Hepatic stellate cell behavior during resolution of liver injury

Seminars in Liver Disease

Volumn 21, Issue 3, 2001, Pages 427-436

  Iredale, J P ^a  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Apoptosis; Death receptor; Hepatic stellate cell; Liver fibrosis; Matrix degradation

Indexed keywords

CYTOKINE; CYTOKINE RECEPTOR; FAS ANTIGEN; FAS LIGAND; GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR; SOMATOMEDIN C; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR RECEPTOR;

ANIMAL CELL; APOPTOSIS; CHRONIC LIVER DISEASE; EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; HUMAN CELL; LIVER CELL; LIVER FIBROSIS; LIVER INJURY; NONHUMAN; PRIORITY JOURNAL; REVIEW; STELLATE CELL;

APOPTOSIS; CELL DIVISION; COLLAGEN; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GROWTH SUBSTANCES; HUMANS; LIVER; LIVER CIRRHOSIS; RECEPTORS, TUMOR NECROSIS FACTOR; REMISSION, SPONTANEOUS;

EID: 0034809414     PISSN: 02728087     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-17557     Document Type: Review

References (93)

1. The cellular basis of hepatic fibrosis: Mechanisms and treatment strategies
2. Pathogenesis of liver fibrosis
3. Hepatic lipocytes: The principal collagen-producing cells of normal rat liver
4. Extracellular matrix gene expression increases preferentially in rat lipocytes and sinusoidal endothelial cells during hepatic fibrosis in vivo
5. Non-parenchymal cell responses in paracetamol (acetaminophen) induced liver injury
6. Mechanisms of spontaneous resolution of rat liver fibrosis: Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
7. Human liver fibroblast capacity for synthesizing interstitial collagenase in vitro
8. Interstitial collagenase gene is differentially expressed in human liver and cultured fat-storing cells
9. Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver
10. Transin (stromelysin) is expressed in early rat lipocyte primary culture
11. Lipocyte proliferation in the C. parvum model of macrophage-induced liver injury is associated with expression of 72 kDa type IV collagenase/gelatinase
12. Kupffer cell-derived 95 kDa type IV collagenase/gelatinase B: Characterisation and expression in cultured cells
13. Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes
14. Increased expression of mRNA for gelatinase A and TIMP-2 in human fibrotic liver disease
15. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen
16. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
17. Expression of tissue inhibitor of metalloproteinases-1 and -2 is increased in fibrotic human liver
18. Matrix metallo-proteinase-2 is an interstitial collagenase. Inhibitor-free enzyme catalyses the cleavage of collagen fibrils and soluble native type I collagen generating the specific 3/4-and 1/4-length fragments
19. Membrane type 1 matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
20. Collagenolytic activity in experimental cirrhosis of the liver
21. Collagenase activity in experimental hepatic fibrosis
22. Mammalian collagenase increases in early alcoholic liver disease and decreases with cirrhosis
23. Collagenase in experimental carbon tetrachloride cirrhosis of the liver
24. Liver collagenase in murine schistosomiasis
25. Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis
26. Comparison of matrix metalloproteinase expression in normal and cirrhotic human liver
27. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNFalpha and TGF-beta1
28. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1 (TIMP-1): Implications for regulation of matrix degradation in liver
29. Regression of hepatic fibrosis in hepatitis C with long-term interferon treatment
30. Reversibility of hepatic fibrosis in autoimmune hepatitis
31. Survival and causes of death in cirrhotic and in noncirrhotic patients with primary haemochromatosis
32. Modeling the impact of interferon alfa treatment on liver fibrosis progression in chronic hepatitis C: A dynamic view
33. Regression of liver fibrosis after biliary drainage in patients with chronic pancreatitis and stenosis of the common bile duct
34. Reversibility of severe hepatic damage caused by jejunoileal bypass after re-establishment of normal intestinal continuity
35. Reversal of "cirrhosis" in idiopathic haemochromatosis following long-term intensive venesection therapy
36. Improvements in liver histology and cirrhosis with extended lamivudine therapy
37. A randomised, controlled trial of maintenance interferon therapy for patients with chronic hepatitis C virus and persistent viremia
38. Impact of interferon alfa-2b and ribavirin on progression of liver fibrosis in patients with chronic hepatitis C
39. Resolution of chronic delta hepatitis after 12 years of interferon alfa therapy
40. Sustained biochemical and histological remission of primary biliary cirrhosis in response to medical treatment
41. Regression of human cirrhosis. Morphologic features and the genesis of incomplete septal cirrhosis
42. The interaction of Bcl-2 and Bax regulates apoptosis in biliary epithelial cells of rats with obstructive jaundice
43. Reversibility of hepatic fibrosis in experimentally induced cholestasis in rat
44. Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
45. CD95/CD95-L-mediated apoptosis of the hepatic stellate cell
46. Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride
47. Mesangial cell apoptosis: The major mechanism for resolution of glomerular hypercellularity in experimental mesangial proliferative nephritis
48. Alpha-smooth muscle actin is transiently expressed by myofibroblasts during experimental wound healing
49. CD95's deadly mission in the immune system
50. Apoptosis in the nervous system
51. Defying death after DNA damage
52. Apoptosis in development
53. The biochemistry of apoptosis
54. Corpse clearance defines the meaning of cell death
55. Induction of apoptosis in fibroblasts by c-myc protein
56. Social controls on cell survival and cell death
57. Programmed cell death and control of cell survival: Lessons from the nervous system
58. Characterisation of insulin-like growth factor (IGF)-I-receptor binding sites during in vitro transformation of rat hepatic stellate cells to myofibroblasts
59. Secretion of insulin-like growth factor-I and binding proteins by rat liver fat-storing cells: Regulatory role of platelet-derived growth factor
60. Insulin-like growth factor-I-mediated survival from anoikis: Role of cell aggregation and focal adhesion kinase
61. Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor I receptors
62. The insulin-like growth factor I receptor protects tumour cells from apoptosis in vivo
63. Cytokines promote glomerular mesangial cell survival in vitro by stimulus-dependent inhibition of apoptosis
64. Characterisation of the insulin-like growth factor axis in a human hepatoma cell line (PLC)
65. Transforming growth factor beta and tumour necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells
66. Extracellular matrix regulates hepatic stellate cell phenotype and survival
67. Hepatic stellate cell phenotype is regulated by extracellular matrix: Implications for liver fibrogenesis
68. Induction of apoptosis in rat hepatic stellate cells by disruption of integrin-mediated cell adhesion
69. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human and rat HSC
70. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1
71. Fas ligand in human serum
72. Rescue of mammary epithelial cell apoptosis and entactin degradation by a tissue inhibitor of metalloproteinases-1 transgene
73. Suppression of ICE and apoptosis in mammary epithelial cells by extracellular matrix
74. Intact collagen-I inhibits hepatic stellate cell (HSC) activation and promotes persistence of activated HSC in vivo
75. The molecular biology of apoptosis
76. Involvement of the CD95 (APO-1Fas) receptor and ligand in liver damage
77. Contenders in FasL/TNF death signalling
78. The TNF receptor superfamily of cellular and viral proteins: Activation, co-stimulation and death
79. Signalling through the neutrophil receptor p75NTR
80. Transformation-independent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand
81. Hepatic stellate cells express the low affinity nerve growth factor receptor p75 and undergo apoptosis in response to nerve growth factor stimulation
82. NTR reduces NGF binding to TrkA on PC12 cells
83. The p75 neurotrophin receptor mediates neuronal apoptosis and is essential for naturally occurring sympathetic neuron death
84. Dependence on p75 for innervation of some sympathetic targets
85. Survival of cholinergic forebrain neurons in the developing p75 (NGRF) deficient mice
86. Mast cells synthesize, store and release nerve growth factor
87. Persistent activation of nuclear factor-κB in cultured rat hepatic stellate cells involves the induction of potentially novel Rel-like factors and prolonged changes in the expression of IκB family proteins
88. Nuclear factor kappaB in proliferation, activation, and apoptosis of rat hepatic stellate cells
89. Gliotoxin stimulates the apoptosis of hepatic stellate cells: A mechanism for modulating liver fibrosis
90. Selective sensitisation to tumour necrosis factor-alphainduced apoptosis by blockade of NF-kappaB in primary glomerular mesangial cells
91. The neurtrophin NGF downregulates transcriptional activity of NFκB in hepatic stellate cells
92. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
93. Inhibition of experimental liver cirrhosis in mice by telomerase gene delivery