Genomic instability: On the birth and death of cancer

Clinical and Translational Oncology

Volumn 9, Issue 4, 2007, Pages 216-220

  Murga, M ^a   Fernandez Capetillo O ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

Author keywords

Cancer; DNA damage response; Genomic instability; Oncogene induced senescence

Indexed keywords

ATM PROTEIN; CYCLIN E; GENOMIC DNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN TYROSINE PHOSPHATASE; RAS PROTEIN; TRANSCRIPTION FACTOR E2F1; TUMOR SUPPRESSOR PROTEIN;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER GENETICS; CANCER RESEARCH; CARCINOGENESIS; CHROMOSOMAL INSTABILITY; DNA REPAIR; DNA REPLICATION; DRUG TARGETING; GENE MUTATION; GENETIC ANALYSIS; GENETIC PREDISPOSITION; GENOMIC INSTABILITY; GERM LINE; HUMAN; MALIGNANT NEOPLASTIC DISEASE; MICROSATELLITE INSTABILITY; NONHUMAN; OVARY CANCER; SIGNAL TRANSDUCTION; B CELL LYMPHOMA; BREAST TUMOR; CELL AGING; CLINICAL TRIAL; COMPARATIVE STUDY; DNA DAMAGE; FEMALE; GENETICS; MALE; MUTATION; NEOPLASM; ONCOGENE; PRECANCER; REVIEW; SPECTRAL KARYOTYPING;

BREAST NEOPLASMS; CELL AGING; CLINICAL TRIALS; DNA DAMAGE; DNA REPAIR; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENETIC RESEARCH; GENOMIC INSTABILITY; HUMANS; LYMPHOMA, B-CELL; MALE; MUTATION; NEOPLASMS; ONCOGENES; PRECANCEROUS CONDITIONS; SPECTRAL KARYOTYPING;

EID: 34447108090     PISSN: 1699048X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12094-007-0042-3     Document Type: Article

References (37)

1. Boveri T (1914) Zur Frage der Entstehung maligner tumoren. Gustav Fischer Verlag, Germany
2. Reddy EP, Reynolds RK, Santos E, Barbacid M (1982) A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene. Nature 300:149-152
3. Tabin CJ, Bradley SM, Bargmann CI et al (1982) Mechanism of activation of a human oncogene. Nature 300:143-149
4. Taparowsky E, Suard Y, Fasano O et al (1982) Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature 300:762-765
5. Friend SH, Bernards R, Rogelj S et al (1986) A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323:643-646
6. Sieber OM, Heinimann K, Tomlinson IP (2003) Genomic instability - the engine of tumorigenesis? Nat Rev Cancer 3:701-708
7. Vogelstein B, Fearon ER, Hamilton SR et al (1988) Genetic alterations during colorectal-tumor development. N Engl J Med 319:525-532
8. Goessel G, Quante M, Hahn WC et al (2005) Creating oral squamous cancer cells: A cellular model of oral-esophageal carcinogenesis. Proc Natl Acad Sci U S A 102:15599-15604
9. Boehm JS, Hession MT, Bulmer SE, Hahn WC (2005) Transformation of human and murine fibroblasts without viral oncoproteins. Mol Cell Biol 25:6464-6474
10. Elenbaas B, Spirio L, Koerner F et al (2001) Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells. Genes Dev 15:50-65
11. Hahn WC, Counter CM, Lundberg AS et al (1999) Creation of human tumour cells with defined genetic elements. Nature 400:464-468
12. Liu J, Yang G, Thompson-Lanza JA et al (2004) A genetically defined model for human ovarian cancer. Cancer Res 64:1655-1663
13. Zimonjic D, Brooks MW, Popescu N et al (2001) Derivation of human tumor cells in vitro without widespread genomic instability. Cancer Res 61: 8838-8844
14. Sjoblom T, Jones S, Wood LD et al (2006) The consensus coding sequences of human breast and colorectal cancers. Science 314:268-274
15. Markowitz S (2000) DNA repair defects inactivate tumor suppressor genes and induce hereditary and sporadic colon cancers. J Clin Oncol 18:75S-80S
16. Hoeijmakers JH (2001) Genome maintenance mechanisms for preventing cancer. Nature 411: 366-374
17. Prolla TA, Baker SM, Harris AC et al (1998) Tumour susceptibility and spontaneous mutation in mice deficient in Mlh1, Pms1 and Pms2 DNA mismatch repair. Nat Genet 18:276-279
18. Baker SM, Plug AW, Prolla TA et al (1996) Involvement of mouse Mlh1 in DNA mismatch repair and meiotic crossing over. Nat Genet 13: 336-342
19. Connor F, Bertwistle D, Mee PJ et al (1997) Tumorigenesis and a DNA repair defect in mice with a truncating Brca2 mutation. Nat Genet 17: 423-430
20. Edelmann W, Yang K, Umar A et al (1997) Mutation in the mismatch repair gene Msh6 causes cancer susceptibility. Cell 91:467-477
21. de Vries A, van Oostrom CT, Hofhuis FM et al (1995) Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377:169-173
22. Celeste A, Difilippantonio S, Difilippantonio MJ et al (2003) H2AX haploinsufficiency modifies genomic stability and tumor susceptibility. Cell 114:371-383
23. Barlow C, Hirotsune S, Paylor R et al (1996) ATM-deficient mice: A paradigm of ataxia telangiectasia. Cell 86:159-171
24. Greenman C, Stephens P, Smith R et al (2007) Patterns of somatic mutation in human cancer genomes. Nature 446:153-158
25. Vafa O, Wade M, Kern S et al (2002) c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: A mechanism for oncogene-induced genetic instability. Mol Cell 9:1031-1044
26. Di Micco R, Fumagalli M, Cicalese A et al (2006) Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication. Nature 444:638-642
27. Bartkova J, Rezaei N, Liontos M et al (2006) Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444:633-637
28. Bartkova J, Horejsi Z, Koed K et al (2005) DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. Nature 434:864-870
29. Puc J, Keniry M, Li HS et al (2005) Lack of PTEN sequesters CHK1 and initiates genetic instability. Cancer Cell 7:193-204
30. Pickering MT, Kowalik TF (2006) Rb inactivation leads to E2F1-mediated DNA double-strand break accumulation. Oncogene 25:746-755
31. Gorgoulis VG, Vassiliou LV, Karakaidos P et al (2005) Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434:907-913
32. Pusapati RV, Rounbehler RJ, Hong S et al (2006) ATM promotes apoptosis and suppresses tumorigenesis in response to Myc. Proc Natl Acad Sci U S A 103:1446-1451
33. Chen Z, Trotman LC, Shaffer D et al (2005) Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis. Nature 436:725-730
34. Michaloglou C, Vredeveld LC, Soengas MS et al (2005) BRAFE600-associated senescence-like cell cycle arrest of human naevi. Nature 436: 720-724
35. Collado M, Gil J, Efeyan A et al (2005) Tumour biology: Senescence in premalignant tumours. Nature 436:642
36. Bryant HE, Schultz N, Thomas HD et al (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434:913-917
37. Farmer H, McCabe N, Lord CJ et al (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434:917-921