Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts

Biochemical and Biophysical Research Communications

Volumn 283, Issue 3, 2001, Pages 554-562

  Dooley, Steven ^a   Streckert, Maike ^a   Delvoux, Bert ^a   Gressner, Axel M ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

Author keywords

Hepatic stellate cells; Liver fibrogenesis; Smad; TGF signal transduction

Indexed keywords

ALPHA ACTIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL ISOLATION; CONTROLLED STUDY; LIVER CELL; LIVER FIBROSIS; MALE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION;

EID: 0034804663     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.4811     Document Type: Article

References (23)

1. Specificity, diversity, and regulation in TGF-beta superfamily signaling
2. Transforming growth factor beta (TGF-beta) expression in isolated and cultured rat hepatocytes
3. TGF-beta and fibrosis
4. Molecular mechanisms of liver fibrogenesis - A homage to the role of activated fat-storing cells
5. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
6. Blockade of type beta transforming growth factor signaling prevents liver fibrosis and dysfunction in the rat
7. Inhibition of transforming growth factor beta prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats
8. A soluble transforming growth factor beta receptor expressed in muscle prevents liver fibrogenesis and dysfunction in rats
9. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts
10. The synthesis of proteoglycans in fat-storing cells of rat liver
11. Isolation and culture of hepatic lipocytes, Kupffer cells, and sinusoidal endothelial cells by density gradient centrifugation with stractan
12. Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling
13. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4
14. Enhanced expression of a glyceraldehyde-3-phosphate dehydrogenase gene in human lung cancers
15. High levels of nm23-mH1 and nm23-H2 messenger RNA in human squamous-cell lung carcinoma are associated with poor differentiation and advanced tumor stages
16. TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
17. The cell biology of liver fibrogenesis - An imbalance of proliferation, growth arrest and apoptosis of myofibroblasts
18. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis
19. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
20. Alternatively spliced variant of Smad2 lacking exon 3. Comparison with wild-type Smad2 and Smad3
21. Induction of apoptosis by Smad3 and down-regulation of Smad3 expression in response to TGF-beta in human normal lung epithelial cells
22. A short amino-acid sequence in MH1 domain is responsible for functional differences between Smad2 and Smad3