Dominant-negative soluble PDGF-β receptor inhibits hepatic stellate cell activation and attenuates liver fibrosis

Laboratory Investigation

Volumn 84, Issue 6, 2004, Pages 766-777

  Borkham Kamphorst, Erawan ^a   Herrmann, Jens ^a   Stoll, Doris ^a   Treptau, Jens ^a   Gressner, Axel M ^a   Weiskirchen, Ralf ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Bile duct ligature; Fibrosis; Hepatic stellate cell; Liver; Myofibroblast; PDGF; TGF 1

Indexed keywords

ALPHA ACTIN; ALPHA SMOOTH MUSCLE ACTIN; COLLAGEN; IMMUNOGLOBULIN G; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR BLOCKING AGENT; RAF PROTEIN; RAS PROTEIN; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ADENOVIRUS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTOCRINE EFFECT; CELL ACTIVATION; CELL DIFFERENTIATION; CELL MIGRATION; CELL PROLIFERATION; CHIMERA; COMMON BILE DUCT; ENZYME PHOSPHORYLATION; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE EXPRESSION; GENE OVEREXPRESSION; LIVER FIBROSIS; LIVER INJURY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RAT; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; STELLATE CELL; TRANSGENE;

ADENOVIRIDAE; AMINO ACID SEQUENCE; ANIMALS; BASE SEQUENCE; CELLS, CULTURED; COMMON BILE DUCT; DISEASE MODELS, ANIMAL; DNA, COMPLEMENTARY; GENE EXPRESSION; GENETIC VECTORS; HEPATOCYTES; LIGATION; LIVER CIRRHOSIS; MOLECULAR SEQUENCE DATA; PLATELET-DERIVED GROWTH FACTOR; RATS; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; SOLUBILITY;

EID: 2642517210     PISSN: 00236837     EISSN: None     Source Type: Journal    
DOI: 10.1038/labinvest.3700094     Document Type: Article

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