Cisplatin-induced premature senescence with concomitant reduction of gap junctions in human fibroblasts

Cell Research

Volumn 14, Issue 1, 2004, Pages 60-66

  Zhao, Wei ^a   Lin, Zhong Xiang ^a   Zhang, Zhi Qian ^a  

^a PEKING UNIVERSITY CANCER HOSPITAL AND INSTITUTE   (China)

Author keywords

Cisplatin; Connexin 43; Fibroblasts; Gap junction; Intercellular communication; Premature senescence

Indexed keywords

4',6 DIAMIDINO 2 PHENYLINDOLE; CISPLATIN; CONNEXIN 43; INDOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; LUCIFER YELLOW; PROTEIN P53;

APOPTOSIS; ARTICLE; CELL AGING; CELL COMMUNICATION; CELL CULTURE; CELL CYCLE; CELL DIVISION; CELL JUNCTION; CELL MEMBRANE; CHEMISTRY; CYTOLOGY; DRUG EFFECT; FIBROBLAST; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; MITOSIS; TRANSPORT AT THE CELLULAR LEVEL;

APOPTOSIS; BIOLOGICAL TRANSPORT; CELL AGING; CELL COMMUNICATION; CELL CYCLE; CELL DIVISION; CELL MEMBRANE; CELLS, CULTURED; CISPLATIN; CONNEXIN 43; FIBROBLASTS; FLOW CYTOMETRY; GAP JUNCTIONS; HUMANS; IMMUNOHISTOCHEMISTRY; INDOLES; ISOQUINOLINES; MICROSCOPY, FLUORESCENCE; MITOSIS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 11144290236     PISSN: 10010602     EISSN: 17487838     Source Type: Journal    
DOI: 10.1038/sj.cr.7290203     Document Type: Article

References (27)

1. Hayflick L, The limited in vitro lifetime of human diploid cell strains. Exp Cell Res 1965; 37:614-36.
2. Smith JR, Pereira-Smith OM, Replicative senescence implications for in vivo aging and tumor suppression. Science 1996; 273:63-7.
3. Yeo EJ, Hwang YC, Kang CM, et al. Senescence-like changes induced by hydroxyurea in human diploid fibroblasts. Exp Gerontol 2000; 35:553-71.
4. 2-induced senescent-like growth arrest in normal human fibroblasts: p53 and Rb control G1 arrest but not cell replication. Biochem J 1998; 332:43-50.
5. Saretzki G, Feng J, Zglinicki T, et al. Similar gene expression pattern in senescent and hyperoxic-treated fibroblasts. J. Gerontol. Series A- Biol Sci & Med Sci 1998; 53(6):B438-42.
6. Wang X, Liu Y, Chow LS , et al. Cisplatin-induced p53-independent growth arrest and cell death in cancer cells. Intl J Oncol 1999; 15:1097-102.
7. Meenakshi J, Nupama A, Goswami SK, Datta K, Constitutive expression of hyluronan binding protein 1 (HABP1/p32/gC1qR) in normal fibroblast cells perturbs its growth characters and induces apoptosis. BBRC 2003; 300(3):686-93.
8. Chang LC, Sheu HM, Huang YS, Tsai TR, Kuo KW, A novel function of emodin: enhancement of the nucleotide excision repair of UV- and cisplatin-induced DNA damage in human cells. Biochemical Pharmacology 1999; 58(1):49-57.
9. Naus CG, Gap junctions and tumour progression. Can J Physiol Pharmacol 2002; 80:136-41.
10. Wilson MR, Close TW, Trosko JE , Cell population dynamics (apoptosis, mitosis, and cell-cell communication) during disruption of homeostasis. Exp Cell Res 2000; 254:257-68.
11. Statuto M, Bianchi C, Perego R, Monte UD, Drop of connexin 43 in replicative senescence of human fibroblasts HEL-299 as a possible biomarker of senescence. Exp Gerontol 2002; 37:1113-20.
12. Xie HQ, Hu VW, Modulation of gap junctions in senescent endothelial cells. Exp Cell Res 1994; 214 (1):172-6.
13. Zhang ZQ, LIN ZX, Lu YY, Meng SN, Han YL , Expression of gap junction protein CX43 in cultured normal human embryonic lung cells and lung carcinoma cells. Acta Biophysica Sinica 1994; 10(3):411-6.
14. Zhang WJ, Zhang ZQ, Lin ZX, et al. Correlation between expression of cadherin and gap junctional communication in human lung carcinoma cells. Science in CHINA (series C) 1998; 41(4): 419-25.
15. Chang CC, Ruth E, Gibson-D A, et al. Growth-promoting effect of 12-O-tetradecanoylphorbol-13-acetate on cultured normal human fetal kidney epithelial cells. Cancer Res 1986; 46:6360-3.
16. Tepper CG, Seldin MF, Mudryj M, Fas-mediated apoptosis of proliferating, transiently growth-arrested, and senescent normal human fibroblasts. Exp Cell Res 2000; 260:9-19.
17. Storz P, Döppler H, Horn-Müller J, et al. TNF down-regulation of receptor tyrosine kinase-dependent mitogenic signal pathways as an important step in cytostasis induction and commitment to apoptosis of Kym-1 rhabdomyosarcoma cells. Cell Death and Differentiation 2000; 7:955-65.
18. EL-Fouly MH, Trosko JE, Chang CC, Scrape-loading and dye transfer: A rapid and simple technique to study gap junctional intercellular communication. Exp Cell Res 1987; 168:422-30.
19. Trosko JE, Chang CC, Wilson MR, et al, Gap junctions and the regulation of cellular functions of stem cells during development and differentiation. Methods 2000; 20:245-264.
20. Lin ZX , Zhang ZQ, Yu KR, et al. Increased junctional communication and forced expression of connexin 43 retards cell growth and enhances myogenic differentiation in rhabdomyosarcoma cells. Progress in Cell Research 1995; Vol. 4 , pp. 31-35. edts. Y. Kanno, et al., Elsevier Science B. V. press.
21. Lakin ND, Jackson SP, Regulation of p53 in response to DNA damage. Oncogene 1999; 18:7644-55.
22. Kuliu KS, Lehman JM, Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res 1995; 217:336-45.
23. 16INK4a-, and telomere-regulating genes in replicative senescent primary human, mouse, and chicken fibroblast cells. Exp Cell Res 2002; 272:199-208.
24. Watanable H, Tonosaki A, Gap junction in the apoptosis: TEM observation of membrana-granulosa cells of mouse ovarian follicle. in "Progress in Cell Research" 1995; Vol. 4, pp37-40. Elsevier BV. Edts: Kanno Y. et al., Elsevier Science B. V. press
25. Yasui K, Kada K, Hojo M, et al,. Cell-to-cell interaction prevents cell death in cultured neonatal rat ventricular myocytes. Cardiovascular Research 2000; 48:68-76.
26. Sai K, Kang KS, Hirose A, et al., Inhibition of apoptosis by pentachlorophenol in v-myc-transfected rat liver epithelial cells: relation to down-regulation of gap junctional intercellular communication. Cancer Letters 2001; 173(2):163-74.
27. Krutovskikh VA, Piccoli C, Yamasaki H, et al. Gap junction intercellular communication propagates cell death in cancerous cells. Oncogene 2002; 21 (13):1989-99.