Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: Regulation by TNF-α and TGF-β1

Journal of Hepatology

Volumn 30, Issue 1, 1999, Pages 48-60

  Knittel, Thomas ^a   Mehde, Mirko ^a   Kobold, Dominik ^a   Saile, Bernhard ^a   Dinter, Christina ^a   Ramadori, Giuliano ^a  

^a UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Fibrosis; Hepatic stellate cell; Hepatocyte; Inflammation; Kupffer cell; Matrix metalloproteinase; MMP; TGF ; TIMP; Tissue inhibitor of matrix metalloproteinase; TNF

Indexed keywords

MATRIX METALLOPROTEINASE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ALTERNATIVE RNA SPLICING; ANIMAL CELL; ARTICLE; ENZYME DENATURATION; ENZYME INHIBITION; EXTRACELLULAR MATRIX; FIBROSIS; INFLAMMATION; KUPFFER CELL; LIVER INJURY; LIVER PARENCHYMA; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STELLATE CELL; TISSUE INJURY;

EID: 0032952079     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(99)80007-5     Document Type: Article

References (80)

1. Cawston TE. Proteinases and inhibitors. Br Med Bull. 51:1995;385-401.
2. Basbaum CB, Werb Z. Focalized proteolysis: spatial and temporal regulation of extracellular matrix degradation at the cell surface. Curr Opin Cell Biol. 8:1996;731-738.
3. Birkedal-Hansen H. Proteolytic remodeling of extracellular matrix. Curr Opin Cell Biol. 7:1995;728-735.
4. Ries C, Petrides PE. Cytokine regulation of matrix metalloproteinase activity and its regulatory dysfunction in disease. Biol Chem H-S. 376:1995;345-355.
5. Iredale JP. Matrix turnover in fibrogenesis. Hepato-Gastroenterol. 43:1996;56-71.
6. Arthur MJ. Collagenases and liver fibrosis. J Hepatol. 22:1995;S43-S48.
7. Arthur MJ. Role of Ito cells in the degradation of matrix in liver. J Gastroenterol Hepatol. 10:1995;S57-S62.
8. Herbst H, Heinrichs O, Schuppan D, Milani S, Stein H. Temporal and spatial patterns of transin/stromelysin RNA expression following toxic injury in rat liver. Virchows Arch B. 60:1991;295-300.
9. Herbst H, Wege T, Milani S, Pellegrini G, Orzechowski HD, Bechstein WO, et al. Tissue inhibitor of metalloproteinase-1 and -2 RNA expression in rat and human liver fibrosis. Am J Pathol. 150:1997;1647-1659.
10. Iredale JP, Benyon RC, Arthur MJ, Ferris WF, Alcolado R, Winwood PJ, et al. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology. 24:1996;176-184.
11. Roeb L, Purucker E, Breuer B, Nguyen H, Heinrich P, Rose-John S, et al. TIMP expression in toxic and cholestatic liver injury in rat. J Hepatol. 27:1997;535-544.
12. Arii S, Mise M, Harada T, Furutani M, Ishigami S, Niwano M, et al. Overexpression of matrix metalloproteinase 9 gene in hepatocellular carcinoma with invasive potential. Hepatology. 24:1996;316-322.
13. Ashida K, Nakatsukasa H, Higashi T, Ohguchi S, Hino N, Nouso K, et al. Cellular distribution of 92-kd type IV collagenase/gelatinase B in human hepatocellular carcinoma. Am J Pathol. 149:1996;1803-1811.
14. Nakatsukasa H, Ashida K, Higashi T, Ohguchi S, Tsuboi S, Hino N, et al. Cellular distribution of transcripts for tissue inhibitor of metalloproteinases 1 and 2 in human hepatocellular carcinomas. Hepatology. 24:1996;82-88.
15. Terada T, Okada Y, Nakanuma Y. Expression of immunoreactive matrix metalloproteinases and tissue inhibitors of matrix metalloproteinases in human normal livers and primary liver tumors. Hepatology. 23:1996;1341-1344.
16. Hayasaka A, Suzuki N, Fujimoto N, Iwama S, Fukuyama E, Kanda Y, et al. Elevated plasma levels of matrix metalloproteinase-9 (92-kd type IV collagenase/gelatinase B) in hepatocellular carcinoma. Hepatology. 24:1996;1058-1062.
17. Musso O, Theret N, Campion JP, Turlin B, Milani S, Grappone C, et al. In situ detection of matrix metalloproteinase-2 (MMP-2) and the metalloproteinase inhibitor TIMP2 transcripts in human primary hepatocellular carcinoma and in liver metastasis. J Hepatol. 26:1997;593-605.
18. Lichtinghagen R, Helmbrecht T, Arndt B, Boker KH. Expression pattern of matrix metalloproteinases in human liver. Eur J Clin Chem Clin. 33:1995;65-71.
19. Friedman SL. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N Engl J Med. 328:1993;1828-1835.
20. Gressner AM, Bachem MG. Molecular mechanisms of liver fibrogenesis - a homage to the role of activated fat-storing cells. Digestion. 56:1995;335-346.
21. Knittel T, Ramadori G. Current concepts of liver fibrosis. Forum Trends Exp Clin Med. 4:1994;236-257.
22. Friedman SL. Closing in on the signals of hepatic fibrosis. Gastroenterology. 112:1997;1406-1409.
23. Alcolado R, Arthur MJ, Iredale JP. Pathogenesis of liver fibrosis. Clin Sci. 92:1997;103-112.
24. Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJ. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology. 110:1996;821-831.
25. Iredale JP, Goddard S, Murphy G, Benyon RC, Arthur MJ. Tissue inhibitor of metalloproteinase-J and interstitial collagenase expression in autoimmune chronic active hepatitis and activated human hepatic lipocytes. Clin Sci. 89:1995;75-81.
26. Milani S, Herbst H, Schuppan D, Grappone C, Pellegrini G, Pinzani M, et al. Differential expression of matrix-metalloproteinase-1 and -2 genes in normal and fibrotic human liver. Am J Pathol. 144:1994;528-537.
27. Takahara T, Furui K, Funaki J, Nakayama Y, Itoh H, Miyabayashi C, et al. Increased expression of matrix metalloproteinase-II in experimental liver fibrosis in rats. Hepatology. 21:1995;787-795.
28. Maruyama K, Feinman L, Fainsilber Z, Nakano M, Okazaki I, Lieber C. Mammalian collagenase increases in early alcoholic liver diseases and decreases with cirrhosis. Life Sci. 30:1982;1379-1384.
29. Perez-Tamayo R, Montfort I, Gonzalez I. Collagenolytic activity in experimental cirrhosis of the liver. Exp Mol Pathol. 47:1987;300-308.
30. Arthur MJ, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem J. 287:1992;701-707.
31. Iredale JP, Murphy G, Hembry RM, Friedman SL, Arthur MJ. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. J Clin Invest. 90:1992;282-287.
32. Arthur MJ, Friedman SL, Roll FJ, Bissell DM. Lipocytes from normal rat liver release a neutral metalloproteinase that degrades basement membrane (type IV) collagen. J Clin Invest. 84:1989;1076-1085.
33. Vyas SK, Leyland H, Gentry J, Arthur MJ. Rat hepatic lipocytes synthesize and secrete transin (stromelysin) in early primary culture. Gastroenterology. 109:1995;889-898.
34. Casini A, Ceni E, Salzano R, Milani S, Schuppan D, Surrenti C. Acetaldehyde regulates the gene expression of matrix-metalloproteinase-1 and -2 in human fat-storing cells. Life Sci. 55:1994;1311-1316.
35. Theret N, Musso O, L'Helgoualc'h A, Clement B. Activation of matrix metalloproteinase-2 from hepatic stellate cells requires interactions with hepatocytes. Am J Pathol. 150:1997;51-58.
36. Takahara T, Furui K, Yata Y, Jin B, Zhang LP, Nambu S, et al. Dual expression of matrix metalloproteinase-2 and membrane-type 1 - matrix metalloproteinase in fibrotic human livers. Hepatology. 26:1997;1521-1529.
37. Winwood PJ, Schuppan D, Iredale JP, Kawser CA, Docherty AJ, Arthur MJ. Kupffer cell-derived 95-kd type IV collagenase/gelatinase B: characterization and expression in cultured cells. Hepatology. 22:1995;304-315.
38. Bhatnagar R, Schade U, Rietschel ET, Decker K. Involvement of prostaglandin E and adenosine 3′5′-monophosphate in lipopoly-saccharide-stimulated collagenase release by rat Kupffer cells. Eur J Biochem. 124:1982;2405-2409.
39. Upadhya A, Harvey R, Howard T, Lowell J, Sheno S, Strasberg S. Evidence of a role of matrix metalloproteinases in cold preservation injury of the liver in humans and in the rat. Hepatology. 26:1997;922-928.
40. Roeb E, Graeve L, Hoffmann R, Decker K, Edwards DR, Heinrich PC. Regulation of tissue inhibitor of metalloproteinases-1 gene expression by cytokines and dexamethasone in rat hepatocyte primary cultures. Hepatology. 18:1993;1437-1442.
41. Roeb E, Graeve L, Mullberg J, Matern S, Rose John S. TIMP-1 protein expression is stimulated by IL-1 beta and IL-6 in primary rat hepatocytes. FEBS Lett. 349:1994;45-49.
42. Roeb E, Rose John S, Erren A, Edwards DR, Matern S, Graeve L, et al. Tissue inhibitor of metalloproteinases-2 (TIMP-2) in rat liver cells in increased by lipopolysaccharide and prostaglandin E2. FEBS Lett. 357:1995;33-36.
43. Nagai Y, Hori H, Hata R-I, Konomi H, Sunafa H. Collagenase production by adult rat hepatocytes in primary culture. Biomed Res. 3:1982;345-349.
44. Montfort I, Perez TR, Alvizouri AM, Tello E. Collagenase of hepatocytes and sinusoidal liver cells in the reversibility of experimental cirrhosis of the liver. Virchows Arch B Cell Pathol. 59:1990;281-289.
45. Knittel T, Müller L, Saile B, Ramadori G. Effect of tumor necrosis factor-alpha on proliferation, activation and protein synthesis of rat hepatic stellate cells. J Hepatol. 27:1997;1067-1080.
46. Knittel T, Janneck T, Müller L, Fellmer P, Ramadori G. Transforming growth factor-β1 regulated gene expression of Ito cells. Hepatology. 24:1996;352-360.
47. Devereux J, Haeberli P, Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res. 12:1984;387-395.
48. Marti HP, McNeil L, Davies M, Martin J, Lovett DH. Homology cloning of rat 72 kDa type IV collagenase: cytokine and second-messenger inducibility in glomerular mesangial cells. Biochem J. 291:1993;441-446.
49. Matrisian LM, Glaichenhaus N, Gesnel MC, Breathnach R. Epidermal growth factor and oncogenes induce transcription of the same cellular mRNA in rat fibroblasts. EMBO J. 4:1985;1435-1440.
50. Okada A, Santavicca M, Basset P. The cDNA cloning and expression of the gene encoding rat gelatinase B. Gene. 164:1995;317-321.
51. Breathnach R, Matrisian LM, Gesnel MC, Staub A, Leroy P. Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Nucleic Acids Res. 15:1987;1139-1151.
52. Quinn CO, Scott DK, Brinckerhoff CE, Matrisian LM, Jeffrey JJ, Partridge NC. Rat collagenase. Cloning, amino acid sequence comparison, and parathyroid hormone regulation in osteoblastic cells. J Biol Chem. 265:1990;22342-22347.
53. Okada A, Bellocq JP, Rouyer N, Chenard MP, Rio MC, Chambon P, et al. Membrane-type matrix metalloproteinase (MT-MMP) gene is expressed in stromal cells of human colon, breast, and head and neck carcinomas. Proc Natl Acad Sci USA. 92:1995;2730-2734.
54. Okada A, Garnier JM, Vicaire S, Basset P. Cloning of the cDNA encoding rat tissue inhibitor of metalloproteinase 1 (TIMP-1), amino acid comparison with other TIMPs, and gene expression in rat tissues. Gene. 147:1994;301-302.
55. Cook TF, Burke JS, Bergman K, Quinn CO, Jeffrey JJ, Partridge NC. Cloning and regulation of rat tissue inhibitor of metalloproteinases-2 in osteoblastic cells. Arch Biochem Biophys. 311:1994;313-320.
56. Knittel T, Armbrust T, Schwögler S, Schuppan D, Meyer zum Büschenfelde K-H, Ramadori G. Distribution and cellular origin of undulin in the rat liver. Lab Invest. 67:1992;779-787.
57. Knittel T, Schuppan D, Meyer zum Büschenfelde K-H, Ramadori G. Differential expression of collagen types I, III, and IV by fatstoring (Ito) cells in vitro. Gastroenterology. 102:1992;1724-1735.
58. Knittel T, Odenthal M, Schuppan D, Schwögler S, Just M, Meyer zum Büschenfelde K-H, Ramadori G. Synthesis of undulin by rat liver fat storing cells: comparison with fibronectin and tenascin. Exp Cell Res. 203:1992;312-320.
59. Knittel T, Armbrust T, Neubauer K, Ramadori G. Expression of von Willebrand factor in normal and diseased rat livers and in cultivated liver cells. Hepatology. 21:1995;470-476.
60. Knittel T, Fellmer P, Ramadori G. Genexpression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver. Gastroenterology. 111:1996;745-754.
61. Knittel T, Aurisch S, Neubauer K, Eichhorst S, Ramadori G. Cell type specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver; up-regulation during in vitro activation and in hepatic tissue repair. Am J Pathol. 149:1996;449-462.
62. Knittel T, Fellmer P, Müller L, Ramadori G. Bone morphogenetic protein-6 is expressed in non-parenchymal liver cells and up-regulated by transforming growth factor-β1. Exp Cell Res. 232:1997;263-269.
63. Knittel T, Fellmer P, Neubauer K, Kawakami M, Grundmann A, Ramadori G. The complement activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro und during the acute phase reaction in vivo. Lab Invest. 77:1997;221-230.
64. Neubauer K, Knittel T, Aurisch S, Fellmer P, Ramadori G. Glial fibrillary acidic protein: a cell type specific marker protein for Ito cells in vivo and in vitro. J Hepatol. 24:1996;719-730.
65. Neubauer K, Knittel T, Armbrust T, Ramadori G. Accumulation and cellular localisation of fibrinogen/fibrin during short-term and long-term rat liver injury. Gastroenterology. 108:1995;1124-1135.
66. Ramadori G. Is there a role for hepatocytes in liver fibrosis? Gressner A, Ramadori G, . Molecular and Cell Biology of Liver Fibrogenesis. 1992;373-384 Kluwer Academic Publishers, Dordrecht/Boston/London.
67. Armbrust T, Schwögler S, Zöhrens G, Ramadori G. Cl esterase inhibitor gene expression in rat Kupffer cells, peritoneal macrophages and blood monocytes: modulation by interferon gamma. J Exp Med. 178:1993;373-380.
68. Chirgwin JM, Przybyla AE, McDonnald RJ, Rutter WJ. Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry. 18:1979;5294-5300.
69. Fort P, Marty L, Piechaczyk M, Sabrouty SE, Dani C, Jeanteur P, et al. Various adult tissues express only one major mRNA species from the glyceraldehyde-3-phosphate-dehydrogenase multigenic family. Nucleic Acids Res. 13:1985;1431-1442.
70. Barbu V, Dautry F. Northern blot normalization with a 28S rRNA oligonucleotide probe. Nucleic Acids Res. 17:1989;7115.
71. Kornblihtt A, Vibe Pedersen K, Baralle F. Human fibronectin: molecular cloning evidence for two mRNA species differing by an internal segment coding for a structural domain. EMBO J. 3:1984;221-226.
72. Weller A, Beck S, Ekblom P. Amino acid sequence of mouse tenascin and differential expression of two tenascin isoforms during embryogenesis. J Cell Biol. 112:1991;355-362.
73. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 227:1970;680-682.
74. Bendeck MP, Zempo N, Clowes AW, Galardy RE, Reidy MA. Smooth muscle cell migration and matrix metalloproteinase expression after arterial injury in the rat. Circ Res. 75:1994;539-545.
75. Okada A, Tomasetto C, Lutz Y, Bellocq J-P, Rio M-C, Basset P. Expression of matrix metalloproteinases during rat skin wound healing: evidence that membrane type-1 matrix metalloproteinase is a stromal activator of pro-gelatinase A. J Cell Biol. 137:1997;67-77.
76. Overall CM. Repression of tissue inhibitor of matrix metalloproteinase expression by all-trans-retinoic acid in rat bone cell populations: comparison with transforming growth factor-beta 1. J Cell Physiol. 164:1995;17-25.
77. Silbiger SM, Jacobsen VL, Cupples RL, Koski RA. Cloning of cDNAs encoding human TIMP-3, a novel member of the tissue inhibitor of metalloproteinase family. Gene. 141:1994;293-297.
78. Knittel T, Dinter C, Müller L, Ramadori G. Regulation of cell adhesion molecule expression by growth factors and inflammatory cytokines in hepatic stellate cells. J Hepatol. 26:1997;S110.
79. Poulos JE, Weber JD, Bellezzo JM, Dibisceglie AM, Britton RS, Bacon BR, et al. Fibronectin and cytokines increase jnk, erk, apl activity, and transin gene expression in rat hepatic stellate cells. Am J Physiol. 36:1997;G804-G811.
80. Czaja MJ, Flanders KC, Biempica L, Klein C, Zern MA, Weiner FR. Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury. Growth Factors. 1:1989;219-226.