Hepatocyte growth factor gene therapy of liver cirrhosis in rats

Nature Medicine

Volumn 5, Issue 2, 1999, Pages 226-230

  Ueki, Takahiro ^a   Kaneda, Yasufumi ^b   Tsutsui, Hiroko ^d   Nakanishi, Kenji ^d   Sawa, Yoshiki ^d   Morishita, Ryuichi ^d   Matsumoto, Kunio ^d   Nakamura, Toshikazu ^d   Takahashi, Hiroshi ^c   Okamoto, Eizo ^a   Fujimoto, Jiro ^a  

^a HYOGO COLLEGE OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

SCATTER FACTOR; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; DISEASE COURSE; FIBROGENESIS; GENE THERAPY; GENETIC TRANSFECTION; LIVER CELL; LIVER CIRRHOSIS; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; RAT; SURVIVAL RATE;

ANIMALS; APOPTOSIS; BLOTTING, NORTHERN; GENE THERAPY; HEPATOCYTE GROWTH FACTOR; HUMANS; LIVER; LIVER CIRRHOSIS, EXPERIMENTAL; RATS; RATS, SPRAGUE-DAWLEY; TRANSFECTION; TRANSFORMING GROWTH FACTOR BETA;

ANIMALIA; RODENTIA;

EID: 0032903634     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/5593     Document Type: Article

References (30)

1. Conn, H.O. & Atterbury, C.E. in Diseases of the Liver Vol. 2 (eds. Schiff, L. & Schiff, E.R.) 875-941 (J.B. Lippencott, Philadelphia, 1993).
2. Nakamura, T., Nawa, K. & Ichihara, A. Partial purification and characterization of hepatocyte growth factor from serum of hepatectomized rats. Biochem. Biophys. Res. Commun. 122, 1450-1459 (1984).
3. Russell, W.E., Mcgowan, J.A. & Bucher, N.L. Partial characterization of a hepatocyte growth factor from platelets. J. Cell. Physiol. 119, 183-192 (1984).
4. Nakamura, T. et al. Molecular cloning and expression of human hepatocyte growth factor. Nature 342, 440-443 (1989).
5. Miyazawa, K. et al. Molecular cloning and sequence analysis of cDNA for human hepatocyte growth factor. Biochem. Biophys Res. Commun. 163, 967-973 (1989).
6. Boros, P. & Miller, C.M. Hepatocyte growth factor: a multifunctional cytokine. Lancet 345, 293-295 (1995).
7. Michalopoulos, G.K. & DeFrances, M.C. Liver Regeneration. Science 276, 60-66 (1997).
8. Gherardi, E., et al. Purification of scatter factor, a fibroblast-derived basic protein that modulates epithelial interactions and movement. Proc. Natl Acad. Sci. USA 86, 5844-5848 (1989).
9. Weidner, K.M. et al. Evidence for the identity of human scatter factor and human hepatocyte growth factor. Proc Natl. Acad. Sci. USA 88, 7001-7005 (1991).
10. Schmidt, C. et al. Scatter factor/ hepatocyte growth factor is essential for liver development. Nature 373, 699-702 (1995).
11. Bardelli, A. et al. HGF receptor associates with anti-apoptotic protein BAG-1 and prevents cell death. EMBO J. 15, 6205-6212 (1996).
12. Jezequel, A., M. et al. Dimethylnitrosamirte-induced cirrhosis. Evidence for an immunological mechanism. J. Hepatol. 8, 42-52 (1989).
13. Pritchard, D., J. & Butler, W., H. Apoptosis-the mechanism of cell death in dimethylnitrosamine-induced hepatotoxicity. J. Pathol. 158, 253-260 (1989).
14. Kaneda, Y., Iwaki, K. & Uchida, T. Increased expression of DNA cointroduced with nuclear protein in adult rat liver. Science 243, 375-378 (1989).
15. Morishita, R. et al. In vivo transfection of cis element "decoy" against nuclear factor-kB binding site prevents myocardial infarction. Nature Med. 3, 894-899 (1997).
16. Hirano, T. et al. Persistent gene expression in rat liver in vivo by repetitive transfections using HVJ-liposome. Gene Ther. 5, 459-464 (1998).
17. Hayashi, S. et al. Autocrine-paracrine effect of overexpression of hepatocyte growth factor gene on growth of endothelial cells. Biochem. Biophys. Res. Commun. 220, 539-545 (1996).
18. Bottaro, D., P. et al. Identification of the hepatocyte growth factor receptor as the c-met protooncogene product. Science 251, 802-804 (1991).
19. Friedman, S.L. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med 328, 1828-1835 (1993).
20. Blomhoff, R. & Wake, K. Perisinusoidal stellate cells of the liver: important roles in retinol metabolism and fibrosis. FASEB J. 5, 271-277 (1991).
21. Border, W.A., & Noble, N.A. Transforming growth factor β in tissue fibrosis. N. Engl. J. Med. 331, 1286-1292 (1994).
22. Sanderson, N. et al. Hepatic expression of mature transforming growth factor β1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA 92, 2572-2576 (1995).
23. Nakamura, T. et al. Inhibitory effect of transforming growth factor β on DNA synthesis of adult rat hepatocytes in primary culture. Biochem. Biophys. Res. Commun. 133, 1042-1050 (1985).
24. Oberhammer, F.A. et al. Induction of apoptosis in cultured hepatocyte and regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA 89, 5408-5412 (1992).
25. Tanaka, Y. et al. Phenotypic modulation in lipocytes in experimental liver fibrosis. J. Pathol. 164, 273-278 (1991).
26. Coombs, D., W., Colburn, R., W., DeLeo, J., A., Hoopes, P., J. & Twitchell, B., B. Comparative histopathology of epidural hydrogel and silicone elastomer catheters following 30 and 180 days implant in the eye. Acta Anaesthesiol. Scand. 38, 388-395 (1994).
27. Takayama, H. et al. Diverse tumorigenesis associated with aberrant development in mice overexpressing hepatocyte growth factor/scatter factor. Proc. Natl. Acad. Sci. USA 94, 701-706 (1997).
28. Santoni-Rugu, E. et al. Inhibition of neoplastic development in the liver by hepatocyte growth factor in a transgenic mouse model. Proc. Natl. Acad. Sci. USA 93, 9577-9582 (1996).
29. Seki, T. et al. Isolation and expression of cDNA for different forms of hepatocyte growth factor from human leukocyte. Biochem. Biophys. Res. Commun. 172, 321-327(1990).
30. Gavrieli, Y., Sherman, Y. & Ben-Sasson, S., A. Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation, J. Cell Biol. 119, 493-501 (1992).