Fibrogenesis II. Metalloproteinases and their inhibitors in liver fibrosis

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 279, Issue 2 42-2, 2000, Pages

  Arthur, Michael J P ^a,b  

^a UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^b SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

Cirrhosis; Collagenase; Gelatinase; Hepatic stellate cells; Matrix degradation; Stromelysin

Indexed keywords

COLLAGEN; COLLAGENASE; GELATINASE A; GELATINASE B; HERMES ANTIGEN; MATRIX METALLOPROTEINASE; METALLOPROTEINASE; METALLOPROTEINASE INHIBITOR; STROMELYSIN; TISSUE INHIBITOR OF METALLOPROTEINASE; TRANSFORMING GROWTH FACTOR;

EXTRACELLULAR MATRIX; FIBROGENESIS; HUMAN; LIVER FIBROSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW;

EID: 0033858063     PISSN: 01931857     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpgi.2000.279.2.g245     Document Type: Review

References (22)

1. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen
2. Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation
3. Expression of tissue inhibitor of metalloproteinases-1 and -2 is increased in fibrotic human liver
4. In vitro suppression of programmed cell death of B cells by tissue inhibitor of metalloproteinases-1
5. Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver
6. Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis
7. Enhanced interstitial collagenase (matrix metalloproteinase-13) production of Kupffer cell by gadolinium chloride prevents pig serum-induced rat liver fibrosis
8. 1-MMP-deficient mice develop dwarfism, osteopenia, arthritis, and connective tissue disease due to inadequate collagen turnover
9. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis
10. Mechanisms of spontaneous resolution of rat liver fibrosis: Hepatic stellate cell apoptosis and reduced hepatic expression of metalloproteinase inhibitors
11. Tissue inhibitor of metalloproteinase-1 and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes
12. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1 (TIMP-1): Implications for regulation of matrix degradation in liver
13. Collagen breakdown in soft connective tissue explants is associated with the level of active gelatinase A (MMP-2) but not with collagenase
14. Altered balance between matrix metalloproteinases and their inhibitors in experimental biliary fibrosis
15. The plasminogen activating system in hepatic stellate cells
16. Tissue inhibitor of metalloproteinase-1 inhibits apoptosis of human breast epithelial cells
17. Membrane type I matrix metalloproteinase digests interstitial collagens and other extracellular matrix macromolecules
18. Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats
19. Dual expression of matrix metalloproteinase-2 and membrane-type 1-matrix metalloproteinase in fibrotic human livers
20. MMP2 activation by collagen I and concanavalin A in cultured human hepatic stellate cells
21. Kupffer cell-derived 95 kDa type IV collagenase/gelatinase B: Characterisation and expression in cultured cells
22. Cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-β and promotes tumor invasion and angiogenesis