Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation

Hepatology

Volumn 30, Issue 4, 1999, Pages 977-986

  Christopher Benyon, R ^a   Hovell, Christopher J ^a   Da Gaça, Marianna ^a   Jones, Emma H ^a   Iredale, John P ^a   Arthur, Michael J P ^a  

^a SOUTHAMPTON GENERAL HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; GELATINASE A; MESSENGER RNA; METALLOPROTEINASE; PROCOLLAGEN; PROGELATINASE A; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME SYNTHESIS; IN VITRO STUDY; LIVER FIBROSIS; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; STELLATE CELL;

ANIMALS; BIOCOMPATIBLE MATERIALS; CELL DIVISION; CELLS, CULTURED; COLLAGEN; DRUG COMBINATIONS; ENZYME ACTIVATION; ENZYME PRECURSORS; GELATINASES; ISOENZYMES; LAMININ; LIVER; MALE; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; METALLOENDOPEPTIDASES; PROTEOGLYCANS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; TISSUE INHIBITOR OF METALLOPROTEINASE-2;

EID: 20644465610     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.510300431     Document Type: Article

References (21)

1. Mak KM, Leo AM, Lieber CS. Alcoholic liver injury in baboons: transformation of lipocytes to transitional cells. Gastroenterology 1984; 87:188-200.
2. Milani S, Herbst H, Schuppan D, Hahn EG, Stein H. In situ hybridization for procollagen types I, III and IV mRNA in normal and fibrotic rat liver: evidence for predominant expression in nonparenchymal liver cells. HEPATOLOGY 1989;10:84-92.
3. Milani S, Herbst H, Schuppan D, Surrenti C, Riecken EO, Stein H. Cellular localization of type I, III and IV procollagen gene transcripts in normal and fibrotic human liver. Am J Pathol 1990;137:59-70.
4. Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci U S A 1985;82:8681-8685.
5. Ramadori G, Rieder H, Knittel TH, Dienes HP, Meyer zum Buschenfelde K-H. Fat storing cells (FSC) of rat liver synthesize and secrete fibronectin. J Hepatol 1987;4:190-197.
6. Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 1988;94:1053-1062.
7. Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 1989;264:10756-10762.
8. Matrisian LM. The matrix-degrading metalloproteinases. Bioessays 1992;14:455-463.
9. Murphy G, Cockett MI, Ward RV, Docherty AJP. Matrix metalloproteinase degradation of elastin, type IV collagen and proteoglycans. Biochem J 1991;277:277-279.
10. Benyon RC, Iredale JP, Goddard S, Wimvood PJ, Arthur MJP. Expression of tissue inhibitor of metalloproteinases-1 and -2 increased in fibrotic human liver. Gastroenterology 1996;110:821-831.
11. Benyon RC, Hovell CJ, Iredale JP, Ferris WF, Arthur MJP. Expression of gelatinase A is increased in progressive liver fibrosis [Abstract]. HEPATOLOGY 1995;22:369A.
12. Milani S, Herbst H, Schuppan D, Grappone SC, Pellegrini G, Pinzani M, Casini A, et al. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol 1994;144:528-537.
13. Takahara T, Furui K, Funaki J, Nakayama Y, Itoh H, Miyabayashi C, Sato H, et al. Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats. HEPATOLOGY 1995;21:787-795.
14. Takahara T, Furui K, Yata Y, Jin B, Zhang LP, Nambu S, Sato H, et al. Dual expression of matrix metalloproteinase-2 and membrane-type I-matrix metalloproteinase in fibrotic human livers. HEPATOLOGY 1997;26:1521-1529.
15. Arthur MJP, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes: analysis of gene expression, protein synthesis and proteinase activity. Biochem J 1992;287:701-707.
16. Arthur MJP, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest 1989;84:1076-1085.
17. Swiderski RE, Dencoff JE, Floerchinger CS, Shapiro SD, Hunninghake GW. Differential expression of extracellular matrix remodeling genes in a murine model of bleomycin-induced pulmonary fibrosis. Am J Pathol 1998;152:821-828.
18. Fukuda Y, Ishizaki M, Kudoh S, Kitaichi M, Yamanaka N. Localization of matrix metalloproteinases-1, -2, and -9 and tissue inhibitor of metalloproteinase-2 in interstitial lung diseases. Lab Invest 1998;78:687-698.
19. Bakowska J, Adamson IY. Collagenase and gelatinase activities in bronchoalveolar lavage fluids during bleomycin-induced lung injury. J Pathol 1998;185:319-323.
20. Nakamura T, Fukue M, Ebihara I, Tomino Y, Koide H. Low protein diet blunts the rise in glomerular gene expression in focal glomerulosclerosis. Kidney Int 1994;45:1593-1605.
21. Shimizu T, Kuroda T, Hata S, Fukagawa M, Margolin SB, Kurokawa K. Pirfenidone improves renal function and fibrosis in the post-obstructed kidney. Kidney Int 1998;54:99-109.