1
  • 95
    • 0033562997 scopus 로고    scopus 로고
    • Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
    • (1999) Cancer Res. , vol.59 , pp. 2464-2469
    • Kamijo, T.1
  • 96
    • 0035905742 scopus 로고    scopus 로고
    • Ataxia-telangiectasia: Chronic activation of damage-responsive functions is reduced by alpha-lipoic acid
    • (2001) Oncogene , vol.20 , pp. 289-294
    • Gatei, M.1
  • 98
    • 0030728468 scopus 로고    scopus 로고
    • Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF
    • (1997) Cell , vol.91 , pp. 649-659
    • Kamijo, T.1
  • 99
    • 0034632717 scopus 로고    scopus 로고
    • Telomere dysfunction promotes non-reciprocal translocations and epithelial cancers in mice
    • (2000) Nature , vol.406 , pp. 641-645
    • Artandi, S.E.1
  • 101
    • 0033553516 scopus 로고    scopus 로고
    • p53 deficiency rescues the adverse effects of telomere loss and cooperates with telomere dysfunction to accelerate carcinogenesis
    • (1999) Cell , vol.97 , pp. 527-538
    • Chin, L.1
  • 104
    • 0032508608 scopus 로고    scopus 로고
    • Activation of the ATM kinase by ionizing radiation and phosphorylation of p53
    • (1998) Science , vol.281 , pp. 1677-1679
    • Canman, C.E.1
  • 105
    • 0032508504 scopus 로고    scopus 로고
    • Enhanced phosphorylation of p53 by ATM in response to DNA damage
    • (1998) Science , vol.281 , pp. 1674-1677
    • Banin, S.1
  • 107
    • 0033555260 scopus 로고    scopus 로고
    • A role for ATR in the DNA damage-induced phosphorylation of p53
    • (1999) Genes Dev. , vol.13 , pp. 152-157
    • Tibbetts, R.S.1
  • 113
    • 0034629072 scopus 로고    scopus 로고
    • DNA damage-induced activation of p53 by the checkpoint kinase Chk2
    • (2000) Science , vol.287 , pp. 1824-1827
    • Hirao, A.1
  • 115
    • 0033119627 scopus 로고    scopus 로고
    • Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2
    • (1999) EMBO J. , vol.18 , pp. 1805-1814
    • Unger, T.1
  • 117
    • 0033601346 scopus 로고    scopus 로고
    • Heterozygous germ line hCHK2 mutations in Li-Fraumeni syndrome
    • (1999) Science , vol.286 , pp. 2528-2531
    • Bell, D.W.1
  • 121
    • 0032504783 scopus 로고    scopus 로고
    • p14ARF links the tumour suppressors RB and p53
    • (1998) Nature , vol.395 , pp. 124-125
    • Bates, S.1
  • 124
    • 0026496885 scopus 로고
    • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
    • (1992) Cell , vol.71 , pp. 587-597
    • Kastan, M.B.1
  • 125
    • 0027332996 scopus 로고
    • Differential induction of transcriptionally active p53 following UV or ionizing radiation: Defects in chromosome instability syndromes?
    • (1993) Cell , vol.75 , pp. 765-778
    • Lu, X.1    Lane, D.P.2
  • 126
    • 0030874616 scopus 로고    scopus 로고
    • p53-mediated accumulation of hypophosphorylated pRb after the G1 restriction point fails to halt cell cycle progression
    • (1997) Oncogene , vol.15 , pp. 337-345
    • Linke, S.P.1
  • 128
    • 0035219571 scopus 로고    scopus 로고
    • Radiation-induced senescence-like growth arrest requires TP53 function but not telomere shortening
    • (2001) Radiat. Res. , vol.155 , pp. 248-253
    • Suzuki, K.1
  • 133
    • 0029858143 scopus 로고    scopus 로고
    • V(D)J recombination activates a p53-dependent DNA damage checkpoint in scid lymphocyte precursors
    • (1996) Genes Dev. , vol.10 , pp. 2038-2054
    • Guidos, C.J.1
  • 136
    • 0029003061 scopus 로고
    • Increased and altered DNA binding of human p53 by S and G2/M but not G1 cyclin-dependent kinases
    • (1995) Nature , vol.376 , pp. 88-91
    • Wang, Y.1    Prives, C.2
  • 137
    • 7344231094 scopus 로고    scopus 로고
    • Differential p53 phosphorylation and activation of apoptosis-promoting genes Bax and Fas/APO-1 by irradiation and ara-C treatment
    • (1998) Cell Death Differ. , vol.5 , pp. 584-591
    • Kobayashi, T.1
  • 138
    • 20244385424 scopus 로고    scopus 로고
    • Drosophila p53 is a structural and functional homolog of the tumor suppressor p53
    • (2000) Cell , vol.101 , pp. 91-101
    • Ollmann, M.1
  • 139
    • 0034737292 scopus 로고    scopus 로고
    • Drosophila p53 binds a damage response element at the reaper locus
    • (2000) Cell , vol.101 , pp. 103-113
    • Brodsky, M.H.1
  • 145
    • 0035140981 scopus 로고    scopus 로고
    • Regulation of p53 by hypoxia: Dissociation of transcriptional repression and apoptosis from p53-dependent transactivation
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 1297-1310
    • Koumenis, C.1
  • 146
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1- phase checkpoint by low-oxygen conditions is independent of p53 status
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1
  • 150
    • 0026642195 scopus 로고
    • Induction of apoptosis in fibroblasts by c-myc protein
    • (1992) Cell , vol.69 , pp. 119-128
    • Evan, G.I.1
  • 155
    • 0028089984 scopus 로고
    • Overexpression of c-myc precedes amplification of the gene encoding dihydrofolate reductase
    • (1994) Gene , vol.148 , pp. 253-260
    • Mai, S.1
  • 159
    • 0034644506 scopus 로고    scopus 로고
    • Opposing effects of Ras on p53: Transcriptional activation of mdm2 and induction of p19ARF
    • (2000) Cell , vol.103 , pp. 321-330
    • Ries, S.1
  • 162
    • 0034745050 scopus 로고    scopus 로고
    • Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2743-2754
    • Buschmann, T.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.