-
2
-
-
33947127410
-
Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells
-
Arias E.E., and Walter J.C. Strength in numbers: preventing rereplication via multiple mechanisms in eukaryotic cells. Genes Dev. 21 (2007) 497-518
-
(2007)
Genes Dev.
, vol.21
, pp. 497-518
-
-
Arias, E.E.1
Walter, J.C.2
-
3
-
-
0028314007
-
Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites
-
Bailly V., Lamb J., Sung P., Prakash S., and Prakash L. Specific complex formation between yeast RAD6 and RAD18 proteins: a potential mechanism for targeting RAD6 ubiquitin-conjugating activity to DNA damage sites. Genes Dev. 8 (1994) 811-820
-
(1994)
Genes Dev.
, vol.8
, pp. 811-820
-
-
Bailly, V.1
Lamb, J.2
Sung, P.3
Prakash, S.4
Prakash, L.5
-
4
-
-
0037472924
-
DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation
-
Bakkenist C.J., and Kastan M.B. DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation. Nature 421 (2003) 499-506
-
(2003)
Nature
, vol.421
, pp. 499-506
-
-
Bakkenist, C.J.1
Kastan, M.B.2
-
5
-
-
35848949304
-
DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'
-
Bartek J., Lukas J., and Bartkova J. DNA damage response as an anti-cancer barrier: damage threshold and the concept of 'conditional haploinsufficiency'. Cell Cycle 6 (2007) 2344-2347
-
(2007)
Cell Cycle
, vol.6
, pp. 2344-2347
-
-
Bartek, J.1
Lukas, J.2
Bartkova, J.3
-
6
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen S., Lukas C., Kitagawa R., Melander F., Kastan M.B., Bartek J., and Lukas J. Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J. Cell Biol. 173 (2006) 195-206
-
(2006)
J. Cell Biol.
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
Lukas, C.2
Kitagawa, R.3
Melander, F.4
Kastan, M.B.5
Bartek, J.6
Lukas, J.7
-
7
-
-
0035034417
-
UBA domains of DNA damage-inducible proteins interact with ubiquitin
-
Bertolaet B.L., Clarke D.J., Wolff M., Watson M.H., Henze M., Divita G., and Reed S.I. UBA domains of DNA damage-inducible proteins interact with ubiquitin. Nat. Struct. Biol. 8 (2001) 417-422
-
(2001)
Nat. Struct. Biol.
, vol.8
, pp. 417-422
-
-
Bertolaet, B.L.1
Clarke, D.J.2
Wolff, M.3
Watson, M.H.4
Henze, M.5
Divita, G.6
Reed, S.I.7
-
8
-
-
29144499065
-
Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis
-
Bienko M., Green C.M., Crosetto N., Rudolf F., Zapart G., Coull B., Kannouche P., Wider G., Peter M., Lehmann A.R., et al. Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis. Science 310 (2005) 1821-1824
-
(2005)
Science
, vol.310
, pp. 1821-1824
-
-
Bienko, M.1
Green, C.M.2
Crosetto, N.3
Rudolf, F.4
Zapart, G.5
Coull, B.6
Kannouche, P.7
Wider, G.8
Peter, M.9
Lehmann, A.R.10
-
9
-
-
34249946978
-
Interplay of replication checkpoints and repair proteins at stalled replication forks
-
Branzei D., and Foiani M. Interplay of replication checkpoints and repair proteins at stalled replication forks. DNA Repair (Amst.) 6 (2007) 994-1003
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 994-1003
-
-
Branzei, D.1
Foiani, M.2
-
10
-
-
18244371925
-
Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint
-
Byun T.S., Pacek M., Yee M.C., Walter J.C., and Cimprich K.A. Functional uncoupling of MCM helicase and DNA polymerase activities activates the ATR-dependent checkpoint. Genes Dev. 19 (2005) 1040-1052
-
(2005)
Genes Dev.
, vol.19
, pp. 1040-1052
-
-
Byun, T.S.1
Pacek, M.2
Yee, M.C.3
Walter, J.C.4
Cimprich, K.A.5
-
11
-
-
34347258156
-
Emerging links between the biological clock and the DNA damage response
-
Collis S.J., and Boulton S.J. Emerging links between the biological clock and the DNA damage response. Chromosoma 116 (2007) 331-339
-
(2007)
Chromosoma
, vol.116
, pp. 331-339
-
-
Collis, S.J.1
Boulton, S.J.2
-
13
-
-
0029808466
-
Cell cycle checkpoints: preventing an identity crisis
-
Elledge S.J. Cell cycle checkpoints: preventing an identity crisis. Science 274 (1996) 1664-1672
-
(1996)
Science
, vol.274
, pp. 1664-1672
-
-
Elledge, S.J.1
-
14
-
-
33750617461
-
DNA-damage control: Claspin destruction turns off the checkpoint
-
Gewurz B.E., and Harper J.W. DNA-damage control: Claspin destruction turns off the checkpoint. Curr. Biol. 16 (2006) R932-R934
-
(2006)
Curr. Biol.
, vol.16
-
-
Gewurz, B.E.1
Harper, J.W.2
-
15
-
-
34247577746
-
The Fanconi family adds a fraternal twin
-
Grompe M., and van de Vrugt H. The Fanconi family adds a fraternal twin. Dev. Cell 12 (2007) 661-662
-
(2007)
Dev. Cell
, vol.12
, pp. 661-662
-
-
Grompe, M.1
van de Vrugt, H.2
-
16
-
-
33645960654
-
Stabilizers and destabilizers controlling cell cycle oscillators
-
Guardavaccaro D., and Pagano M. Stabilizers and destabilizers controlling cell cycle oscillators. Mol. Cell 22 (2006) 1-4
-
(2006)
Mol. Cell
, vol.22
, pp. 1-4
-
-
Guardavaccaro, D.1
Pagano, M.2
-
17
-
-
33645708319
-
Regulation of monoubiquitinated PCNA by DUB autocleavage
-
Huang T.T., Nijman S.M., Mirchandani K.D., Galardy P.J., Cohn M.A., Haas W., Gygi S.P., Ploegh H.L., Bernards R., and D'Andrea A.D. Regulation of monoubiquitinated PCNA by DUB autocleavage. Nat. Cell Biol. 8 (2006) 339-347
-
(2006)
Nat. Cell Biol.
, vol.8
, pp. 339-347
-
-
Huang, T.T.1
Nijman, S.M.2
Mirchandani, K.D.3
Galardy, P.J.4
Cohn, M.A.5
Haas, W.6
Gygi, S.P.7
Ploegh, H.L.8
Bernards, R.9
D'Andrea, A.D.10
-
18
-
-
36249031962
-
RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
-
10.1016/j.cell.2007.09.041 in press. Published online November 13, 2007
-
Huen M.S., Grant R., Manke I., Minn K., Yu X., Yaffe M.B., and Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell (2007) 10.1016/j.cell.2007.09.041 in press. Published online November 13, 2007
-
(2007)
Cell
-
-
Huen, M.S.1
Grant, R.2
Manke, I.3
Minn, K.4
Yu, X.5
Yaffe, M.B.6
Chen, J.7
-
19
-
-
9244252580
-
Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks
-
Huyen Y., Zgheib O., Ditullio Jr. R.A., Gorgoulis V.G., Zacharatos P., Petty T.J., Sheston E.A., Mellert H.S., Stavridi E.S., and Halazonetis T.D. Methylated lysine 79 of histone H3 targets 53BP1 to DNA double-strand breaks. Nature 432 (2004) 406-411
-
(2004)
Nature
, vol.432
, pp. 406-411
-
-
Huyen, Y.1
Zgheib, O.2
Ditullio Jr., R.A.3
Gorgoulis, V.G.4
Zacharatos, P.5
Petty, T.J.6
Sheston, E.A.7
Mellert, H.S.8
Stavridi, E.S.9
Halazonetis, T.D.10
-
20
-
-
0037115914
-
Homologous repair of DNA damage and tumorigenesis: the BRCA connection
-
Jasin M. Homologous repair of DNA damage and tumorigenesis: the BRCA connection. Oncogene 21 (2002) 8981-8993
-
(2002)
Oncogene
, vol.21
, pp. 8981-8993
-
-
Jasin, M.1
-
21
-
-
36749084931
-
Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase
-
10.1126/science.1150034 in press. Published online November 15, 2007
-
Kolas N.K., Chapman J.R., Nakada S., Ylanko J., Chahwan R., Sweeney F.D., Panier S., Mendez M., Wildenhain J., Thomson T.M., et al. Orchestration of the DNA-damage response by the RNF8 ubiquitin ligase. Science (2007) 10.1126/science.1150034 in press. Published online November 15, 2007
-
(2007)
Science
-
-
Kolas, N.K.1
Chapman, J.R.2
Nakada, S.3
Ylanko, J.4
Chahwan, R.5
Sweeney, F.D.6
Panier, S.7
Mendez, M.8
Wildenhain, J.9
Thomson, T.M.10
-
22
-
-
0033634679
-
Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts
-
Kumagai A., and Dunphy W.G. Claspin, a novel protein required for the activation of Chk1 during a DNA replication checkpoint response in Xenopus egg extracts. Mol. Cell 6 (2000) 839-849
-
(2000)
Mol. Cell
, vol.6
, pp. 839-849
-
-
Kumagai, A.1
Dunphy, W.G.2
-
23
-
-
33644757806
-
TopBP1 activates the ATR-ATRIP complex
-
Kumagai A., Lee J., Yoo H.Y., and Dunphy W.G. TopBP1 activates the ATR-ATRIP complex. Cell 124 (2006) 943-955
-
(2006)
Cell
, vol.124
, pp. 943-955
-
-
Kumagai, A.1
Lee, J.2
Yoo, H.Y.3
Dunphy, W.G.4
-
24
-
-
34249944668
-
Arrested replication fork processing: interplay between checkpoints and recombination
-
Lambert S., Froget B., and Carr A.M. Arrested replication fork processing: interplay between checkpoints and recombination. DNA Repair (Amst.) 6 (2007) 1042-1061
-
(2007)
DNA Repair (Amst.)
, vol.6
, pp. 1042-1061
-
-
Lambert, S.1
Froget, B.2
Carr, A.M.3
-
25
-
-
17644409069
-
ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex
-
Lee J.H., and Paull T.T. ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex. Science 308 (2005) 551-554
-
(2005)
Science
, vol.308
, pp. 551-554
-
-
Lee, J.H.1
Paull, T.T.2
-
26
-
-
33947532026
-
Histone acetyltransferase complexes: one size doesn't fit all
-
Lee K.K., and Workman J.L. Histone acetyltransferase complexes: one size doesn't fit all. Nat. Rev. Mol. Cell Biol. 8 (2007) 284-295
-
(2007)
Nat. Rev. Mol. Cell Biol.
, vol.8
, pp. 284-295
-
-
Lee, K.K.1
Workman, J.L.2
-
27
-
-
36248966246
-
RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
-
10.1016/j.cell.2007.09.040 in press. Published November 13, 2007
-
Mailand N., Bekker-Jensen S., Faustrup H., Melander F., Bartek J., Lukas C., and Lukas J. RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins. Cell (2007) 10.1016/j.cell.2007.09.040 in press. Published November 13, 2007
-
(2007)
Cell
-
-
Mailand, N.1
Bekker-Jensen, S.2
Faustrup, H.3
Melander, F.4
Bartek, J.5
Lukas, C.6
Lukas, J.7
-
28
-
-
33845607102
-
The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint
-
Majka J., Niedziela-Majka A., and Burgers P.M. The checkpoint clamp activates Mec1 kinase during initiation of the DNA damage checkpoint. Mol. Cell 24 (2006) 891-901
-
(2006)
Mol. Cell
, vol.24
, pp. 891-901
-
-
Majka, J.1
Niedziela-Majka, A.2
Burgers, P.M.3
-
29
-
-
34249947699
-
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
-
Matsuoka S., Ballif B.A., Smogorzewska A., McDonald III E.R., Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., and Elledge S.J. ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 316 (2007) 1160-1166
-
(2007)
Science
, vol.316
, pp. 1160-1166
-
-
Matsuoka, S.1
Ballif, B.A.2
Smogorzewska, A.3
McDonald III, E.R.4
Hurov, K.E.5
Luo, J.6
Bakalarski, C.E.7
Zhao, Z.8
Solimini, N.9
Lerenthal, Y.10
Shiloh, Y.11
Gygi, S.P.12
Elledge, S.J.13
-
30
-
-
34249066085
-
PCNA, the maestro of the replication fork
-
Moldovan G.L., Pfander B., and Jentsch S. PCNA, the maestro of the replication fork. Cell 18 (2007) 665-679
-
(2007)
Cell
, vol.18
, pp. 665-679
-
-
Moldovan, G.L.1
Pfander, B.2
Jentsch, S.3
-
31
-
-
33646777679
-
Rapid activation of ATR by ionizing radiation requires ATM and Mre11
-
Myers J.S., and Cortez D. Rapid activation of ATR by ionizing radiation requires ATM and Mre11. J. Biol. Chem. 281 (2006) 9346-9350
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 9346-9350
-
-
Myers, J.S.1
Cortez, D.2
-
32
-
-
33847727050
-
Ubiquitin proteasome system (UPS): what can chromatin do for you?
-
O'Connell B.C., and Harper J.W. Ubiquitin proteasome system (UPS): what can chromatin do for you?. Curr. Opin. Cell Biol. 19 (2007) 206-214
-
(2007)
Curr. Opin. Cell Biol.
, vol.19
, pp. 206-214
-
-
O'Connell, B.C.1
Harper, J.W.2
-
33
-
-
34249934450
-
Cell signaling: a touching response to damage
-
Petrini J.H. Cell signaling: a touching response to damage. Science 316 (2007) 1138-1139
-
(2007)
Science
, vol.316
, pp. 1138-1139
-
-
Petrini, J.H.1
-
34
-
-
33846821915
-
p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage
-
Reinhardt H.C., Aslanian A.S., Lees J.A., and Yaffe M.B. p53-deficient cells rely on ATM- and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after DNA damage. Cancer Cell 11 (2007) 175-189
-
(2007)
Cancer Cell
, vol.11
, pp. 175-189
-
-
Reinhardt, H.C.1
Aslanian, A.S.2
Lees, J.A.3
Yaffe, M.B.4
-
35
-
-
0032489520
-
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139
-
Rogakou E.P., Pilch D.R., Orr A.H., Ivanova V.S., and Bonner W.M. DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139. J. Biol. Chem. 273 (1998) 5858-5868
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 5858-5868
-
-
Rogakou, E.P.1
Pilch, D.R.2
Orr, A.H.3
Ivanova, V.S.4
Bonner, W.M.5
-
36
-
-
0035942190
-
Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity
-
Ruffner H., Joazeiro C.A., Hemmati D., Hunter T., and Verma I.M. Cancer-predisposing mutations within the RING domain of BRCA1: loss of ubiquitin protein ligase activity and protection from radiation hypersensitivity. Proc. Natl. Acad. Sci. USA 98 (2001) 5134-5139
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 5134-5139
-
-
Ruffner, H.1
Joazeiro, C.A.2
Hemmati, D.3
Hunter, T.4
Verma, I.M.5
-
37
-
-
0028847989
-
A ubiquitin mutant with specific defects in DNA repair and multiubiquitination
-
Spence J., Sadis S., Haas A.L., and Finley D. A ubiquitin mutant with specific defects in DNA repair and multiubiquitination. Mol. Cell. Biol. 15 (1995) 1265-1273
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 1265-1273
-
-
Spence, J.1
Sadis, S.2
Haas, A.L.3
Finley, D.4
-
38
-
-
33646106590
-
gammaH2AX and MDC1: anchoring the DNA damage-response machinery to broken chromosomes
-
Stucki M., and Jackson S.P. gammaH2AX and MDC1: anchoring the DNA damage-response machinery to broken chromosomes. DNA Repair (Amst.) 5 (2006) 534-543
-
(2006)
DNA Repair (Amst.)
, vol.5
, pp. 534-543
-
-
Stucki, M.1
Jackson, S.P.2
-
39
-
-
0345086463
-
One ring to rule a superfamily of E3 ubiquitin ligases
-
603-604
-
Tyers M., and Willems A.R. One ring to rule a superfamily of E3 ubiquitin ligases. Science 284 (1999) 601 603-604
-
(1999)
Science
, vol.284
, pp. 601
-
-
Tyers, M.1
Willems, A.R.2
-
40
-
-
36749025467
-
Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage
-
10.1073/pnas.0710061104 in press. Published online December 5, 2007
-
Wang B., and Elledge S.J. Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage. Proc. Natl. Acad. Sci. USA (2007) 10.1073/pnas.0710061104 in press. Published online December 5, 2007
-
(2007)
Proc. Natl. Acad. Sci. USA
-
-
Wang, B.1
Elledge, S.J.2
-
41
-
-
0027367944
-
The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function
-
Watkins J.F., Sung P., Prakash L., and Prakash S. The Saccharomyces cerevisiae DNA repair gene RAD23 encodes a nuclear protein containing a ubiquitin-like domain required for biological function. Mol. Cell. Biol. 13 (1993) 7757-7765
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 7757-7765
-
-
Watkins, J.F.1
Sung, P.2
Prakash, L.3
Prakash, S.4
-
42
-
-
33748350041
-
Checkpoint and coordinated cellular responses to DNA damage
-
Yang X.H., and Zou L. Checkpoint and coordinated cellular responses to DNA damage. Results Probl. Cell Differ. 42 (2006) 65-92
-
(2006)
Results Probl. Cell Differ.
, vol.42
, pp. 65-92
-
-
Yang, X.H.1
Zou, L.2
-
43
-
-
2542459341
-
Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase
-
Yoo H.Y., Kumagai A., Shevchenko A., Shevchenko A., and Dunphy W.G. Adaptation of a DNA replication checkpoint response depends upon inactivation of Claspin by the Polo-like kinase. Cell 117 (2004) 575-588
-
(2004)
Cell
, vol.117
, pp. 575-588
-
-
Yoo, H.Y.1
Kumagai, A.2
Shevchenko, A.3
Shevchenko, A.4
Dunphy, W.G.5
-
44
-
-
0037567268
-
Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes
-
Zou L., and Elledge S.J. Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes. Science 300 (2003) 1542-1548
-
(2003)
Science
, vol.300
, pp. 1542-1548
-
-
Zou, L.1
Elledge, S.J.2
|