메뉴 건너뛰기




Volumn , Issue , 2009, Pages 407-432

Hepatic stellate cells

Author keywords

[No Author keywords available]

Indexed keywords


EID: 80052285229     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470747919.ch28     Document Type: Chapter
Times cited : (15)

References (373)
  • 1
    • 0012119538 scopus 로고    scopus 로고
    • (eds I.M. Arias, F.V. Boyer, J.L. Chisari, W.B. Fausto, D. Schachter and D.A. Shafritz), Lipcott Press
    • Rojkind, M. and Greenwel, P. (2001) in Pathophysiology of Liver Fibrosis (eds I.M. Arias, F.V. Boyer, J.L. Chisari, W.B. Fausto, D. Schachter and D.A. Shafritz), Lipcott Press, pp. 721-38.
    • (2001) Pathophysiology of Liver Fibrosis , pp. 721-738
    • Rojkind, M.1    Greenwel, P.2
  • 3
    • 34848864570 scopus 로고    scopus 로고
    • Liver regeneration
    • Michalopoulos, G.K. (2007) Liver regeneration. J Cell Physiol, 213, 286-300.
    • (2007) J Cell Physiol , vol.213 , pp. 286-300
    • Michalopoulos, G.K.1
  • 4
    • 47649091388 scopus 로고    scopus 로고
    • Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go?
    • Gressner, O.A., Rizk, M.S., Kovalenko, E., Weiskirchen, R. and Gressner, A.M. (2008) Changing the pathogenetic roadmap of liver fibrosis? Where did it start; where will it go? J Gastroenterol Hepatol, 23 (7Pt 1), 1024-35.
    • (2008) J Gastroenterol Hepatol , vol.23 , Issue.7 , pp. 1024-1035
    • Gressner, O.A.1    Rizk, M.S.2    Kovalenko, E.3    Weiskirchen, R.4    Gressner, A.M.5
  • 5
    • 35948954244 scopus 로고    scopus 로고
    • Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver
    • Friedman, S.L. (2008) Hepatic stellate cells: protean, multifunctional, and enigmatic cells of the liver. Physiol Rev, 88, 125-72.
    • (2008) Physiol Rev , vol.88 , pp. 125-172
    • Friedman, S.L.1
  • 6
    • 0029909655 scopus 로고    scopus 로고
    • Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB)
    • Somasundaram, R. and Schuppan, D. (1996) Type I, II, III, IV, V, and VI collagens serve as extracellular ligands for the isoforms of platelet-derived growth factor (AA, BB, and AB). J Biol Chem, 271, 26884-91.
    • (1996) J Biol Chem , vol.271 , pp. 26884-26891
    • Somasundaram, R.1    Schuppan, D.2
  • 8
    • 0041023717 scopus 로고    scopus 로고
    • Soluble collagen VI induces tyrosine phosphorylation of paxillin and focal adhesion kinase and activates the MAP kinase Erk2 in fibroblasts
    • Ruhl, M., Johannsen, M., Atkinson, J., Manski, D., Sahin, E., Somasundaram, R., Riecken, E.O. and Schuppan, D. (1999) Soluble collagen VI induces tyrosine phosphorylation of paxillin and focal adhesion kinase and activates the MAP kinase Erk2 in fibroblasts. Exp Cell Res, 250, 548-57.
    • (1999) Exp Cell Res , vol.250 , pp. 548-557
    • Ruhl, M.1    Johannsen, M.2    Atkinson, J.3    Manski, D.4    Sahin, E.5    Somasundaram, R.6    Riecken, E.O.7    Schuppan, D.8
  • 11
    • 39749150904 scopus 로고    scopus 로고
    • Fibrillin-rich microfibrils-structural and instructive determinants of mammalian development and physiology
    • Ramirez, F., Carta, L., Lee-Arteaga, S., Liu, C., Nistala, H. and Smaldone, S. (2008) Fibrillin-rich microfibrils-structural and instructive determinants of mammalian development and physiology. Connect Tissue Res, 49, 1-6.
    • (2008) Connect Tissue Res , vol.49 , pp. 1-6
    • Ramirez, F.1    Carta, L.2    Lee-Arteaga, S.3    Liu, C.4    Nistala, H.5    Smaldone, S.6
  • 12
    • 33845314279 scopus 로고    scopus 로고
    • Hepatic fibrosis, stellate cells, and portal hypertension
    • vii-viii
    • Rockey, D.C. (2006) Hepatic fibrosis, stellate cells, and portal hypertension. Clin Liver Dis, 10, 459-79, vii-viii.
    • (2006) Clin Liver Dis , vol.10 , pp. 459-479
    • Rockey, D.C.1
  • 13
    • 33744538682 scopus 로고    scopus 로고
    • Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets
    • Gressner, A.M. and Weiskirchen, R. (2006) Modern pathogenetic concepts of liver fibrosis suggest stellate cells and TGF-beta as major players and therapeutic targets. J Cell Mol Med, 10, 76-99.
    • (2006) J Cell Mol Med , vol.10 , pp. 76-99
    • Gressner, A.M.1    Weiskirchen, R.2
  • 15
    • 34249776715 scopus 로고    scopus 로고
    • Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis
    • Kisseleva, T. and Brenner, D.A. (2007) Role of hepatic stellate cells in fibrogenesis and the reversal of fibrosis. J Gastroenterol Hepatol, 22 (Suppl 1), S73-78.
    • (2007) J Gastroenterol Hepatol , vol.22 , pp. S73-S78
    • Kisseleva, T.1    Brenner, D.A.2
  • 16
    • 45849126148 scopus 로고    scopus 로고
    • Regulation of sinusoidal perfusion in portal hypertension
    • Reynaert, H., Urbain, D. and Geerts, A. (2008) Regulation of sinusoidal perfusion in portal hypertension. Anat Rec (Hoboken), 291, 693-98.
    • (2008) Anat Rec (Hoboken) , vol.291 , pp. 693-698
    • Reynaert, H.1    Urbain, D.2    Geerts, A.3
  • 17
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • Friedman, S.L. (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology, 134, 1655-69.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 19
    • 0034809804 scopus 로고    scopus 로고
    • Hepatic stellate cells as a target for the treatment of liver fibrosis
    • Bataller, R. and Brenner, D.A. (2001) Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin Liver Dis, 21, 437-51.
    • (2001) Semin Liver Dis , vol.21 , pp. 437-451
    • Bataller, R.1    Brenner, D.A.2
  • 20
    • 33747584867 scopus 로고    scopus 로고
    • Hepatic stellate cells and the reversal of fibrosis
    • Kisseleva, T. and Brenner, D.A. (2006) Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol, 21 (Suppl 3), S84-87.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. S84-S87
    • Kisseleva, T.1    Brenner, D.A.2
  • 21
    • 33751221303 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF
    • Bueno, M., Salgado, S., Beas-Zárate, C. and Armendariz-Borunda, J. (2006) Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. J Gene Med, 8, 1291-99.
    • (2006) J Gene Med , vol.8 , pp. 1291-1299
    • Bueno, M.1    Salgado, S.2    Beas-Zárate, C.3    Armendariz-Borunda, J.4
  • 24
    • 0030858931 scopus 로고    scopus 로고
    • Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis
    • Windmeier, C. and Gressner, A.M. (1997) Pharmacological aspects of pentoxifylline with emphasis on its inhibitory actions on hepatic fibrogenesis. Gen Pharmacol, 29, 181-96.
    • (1997) Gen Pharmacol , vol.29 , pp. 181-196
    • Windmeier, C.1    Gressner, A.M.2
  • 25
    • 0032054482 scopus 로고    scopus 로고
    • Halofuginone: A novel antifibrotic therapy
    • Pines, M. and Nagler, A. (1998) Halofuginone: a novel antifibrotic therapy. Gen Pharmacol, 30, 445-50.
    • (1998) Gen Pharmacol , vol.30 , pp. 445-450
    • Pines, M.1    Nagler, A.2
  • 26
    • 0034830886 scopus 로고    scopus 로고
    • Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats
    • Wright, M.C., Issa, R., Smart, D.E., Trim, N., Murray, G.I., Primrose, J.N., Arthur, M.J., Iredale, J.P. and Mann, D.A. (2001) Gliotoxin stimulates the apoptosis of human and rat hepatic stellate cells and enhances the resolution of liver fibrosis in rats. Gastroenterology, 121, 685-98.
    • (2001) Gastroenterology , vol.121 , pp. 685-698
    • Wright, M.C.1    Issa, R.2    Smart, D.E.3    Trim, N.4    Murray, G.I.5    Primrose, J.N.6    Arthur, M.J.7    Iredale, J.P.8    Mann, D.A.9
  • 27
    • 0034809414 scopus 로고    scopus 로고
    • Hepatic stellate cell behavior during resolution of liver injury
    • Iredale, J.P. (2001) Hepatic stellate cell behavior during resolution of liver injury. Semin Liver Dis, 21, 427-36.
    • (2001) Semin Liver Dis , vol.21 , pp. 427-436
    • Iredale, J.P.1
  • 29
    • 33751221303 scopus 로고    scopus 로고
    • Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF
    • Bueno, M., Salgado, S., Beas-Zárate, C. and Armendariz-Borunda, J. (2006) Urokinase-type plasminogen activator gene therapy in liver cirrhosis is mediated by collagens gene expression down-regulation and up-regulation of MMPs, HGF and VEGF. J Gene Med, 8, 1291-99.
    • (2006) J Gene Med , vol.8 , pp. 1291-1299
    • Bueno, M.1    Salgado, S.2    Beas-Zárate, C.3    Armendariz-Borunda, J.4
  • 30
    • 33646745744 scopus 로고    scopus 로고
    • Emerging therapies for liver fibrosis
    • Fowell, A.J. and Iredale, J.P. (2006) Emerging therapies for liver fibrosis. Dig Dis, 24, 174-83.
    • (2006) Dig Dis , vol.24 , pp. 174-183
    • Fowell, A.J.1    Iredale, J.P.2
  • 31
  • 32
    • 33744956853 scopus 로고    scopus 로고
    • Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB
    • Popov, Y., Patsenker, E., Bauer, M., Niedobitek, E., Schulze-Krebs, A. and Schuppan, D. (2006) Halofuginone induces matrix metalloproteinases in rat hepatic stellate cells via activation of p38 and NFkappaB. J Biol Chem, 281, 15090-98.
    • (2006) J Biol Chem , vol.281 , pp. 15090-15098
    • Popov, Y.1    Patsenker, E.2    Bauer, M.3    Niedobitek, E.4    Schulze-Krebs, A.5    Schuppan, D.6
  • 34
    • 39149111268 scopus 로고    scopus 로고
    • Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis
    • Siegmund, S.V. and Schwabe, R.F. (2008) Endocannabinoids and liver disease. II. Endocannabinoids in the pathogenesis and treatment of liver fibrosis. Am J Physiol Gastrointest Liver Physiol, 294, G357-62.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G357-G362
    • Siegmund, S.V.1    Schwabe, R.F.2
  • 36
    • 39249083049 scopus 로고    scopus 로고
    • Matrix metalloproteinase gene delivery for liver fibrosis
    • Iimuro, Y. and Brenner, D.A. (2008) Matrix metalloproteinase gene delivery for liver fibrosis. Pharm Res, 25 (2), 249-58.
    • (2008) Pharm Res , vol.25 , Issue.2 , pp. 249-258
    • Iimuro, Y.1    Brenner, D.A.2
  • 39
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis
    • George, J., Roulot, D., Koteliansky, V.E. and Bissell, D.M. (1999) In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci U S A, 96, 12719-24.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 40
    • 0033984336 scopus 로고    scopus 로고
    • A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats
    • Ueno, H., Sakamoto, T., Nakamura, T., Qi, Z., Astuchi, N., Takeshita, A., Shimizu, K. and Ohashi, H. (2000) A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats. Hum Gene Ther, 11, 33-42.
    • (2000) Hum Gene Ther , vol.11 , pp. 33-42
    • Ueno, H.1    Sakamoto, T.2    Nakamura, T.3    Qi, Z.4    Astuchi, N.5    Takeshita, A.6    Shimizu, K.7    Ohashi, H.8
  • 41
    • 0036242557 scopus 로고    scopus 로고
    • Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: Implications for antifibrotic therapy
    • Yata, Y., Gotwals, P., Koteliansky, V. and Rockey, D.C. (2002) Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy. Hepatology, 35, 1022-30.
    • (2002) Hepatology , vol.35 , pp. 1022-1030
    • Yata, Y.1    Gotwals, P.2    Koteliansky, V.3    Rockey, D.C.4
  • 42
    • 10744230440 scopus 로고    scopus 로고
    • Inhibitory effect of a soluble transforming growth factor beta type II receptor on the activation of rat hepatic stellate cells in primary culture
    • Cui, X., Shimizu, I., Lu, G., Itonaga, M., Inoue, H., Shono, M., Tamaki, K., Fukuno, H., Ueno, H. and Ito, S. (2003) Inhibitory effect of a soluble transforming growth factor beta type II receptor on the activation of rat hepatic stellate cells in primary culture. J Hepatol, 39, 731-37.
    • (2003) J Hepatol , vol.39 , pp. 731-737
    • Cui, X.1    Shimizu, I.2    Lu, G.3    Itonaga, M.4    Inoue, H.5    Shono, M.6    Tamaki, K.7    Fukuno, H.8    Ueno, H.9    Ito, S.10
  • 44
    • 0015819368 scopus 로고
    • Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride
    • Rojkind, M. (1973) Inhibition of liver fibrosis by 1-azetidine-2-carboxylic acid in rats treated with carbon tetrachloride. J Clin Invest, 52, 2451-56.
    • (1973) J Clin Invest , vol.52 , pp. 2451-2456
    • Rojkind, M.1
  • 45
    • 0015915747 scopus 로고
    • Colchicine and the treatment of liver cirrhosis
    • Rojkind, M., Uribe, M. and Kershenobich, D. (1973) Colchicine and the treatment of liver cirrhosis. Lancet, i, 38-39.
    • (1973) Lancet , vol.1 , pp. 38-39
    • Rojkind, M.1    Uribe, M.2    Kershenobich, D.3
  • 47
    • 0021158154 scopus 로고
    • Antiinflammatory and antifibrogenic activities of colchicine: Treatment of liver cirrhosis
    • Rojkind, M., Mourelle, M. and Kershenobich, D. (1984) Antiinflammatory and antifibrogenic activities of colchicine: treatment of liver cirrhosis. Prog Clin Biol Res, 154, 475-89.
    • (1984) Prog Clin Biol Res , vol.154 , pp. 475-489
    • Rojkind, M.1    Mourelle, M.2    Kershenobich, D.3
  • 49
    • 0034808310 scopus 로고    scopus 로고
    • History, heterogeneity, developmental biology and functions of quiescent hepatic stellate cells
    • Geerts, A. (2001) History, heterogeneity, developmental biology and functions of quiescent hepatic stellate cells. Semin Liver Dis, 21, 311-35.
    • (2001) Semin Liver Dis , vol.21 , pp. 311-335
    • Geerts, A.1
  • 50
    • 1642491768 scopus 로고    scopus 로고
    • On the origin of stellate cells: Mesodermal, endodermal or neuro-ectodermal?
    • Geerts, A. (2004) On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal? J Hepatol, 40, 331-34.
    • (2004) J Hepatol , vol.40 , pp. 331-334
    • Geerts, A.1
  • 51
    • 0021131587 scopus 로고
    • The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver
    • Martinez-Hernandez, A. (1984) The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver. Lab Invest, 51, 57.
    • (1984) Lab Invest , vol.51 , pp. 57
    • Martinez-Hernandez, A.1
  • 52
    • 0027227345 scopus 로고
    • The hepatic extracellular matrix. I. Components and distribution in normal liver
    • Martinez-Hernandez, A. and Amenta, P.S. (1993) The hepatic extracellular matrix. I. Components and distribution in normal liver. Virchows Arch A Pathol Anat Histopathol, 423 (1), 1-11.
    • (1993) Virchows Arch A Pathol Anat Histopathol , vol.423 , Issue.1 , pp. 1-11
    • Martinez-Hernandez, A.1    Amenta, P.S.2
  • 53
    • 0021808620 scopus 로고
    • The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis
    • Martinez-Hernandez, A. (1985) The hepatic extracellular matrix. II. Electron immunohistochemical studies in rats with CCl4-induced cirrhosis. Lab Invest, 53, 166-86.
    • (1985) Lab Invest , vol.53 , pp. 166-186
    • Martinez-Hernandez, A.1
  • 54
    • 0027251069 scopus 로고
    • Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43
    • Greenwel, P., Rubin, J., Schwartz, M., Hertzberg, E.L. and Rojkind, M. (1993) Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, and connexin 43. Lab Invest, 69, 210-16.
    • (1993) Lab Invest , vol.69 , pp. 210-216
    • Greenwel, P.1    Rubin, J.2    Schwartz, M.3    Hertzberg, E.L.4    Rojkind, M.5
  • 57
    • 0021275006 scopus 로고
    • Purified rat liver fat-storing cells in culture divide and contain collagen
    • de Leeuw, A.M., McCarthy, S.P., Geerts, A. and Knook, D.L. (1984) Purified rat liver fat-storing cells in culture divide and contain collagen. Hepatology, 4, 392-403.
    • (1984) Hepatology , vol.4 , pp. 392-403
    • de Leeuw, A.M.1    McCarthy, S.P.2    Geerts, A.3    Knook, D.L.4
  • 58
    • 0001520008 scopus 로고
    • Hepatic lipocytes: The principal collagen-producing cells of normal rat liver
    • Friedman, S.L., Roll, F.J., Boyles, J. and Bissell, D.M. (1985) Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A, 82, 8681-85.
    • (1985) Proc Natl Acad Sci U S A , vol.82 , pp. 8681-8685
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Bissell, D.M.4
  • 59
    • 0023113248 scopus 로고
    • Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan
    • Friedman, S.L. and Roll, F.J. (1987) Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with Stractan. Anal Biochem, 161, 207-18.
    • (1987) Anal Biochem , vol.161 , pp. 207-218
    • Friedman, S.L.1    Roll, F.J.2
  • 60
    • 0023579847 scopus 로고
    • The role of hepatic fat-storing (stellate) cells in retinoid metabolism
    • Hendriks, H.F., Brouwer, A. and Knook, D.L. (1987) The role of hepatic fat-storing (stellate) cells in retinoid metabolism. Hepatology, 7, 1368-71.
    • (1987) Hepatology , vol.7 , pp. 1368-1371
    • Hendriks, H.F.1    Brouwer, A.2    Knook, D.L.3
  • 61
    • 0033044052 scopus 로고    scopus 로고
    • All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially
    • Hellemans, K., Grinko, I., Rombouts, K., Schuppan, D. and Geerts, A. (1999) All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially. Gut, 45, 134-42.
    • (1999) Gut , vol.45 , pp. 134-142
    • Hellemans, K.1    Grinko, I.2    Rombouts, K.3    Schuppan, D.4    Geerts, A.5
  • 62
    • 0025734994 scopus 로고
    • Perisinusoidal stellate cells of the liver: Important roles in retinol metabolism and fibrosis
    • Blomhoff, R. and Wake, K. (1991) Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J, 5, 271-77.
    • (1991) FASEB J , vol.5 , pp. 271-277
    • Blomhoff, R.1    Wake, K.2
  • 63
    • 0026565799 scopus 로고
    • Ito cell expression of a nuclear retinoic acid receptor
    • Weiner, F.R., Blaner, W.S., Czaja, M.J., Shah, A. and Geerts, A. (1992) Ito cell expression of a nuclear retinoic acid receptor. Hepatology, 15, 336-42.
    • (1992) Hepatology , vol.15 , pp. 336-342
    • Weiner, F.R.1    Blaner, W.S.2    Czaja, M.J.3    Shah, A.4    Geerts, A.5
  • 66
    • 34548452170 scopus 로고    scopus 로고
    • Rat hepatic stellate cells acquire retinoid responsiveness after activation in vitro by post-transcriptional regulation of retinoic acid receptor alpha gene expression
    • Mezaki, Y., Yoshikawa, K., Yamaguchi, N., Miura, M., Imai, K., Kato, S. and Senoo, H. (2007) Rat hepatic stellate cells acquire retinoid responsiveness after activation in vitro by post-transcriptional regulation of retinoic acid receptor alpha gene expression. Arch Biochem Biophys, 465, 370-79.
    • (2007) Arch Biochem Biophys , vol.465 , pp. 370-379
    • Mezaki, Y.1    Yoshikawa, K.2    Yamaguchi, N.3    Miura, M.4    Imai, K.5    Kato, S.6    Senoo, H.7
  • 67
    • 33947248972 scopus 로고    scopus 로고
    • Vitamin A-storing cells (stellate cells)
    • Senoo, H., Kojima, N. and Sato, M. (2007) Vitamin A-storing cells (stellate cells). Vitam Horm, 75, 131-59.
    • (2007) Vitam Horm , vol.75 , pp. 131-159
    • Senoo, H.1    Kojima, N.2    Sato, M.3
  • 69
    • 51649131465 scopus 로고    scopus 로고
    • All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production
    • Hisamori, S., Tabata, C., Kadokawa, Y., Okoshi, K., Tabata, R., Mori, A., Nagayama, S., Watanabe, G., Kubo, H. and Sakai, Y. (2008) All-trans-retinoic acid ameliorates carbon tetrachloride-induced liver fibrosis in mice through modulating cytokine production. Liver Int, 28, 1217-25.
    • (2008) Liver Int , vol.28 , pp. 1217-1225
    • Hisamori, S.1    Tabata, C.2    Kadokawa, Y.3    Okoshi, K.4    Tabata, R.5    Mori, A.6    Nagayama, S.7    Watanabe, G.8    Kubo, H.9    Sakai, Y.10
  • 70
    • 0025811045 scopus 로고
    • Liver damage caused by therapeutic vitamin A administration: Estimate of dose-related toxicity in 41 cases
    • Geubel, A.P., De Galocsy, C., Alves, N., Rahier, J. and Dive, C. (1991) Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology, 100, 1701-9.
    • (1991) Gastroenterology , vol.100 , pp. 1701-1709
    • Geubel, A.P.1    De Galocsy, C.2    Alves, N.3    Rahier, J.4    Dive, C.5
  • 71
    • 0027503219 scopus 로고
    • Fat-storing cells: Hyper- and hypovitaminosis A and the relationships with liver fibrosis
    • Hendriks, H.F., Bosma, A. and Brouwer, A. (1993) Fat-storing cells: hyper- and hypovitaminosis A and the relationships with liver fibrosis. Semin Liver Dis, 13, 72-80.
    • (1993) Semin Liver Dis , vol.13 , pp. 72-80
    • Hendriks, H.F.1    Bosma, A.2    Brouwer, A.3
  • 72
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman, S.L. (2000) Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem, 275, 2247-2250.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 73
    • 33645999089 scopus 로고    scopus 로고
    • Hypervitaminosis A-induced liver fibrosis: Stellate cell activation and daily dose consumption
    • Nollevaux, M.C., Guiot, Y., Horsmans, Y., Leclercq, I., Rahier, J., Geubel, A.P. and Sempoux, C. (2006) Hypervitaminosis A-induced liver fibrosis: stellate cell activation and daily dose consumption. Liver Int, 26, 182-86.
    • (2006) Liver Int , vol.26 , pp. 182-186
    • Nollevaux, M.C.1    Guiot, Y.2    Horsmans, Y.3    Leclercq, I.4    Rahier, J.5    Geubel, A.P.6    Sempoux, C.7
  • 74
    • 33845627110 scopus 로고    scopus 로고
    • Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice
    • Wang, L., Potter, J.J., Rennie-Tankersley, L., Novitskiy, G., Sipes, J. and Mezey, E. (2007) Effects of retinoic acid on the development of liver fibrosis produced by carbon tetrachloride in mice. Biochim Biophys Acta, 1772, 66-71.
    • (2007) Biochim Biophys Acta , vol.1772 , pp. 66-71
    • Wang, L.1    Potter, J.J.2    Rennie-Tankersley, L.3    Novitskiy, G.4    Sipes, J.5    Mezey, E.6
  • 75
    • 0027090129 scopus 로고
    • Vitamin A abuse: Development of cirrhosis despite cessation of vitamin A. A six-year clinical and histopathologic follow-up
    • Jorens, P.G., Michielsen, P.P., Pelckmans, P.A., Fevery, J., Desmet, V.J., Geubel, A.P., Rahier, J. and Van Maercke, Y.M. (1992) Vitamin A abuse: development of cirrhosis despite cessation of vitamin A. A six-year clinical and histopathologic follow-up. Liver, 12, 381-86.
    • (1992) Liver , vol.12 , pp. 381-386
    • Jorens, P.G.1    Michielsen, P.P.2    Pelckmans, P.A.3    Fevery, J.4    Desmet, V.J.5    Geubel, A.P.6    Rahier, J.7    Van Maercke, Y.M.8
  • 76
    • 0034804406 scopus 로고    scopus 로고
    • Hepatic blood flow regulation by stellate cells in normal and injured liver
    • Rockey, D.C. (2001) Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin Liver Dis, 21, 337-49.
    • (2001) Semin Liver Dis , vol.21 , pp. 337-349
    • Rockey, D.C.1
  • 77
    • 45849089572 scopus 로고    scopus 로고
    • The hepatic microvascular system in health and its response to toxicants
    • McCuskey, R.S. (2008) The hepatic microvascular system in health and its response to toxicants. Anat Rec (Hoboken), 291, 661-71.
    • (2008) Anat Rec (Hoboken) , vol.291 , pp. 661-671
    • McCuskey, R.S.1
  • 78
    • 0032775098 scopus 로고    scopus 로고
    • Quantitation of rat hepatic stellate cell contraction: Stellate cells’ contribution to sinusoidal resistance
    • Thimgan, M.S. and Yee, H.F. Jr. (1999) Quantitation of rat hepatic stellate cell contraction: stellate cells’ contribution to sinusoidal resistance. Am J Physiol, 277 (1Pt 1), G137-43.
    • (1999) Am J Physiol , vol.277 , Issue.1 , pp. G137-G143
    • Thimgan, M.S.1    Yee, H.F.2
  • 80
    • 49749134756 scopus 로고    scopus 로고
    • Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells
    • Wirz, W., Antoine, M., Tag, C.G., Gressner, A.M., Korff, T., Hellerbrand, C. and Kiefer, P. (2008) Hepatic stellate cells display a functional vascular smooth muscle cell phenotype in a three-dimensional co-culture model with endothelial cells. Differentiation, 76, 784-94.
    • (2008) Differentiation , vol.76 , pp. 784-794
    • Wirz, W.1    Antoine, M.2    Tag, C.G.3    Gressner, A.M.4    Korff, T.5    Hellerbrand, C.6    Kiefer, P.7
  • 82
    • 0035232487 scopus 로고    scopus 로고
    • Cooperation of liver cells in health and disease
    • Kmieć, Z. (2001) Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol, 161, 1-151.
    • (2001) Adv Anat Embryol Cell Biol , vol.161 , pp. 1-151
    • Kmieć, Z.1
  • 83
    • 54549111222 scopus 로고    scopus 로고
    • Stellate cell contraction: Role, regulation, and potential therapeutic target
    • Soon, R.K. Jr. and Yee, H.F. Jr. (2008) Stellate cell contraction: role, regulation, and potential therapeutic target. Clin Liver Dis, 12, 791-803.
    • (2008) Clin Liver Dis , vol.12 , pp. 791-803
    • Soon, R.K.1    Yee, H.F.2
  • 84
    • 3442881345 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces contraction of activated hepatic stellate cells
    • Kharbanda, K.K., Rogers, D.D. II, Wyatt, T.A., Sorrell, M.F. and Tuma, D.J. (2004) Transforming growth factor-beta induces contraction of activated hepatic stellate cells. J Hepatol, 41, 60-66.
    • (2004) J Hepatol , vol.41 , pp. 60-66
    • Kharbanda, K.K.1    Rogers, D.D.I.I.2    Wyatt, T.A.3    Sorrell, M.F.4    Tuma, D.J.5
  • 85
    • 0027190038 scopus 로고
    • The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus
    • Kawada, N., Tran-Thi, T.A., Klein, H. and Decker, K. (1993) The contraction of hepatic stellate (Ito) cells stimulated with vasoactive substances. Possible involvement of endothelin 1 and nitric oxide in the regulation of the sinusoidal tonus. Eur J Biochem, 213, 815-23.
    • (1993) Eur J Biochem , vol.213 , pp. 815-823
    • Kawada, N.1    Tran-Thi, T.A.2    Klein, H.3    Decker, K.4
  • 86
    • 0033590105 scopus 로고    scopus 로고
    • ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1
    • Kawada, N., Seki, S., Kuroki, T. and Kaneda, K. (1999) ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1. Biochem Biophys Res Commun, 266, 296-300.
    • (1999) Biochem Biophys Res Commun , vol.266 , pp. 296-300
    • Kawada, N.1    Seki, S.2    Kuroki, T.3    Kaneda, K.4
  • 87
    • 1842836633 scopus 로고    scopus 로고
    • Myosin mediates contractile force generation by hepatic stellate cells in response to endothelin-1
    • Saab, S., Tam, S.P., Tran, B.N., Melton, A.C., Tangkijvanich, P., Wong, H. and Yee, H.F. Jr. (2002) Myosin mediates contractile force generation by hepatic stellate cells in response to endothelin-1. J Biomed Sci, 9 (6Pt 2), 607-12.
    • (2002) J Biomed Sci , vol.9 , Issue.6 , pp. 607-612
    • Saab, S.1    Tam, S.P.2    Tran, B.N.3    Melton, A.C.4    Tangkijvanich, P.5    Wong, H.6    Yee, H.F.7
  • 88
    • 33644807897 scopus 로고    scopus 로고
    • [Ca2+]i-independent contractile force generation by rat hepatic stellate cells in response to endothelin-1
    • Melton, A.C., Datta, A. and Yee, H.F. Jr. (2006) [Ca2+]i-independent contractile force generation by rat hepatic stellate cells in response to endothelin-1. Am J Physiol Gastrointest Liver Physiol, 290, G7-13.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G7-G13
    • Melton, A.C.1    Datta, A.2    Yee, H.F.3
  • 91
    • 17344370669 scopus 로고    scopus 로고
    • Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton
    • Yee, H.F. Jr. (1998) Rho directs activation-associated changes in rat hepatic stellate cell morphology via regulation of the actin cytoskeleton. Hepatology, 28, 843-50.
    • (1998) Hepatology , vol.28 , pp. 843-850
    • Yee, H.F.1
  • 93
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • Trebicka, J., Hennenberg, M., Laleman, W., Shelest, N., Biecker, E., Schepke, M., Nevens, F., Sauerbruch, T. and Heller, J. (2007) Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology, 46, 242-53.
    • (2007) Hepatology , vol.46 , pp. 242-253
    • Trebicka, J.1    Hennenberg, M.2    Laleman, W.3    Shelest, N.4    Biecker, E.5    Schepke, M.6    Nevens, F.7    Sauerbruch, T.8    Heller, J.9
  • 96
    • 0035200716 scopus 로고    scopus 로고
    • Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors
    • Cassiman, D., Denef, C., Desmet, V.J. and Roskams, T. (2001) Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology, 33, 148-58.
    • (2001) Hepatology , vol.33 , pp. 148-158
    • Cassiman, D.1    Denef, C.2    Desmet, V.J.3    Roskams, T.4
  • 97
    • 0021869590 scopus 로고
    • Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver
    • Gard, A.L., White, F.P. and Dutton, G.R. (1985) Extra-neural glial fibrillary acidic protein (GFAP) immunoreactivity in perisinusoidal stellate cells of rat liver. J Neuroimmunol, 8, 359-75.
    • (1985) J Neuroimmunol , vol.8 , pp. 359-375
    • Gard, A.L.1    White, F.P.2    Dutton, G.R.3
  • 98
    • 9644267507 scopus 로고    scopus 로고
    • N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1
    • Murphy, F., Waung, J., Collins, J., Arthur, M.J., Nagase, H., Mann, D., Benyon, R.C. and Iredale, J.P. (2004) N-Cadherin cleavage during activated hepatic stellate cell apoptosis is inhibited by tissue inhibitor of metalloproteinase-1. Comp Hepatol, 3 (Suppl 1), S8.
    • (2004) Comp Hepatol , vol.3 , pp. S8
    • Murphy, F.1    Waung, J.2    Collins, J.3    Arthur, M.J.4    Nagase, H.5    Mann, D.6    Benyon, R.C.7    Iredale, J.P.8
  • 100
    • 0030056244 scopus 로고    scopus 로고
    • Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair
    • Knittel, T., Aurisch, S., Neubauer, K., Eichhorst, S. and Ramadori, G. (1996) Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair. Am J Pathol, 149, 449-62.
    • (1996) Am J Pathol , vol.149 , pp. 449-462
    • Knittel, T.1    Aurisch, S.2    Neubauer, K.3    Eichhorst, S.4    Ramadori, G.5
  • 101
    • 0030048097 scopus 로고    scopus 로고
    • Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver
    • Nakatani, K., Seki, S., Kawada, N., Kobayashi, K. and Kaneda, K. (1996) Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver. Cell Tissue Res, 283, 159-65.
    • (1996) Cell Tissue Res , vol.283 , pp. 159-165
    • Nakatani, K.1    Seki, S.2    Kawada, N.3    Kobayashi, K.4    Kaneda, K.5
  • 102
    • 0027203323 scopus 로고
    • Localization of neurotrophin-3-like immunoreactivity in peripheral tissues of the rat
    • Zhou, X.F. and Rush, R.A. (1993) Localization of neurotrophin-3-like immunoreactivity in peripheral tissues of the rat. Brain Res, 621, 189-99.
    • (1993) Brain Res , vol.621 , pp. 189-199
    • Zhou, X.F.1    Rush, R.A.2
  • 107
    • 33846408369 scopus 로고    scopus 로고
    • Switch of cadherin expression from E- to N-type during the activation of rat hepatic stellate cells
    • Lim, Y.S., Lee, H.C. and Lee, H.S. (2007) Switch of cadherin expression from E- to N-type during the activation of rat hepatic stellate cells. Histochem Cell Biol, 127, 149-60.
    • (2007) Histochem Cell Biol , vol.127 , pp. 149-160
    • Lim, Y.S.1    Lee, H.C.2    Lee, H.S.3
  • 110
    • 0025821563 scopus 로고
    • Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers
    • Schmitt-Gräff, A., Krüger, S., Bochard, F., Gabbiani, G. and Denk, H. (1991) Modulation of alpha smooth muscle actin and desmin expression in perisinusoidal cells of normal and diseased human livers. Am J Pathol, 138, 1233-42.
    • (1991) Am J Pathol , vol.138 , pp. 1233-1242
    • Schmitt-Gräff, A.1    Krüger, S.2    Bochard, F.3    Gabbiani, G.4    Denk, H.5
  • 111
    • 0022521338 scopus 로고
    • Desmin-containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury
    • Burt, A.D., Robertson, J.L., Heir, J. and MacSween, R.N. (1986) Desmin-containing stellate cells in rat liver; distribution in normal animals and response to experimental acute liver injury. J Pathol, 150, 29-35.
    • (1986) J Pathol , vol.150 , pp. 29-35
    • Burt, A.D.1    Robertson, J.L.2    Heir, J.3    MacSween, R.N.4
  • 113
    • 0031452945 scopus 로고    scopus 로고
    • Sarcomeric gene expression and contractility in myofibroblasts
    • Mayer, D.C. and Leinwand, L.A. (1997) Sarcomeric gene expression and contractility in myofibroblasts. J Cell Biol, 139, 1477-784.
    • (1997) J Cell Biol , vol.139 , pp. 1477-1784
    • Mayer, D.C.1    Leinwand, L.A.2
  • 115
    • 0027992661 scopus 로고
    • Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration
    • Mullhaupt, B., Feren, A., Fodor, E. and Jones, A. (1994) Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration. J Biol Chem, 269, 19667-70.
    • (1994) J Biol Chem , vol.269 , pp. 19667-19670
    • Mullhaupt, B.1    Feren, A.2    Fodor, E.3    Jones, A.4
  • 116
    • 0028085979 scopus 로고
    • Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells
    • Marra, F., Choudhury, G.G., Pinzani, M. and Abboud, H.E. (1994) Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells. Gastroenterology, 107, 1110-17.
    • (1994) Gastroenterology , vol.107 , pp. 1110-1117
    • Marra, F.1    Choudhury, G.G.2    Pinzani, M.3    Abboud, H.E.4
  • 117
    • 23944496113 scopus 로고    scopus 로고
    • Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC)
    • Breitkopf, K., Roeyen, C., Sawitza, I., Wickert, L., Floege, J. and Gressner, A.M. (2005) Expression patterns of PDGF-A, -B, -C and -D and the PDGF-receptors alpha and beta in activated rat hepatic stellate cells (HSC). Cytokine, 31, 349-57.
    • (2005) Cytokine , vol.31 , pp. 349-357
    • Breitkopf, K.1    Roeyen, C.2    Sawitza, I.3    Wickert, L.4    Floege, J.5    Gressner, A.M.6
  • 118
    • 0026526140 scopus 로고
    • The gene of hepatocyte growth factor is expressed in fat-storing cells of rat liver and is downregulated during cell growth and by transforming growth factor-beta
    • Ramadori, G., Neubauer, K., Odenthal, M., Nakamura, T., Knittel, T., Schwögler, S. and Meyer zum Büschenfelde, K.H. (1992) The gene of hepatocyte growth factor is expressed in fat-storing cells of rat liver and is downregulated during cell growth and by transforming growth factor-beta. Biochem Biophys Res Commun, 183, 739-42.
    • (1992) Biochem Biophys Res Commun , vol.183 , pp. 739-742
    • Ramadori, G.1    Neubauer, K.2    Odenthal, M.3    Nakamura, T.4    Knittel, T.5    Schwögler, S.6    Meyer zum Büschenfelde, K.H.7
  • 119
    • 0026593063 scopus 로고
    • Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells
    • Schirmacher, P., Geerts, A., Pietrangelo, A., Dienes, H.P. and Rogler, C.E. (1992) Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells. Hepatology, 15, 5-11.
    • (1992) Hepatology , vol.15 , pp. 5-11
    • Schirmacher, P.1    Geerts, A.2    Pietrangelo, A.3    Dienes, H.P.4    Rogler, C.E.5
  • 120
    • 0027636320 scopus 로고
    • Activation of hepatic stem cell compartment in the rat: Role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation
    • Evarts, R.P., Hu, Z., Fujio, K., Marsden, E.R. and Thorgeirsson, S.S. (1993) Activation of hepatic stem cell compartment in the rat: role of transforming growth factor alpha, hepatocyte growth factor, and acidic fibroblast growth factor in early proliferation. Cell Growth Differ, 4, 555-61.
    • (1993) Cell Growth Differ , vol.4 , pp. 555-561
    • Evarts, R.P.1    Hu, Z.2    Fujio, K.3    Marsden, E.R.4    Thorgeirsson, S.S.5
  • 121
    • 0030830203 scopus 로고    scopus 로고
    • Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells
    • Skrtic, S., Wallenius, V., Ekberg, S., Brenzel, A., Gressner, A.M. and Ansson, J.O. (1997) Insulin-like growth factors stimulate expression of hepatocyte growth factor but not transforming growth factor beta1 in cultured hepatic stellate cells. Endocrinology, 138, 4683-89.
    • (1997) Endocrinology , vol.138 , pp. 4683-4689
    • Skrtic, S.1    Wallenius, V.2    Ekberg, S.3    Brenzel, A.4    Gressner, A.M.5    Ansson, J.O.6
  • 122
    • 0032921698 scopus 로고    scopus 로고
    • Hepatocyte-stimulated expression of hepatocyte growth factor (HGF) in cultured rat hepatic stellate cells
    • Skrtic, S., Wallenius, V., Ekberg, S., Brenzel, A., Gressner, A.M. and Jansson, J.O. (1999) Hepatocyte-stimulated expression of hepatocyte growth factor (HGF) in cultured rat hepatic stellate cells. J Hepatol, 30, 115-24.
    • (1999) J Hepatol , vol.30 , pp. 115-124
    • Skrtic, S.1    Wallenius, V.2    Ekberg, S.3    Brenzel, A.4    Gressner, A.M.5    Jansson, J.O.6
  • 124
    • 35348990180 scopus 로고    scopus 로고
    • Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells
    • Barnaeva, E., Nadezhda, A., Hannappel, E., Sjogren, M.H. and Rojkind, M. (2007) Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells. Ann N Y Acad Sci, 1112, 154-60.
    • (2007) Ann N Y Acad Sci , vol.1112 , pp. 154-160
    • Barnaeva, E.1    Nadezhda, A.2    Hannappel, E.3    Sjogren, M.H.4    Rojkind, M.5
  • 125
    • 0026480808 scopus 로고
    • Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation
    • Marsden, E.R., Hu, Z., Fujio, K., Nakatsukasa, H., Thorgeirsson, S.S. and Evarts, R.P. (1992) Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation. Lab Invest, 67, 427-33.
    • (1992) Lab Invest , vol.67 , pp. 427-433
    • Marsden, E.R.1    Hu, Z.2    Fujio, K.3    Nakatsukasa, H.4    Thorgeirsson, S.S.5    Evarts, R.P.6
  • 127
    • 0342264463 scopus 로고    scopus 로고
    • Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells
    • Williams, E.J., Gaça, M.D., Brigstock, D.R., Arthur, M.J. and Benyon, R.C. (2000) Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol, 32, 754-61.
    • (2000) J Hepatol , vol.32 , pp. 754-761
    • Williams, E.J.1    Gaça, M.D.2    Brigstock, D.R.3    Arthur, M.J.4    Benyon, R.C.5
  • 128
    • 0036281460 scopus 로고    scopus 로고
    • Effects and regulation of connective tissue growth factor on hepatic stellate cells
    • Paradis, V., Dargere, D., Bonvoust, F., Vidaud, M., Segarini, P. and Bedossa, P. (2002) Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest, 82, 767-74.
    • (2002) Lab Invest , vol.82 , pp. 767-774
    • Paradis, V.1    Dargere, D.2    Bonvoust, F.3    Vidaud, M.4    Segarini, P.5    Bedossa, P.6
  • 129
    • 0242690484 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells
    • Gao, R. and Brigstock, D.R. (2003) Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res, 27, 214-20.
    • (2003) Hepatol Res , vol.27 , pp. 214-220
    • Gao, R.1    Brigstock, D.R.2
  • 130
    • 1542305557 scopus 로고    scopus 로고
    • Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan
    • Gao, R. and Brigstock, D.R. (2004) Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J Biol Chem, 279, 8848-55.
    • (2004) J Biol Chem , vol.279 , pp. 8848-8855
    • Gao, R.1    Brigstock, D.R.2
  • 131
    • 1242292348 scopus 로고    scopus 로고
    • Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells
    • Gao, R., Ball, D.K., Perbal, B. and Brigstock, D.R. (2004) Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells. J Hepatol, 40, 431-38.
    • (2004) J Hepatol , vol.40 , pp. 431-438
    • Gao, R.1    Ball, D.K.2    Perbal, B.3    Brigstock, D.R.4
  • 132
    • 34848865661 scopus 로고    scopus 로고
    • Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes
    • Gressner, O.A., Lahme, B., Demirci, I., Gressner, A.M. and Weiskirchen, R. (2007) Differential effects of TGF-beta on connective tissue growth factor (CTGF/CCN2) expression in hepatic stellate cells and hepatocytes. J Hepatol, 47, 699-710.
    • (2007) J Hepatol , vol.47 , pp. 699-710
    • Gressner, O.A.1    Lahme, B.2    Demirci, I.3    Gressner, A.M.4    Weiskirchen, R.5
  • 133
    • 0025043870 scopus 로고
    • Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: Regulatory role of platelet-derived growth factor
    • Pinzani, M., Abboud, H.E. and Aron, D.C. (1990) Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: regulatory role of platelet-derived growth factor. Endocrinology, 127, 2343-49.
    • (1990) Endocrinology , vol.127 , pp. 2343-2349
    • Pinzani, M.1    Abboud, H.E.2    Aron, D.C.3
  • 134
    • 0031979123 scopus 로고    scopus 로고
    • Characterization of the IGF axis components in isolated rat hepatic stellate cells
    • Scharf, J.G., Knittel, T., Dombrowski, F. et al. (1998) Characterization of the IGF axis components in isolated rat hepatic stellate cells. Hepatology, 27, 1275-84.
    • (1998) Hepatology , vol.27 , pp. 1275-1284
    • Scharf, J.G.1    Knittel, T.2    Dombrowski, F.3
  • 136
    • 38849166772 scopus 로고    scopus 로고
    • Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling
    • Chen, A. and Zheng, S. (2008) Curcumin inhibits connective tissue growth factor gene expression in activated hepatic stellate cells in vitro by blocking NF-kappaB and ERK signalling. Br J Pharmacol, 153, 557-67.
    • (2008) Br J Pharmacol , vol.153 , pp. 557-567
    • Chen, A.1    Zheng, S.2
  • 137
    • 0029817895 scopus 로고    scopus 로고
    • Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats
    • Yasuda, H., Imai, E., Shiota, A., Fujise, N., Morinaga, T. and Higashio, K. (1996) Antifibrogenic effect of a deletion variant of hepatocyte growth factor on liver fibrosis in rats. Hepatology, 24, 636-42.
    • (1996) Hepatology , vol.24 , pp. 636-642
    • Yasuda, H.1    Imai, E.2    Shiota, A.3    Fujise, N.4    Morinaga, T.5    Higashio, K.6
  • 138
  • 140
    • 33646501750 scopus 로고    scopus 로고
    • Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation
    • Xia, J.L., Dai, C., Michalopoulos, G.K. and Liu, Y. (2006) Hepatocyte growth factor attenuates liver fibrosis induced by bile duct ligation. Am J Pathol, 168, 1500-12.
    • (2006) Am J Pathol , vol.168 , pp. 1500-1512
    • Xia, J.L.1    Dai, C.2    Michalopoulos, G.K.3    Liu, Y.4
  • 141
    • 35648931933 scopus 로고    scopus 로고
    • Hepatocyte growth factor promotes remodeling of murine liver fibrosis, accelerating recruitment of bone marrow-derived cells into the liver
    • Asano, Y., Iimuro, Y., Son, G., Hirano, T. and Fujimoto, J. (2007) Hepatocyte growth factor promotes remodeling of murine liver fibrosis, accelerating recruitment of bone marrow-derived cells into the liver. Hepatol Res, 37, 1080-94.
    • (2007) Hepatol Res , vol.37 , pp. 1080-1094
    • Asano, Y.1    Iimuro, Y.2    Son, G.3    Hirano, T.4    Fujimoto, J.5
  • 142
    • 48949092177 scopus 로고    scopus 로고
    • Hepatocyte growth factor gene transfer with naked plasmid DNA ameliorates dimethylnitrosamineinduced liver fibrosis in rats
    • Kanemura, H., Iimuro, Y., Takeuchi, M., Ueki, T., Hirano, T., Horiguchi, K., Asano, Y. and Fujimoto, J. (2008) Hepatocyte growth factor gene transfer with naked plasmid DNA ameliorates dimethylnitrosamineinduced liver fibrosis in rats. Hepatol Res, 38, 930-39.
    • (2008) Hepatol Res , vol.38 , pp. 930-939
    • Kanemura, H.1    Iimuro, Y.2    Takeuchi, M.3    Ueki, T.4    Hirano, T.5    Horiguchi, K.6    Asano, Y.7    Fujimoto, J.8
  • 143
    • 3242751775 scopus 로고    scopus 로고
    • Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis
    • Borkham-Kamphorst, E., Stoll, D., Gressner, A.M. and Weiskirchen, R. (2004) Antisense strategy against PDGF B-chain proves effective in preventing experimental liver fibrogenesis. Biochem Biophys Res Commun, 321, 413-23.
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 413-423
    • Borkham-Kamphorst, E.1    Stoll, D.2    Gressner, A.M.3    Weiskirchen, R.4
  • 144
    • 1842426610 scopus 로고    scopus 로고
    • Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells
    • Borkham-Kamphorst, E., Stoll, D., Gressner, A.M. and Weiskirchen, R. (2004) Inhibitory effect of soluble PDGF-beta receptor in culture-activated hepatic stellate cells. Biochem Biophys Res Commun, 317, 451-62.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 451-462
    • Borkham-Kamphorst, E.1    Stoll, D.2    Gressner, A.M.3    Weiskirchen, R.4
  • 145
    • 2642517210 scopus 로고    scopus 로고
    • Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis
    • Borkham-Kamphorst, E., Herrmann, J., Stoll, D., Treptau, J., Gressner, A.M. and Weiskirchen, R. (2004) Dominant-negative soluble PDGF-beta receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis. Lab Invest, 84, 766-77.
    • (2004) Lab Invest , vol.84 , pp. 766-777
    • Borkham-Kamphorst, E.1    Herrmann, J.2    Stoll, D.3    Treptau, J.4    Gressner, A.M.5    Weiskirchen, R.6
  • 149
    • 0026341256 scopus 로고
    • Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6
    • Greenwel, P., Schwartz, M., Rosas, M., Peyrol, S., Grimaud, J.A. and Rojkind, M. (1991) Characterization of fat-storing cell lines derived from normal and CCl4-cirrhotic livers. Differences in the production of interleukin-6. Lab Invest, 65, 644-53.
    • (1991) Lab Invest , vol.65 , pp. 644-653
    • Greenwel, P.1    Schwartz, M.2    Rosas, M.3    Peyrol, S.4    Grimaud, J.A.5    Rojkind, M.6
  • 150
    • 0029123135 scopus 로고
    • Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha
    • Tiggelman, A.M., Boers, W., Linthorst, C., Brand, H.S., Sala, M. and Chamuleau, R.A. (1995) Interleukin-6 production by human liver (myo)fibroblasts in culture. Evidence for a regulatory role of LPS, IL-1 beta and TNF alpha. J Hepatol, 23, 295-306.
    • (1995) J Hepatol , vol.23 , pp. 295-306
    • Tiggelman, A.M.1    Boers, W.2    Linthorst, C.3    Brand, H.S.4    Sala, M.5    Chamuleau, R.A.6
  • 151
    • 0035968289 scopus 로고    scopus 로고
    • JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells
    • Smart, D.E., Vincent, K.J., Arthur, M.J., Eickelberg, O., Castellazzi, M., Mann, J. and Mann, D.A. (2001) JunD regulates transcription of the tissue inhibitor of metalloproteinases-1 and interleukin-6 genes in activated hepatic stellate cells. J Biol Chem, 276, 24414-21.
    • (2001) J Biol Chem , vol.276 , pp. 24414-24421
    • Smart, D.E.1    Vincent, K.J.2    Arthur, M.J.3    Eickelberg, O.4    Castellazzi, M.5    Mann, J.6    Mann, D.A.7
  • 152
    • 0030762368 scopus 로고    scopus 로고
    • Accelerated development of liver fibrosis in CCl4-treated rats by the weekly induction of acute phase response episodes: Upregulation of alpha1(I) procollagen and tissue inhibitor of metalloproteinase-1 mRNAs
    • Greenwel, P. and Rojkind, M. (1997) Accelerated development of liver fibrosis in CCl4-treated rats by the weekly induction of acute phase response episodes: upregulation of alpha1(I) procollagen and tissue inhibitor of metalloproteinase-1 mRNAs. Biochim Biophys Acta, 1361, 177-84.
    • (1997) Biochim Biophys Acta , vol.1361 , pp. 177-184
    • Greenwel, P.1    Rojkind, M.2
  • 153
    • 0035124049 scopus 로고    scopus 로고
    • Rat hepatic stellate cells contribute to the acute-phase response with increased expression of alpha1(I) and alpha1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs
    • Nieto, N., Dominguez-Rosales, J.A., Fontana, L., Salazar, A., Armendariz-Borunda, J., Greenwel, P. and Rojkind, M. (2001) Rat hepatic stellate cells contribute to the acute-phase response with increased expression of alpha1(I) and alpha1(IV) collagens, tissue inhibitor of metalloproteinase-1, and matrix-metalloproteinase-2 messenger RNAs. Hepatology, 33, 597-607.
    • (2001) Hepatology , vol.33 , pp. 597-607
    • Nieto, N.1    Dominguez-Rosales, J.A.2    Fontana, L.3    Salazar, A.4    Armendariz-Borunda, J.5    Greenwel, P.6    Rojkind, M.7
  • 154
    • 0031972755 scopus 로고    scopus 로고
    • Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells
    • Wang, S.C., Ohata, M., Schrum, L., Rippe, R.A. and Tsukamoto, H. (1998) Expression of interleukin-10 by in vitro and in vivo activated hepatic stellate cells. J Biol Chem, 273, 302-8.
    • (1998) J Biol Chem , vol.273 , pp. 302-308
    • Wang, S.C.1    Ohata, M.2    Schrum, L.3    Rippe, R.A.4    Tsukamoto, H.5
  • 155
    • 0031769880 scopus 로고    scopus 로고
    • Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro
    • Thompson, K.C., Trowern, A., Fowell, A., Marathe, M., Haycock, C., Arthur, M.J. and Sheron, N. (1998) Primary rat and mouse hepatic stellate cells express the macrophage inhibitor cytokine interleukin-10 during the course of activation in vitro. Hepatology, 28, 1518-24.
    • (1998) Hepatology , vol.28 , pp. 1518-1524
    • Thompson, K.C.1    Trowern, A.2    Fowell, A.3    Marathe, M.4    Haycock, C.5    Arthur, M.J.6    Sheron, N.7
  • 156
    • 0031769883 scopus 로고    scopus 로고
    • Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis
    • Thompson, K., Maltby, J., Fallowfield, J., McAulay, M., Millward-Sadler, H. and Sheron, N. (1998) Interleukin-10 expression and function in experimental murine liver inflammation and fibrosis. Hepatology, 28, 1597-606.
    • (1998) Hepatology , vol.28 , pp. 1597-1606
    • Thompson, K.1    Maltby, J.2    Fallowfield, J.3    McAulay, M.4    Millward-Sadler, H.5    Sheron, N.6
  • 161
    • 49649114387 scopus 로고    scopus 로고
    • Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells
    • Deng, X., Chen, Y.X., Zhang, X., Zhang, J.P., Yin, C., Yue, H.Y., Lin, Y., Han, Z.G. and Xie, W.F. (2008) Hepatic stellate cells modulate the differentiation of bone marrow mesenchymal stem cells into hepatocyte-like cells. J Cell Physiol, 217, 138-44.
    • (2008) J Cell Physiol , vol.217 , pp. 138-144
    • Deng, X.1    Chen, Y.X.2    Zhang, X.3    Zhang, J.P.4    Yin, C.5    Yue, H.Y.6    Lin, Y.7    Han, Z.G.8    Xie, W.F.9
  • 162
    • 51349168307 scopus 로고    scopus 로고
    • Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence
    • Deleve, L.D., Wang, X. and Guo, Y. (2008) Sinusoidal endothelial cells prevent rat stellate cell activation and promote reversion to quiescence. Hepatology, 48, 920-30.
    • (2008) Hepatology , vol.48 , pp. 920-930
    • Deleve, L.D.1    Wang, X.2    Guo, Y.3
  • 165
    • 14544301470 scopus 로고    scopus 로고
    • Expression of Fc fragment receptors of immunoglobulin G (Fc gammaRs) in rat hepatic stellate cells
    • Shen, H., Zhang, M., Kaita, K., Minuk, G.Y., Rempel, J. and Gong, Y. (2005) Expression of Fc fragment receptors of immunoglobulin G (Fc gammaRs) in rat hepatic stellate cells. Dig Dis Sci, 50, 181-87.
    • (2005) Dig Dis Sci , vol.50 , pp. 181-187
    • Shen, H.1    Zhang, M.2    Kaita, K.3    Minuk, G.Y.4    Rempel, J.5    Gong, Y.6
  • 167
    • 33846431997 scopus 로고    scopus 로고
    • Expression and upregulation of cathepsin S and other early molecules required for antigen presentation in activated hepatic stellate cells upon IFN-gamma treatment
    • Maubach, G., Lim, M.C., Kumar, S. and Zhuo, L. (2007) Expression and upregulation of cathepsin S and other early molecules required for antigen presentation in activated hepatic stellate cells upon IFN-gamma treatment. Biochim Biophys Acta, 1773, 219-31.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 219-231
    • Maubach, G.1    Lim, M.C.2    Kumar, S.3    Zhuo, L.4
  • 169
    • 0028117414 scopus 로고
    • Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease
    • Czaja, M.J., Geerts, A., Xu, J., Schmiedeberg, P. and Ju, Y. (1994) Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease. J Leukoc Biol, 55, 120-26.
    • (1994) J Leukoc Biol , vol.55 , pp. 120-126
    • Czaja, M.J.1    Geerts, A.2    Xu, J.3    Schmiedeberg, P.4    Ju, Y.5
  • 170
    • 0029098308 scopus 로고
    • Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury
    • Marra, F., Grandaliano, G., Valente, A.J. and Abboud, H.E. (1995) Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology, 22, 780-87.
    • (1995) Hepatology , vol.22 , pp. 780-787
    • Marra, F.1    Grandaliano, G.2    Valente, A.J.3    Abboud, H.E.4
  • 171
    • 0029890554 scopus 로고    scopus 로고
    • Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells
    • Xu, Y., Rojkind, M. and Czaja, M.J. (1996) Regulation of monocyte chemoattractant protein 1 by cytokines and oxygen free radicals in rat hepatic fat-storing cells. Gastroenterology, 110, 1870-77.
    • (1996) Gastroenterology , vol.110 , pp. 1870-1877
    • Xu, Y.1    Rojkind, M.2    Czaja, M.J.3
  • 172
    • 0036017172 scopus 로고    scopus 로고
    • Role of Kupffer cells in alcoholic hepatitis
    • Nanji, A.A. (2002) Role of Kupffer cells in alcoholic hepatitis. Alcohol, 27, 13-15.
    • (2002) Alcohol , vol.27 , pp. 13-15
    • Nanji, A.A.1
  • 173
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer, M., Roggel, F. and Gerbes, A.L. (2006) Role of Kupffer cells in host defense and liver disease. Liver Int, 26, 1175-86.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 174
    • 33750110367 scopus 로고    scopus 로고
    • Kupffer cells and alcoholic liver disease
    • Cubero, F.J. and Nieto, N. (2006) Kupffer cells and alcoholic liver disease. Rev Esp Enferm Dig, 98, 460-72.
    • (2006) Rev Esp Enferm Dig , vol.98 , pp. 460-472
    • Cubero, F.J.1    Nieto, N.2
  • 175
    • 58149380812 scopus 로고    scopus 로고
    • Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms
    • Cubero, F.J. and Nieto, N. (2008) Ethanol and arachidonic acid synergize to activate Kupffer cells and modulate the fibrogenic response via tumor necrosis factor alpha, reduced glutathione, and transforming growth factor beta-dependent mechanisms. Hepatology, 48, 2027-39.
    • (2008) Hepatology , vol.48 , pp. 2027-2039
    • Cubero, F.J.1    Nieto, N.2
  • 177
    • 47149105036 scopus 로고    scopus 로고
    • Toll-like receptors and adaptor molecules in liver disease: Update
    • Seki, E. and Brenner, D.A. (2008l) Toll-like receptors and adaptor molecules in liver disease: update. Hepatology, 48, 322-35.
    • (2008) Hepatology , vol.48 , pp. 322-335
    • Seki, E.1    Brenner, D.A.2
  • 178
    • 0030998255 scopus 로고    scopus 로고
    • Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells
    • Sprenger, H., Kaufmann, A., Garn, H., Lahme, B., Gemsa, D. and Gressner, A.M. (1997) Induction of neutrophil-attracting chemokines in transforming rat hepatic stellate cells. Gastroenterology, 113, 277-85.
    • (1997) Gastroenterology , vol.113 , pp. 277-285
    • Sprenger, H.1    Kaufmann, A.2    Garn, H.3    Lahme, B.4    Gemsa, D.5    Gressner, A.M.6
  • 179
    • 0031754502 scopus 로고    scopus 로고
    • Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo
    • Maher, J.J., Lozier, J.S. and Scott, M.K. (1998) Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. Am J Physiol, 275 (4Pt 1), G847-53.
    • (1998) Am J Physiol , vol.275 , Issue.4 , pp. G847-G853
    • Maher, J.J.1    Lozier, J.S.2    Scott, M.K.3
  • 180
    • 0035672819 scopus 로고    scopus 로고
    • Malondialdehydeacetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cells
    • Kharbanda, K.K., Todero, S.L., Shubert, K.A., Sorrell, M.F. and Tuma, D.J. (2001) Malondialdehydeacetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cells. Alcohol, 25, 123-28.
    • (2001) Alcohol , vol.25 , pp. 123-128
    • Kharbanda, K.K.1    Todero, S.L.2    Shubert, K.A.3    Sorrell, M.F.4    Tuma, D.J.5
  • 182
    • 42049092789 scopus 로고    scopus 로고
    • Fibrogenesis of parenchymal organs
    • Kisseleva, T. and Brenner, D.A. (2008) Fibrogenesis of parenchymal organs. Proc Am Thorac Soc, 5, 338-42.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 338-342
    • Kisseleva, T.1    Brenner, D.A.2
  • 184
    • 33747611690 scopus 로고    scopus 로고
    • Transcriptional regulation of stellate cell activation
    • Friedman, S.L. (2006) Transcriptional regulation of stellate cell activation. J Gastroenterol Hepatol, 21 (Suppl 3), S79-83.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. S79-S83
    • Friedman, S.L.1
  • 185
    • 35948978184 scopus 로고    scopus 로고
    • Hepatic fibrogenesis
    • Guo, J. and Friedman, S.L. (2007) Hepatic fibrogenesis. Semin Liver Dis, 27, 413-26.
    • (2007) Semin Liver Dis , vol.27 , pp. 413-426
    • Guo, J.1    Friedman, S.L.2
  • 186
    • 34648840528 scopus 로고    scopus 로고
    • An endothelin A receptor antagonist induces dilatation of sinusoidal endothelial fenestrae: Implications for endothelin-1 in hepatic microcirculation
    • Wtanabe, N., Takashimizu, S., Nishizaki, Y., Kojima, S., Kagawa, T. and Matsuzaki, S. (2007) An endothelin A receptor antagonist induces dilatation of sinusoidal endothelial fenestrae: implications for endothelin-1 in hepatic microcirculation. J Gastroenterol, 42 (9), 775-82.
    • (2007) J Gastroenterol , vol.42 , Issue.9 , pp. 775-782
    • Wtanabe, N.1    Takashimizu, S.2    Nishizaki, Y.3    Kojima, S.4    Kagawa, T.5    Matsuzaki, S.6
  • 189
    • 0343238985 scopus 로고    scopus 로고
    • H(2)O(2) is an important mediator of physiological and pathological healing responses
    • Domínguez-Rosales, J.A., Mavi, G., Levenson, S.M. and Rojkind, M. (2000) H(2)O(2) is an important mediator of physiological and pathological healing responses. Arch Med Res, 31, 15-20.
    • (2000) Arch Med Res , vol.31 , pp. 15-20
    • Domínguez-Rosales, J.A.1    Mavi, G.2    Levenson, S.M.3    Rojkind, M.4
  • 190
    • 0032897278 scopus 로고    scopus 로고
    • UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells
    • Chen, A. and Davis, B.H. (1999) UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells. J Biol Chem, 274, 158-64.
    • (1999) J Biol Chem , vol.274 , pp. 158-164
    • Chen, A.1    Davis, B.H.2
  • 191
    • 0033011847 scopus 로고    scopus 로고
    • Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: Regulation by activator protein-1 DNA binding proteins
    • Bahr, M.J., Vincent, K.J., Arthur, M.J., Fowler, A.V., Smart, D.E., Wright, M.C., Clark, I.M., Benyon, R.C., Iredale, J.P. and Mann, D.A. (1999) Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins. Hepatology, 29, 839-48.
    • (1999) Hepatology , vol.29 , pp. 839-848
    • Bahr, M.J.1    Vincent, K.J.2    Arthur, M.J.3    Fowler, A.V.4    Smart, D.E.5    Wright, M.C.6    Clark, I.M.7    Benyon, R.C.8    Iredale, J.P.9    Mann, D.A.10
  • 192
    • 0036107548 scopus 로고    scopus 로고
    • Transcriptional regulation of hepatic stellate cell activation
    • Mann, D.A. and Smart, D.E. (2002) Transcriptional regulation of hepatic stellate cell activation. Gut, 50, 891-96.
    • (2002) Gut , vol.50 , pp. 891-896
    • Mann, D.A.1    Smart, D.E.2
  • 193
    • 5144234459 scopus 로고    scopus 로고
    • From quiescence to activation: Gene regulation in hepatic stellate cells
    • Rippe, R.A. and Brenner, D.A. (2004) From quiescence to activation: gene regulation in hepatic stellate cells. Gastroenterology, 127, 1260-62.
    • (2004) Gastroenterology , vol.127 , pp. 1260-1262
    • Rippe, R.A.1    Brenner, D.A.2
  • 195
    • 0033053458 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces the expression of alpha1 (I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells
    • García-Trevijano, E.R., Iraburu, M.J., Fontana, L., Domínguez-Rosales, J.A., Auster, A., Covarrubias-Pinedo, A. and Rojkind, M. (1999) Transforming growth factor beta1 induces the expression of alpha1 (I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. Hepatology, 29, 960-70.
    • (1999) Hepatology , vol.29 , pp. 960-970
    • García-Trevijano, E.R.1    Iraburu, M.J.2    Fontana, L.3    Domínguez-Rosales, J.A.4    Auster, A.5    Covarrubias-Pinedo, A.6    Rojkind, M.7
  • 196
    • 0033965330 scopus 로고    scopus 로고
    • Hydrogen peroxide: A link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells
    • Greenwel, P., Domínguez-Rosales, J.A., Mavi, G., Rivas-Estilla, A.M. and Rojkind, M. (2000) Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology, 31, 109-16.
    • (2000) Hepatology , vol.31 , pp. 109-116
    • Greenwel, P.1    Domínguez-Rosales, J.A.2    Mavi, G.3    Rivas-Estilla, A.M.4    Rojkind, M.5
  • 198
    • 14344265751 scopus 로고    scopus 로고
    • Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells
    • Huang, G.C., Zhang, J.S. and Tang, Q.Q. (2004) Involvement of C/EBP-alpha gene in in vitro activation of rat hepatic stellate cells. Biochem Biophys Res Commun, 324, 1309-18.
    • (2004) Biochem Biophys Res Commun , vol.324 , pp. 1309-1318
    • Huang, G.C.1    Zhang, J.S.2    Tang, Q.Q.3
  • 199
    • 35848944310 scopus 로고    scopus 로고
    • C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells
    • Buck, M. and Chojkier, M. (2007) C/EBPbeta associates with caspase 8 complex proteins and modulates apoptosis in hepatic stellate cells. J Clin Gastroenterol, 41 (Suppl 3), S295-99.
    • (2007) J Clin Gastroenterol , vol.41 , pp. S295-S299
    • Buck, M.1    Chojkier, M.2
  • 200
    • 0028838193 scopus 로고
    • Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression
    • Lee, K.S., Buck, M., Houglum, K. and Chojkier, M. (1995) Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest, 96, 2461-68.
    • (1995) J Clin Invest , vol.96 , pp. 2461-2468
    • Lee, K.S.1    Buck, M.2    Houglum, K.3    Chojkier, M.4
  • 201
    • 0032568808 scopus 로고    scopus 로고
    • E-box-binding repressor is down-regulated in hepatic stellate cells during up-regulation of mannose 6-phosphate/insulin-like growth factor-II receptor expression in early hepatic fibrogenesis
    • Weiner, J.A., Chen, A. and Davis, B.H. (1998) E-box-binding repressor is down-regulated in hepatic stellate cells during up-regulation of mannose 6-phosphate/insulin-like growth factor-II receptor expression in early hepatic fibrogenesis. J Biol Chem, 273, 15913-19.
    • (1998) J Biol Chem , vol.273 , pp. 15913-15919
    • Weiner, J.A.1    Chen, A.2    Davis, B.H.3
  • 202
    • 0034650469 scopus 로고    scopus 로고
    • Platelet-derived growth factor is a principal inductive factormodulating mannose 6-phosphate/insulin-like growth factor-II receptorgene expression via a distal E-box in activated hepatic stellate cells
    • Weiner, J.A., Chen, A. and Davis, B.H. (2000) Platelet-derived growth factor is a principal inductive factormodulating mannose 6-phosphate/insulin-like growth factor-II receptorgene expression via a distal E-box in activated hepatic stellate cells. Biochem J, 345 (Pt 2), 225-31.
    • (2000) Biochem J , vol.345 , pp. 225-231
    • Weiner, J.A.1    Chen, A.2    Davis, B.H.3
  • 203
    • 0034014267 scopus 로고    scopus 로고
    • c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells
    • Buck, M., Kim, D.J., Houglum, K., Hassanein, T. and Chojkier, M. (2000) c-Myb modulates transcription of the alpha-smooth muscle actin gene in activated hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol, 278, G321-28.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.278 , pp. G321-G328
    • Buck, M.1    Kim, D.J.2    Houglum, K.3    Hassanein, T.4    Chojkier, M.5
  • 204
    • 0034771455 scopus 로고    scopus 로고
    • Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells
    • Vincent, K.J., Jones, E., Arthur, M.J., Smart, D.E., Trim, J., Wright, M.C. and Mann, D.A. (2001) Regulation of E-box DNA binding during in vivo and in vitro activation of rat and human hepatic stellate cells. Gut, 49, 713-19.
    • (2001) Gut , vol.49 , pp. 713-719
    • Vincent, K.J.1    Jones, E.2    Arthur, M.J.3    Smart, D.E.4    Trim, J.5    Wright, M.C.6    Mann, D.A.7
  • 206
    • 0029097265 scopus 로고
    • Sp1 binding activity increases in activated Ito cells
    • Rippe, R.A., Almounajed, G. and Brenner, D.A. (1995) Sp1 binding activity increases in activated Ito cells. Hepatology, 22, 241-51.
    • (1995) Hepatology , vol.22 , pp. 241-251
    • Rippe, R.A.1    Almounajed, G.2    Brenner, D.A.3
  • 207
    • 0028978771 scopus 로고
    • Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver
    • Inagaki, Y., Truter, S., Greenwel, P., Rojkind, M., Unoura, M., Kobayashi, K. and Ramirez, F. (1995) Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology, 22, 573-79.
    • (1995) Hepatology , vol.22 , pp. 573-579
    • Inagaki, Y.1    Truter, S.2    Greenwel, P.3    Rojkind, M.4    Unoura, M.5    Kobayashi, K.6    Ramirez, F.7
  • 208
    • 0032509217 scopus 로고    scopus 로고
    • Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury
    • Kim, Y., Ratziu, V., Choi, S.G., Lalazar, A., Theiss, G., Dang, Q., Kim, S.J. and Friedman, S.L. (1998) Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. J Biol Chem, 273, 33750-58.
    • (1998) J Biol Chem , vol.273 , pp. 33750-33758
    • Kim, Y.1    Ratziu, V.2    Choi, S.G.3    Lalazar, A.4    Theiss, G.5    Dang, Q.6    Kim, S.J.7    Friedman, S.L.8
  • 210
    • 0035844276 scopus 로고    scopus 로고
    • Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription
    • Inagaki, Y., Nemoto, T., Nakao, A., ten Dijke, P., Kobayashi, K., Takehara, K. and Greenwel, P. (2001) Interaction between GC box binding factors and Smad proteins modulates cell lineage-specific alpha 2(I) collagen gene transcription. J Biol Chem, 276, 16573-79.
    • (2001) J Biol Chem , vol.276 , pp. 16573-16579
    • Inagaki, Y.1    Nemoto, T.2    Nakao, A.3    ten Dijke, P.4    Kobayashi, K.5    Takehara, K.6    Greenwel, P.7
  • 211
    • 0037163121 scopus 로고    scopus 로고
    • Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells
    • García-Ruiz, I., de la Torre, P., Díaz, T., Esteban, E., Fernández, I., Muñoz-Yagüe, T. and Solís-Herruzo, J.A. (2002) Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells. J Biol Chem, 277, 30551-58.
    • (2002) J Biol Chem , vol.277 , pp. 30551-30558
    • García-Ruiz, I.1    de la Torre, P.2    Díaz, T.3    Esteban, E.4    Fernández, I.5    Muñoz-Yagüe, T.6    Solís-Herruzo, J.A.7
  • 213
    • 0032509217 scopus 로고    scopus 로고
    • Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury
    • Kim, Y., Ratziu, V., Choi, S.G., Lalazar, A., Theiss, G., Dang, Q., Kim, S.J. and Friedman, S.L. (1998) Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. J Biol Chem, 273, 33750-58.
    • (1998) J Biol Chem , vol.273 , pp. 33750-33758
    • Kim, Y.1    Ratziu, V.2    Choi, S.G.3    Lalazar, A.4    Theiss, G.5    Dang, Q.6    Kim, S.J.7    Friedman, S.L.8
  • 214
    • 0141786790 scopus 로고    scopus 로고
    • Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats
    • Stärkel, P., Sempoux, C., Leclercq, I., Herin, M., Deby, C., Desager, J.P. and Horsmans, Y. (2003) Oxidative stress, KLF6 and transforming growth factor-beta up-regulation differentiate non-alcoholic steatohepatitis progressing to fibrosis from uncomplicated steatosis in rats. J Hepatol, 39, 538-46.
    • (2003) J Hepatol , vol.39 , pp. 538-546
    • Stärkel, P.1    Sempoux, C.2    Leclercq, I.3    Herin, M.4    Deby, C.5    Desager, J.P.6    Horsmans, Y.7
  • 215
    • 25144468006 scopus 로고    scopus 로고
    • Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10
    • Schnabl, B., Hu, K., Mühlbauer, M., Hellerbrand, C., Stefanovic, B., Brenner, D.A. and Schölmerich, J. (2005) Zinc finger protein 267 is up-regulated during the activation process of human hepatic stellate cells and functions as a negative transcriptional regulator of MMP-10. Biochem Biophys Res Commun, 335, 87-96.
    • (2005) Biochem Biophys Res Commun , vol.335 , pp. 87-96
    • Schnabl, B.1    Hu, K.2    Mühlbauer, M.3    Hellerbrand, C.4    Stefanovic, B.5    Brenner, D.A.6    Schölmerich, J.7
  • 216
    • 5144227348 scopus 로고    scopus 로고
    • Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2
    • Wang, X., Tang, X., Gong, X., Albanis, E., Friedman, S.L. and Mao, Z. (2004) Regulation of hepatic stellate cell activation and growth by transcription factor myocyte enhancer factor 2. Gastroenterology, 127, 1174-88.
    • (2004) Gastroenterology , vol.127 , pp. 1174-1188
    • Wang, X.1    Tang, X.2    Gong, X.3    Albanis, E.4    Friedman, S.L.5    Mao, Z.6
  • 217
    • 0032841856 scopus 로고    scopus 로고
    • Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins
    • Elsharkawy, A.M., Wright, M.C., Hay, R.T., Arthur, M.J., Hughes, T., Bahr, M.J., Degitz, K. and Mann, D.A. (1999) Persistent activation of nuclear factor-kappaB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IkappaB family proteins. Hepatology, 30, 761-69.
    • (1999) Hepatology , vol.30 , pp. 761-769
    • Elsharkawy, A.M.1    Wright, M.C.2    Hay, R.T.3    Arthur, M.J.4    Hughes, T.5    Bahr, M.J.6    Degitz, K.7    Mann, D.A.8
  • 219
    • 0033623899 scopus 로고    scopus 로고
    • Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells
    • Lang, A., Schoonhoven, R., Tuvia, S., Brenner, D.A. and Rippe, R.A. (2000) Nuclear factor kappaB in proliferation, activation, and apoptosis in rat hepatic stellate cells. J Hepatol, 33, 49-58.
    • (2000) J Hepatol , vol.33 , pp. 49-58
    • Lang, A.1    Schoonhoven, R.2    Tuvia, S.3    Brenner, D.A.4    Rippe, R.A.5
  • 220
    • 0033886493 scopus 로고    scopus 로고
    • Involvement of p65 in the regulation of NF-kappaB in rat hepatic stellate cells during cirrhosis
    • Vasiliou, V., Lee, J., Pappa, A. and Petersen, D.R. (2000) Involvement of p65 in the regulation of NF-kappaB in rat hepatic stellate cells during cirrhosis. Biochem Biophys Res Commun, 273, 546-50.
    • (2000) Biochem Biophys Res Commun , vol.273 , pp. 546-550
    • Vasiliou, V.1    Lee, J.2    Pappa, A.3    Petersen, D.R.4
  • 221
    • 0035336310 scopus 로고    scopus 로고
    • CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells
    • Schwabe, R.F., Schnabl, B., Kweon, Y.O. and Brenner, D.A. (2001) CD40 activates NF-kappa B and c-Jun N-terminal kinase and enhances chemokine secretion on activated human hepatic stellate cells. J Immunol, 166, 6812-19.
    • (2001) J Immunol , vol.166 , pp. 6812-6819
    • Schwabe, R.F.1    Schnabl, B.2    Kweon, Y.O.3    Brenner, D.A.4
  • 222
    • 2442572202 scopus 로고    scopus 로고
    • Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter
    • Novitskiy, G., Potter, J.J., Rennie-Tankersley, L. and Mezey, E. (2004) Identification of a novel NF-kappaB-binding site with regulation of the murine alpha2(I) collagen promoter. J Biol Chem, 279, 15639-44.
    • (2004) J Biol Chem , vol.279 , pp. 15639-15644
    • Novitskiy, G.1    Potter, J.J.2    Rennie-Tankersley, L.3    Mezey, E.4
  • 225
    • 33747075792 scopus 로고    scopus 로고
    • Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: Role of p38 MAPK
    • Thirunavukkarasu, C., Watkins, S.C. and Gandhi, C.R. (2006) Mechanisms of endotoxin-induced NO, IL-6, and TNF-alpha production in activated rat hepatic stellate cells: role of p38 MAPK. Hepatology, 44, 389-98.
    • (2006) Hepatology , vol.44 , pp. 389-398
    • Thirunavukkarasu, C.1    Watkins, S.C.2    Gandhi, C.R.3
  • 226
    • 34548707231 scopus 로고    scopus 로고
    • Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis
    • Son, G., Iimuro, Y., Seki, E., Hirano, T., Kaneda, Y. and Fujimoto, J. (2007) Selective inactivation of NF-kappaB in the liver using NF-kappaB decoy suppresses CCl4-induced liver injury and fibrosis. Am J Physiol Gastrointest Liver Physiol, 293, G631-39.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.293 , pp. G631-G639
    • Son, G.1    Iimuro, Y.2    Seki, E.3    Hirano, T.4    Kaneda, Y.5    Fujimoto, J.6
  • 227
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
    • Galli, A., Crabb, D., Price, D., Ceni, E., Salzano, R., Surrenti, C. and Casini, A. (2000) Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. Hepatology, 31, 101-8.
    • (2000) Hepatology , vol.31 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3    Ceni, E.4    Salzano, R.5    Surrenti, C.6    Casini, A.7
  • 231
    • 14244257340 scopus 로고    scopus 로고
    • Adipogenic transcriptional regulation of hepatic stellate cells
    • She, H., Xiong, S., Hazra, S. and Tsukamoto, H. (2005) Adipogenic transcriptional regulation of hepatic stellate cells. J Biol Chem, 280, 4959-67.
    • (2005) J Biol Chem , vol.280 , pp. 4959-4967
    • She, H.1    Xiong, S.2    Hazra, S.3    Tsukamoto, H.4
  • 233
    • 1642524221 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
    • Hazra, S., Xiong, S., Wang, J., Rippe, R.A., Krishna, V., Chatterjee, K. and Tsukamoto, H. (2004) Peroxisome proliferator-activated receptor gamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem, 279, 11392-401.
    • (2004) J Biol Chem , vol.279 , pp. 11392-11401
    • Hazra, S.1    Xiong, S.2    Wang, J.3    Rippe, R.A.4    Krishna, V.5    Chatterjee, K.6    Tsukamoto, H.7
  • 234
    • 0035958883 scopus 로고    scopus 로고
    • Regulation of cell growth by redoxmediated extracellular proteolysis of platelet-derived growth factor receptor beta
    • Okuyama, H., Shimahara, Y., Kawada, N., Seki, S., Kristensen, D.B., Yoshizato, K., Uyama, N. and Yamaoka, Y. (2001) Regulation of cell growth by redoxmediated extracellular proteolysis of platelet-derived growth factor receptor beta. J Biol Chem, 276, 28274-80.
    • (2001) J Biol Chem , vol.276 , pp. 28274-28280
    • Okuyama, H.1    Shimahara, Y.2    Kawada, N.3    Seki, S.4    Kristensen, D.B.5    Yoshizato, K.6    Uyama, N.7    Yamaoka, Y.8
  • 236
    • 0034813705 scopus 로고    scopus 로고
    • Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats
    • Hernández-Muñoz, R., Díaz-Muñoz, M., Suárez-Cuenca, J.A., Trejo-Solís, C., López, V., Sánchez-Sevilla, L., Yáñez, L. and De Sánchez, V.C. (2001) Adenosine reverses a preestablished CCl4-induced micronodular cirrhosis through enhancing collagenolytic activity and stimulating hepatocyte cell proliferation in rats. Hepatology, 34, 677-87.
    • (2001) Hepatology , vol.34 , pp. 677-687
    • Hernández-Muñoz, R.1    Díaz-Muñoz, M.2    Suárez-Cuenca, J.A.3    Trejo-Solís, C.4    López, V.5    Sánchez-Sevilla, L.6    Yáñez, L.7    De Sánchez, V.C.8
  • 241
    • 36348939367 scopus 로고    scopus 로고
    • Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway
    • Che, J., Chan, E.S. and Cronstein, B.N. (2007) Adenosine A2A receptor occupancy stimulates collagen expression by hepatic stellate cells via pathways involving protein kinase A, Src, and extracellular signal-regulated kinases 1/2 signaling cascade or p38 mitogen-activated protein kinase signaling pathway. Mol Pharmacol, 72, 1626-36.
    • (2007) Mol Pharmacol , vol.72 , pp. 1626-1636
    • Che, J.1    Chan, E.S.2    Cronstein, B.N.3
  • 242
    • 0030924252 scopus 로고    scopus 로고
    • Leptin and other secretory products of adipocytes modulate multiple physiological functions
    • Weigle, D.S. (1997) Leptin and other secretory products of adipocytes modulate multiple physiological functions. Ann Endocrinol (Paris), 58, 132-36.
    • (1997) Ann Endocrinol (Paris) , vol.58 , pp. 132-136
    • Weigle, D.S.1
  • 243
    • 2942687834 scopus 로고    scopus 로고
    • Adiponectin: A novel adipokine linking adipocytes and vascular function
    • Goldstein, B.J. and Scalia, R. (2004) Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab, 89, 2563-68.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 2563-2568
    • Goldstein, B.J.1    Scalia, R.2
  • 244
    • 0032489223 scopus 로고    scopus 로고
    • Transdifferentiation of rat hepatic stellate cells results in leptin expression
    • Potter, J.J., Womack, L., Mezey, E. and Anania, F.A. (1998) Transdifferentiation of rat hepatic stellate cells results in leptin expression. Biochem Biophys Res Commun, 244, 178-82.
    • (1998) Biochem Biophys Res Commun , vol.244 , pp. 178-182
    • Potter, J.J.1    Womack, L.2    Mezey, E.3    Anania, F.A.4
  • 245
    • 0036204924 scopus 로고    scopus 로고
    • Leptin in hepatic fibrosis: Evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice
    • Saxena, N.K., Ikeda, K., Rockey, D.C., Friedman, S.L. and Anania, F.A. (2002) Leptin in hepatic fibrosis: evidence for increased collagen production in stellate cells and lean littermates of ob/ob mice. Hepatology, 35, 762-71.
    • (2002) Hepatology , vol.35 , pp. 762-771
    • Saxena, N.K.1    Ikeda, K.2    Rockey, D.C.3    Friedman, S.L.4    Anania, F.A.5
  • 246
    • 0038644530 scopus 로고    scopus 로고
    • Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells
    • Saxena, N.K., Saliba, G., Floyd, J.J. and Anania, F.A. (2003) Leptin induces increased alpha2(I) collagen gene expression in cultured rat hepatic stellate cells. J Cell Biochem, 89, 311-20.
    • (2003) J Cell Biochem , vol.89 , pp. 311-320
    • Saxena, N.K.1    Saliba, G.2    Floyd, J.J.3    Anania, F.A.4
  • 247
    • 1042289785 scopus 로고    scopus 로고
    • Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: Respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways
    • Cao, Q., Mak, K.M., Ren, C. and Lieber, C.S. (2004) Leptin stimulates tissue inhibitor of metalloproteinase-1 in human hepatic stellate cells: respective roles of the JAK/STAT and JAK-mediated H2O2-dependant MAPK pathways. J Biol Chem, 279, 4292-304.
    • (2004) J Biol Chem , vol.279 , pp. 4292-4304
    • Cao, Q.1    Mak, K.M.2    Ren, C.3    Lieber, C.S.4
  • 248
    • 9444223845 scopus 로고    scopus 로고
    • Leptin as a novel profibrogenic cytokine in hepatic stellate cells: Mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation
    • Saxena, N.K., Titus, M.A., Ding, X., Floyd, J., Srinivasan, S., Sitaraman, S.V. and Anania, F.A. (2004) Leptin as a novel profibrogenic cytokine in hepatic stellate cells: mitogenesis and inhibition of apoptosis mediated by extracellular regulated kinase (Erk) and Akt phosphorylation. FASEB J, 18, 1612-14.
    • (2004) FASEB J , vol.18 , pp. 1612-1614
    • Saxena, N.K.1    Titus, M.A.2    Ding, X.3    Floyd, J.4    Srinivasan, S.5    Sitaraman, S.V.6    Anania, F.A.7
  • 249
    • 4544235127 scopus 로고    scopus 로고
    • Leptin facilitates proliferation of hepatic stellate cells through up-regulation of platelet-derived growth factor receptor
    • Lang, T., Ikejima, K., Yoshikawa, M., Enomoto, N., Iijima, K., Kitamura, T., Takei, Y. and Sato, N. (2004) Leptin facilitates proliferation of hepatic stellate cells through up-regulation of platelet-derived growth factor receptor. Biochem Biophys Res Commun, 323, 1091-95.
    • (2004) Biochem Biophys Res Commun , vol.323 , pp. 1091-1095
    • Lang, T.1    Ikejima, K.2    Yoshikawa, M.3    Enomoto, N.4    Iijima, K.5    Kitamura, T.6    Takei, Y.7    Sato, N.8
  • 250
    • 34548162930 scopus 로고    scopus 로고
    • Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells
    • Cao, Q., Mak, K.M. and Lieber, C.S. (2007) Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells. J Hepatol, 46, 124-33.
    • (2007) J Hepatol , vol.46 , pp. 124-133
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 252
    • 42149117692 scopus 로고    scopus 로고
    • Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells
    • Mahadev, K., Wu, X., Donnelly, S., Ouedraogo, R., Eckhart, A.D. and Goldstein, B.J. (2008) Adiponectin inhibits vascular endothelial growth factor-induced migration of human coronary artery endothelial cells. Cardiovasc Res, 78, 376-84.
    • (2008) Cardiovasc Res , vol.78 , pp. 376-384
    • Mahadev, K.1    Wu, X.2    Donnelly, S.3    Ouedraogo, R.4    Eckhart, A.D.5    Goldstein, B.J.6
  • 253
    • 24044538551 scopus 로고    scopus 로고
    • Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
    • Wang, Y., Lam, K.S., Xu, J.Y., Lu, G., Xu, L.Y., Cooper, G.J. and Xu, A. (2005) Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem, 280, 18341-47.
    • (2005) J Biol Chem , vol.280 , pp. 18341-18347
    • Wang, Y.1    Lam, K.S.2    Xu, J.Y.3    Lu, G.4    Xu, L.Y.5    Cooper, G.J.6    Xu, A.7
  • 254
    • 39549093795 scopus 로고    scopus 로고
    • High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphateactivated protein kinase
    • Adachi, M. and Brenner, D.A. (2008) High molecular weight adiponectin inhibits proliferation of hepatic stellate cells via activation of adenosine monophosphateactivated protein kinase. Hepatology, 47, 677-85.
    • (2008) Hepatology , vol.47 , pp. 677-685
    • Adachi, M.1    Brenner, D.A.2
  • 255
    • 0035958625 scopus 로고    scopus 로고
    • Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells
    • Dooley, S., Delvoux, B., Streckert, M., Bonzel, L., Stopa, M., ten Dijke, P. and Gressner, A.M. (2001) Transforming growth factor beta signal transduction in hepatic stellate cells via Smad2/3 phosphorylation, a pathway that is abrogated during in vitro progression to myofibroblasts. TGFbeta signal transduction during transdifferentiation of hepatic stellate cells. FEBS Lett, 502, 4-10.
    • (2001) FEBS Lett , vol.502 , pp. 4-10
    • Dooley, S.1    Delvoux, B.2    Streckert, M.3    Bonzel, L.4    Stopa, M.5    ten Dijke, P.6    Gressner, A.M.7
  • 256
    • 0034804663 scopus 로고    scopus 로고
    • Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts
    • Dooley, S., Streckert, M., Delvoux, B. and Gressner, A.M. (2001) Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts. Biochem Biophys Res Commun, 283, 554-62.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 554-562
    • Dooley, S.1    Streckert, M.2    Delvoux, B.3    Gressner, A.M.4
  • 258
    • 0037837754 scopus 로고    scopus 로고
    • Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
    • Liu, C., Gaça, M.D., Swenson, E.S., Vellucci, V.F., Reiss, M. and Wells, R.G. (2003) Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J BiolChem, 278 (13), 11721-28.
    • (2003) J BiolChem , vol.278 , Issue.13 , pp. 11721-11728
    • Liu, C.1    Gaça, M.D.2    Swenson, E.S.3    Vellucci, V.F.4    Reiss, M.5    Wells, R.G.6
  • 259
    • 16644377297 scopus 로고    scopus 로고
    • Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells
    • Wakahara, K., Kobayashi, H., Yagyu, T., Matsuzaki, H., Kondo, T., Kurita, N., Sekino, H., Inagaki, K., Suzuki, M., Kanayama, N. and Terao, T. (2004) Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells. J Cell Biochem, 93, 437-53.
    • (2004) J Cell Biochem , vol.93 , pp. 437-453
    • Wakahara, K.1    Kobayashi, H.2    Yagyu, T.3    Matsuzaki, H.4    Kondo, T.5    Kurita, N.6    Sekino, H.7    Inagaki, K.8    Suzuki, M.9    Kanayama, N.10    Terao, T.11
  • 260
    • 0033057124 scopus 로고    scopus 로고
    • Acetaldehyde-mediated collagen regulation in hepatic stellate cells
    • Greenwel, P. (1999) Acetaldehyde-mediated collagen regulation in hepatic stellate cells. Alcohol Clin Exp Res, 23 (5), 930-33.
    • (1999) Alcohol Clin Exp Res , vol.23 , Issue.5 , pp. 930-933
    • Greenwel, P.1
  • 262
    • 20044393839 scopus 로고    scopus 로고
    • NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells
    • Adachi, T., Togashi, H., Suzuki, A., Kasai, S., Ito, J., Sugahara, K. and Kawata, S. (2005) NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology, 41, 1272-81.
    • (2005) Hepatology , vol.41 , pp. 1272-1281
    • Adachi, T.1    Togashi, H.2    Suzuki, A.3    Kasai, S.4    Ito, J.5    Sugahara, K.6    Kawata, S.7
  • 263
    • 35649011943 scopus 로고    scopus 로고
    • Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells
    • Pérez de Obanos, M.P., López-Zabalza, M.J., Arriazu, E., Modol, T., Prieto, J., Herraiz, M.T. and Iraburu, M.J. (2007) Reactive oxygen species (ROS) mediate the effects of leucine on translation regulation and type I collagen production in hepatic stellate cells. Biochim Biophys Acta, 1773, 1681-88.
    • (2007) Biochim Biophys Acta , vol.1773 , pp. 1681-1688
    • Pérez de Obanos, M.P.1    López-Zabalza, M.J.2    Arriazu, E.3    Modol, T.4    Prieto, J.5    Herraiz, M.T.6    Iraburu, M.J.7
  • 264
    • 40749104940 scopus 로고    scopus 로고
    • Oxidative stress in alcoholic liver disease: Role of NADPH oxidase complex
    • De Minicis, S. and Brenner, D.A. (2008) Oxidative stress in alcoholic liver disease: role of NADPH oxidase complex. Gastroenterol Hepatol, 23 (Suppl 1), S98-103.
    • (2008) Gastroenterol Hepatol , vol.23 , pp. S98-S103
    • De Minicis, S.1    Brenner, D.A.2
  • 266
    • 58149380810 scopus 로고    scopus 로고
    • Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells
    • De Minicis, S., Seki, E., Oesterreicher, C., Schnabl, B., Schwabe, R.F. and Brenner, D.A. (2008) Reduced nicotinamide adenine dinucleotide phosphate oxidase mediates fibrotic and inflammatory effects of leptin on hepatic stellate cells. Hepatology, 48, 2016-26.
    • (2008) Hepatology , vol.48 , pp. 2016-2026
    • De Minicis, S.1    Seki, E.2    Oesterreicher, C.3    Schnabl, B.4    Schwabe, R.F.5    Brenner, D.A.6
  • 268
    • 33846146019 scopus 로고    scopus 로고
    • Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation
    • Myung, S.J., Yoon, J.H., Gwak, G.Y., Kim, W., Yang, J.I., Lee, S.H., Jang, J.J. and Lee, H.S. (2007) Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation. Biochem Biophys Res Commun, 353, 1091-96.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 1091-1096
    • Myung, S.J.1    Yoon, J.H.2    Gwak, G.Y.3    Kim, W.4    Yang, J.I.5    Lee, S.H.6    Jang, J.J.7    Lee, H.S.8
  • 269
    • 0034109215 scopus 로고    scopus 로고
    • Activation of latent TGF-beta by thrombospondin-1: Mechanisms and physiology
    • Murphy-Ullrich, J.E. and Poczatek, M. (2000) Activation of latent TGF-beta by thrombospondin-1: mechanisms and physiology. Cytokine Growth Factor Rev, 11, 59-69.
    • (2000) Cytokine Growth Factor Rev , vol.11 , pp. 59-69
    • Murphy-Ullrich, J.E.1    Poczatek, M.2
  • 270
    • 46449099523 scopus 로고    scopus 로고
    • Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: A possible contribution of KLF5 to fibrogenic responses
    • Ohara, F., Nii, A., Sakiyama, Y., Tsuchiya, M. and Ogawa, S. (2008) Pathophysiological characteristics of dimethylnitrosamine-induced liver fibrosis in acute and chronic injury models: a possible contribution of KLF5 to fibrogenic responses. Dig Dis Sci, 53, 2222-32.
    • (2008) Dig Dis Sci , vol.53 , pp. 2222-2232
    • Ohara, F.1    Nii, A.2    Sakiyama, Y.3    Tsuchiya, M.4    Ogawa, S.5
  • 271
    • 0034033855 scopus 로고    scopus 로고
    • The DNA binding protein BTEB mediates acetaldehyde-induced, jun N-terminal kinase-dependent alphaI(I) collagen gene expression in rat hepatic stellate cells
    • Chen, A. and Davis, B.H. (2000) The DNA binding protein BTEB mediates acetaldehyde-induced, jun N-terminal kinase-dependent alphaI(I) collagen gene expression in rat hepatic stellate cells. Mol Cell Biol, 20, 2818-26.
    • (2000) Mol Cell Biol , vol.20 , pp. 2818-2826
    • Chen, A.1    Davis, B.H.2
  • 272
    • 34347323993 scopus 로고    scopus 로고
    • Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation
    • Tajima, K., Terai, S., Takami, T., Kawaguchi, K., Okita, K. and Sakaida, I. (2007) Importance of inhibitor of DNA binding/differentiation 2 in hepatic stellate cell differentiation and proliferation. Hepatol Res, 37, 647-55.
    • (2007) Hepatol Res , vol.37 , pp. 647-655
    • Tajima, K.1    Terai, S.2    Takami, T.3    Kawaguchi, K.4    Okita, K.5    Sakaida, I.6
  • 273
    • 33747616182 scopus 로고    scopus 로고
    • Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation
    • Tsukamoto, H., She, H., Hazra, S., Cheng, J. and Miyahara, T. (2006) Anti-adipogenic regulation underlies hepatic stellate cell transdifferentiation. J Gastroenterol Hepatol, 21, S102-5.
    • (2006) J Gastroenterol Hepatol , vol.21 , pp. S102-S105
    • Tsukamoto, H.1    She, H.2    Hazra, S.3    Cheng, J.4    Miyahara, T.5
  • 274
    • 0027376984 scopus 로고
    • Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by northern hybridization analysis
    • Geerts, A., Greenwel, P., Cunningham, M., De Bleser, P., Rogiers, V., Wisse, E. and Rojkind, M. (1993) Identification of connective tissue gene transcripts in freshly isolated parenchymal, endothelial, Kupffer and fat-storing cells by northern hybridization analysis. J Hepatol, 19, 148-58.
    • (1993) J Hepatol , vol.19 , pp. 148-158
    • Geerts, A.1    Greenwel, P.2    Cunningham, M.3    De Bleser, P.4    Rogiers, V.5    Wisse, E.6    Rojkind, M.7
  • 275
    • 33745484285 scopus 로고    scopus 로고
    • Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats
    • Leclercq, I.A., Sempoux, C., Stärkel, P. and Horsmans, Y. (2006) Limited therapeutic efficacy of pioglitazone on progression of hepatic fibrosis in rats. Gut, 55, 1020-29.
    • (2006) Gut , vol.55 , pp. 1020-1029
    • Leclercq, I.A.1    Sempoux, C.2    Stärkel, P.3    Horsmans, Y.4
  • 276
    • 28844502262 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells
    • Yavrom, S., Chen, L., Xiong, S., Wang, J., Rippe, R.A. and Tsukamoto, H. (2005) Peroxisome proliferator-activated receptor gamma suppresses proximal alpha1(I) collagen promoter via inhibition of p300-facilitated NF-I binding to DNA in hepatic stellate cells. J Biol Chem, 280, 40650-59.
    • (2005) J Biol Chem , vol.280 , pp. 40650-40659
    • Yavrom, S.1    Chen, L.2    Xiong, S.3    Wang, J.4    Rippe, R.A.5    Tsukamoto, H.6
  • 278
    • 21744459082 scopus 로고    scopus 로고
    • The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation
    • Planagumà, A., Clària, J., Miquel, R., López-Parra, M., Titos, E., Masferrer, J.L., Arroyo, V. and Rodés, J. (2005) The selective cyclooxygenase-2 inhibitor SC-236 reduces liver fibrosis by mechanisms involving non-parenchymal cell apoptosis and PPARgamma activation. FASEB J, 19, 1120-22.
    • (2005) FASEB J , vol.19 , pp. 1120-1122
    • Planagumà, A.1    Clària, J.2    Miquel, R.3    López-Parra, M.4    Titos, E.5    Masferrer, J.L.6    Arroyo, V.7    Rodés, J.8
  • 280
    • 59449097794 scopus 로고    scopus 로고
    • Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor
    • Bruck, R., Weiss, S., Aeed, H., Pines, M., Halpern, Z. and Zvibel, I. (2008) Additive inhibitory effect of experimentally induced hepatic cirrhosis by agonists of peroxisome proliferator activator receptor gamma and retinoic acid receptor. Dig Dis Sci, 54 (2), 292-9.
    • (2008) Dig Dis Sci , vol.54 , Issue.2 , pp. 292-299
    • Bruck, R.1    Weiss, S.2    Aeed, H.3    Pines, M.4    Halpern, Z.5    Zvibel, I.6
  • 281
    • 25644443217 scopus 로고    scopus 로고
    • Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis
    • Fiorucci, S., Rizzo, G., Antonelli, E., Renga, B., Mencarelli, A., Riccardi, L., Morelli, A., Pruzanski, M. and Pellicciari, R. (2005) Cross-talk between farnesoid-X-receptor (FXR) and peroxisome proliferator-activated receptor gamma contributes to the antifibrotic activity of FXR ligands in rodent models of liver cirrhosis. J Pharmacol Exp Ther, 315, 58-68.
    • (2005) J Pharmacol Exp Ther , vol.315 , pp. 58-68
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Morelli, A.7    Pruzanski, M.8    Pellicciari, R.9
  • 282
    • 33645803853 scopus 로고    scopus 로고
    • Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor
    • Zheng, S. and Chen, A. (2006) Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am J Physiol Gastrointest Liver Physiol, 290, G883-93.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290 , pp. G883-G893
    • Zheng, S.1    Chen, A.2
  • 283
    • 9444252295 scopus 로고    scopus 로고
    • Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro
    • Zheng, S. and Chen, A. (2004) Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. Biochem J, 384, 149-57.
    • (2004) Biochem J , vol.384 , pp. 149-157
    • Zheng, S.1    Chen, A.2
  • 284
    • 33846146367 scopus 로고    scopus 로고
    • Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of proliferator-activated receptor-gamma in rat hepatic stellate cells
    • Zheng, S. and Chen, A. (2007) Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of proliferator-activated receptor-gamma in rat hepatic stellate cells. Am J Physiol Gastrointest Liver Physiol, 292, G113-23.
    • (2007) Am J Physiol Gastrointest Liver Physiol , vol.292 , pp. G113-G123
    • Zheng, S.1    Chen, A.2
  • 285
    • 34247390710 scopus 로고    scopus 로고
    • The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro
    • Zhou, Y., Zheng, S., Lin, J., Zhang, Q.J. and Chen, A. (2007) The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab Invest, 87, 488-98.
    • (2007) Lab Invest , vol.87 , pp. 488-498
    • Zhou, Y.1    Zheng, S.2    Lin, J.3    Zhang, Q.J.4    Chen, A.5
  • 286
    • 42549114387 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells
    • Lin, J. and Chen, A. (2008) Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest, 88, 529-40.
    • (2008) Lab Invest , vol.88 , pp. 529-540
    • Lin, J.1    Chen, A.2
  • 287
    • 38549153486 scopus 로고    scopus 로고
    • Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation
    • Fu, Y., Zheng, S., Lin, J., Ryerse, J. and Chen, A. (2008) Curcumin protects the rat liver from CCl4-caused injury and fibrogenesis by attenuating oxidative stress and suppressing inflammation. Mol Pharmacol, 73, 399-409.
    • (2008) Mol Pharmacol , vol.73 , pp. 399-409
    • Fu, Y.1    Zheng, S.2    Lin, J.3    Ryerse, J.4    Chen, A.5
  • 288
    • 55749102279 scopus 로고    scopus 로고
    • Alternative wnt signaling is initiated by distinct receptors
    • van Amerongen, R., Mikels, A. and Nusse, R. (2008) Alternative wnt signaling is initiated by distinct receptors. Sci Signal, 1, re9.
    • (2008) Sci Signal , vol.1 , pp. re9
    • van Amerongen, R.1    Mikels, A.2    Nusse, R.3
  • 289
    • 51149118892 scopus 로고    scopus 로고
    • Deciphering the function of canonical Wnt signals in development and disease: Conditional lossand gain-of-function mutations of beta-catenin in mice
    • Grigoryan, T., Wend, P., Klaus, A. and Birchmeier, W. (2008) Deciphering the function of canonical Wnt signals in development and disease: conditional lossand gain-of-function mutations of beta-catenin in mice. Genes Dev, 22, 2308-41.
    • (2008) Genes Dev , vol.22 , pp. 2308-2341
    • Grigoryan, T.1    Wend, P.2    Klaus, A.3    Birchmeier, W.4
  • 290
    • 52449116723 scopus 로고    scopus 로고
    • WNT signaling in stem cell biology and regenerative medicine
    • Katoh, M. (2008) WNT signaling in stem cell biology and regenerative medicine. Curr Drug Targets, 9, 565-70.
    • (2008) Curr Drug Targets , vol.9 , pp. 565-570
    • Katoh, M.1
  • 291
    • 52449134519 scopus 로고    scopus 로고
    • Wnt signaling in development, disease and translational medicine (Review)
    • Coombs, G.S., Covey, T.M. and Virshup, D.M. (2008) Wnt signaling in development, disease and translational medicine (Review). Curr Drug Targets, 9 (7), 513-31.
    • (2008) Curr Drug Targets , vol.9 , Issue.7 , pp. 513-531
    • Coombs, G.S.1    Covey, T.M.2    Virshup, D.M.3
  • 292
    • 43049144313 scopus 로고    scopus 로고
    • Wnt signaling and stem cell control
    • Nusse, R. (2008) Wnt signaling and stem cell control. Cell Res, 18, 523-527.
    • (2008) Cell Res , vol.18 , pp. 523-527
    • Nusse, R.1
  • 293
    • 41649116120 scopus 로고    scopus 로고
    • Non-conventional Frizzled ligands and Wnt receptors
    • Hendrickx, M. and Leyns, L. (2008) Non-conventional Frizzled ligands and Wnt receptors. Dev Growth Differ, 50, 229-43.
    • (2008) Dev Growth Differ , vol.50 , pp. 229-243
    • Hendrickx, M.1    Leyns, L.2
  • 294
    • 33746511526 scopus 로고    scopus 로고
    • Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
    • Jiang, F., Parsons, C.J. and Stefanovic, B. (2006) Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol, 45, 401-9.
    • (2006) J Hepatol , vol.45 , pp. 401-409
    • Jiang, F.1    Parsons, C.J.2    Stefanovic, B.3
  • 295
    • 38049086246 scopus 로고    scopus 로고
    • Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells
    • Kordes, C., Sawitza, I. and Häussinger, D. (2008) Canonical Wnt signaling maintains the quiescent stage of hepatic stellate cells. Biochem Biophys Res Commun, 367, 116-23.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 116-123
    • Kordes, C.1    Sawitza, I.2    Häussinger, D.3
  • 298
    • 34248674146 scopus 로고    scopus 로고
    • WNT/betacatenin signaling in liver health and disease
    • Thompson, M.D. and Monga, S.P. (2007) WNT/betacatenin signaling in liver health and disease. Hepatology, 45, 1298-305.
    • (2007) Hepatology , vol.45 , pp. 1298-1305
    • Thompson, M.D.1    Monga, S.P.2
  • 299
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo, M. and Taipale, J. (2008) Hedgehog: functions and mechanisms. Genes Dev, 22, 2454-72.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 302
    • 41549118422 scopus 로고    scopus 로고
    • The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer
    • Omenetti, A. and Diehl, A.M. (2008) The adventures of sonic hedgehog in development and repair. II. Sonic hedgehog and liver development, inflammation, and cancer. Am J Physiol Gastrointest Liver Physiol, 294, G595-98.
    • (2008) Am J Physiol Gastrointest Liver Physiol , vol.294 , pp. G595-G598
    • Omenetti, A.1    Diehl, A.M.2
  • 305
    • 53049097596 scopus 로고    scopus 로고
    • Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review)
    • Katoh, Y. and Katoh, M. (2008) Hedgehog signaling, epithelial-to-mesenchymal transition and miRNA (review). Int J Mol Med, 22, 271-75.
    • (2008) Int J Mol Med , vol.22 , pp. 271-275
    • Katoh, Y.1    Katoh, M.2
  • 306
    • 50249185756 scopus 로고    scopus 로고
    • Role of hedgehog signalling in bile ductular cells
    • Hines, I.N. and Rippe, R.A. (2008) Role of hedgehog signalling in bile ductular cells. Gut, 57, 1198-99.
    • (2008) Gut , vol.57 , pp. 1198-1199
    • Hines, I.N.1    Rippe, R.A.2
  • 307
    • 15444379753 scopus 로고    scopus 로고
    • The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis
    • Wells, R.G. (2005) The role of matrix stiffness in hepatic stellate cell activation and liver fibrosis. J Clin Gastroenterol, 39 (4 Suppl 2), S158-61.
    • (2005) J Clin Gastroenterol , vol.39 , pp. S158-S161
    • Wells, R.G.1
  • 309
    • 36349003677 scopus 로고    scopus 로고
    • Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture
    • Li, Z., Dranoff, J.A., Chan, E.P., Uemura, M., Sévigny, J. and Wells, R.G. (2007) Transforming growth factor-beta and substrate stiffness regulate portal fibroblast activation in culture. Hepatology, 46, 1246-56.
    • (2007) Hepatology , vol.46 , pp. 1246-1256
    • Li, Z.1    Dranoff, J.A.2    Chan, E.P.3    Uemura, M.4    Sévigny, J.5    Wells, R.G.6
  • 310
    • 42249093297 scopus 로고    scopus 로고
    • The role of matrix stiffness in regulating cell behavior
    • Wells, R.G. (2008) The role of matrix stiffness in regulating cell behavior. Hepatology, 47, 1394-400.
    • (2008) Hepatology , vol.47 , pp. 1394-1400
    • Wells, R.G.1
  • 312
    • 0018676475 scopus 로고
    • Native cross-links in collagen fibrils induce resistance to human synovial collagenase
    • Vater, C.A., Harris, E.D. Jr. and Siegel, R.C. (1979) Native cross-links in collagen fibrils induce resistance to human synovial collagenase. Biochem J, 181, 639-45.
    • (1979) Biochem J , vol.181 , pp. 639-645
    • Vater, C.A.1    Harris, E.D.2    Siegel, R.C.3
  • 314
    • 0020792570 scopus 로고
    • In vivo collagen synthesis and deposition in fibrotic and regenerating rat livers
    • Rojkind, M., Rojkind, M.H. and Cordero-Hernández, J. (1983) In vivo collagen synthesis and deposition in fibrotic and regenerating rat livers. Coll Relat Res, 3, 335-47.
    • (1983) Coll Relat Res , vol.3 , pp. 335-347
    • Rojkind, M.1    Rojkind, M.H.2    Cordero-Hernández, J.3
  • 315
    • 41649106542 scopus 로고    scopus 로고
    • Matrix elasticity, cytoskeletal tension, and TGF-beta: The insoluble and soluble meet
    • Wells, R.G. and Discher, D.E. (2008) Matrix elasticity, cytoskeletal tension, and TGF-beta: the insoluble and soluble meet. Sci Signal, 1, pe13.
    • (2008) Sci Signal , vol.1 , pp. pe13
    • Wells, R.G.1    Discher, D.E.2
  • 316
    • 0033057125 scopus 로고    scopus 로고
    • Role of metalloproteinases in liver fibrosis
    • Rojkind, M. (1999) Role of metalloproteinases in liver fibrosis. Alcohol Clin Exp Res, 23, 934-39.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 934-939
    • Rojkind, M.1
  • 317
    • 33645243410 scopus 로고    scopus 로고
    • Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo
    • Zhan, S.S., Jiang, J.X., Wu, J., Halsted, C., Friedman, S.L., Zern, M.A. and Torok, N.J. (2006) Phagocytosis of apoptotic bodies by hepatic stellate cells induces NADPH oxidase and is associated with liver fibrosis in vivo. Hepatology, 43, 435-43.
    • (2006) Hepatology , vol.43 , pp. 435-443
    • Zhan, S.S.1    Jiang, J.X.2    Wu, J.3    Halsted, C.4    Friedman, S.L.5    Zern, M.A.6    Torok, N.J.7
  • 318
    • 51349102719 scopus 로고    scopus 로고
    • Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis
    • Muhanna, N., Doron, S., Wald, O., Horani, A., Eid, A., Pappo, O., Friedman, S.L. and Safadi, R. (2008) Activation of hepatic stellate cells after phagocytosis of lymphocytes: A novel pathway of fibrogenesis. Hepatology, 48, 963-77.
    • (2008) Hepatology , vol.48 , pp. 963-977
    • Muhanna, N.1    Doron, S.2    Wald, O.3    Horani, A.4    Eid, A.5    Pappo, O.6    Friedman, S.L.7    Safadi, R.8
  • 319
    • 56149119778 scopus 로고    scopus 로고
    • Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism
    • Jiang, J.X., Mikami, K., Shah, V.H. and Torok, N.J. (2008) Leptin induces phagocytosis of apoptotic bodies by hepatic stellate cells via a Rho guanosine triphosphatase-dependent mechanism. Hepatology, 48, 1497-505.
    • (2008) Hepatology , vol.48 , pp. 1497-1505
    • Jiang, J.X.1    Mikami, K.2    Shah, V.H.3    Torok, N.J.4
  • 321
    • 58649089811 scopus 로고    scopus 로고
    • Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver
    • Holt, A.P., Haughton, E.L., Lalor, P.F., Filer, A., Buckley, C.D. and Adams, D.H. (2009) Liver myofibroblasts regulate infiltration and positioning of lymphocytes in human liver. Gastroenterology, 136 (2), 705-14.
    • (2009) Gastroenterology , vol.136 , Issue.2 , pp. 705-714
    • Holt, A.P.1    Haughton, E.L.2    Lalor, P.F.3    Filer, A.4    Buckley, C.D.5    Adams, D.H.6
  • 322
    • 34247171754 scopus 로고    scopus 로고
    • Lymphocyte-hepatic stellate cell proximity suggests a direct interaction
    • Muhanna, N., Horani, A., Doron, S. and Safadi, R. (2007) Lymphocyte-hepatic stellate cell proximity suggests a direct interaction. Clin Exp Immunol, 148, 338-47.
    • (2007) Clin Exp Immunol , vol.148 , pp. 338-347
    • Muhanna, N.1    Horani, A.2    Doron, S.3    Safadi, R.4
  • 323
    • 1842426689 scopus 로고    scopus 로고
    • Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells
    • Wang, Y.Q., Luk, J.M., Ikeda, K., Man, K., Chu, A.C., Kaneda, K. and Fan, S.T. (2004) Regulatory role of vHL/HIF-1alpha in hypoxia-induced VEGF production in hepatic stellate cells. Biochem Biophys Res Commun, 317, 358-62.
    • (2004) Biochem Biophys Res Commun , vol.317 , pp. 358-362
    • Wang, Y.Q.1    Luk, J.M.2    Ikeda, K.3    Man, K.4    Chu, A.C.5    Kaneda, K.6    Fan, S.T.7
  • 324
    • 33846209631 scopus 로고    scopus 로고
    • Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway
    • Shi, Y.F., Fong, C.C., Zhang, Q., Cheung, P.Y., Tzang, C.H., Wu, R.S. and Yang, M. (2007) Hypoxia induces the activation of human hepatic stellate cells LX-2 through TGF-beta signaling pathway. FEBS Lett, 581, 203-10.
    • (2007) FEBS Lett , vol.581 , pp. 203-210
    • Shi, Y.F.1    Fong, C.C.2    Zhang, Q.3    Cheung, P.Y.4    Tzang, C.H.5    Wu, R.S.6    Yang, M.7
  • 326
    • 27544504817 scopus 로고    scopus 로고
    • Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases
    • Hirota, K. and Semenza, G.L. (2005) Regulation of hypoxia-inducible factor 1 by prolyl and asparaginyl hydroxylases. Biochem Biophys Res Commun, 338, 610-16.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 610-616
    • Hirota, K.1    Semenza, G.L.2
  • 327
    • 33747621613 scopus 로고    scopus 로고
    • Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1
    • Semenza, G.L. (2006) Regulation of physiological responses to continuous and intermittent hypoxia by hypoxia-inducible factor 1. Exp Physiol, 91, 803-6.
    • (2006) Exp Physiol , vol.91 , pp. 803-806
    • Semenza, G.L.1
  • 328
    • 33751169387 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-1 (HIF-1)
    • Ke, Q. and Costa, M. (2006) Hypoxia-inducible factor-1 (HIF-1). Mol Pharmacol, 70, 1469-80.
    • (2006) Mol Pharmacol , vol.70 , pp. 1469-1480
    • Ke, Q.1    Costa, M.2
  • 329
    • 0032146551 scopus 로고    scopus 로고
    • Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
    • Iredale, J.P., Benyon, R.C., Pickering, J., McCullen, M., Northrop, M., Pawley, S., Hovell, C. and Arthur, M.J. (1998) Mechanisms of spontaneous resolution of rat liver fibrosis. Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors. J Clin Invest, 102, 538-49.
    • (1998) J Clin Invest , vol.102 , pp. 538-549
    • Iredale, J.P.1    Benyon, R.C.2    Pickering, J.3    McCullen, M.4    Northrop, M.5    Pawley, S.6    Hovell, C.7    Arthur, M.J.8
  • 330
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • Issa, R., Williams, E., Trim, N., Kendall, T., Arthur, M.J., Reichen, J., Benyon, R.C. and Iredale, J.P. (2001) Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut, 48, 548-57.
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1    Williams, E.2    Trim, N.3    Kendall, T.4    Arthur, M.J.5    Reichen, J.6    Benyon, R.C.7    Iredale, J.P.8
  • 331
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • Elsharkawy, A.M., Oakley, F. and Mann, D.A. (2005) The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis, 10, 927-39.
    • (2005) Apoptosis , vol.10 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 333
    • 22944449688 scopus 로고    scopus 로고
    • A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis
    • Fiorucci, S., Rizzo, G., Antonelli, E., Renga, B., Mencarelli, A., Riccardi, L., Orlandi, S., Pruzanski, M., Morelli, A. and Pellicciari, R. (2005) A farnesoid x receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. J Pharmacol Exp Ther, 314, 584-95.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 584-595
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Orlandi, S.7    Pruzanski, M.8    Morelli, A.9    Pellicciari, R.10
  • 336
    • 0024314801 scopus 로고
    • Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
    • Friedman, S.L., Roll, F.J., Boyles, J., Arenson, D.M. and Bissell, D.M. (1989) Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem, 264, 10756-62.
    • (1989) J Biol Chem , vol.264 , pp. 10756-10762
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Arenson, D.M.4    Bissell, D.M.5
  • 337
    • 0028596335 scopus 로고
    • Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
    • Jarnagin, W.R., Rockey, D.C., Koteliansky, V.E., Wang, S.S. and Bissell, D.M. (1994) Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol, 127, 2037-48.
    • (1994) J Cell Biol , vol.127 , pp. 2037-2048
    • Jarnagin, W.R.1    Rockey, D.C.2    Koteliansky, V.E.3    Wang, S.S.4    Bissell, D.M.5
  • 338
    • 0036696026 scopus 로고    scopus 로고
    • Mesenchymal cells in the liver-one cell type or two?
    • Ramadori, G. and Saile, B. (2002) Mesenchymal cells in the liver-one cell type or two? Liver, 22, 283-94.
    • (2002) Liver , vol.22 , pp. 283-294
    • Ramadori, G.1    Saile, B.2
  • 339
    • 1542504567 scopus 로고    scopus 로고
    • Portal tract fibrogenesis in the liver
    • Ramadori, G. and Saile, B. (2004) Portal tract fibrogenesis in the liver. Lab Invest, 84 (2), 153-59.
    • (2004) Lab Invest , vol.84 , Issue.2 , pp. 153-159
    • Ramadori, G.1    Saile, B.2
  • 340
    • 0024597449 scopus 로고
    • Hepatocyte heterogeneity: The coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation
    • Gumucio, J.J. (1989) Hepatocyte heterogeneity: the coming of age from the description of a biological curiosity to a partial understanding of its physiological meaning and regulation. Hepatology, 9, 154-60.
    • (1989) Hepatology , vol.9 , pp. 154-160
    • Gumucio, J.J.1
  • 341
    • 0027082241 scopus 로고
    • Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs
    • Groothuis, G.M. and Meijer, D.K. (1992) Hepatocyte heterogeneity in bile formation and hepatobiliary transport of drugs. Enzyme, 46, 94-138.
    • (1992) Enzyme , vol.46 , pp. 94-138
    • Groothuis, G.M.1    Meijer, D.K.2
  • 342
    • 0027093850 scopus 로고
    • Hepatocyte heterogeneity in the metabolism of fatty acids: Discrepancies on zonation of acetyl-CoA carboxylase
    • Quistorff, B., Katz, N. and Witters, L.A. (1992) Hepatocyte heterogeneity in the metabolism of fatty acids: discrepancies on zonation of acetyl-CoA carboxylase. Enzyme, 46, 59-71.
    • (1992) Enzyme , vol.46 , pp. 59-71
    • Quistorff, B.1    Katz, N.2    Witters, L.A.3
  • 343
    • 0027080622 scopus 로고
    • Hepatocyte heterogeneity in the metabolism of carbohydrates
    • Jungermann, K. and Thurman, R.G. (1992) Hepatocyte heterogeneity in the metabolism of carbohydrates. Enzyme, 46, 33-58.
    • (1992) Enzyme , vol.46 , pp. 33-58
    • Jungermann, K.1    Thurman, R.G.2
  • 344
    • 0035120616 scopus 로고    scopus 로고
    • Heterogeneity and plasticity of hepatocyte lineage cells
    • Sell, S. (2001) Heterogeneity and plasticity of hepatocyte lineage cells. Hepatology, 33, 738-50.
    • (2001) Hepatology , vol.33 , pp. 738-750
    • Sell, S.1
  • 345
    • 0037346969 scopus 로고    scopus 로고
    • The hepatocyte: Heterogeneity and plasticity of liver cells
    • Sell, S. (2003) The hepatocyte: heterogeneity and plasticity of liver cells. Int J Biochem Cell Biol, 35, 267-71.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 267-271
    • Sell, S.1
  • 346
    • 42049092789 scopus 로고    scopus 로고
    • Fibrogenesis of parenchymal organs
    • Kisseleva, T. and Brenner, D.A. (2008) Fibrogenesis of parenchymal organs. Proc Am Thorac Soc, 5, 338-42.
    • (2008) Proc Am Thorac Soc , vol.5 , pp. 338-342
    • Kisseleva, T.1    Brenner, D.A.2
  • 347
    • 46949105856 scopus 로고    scopus 로고
    • Genesis of hepatic fibrosis and its biochemical markers
    • Das, S.K. and Vasudevan, D.M. (2008) Genesis of hepatic fibrosis and its biochemical markers. Scand J Clin Lab Invest, 68, 260-69.
    • (2008) Scand J Clin Lab Invest , vol.68 , pp. 260-269
    • Das, S.K.1    Vasudevan, D.M.2
  • 348
    • 0021011137 scopus 로고
    • Hepatic proteoglycans-a brief survey of their pathobiochemical implications
    • Gressner, A.M. (1983) Hepatic proteoglycans-a brief survey of their pathobiochemical implications. Hepatogastroenterology, 30, 225-29.
    • (1983) Hepatogastroenterology , vol.30 , pp. 225-229
    • Gressner, A.M.1
  • 349
    • 0028135632 scopus 로고
    • Regulation of proteoglycan expression in fibrotic liver and cultured fat-storing cells
    • Gressner, A.M., Krull, N. and Bachem, M.G. (1994) Regulation of proteoglycan expression in fibrotic liver and cultured fat-storing cells. Pathol Res Pract, 190, 864-82.
    • (1994) Pathol Res Pract , vol.190 , pp. 864-882
    • Gressner, A.M.1    Krull, N.2    Bachem, M.G.3
  • 350
    • 0028346868 scopus 로고
    • Activation of proteoglycan synthesis in injured liver-a brief review of molecular and cellular aspects
    • Gressner, A.M. (1994) Activation of proteoglycan synthesis in injured liver-a brief review of molecular and cellular aspects. Eur J Clin Chem Clin Biochem, 32, 225-37.
    • (1994) Eur J Clin Chem Clin Biochem , vol.32 , pp. 225-237
    • Gressner, A.M.1
  • 351
    • 0027185252 scopus 로고
    • Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor-beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat
    • Krull, N.B., Zimmermann, T. and Gressner, A.M. (1993) Spatial and temporal patterns of gene expression for the proteoglycans biglycan and decorin and for transforming growth factor-beta 1 revealed by in situ hybridization during experimentally induced liver fibrosis in the rat. Hepatology, 18, 581-89.
    • (1993) Hepatology , vol.18 , pp. 581-589
    • Krull, N.B.1    Zimmermann, T.2    Gressner, A.M.3
  • 352
    • 0028346868 scopus 로고
    • Activation of proteoglycan synthesis in injured liver-a brief review of molecular and cellular aspects
    • Gressner, A.M. (1994) Activation of proteoglycan synthesis in injured liver-a brief review of molecular and cellular aspects. Eur J Clin Chem Clin Biochem, 32, 225-37.
    • (1994) Eur J Clin Chem Clin Biochem , vol.32 , pp. 225-237
    • Gressner, A.M.1
  • 353
    • 0018384478 scopus 로고
    • Collagen types in normal and cirrhotic liver
    • Rojkind, M., Giambrone, M.A. and Biempica, L. (1979) Collagen types in normal and cirrhotic liver. Gastroenterology, 76 (4), 710-19.
    • (1979) Gastroenterology , vol.76 , Issue.4 , pp. 710-719
    • Rojkind, M.1    Giambrone, M.A.2    Biempica, L.3
  • 354
    • 0020533194 scopus 로고
    • Liver collagen-type characterization in human schistosomiasis. A histological, ultrastructural, and immunocytochemical correlation
    • Biempica, L., Dunn, M.A., Kamel, I.A., Kamel, R., Hait, P.K., Fleischner, C., Biempica, S.L., Wu, C.H. and Rojkind, M. (1983) Liver collagen-type characterization in human schistosomiasis. A histological, ultrastructural, and immunocytochemical correlation. Am J Trop Med Hyg, 32, 316-25.
    • (1983) Am J Trop Med Hyg , vol.32 , pp. 316-325
    • Biempica, L.1    Dunn, M.A.2    Kamel, I.A.3    Kamel, R.4    Hait, P.K.5    Fleischner, C.6    Biempica, S.L.7    Wu, C.H.8    Rojkind, M.9
  • 356
    • 36749043327 scopus 로고    scopus 로고
    • Biochemistry and functional significance of collagen cross-linking
    • Robins, S.P. (2007) Biochemistry and functional significance of collagen cross-linking. Biochem Soc Trans, 35, 849-52.
    • (2007) Biochem Soc Trans , vol.35 , pp. 849-852
    • Robins, S.P.1
  • 357
    • 16644402719 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis
    • Zhou, X., Hovell, C.J., Pawley, S., Hutchings, M.I., Arthur, M.J., Iredale, J.P. and Benyon, R.C. (2004) Expression of matrix metalloproteinase-2 and -14 persists during early resolution of experimental liver fibrosis and might contribute to fibrolysis. Liver Int, 24, 492-501.
    • (2004) Liver Int , vol.24 , pp. 492-501
    • Zhou, X.1    Hovell, C.J.2    Pawley, S.3    Hutchings, M.I.4    Arthur, M.J.5    Iredale, J.P.6    Benyon, R.C.7
  • 358
    • 33845973033 scopus 로고    scopus 로고
    • Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: Implications for regulation of liver fibrosis
    • Zhou, X., Jamil, A., Nash, A., Chan, J., Trim, N., Iredale, J.P. and Benyon, R.C. (2006) Impaired proteolysis of collagen I inhibits proliferation of hepatic stellate cells: implications for regulation of liver fibrosis. J Biol Chem, 281, 39757-65.
    • (2006) J Biol Chem , vol.281 , pp. 39757-39765
    • Zhou, X.1    Jamil, A.2    Nash, A.3    Chan, J.4    Trim, N.5    Iredale, J.P.6    Benyon, R.C.7
  • 359
    • 0018558974 scopus 로고
    • Cirrhosis of the liver: A reversible disease?
    • Pérez-Tamayo, R. (1979) Cirrhosis of the liver: a reversible disease? Pathol Annu, 14, 183-213.
    • (1979) Pathol Annu , vol.14 , pp. 183-213
    • Pérez-Tamayo, R.1
  • 363
    • 0032952079 scopus 로고    scopus 로고
    • Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-alpha and TGF-beta1
    • Knittel, T., Mehde, M., Kobold, D., Saile, B., Dinter, C. and Ramadori, G. (1999) Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-alpha and TGF-beta1. J Hepatol, 30, 48-60.
    • (1999) J Hepatol , vol.30 , pp. 48-60
    • Knittel, T.1    Mehde, M.2    Kobold, D.3    Saile, B.4    Dinter, C.5    Ramadori, G.6
  • 364
    • 20644465610 scopus 로고    scopus 로고
    • Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
    • Benyon, R.C., Hovell, C.J., Da Gaça, M., Jones, E.H., Iredale, J.P. and Arthur, M.J. (1999) Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation. Hepatology, 30, 977-86.
    • (1999) Hepatology , vol.30 , pp. 977-986
    • Benyon, R.C.1    Hovell, C.J.2    Da Gaça, M.3    Jones, E.H.4    Iredale, J.P.5    Arthur, M.J.6
  • 365
    • 0033921956 scopus 로고    scopus 로고
    • Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat
    • Knittel, T., Mehde, M., Grundmann, A., Saile, B., Scharf, J.G. and Ramadori, G. (2000) Expression of matrix metalloproteinases and their inhibitors during hepatic tissue repair in the rat. Histochem Cell Biol, 113, 443-53.
    • (2000) Histochem Cell Biol , vol.113 , pp. 443-453
    • Knittel, T.1    Mehde, M.2    Grundmann, A.3    Saile, B.4    Scharf, J.G.5    Ramadori, G.6
  • 366
    • 0033858063 scopus 로고    scopus 로고
    • Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis
    • Arthur, M.J. (2000) Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis. Am J Physiol Gastrointest Liver Physiol, 279, G245-49.
    • (2000) Am J Physiol Gastrointest Liver Physiol , vol.279 , pp. G245-G249
    • Arthur, M.J.1
  • 367
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and the role of hepatic stellate cells
    • Benyon, R.C. and Arthur, M.J. (2001) Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis, 21, 373-84.
    • (2001) Semin Liver Dis , vol.21 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.2
  • 368
    • 0037192866 scopus 로고    scopus 로고
    • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: Implications for reversibility of liver fibrosis
    • Murphy, F.R., Issa, R., Zhou, X., Ratnarajah, S., Nagase, H., Arthur, M.J., Benyon, C. and Iredale, J.P. (2002) Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem, 277 (13), 11069-76.
    • (2002) J Biol Chem , vol.277 , Issue.13 , pp. 11069-11076
    • Murphy, F.R.1    Issa, R.2    Zhou, X.3    Ratnarajah, S.4    Nagase, H.5    Arthur, M.J.6    Benyon, C.7    Iredale, J.P.8
  • 370
    • 10444250248 scopus 로고    scopus 로고
    • Interleukin-6 increases rat metalloproteinase-13 gene expression through Janus kinase-2-mediated inhibition of serine/threonine phosphatase-2A
    • de la Torre, P., Díaz-Sanjuán, T., García-Ruiz, I., Esteban, E., Canga, F., Muñoz-Yagüe, T. and Solís-Herruzo, J.A. (2005) Interleukin-6 increases rat metalloproteinase-13 gene expression through Janus kinase-2-mediated inhibition of serine/threonine phosphatase-2A. Cell Signal, 17, 427-35.
    • (2005) Cell Signal , vol.17 , pp. 427-435
    • de la Torre, P.1    Díaz-Sanjuán, T.2    García-Ruiz, I.3    Esteban, E.4    Canga, F.5    Muñoz-Yagüe, T.6    Solís-Herruzo, J.A.7
  • 371
    • 0033033426 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases: Role in liver fibrosis and alcoholic liver disease
    • Arthur, M.J., Iredale, J.P. and Mann, D.A. (1999) Tissue inhibitors of metalloproteinases: role in liver fibrosis and alcoholic liver disease. Alcohol Clin Exp Res, 23, 940-43.
    • (1999) Alcohol Clin Exp Res , vol.23 , pp. 940-943
    • Arthur, M.J.1    Iredale, J.P.2    Mann, D.A.3
  • 372
    • 34250322265 scopus 로고    scopus 로고
    • A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix
    • Han, Y.P., Yan, C., Zhou, L., Qin, L. and Tsukamoto, H. (2007) A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in trans-differentiation in the three-dimensional extracellular matrix. J Biol Chem, 282, 12928-39.
    • (2007) J Biol Chem , vol.282 , pp. 12928-12939
    • Han, Y.P.1    Yan, C.2    Zhou, L.3    Qin, L.4    Tsukamoto, H.5
  • 373
    • 45149093853 scopus 로고    scopus 로고
    • MMP-14 mediated MMP-9 expression is involved in TGF-beta1-induced keratinocyte migration
    • Seomun, Y., Kim, J.T. and Joo, C.K. (2008) MMP-14 mediated MMP-9 expression is involved in TGF-beta1-induced keratinocyte migration. J Cell Biochem, 104, 934-41.
    • (2008) J Cell Biochem , vol.104 , pp. 934-941
    • Seomun, Y.1    Kim, J.T.2    Joo, C.K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.