Role of hydrogen peroxide and oxidative stress in healing responses

Cellular and Molecular Life Sciences

Volumn 59, Issue 11, 2002, Pages 1872-1891

  Rojkind, Marcos ^a   Dominguez Rosales J A ^a   Nieto, N ^b   Greenwel, P ^b,c  

^a GEORGE WASHINGTON UNIVERSITY   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Extracellular matrix; Fibrosis; Hepatic stellate cells; Organ scarring; Oxidative stress; Wound healing

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; BINDING PROTEIN; CAROTENOID; CATALASE; COLLAGEN; CYTOKINE; FLAVONOID; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GROWTH FACTOR; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE; NUCLEAR FACTOR I; PROTEIN LYSINE 6 OXIDASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE DISMUTASE; THIOREDOXIN; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR SP1; TRANSFORMING GROWTH FACTOR BETA1;

AGING; ANTIOXIDANT ACTIVITY; ATHEROSCLEROSIS; DNA BINDING; ENERGY METABOLISM; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FIBROSIS; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LIVER CELL; LIVER FIBROSIS; METAL BINDING; NONHUMAN; OXIDATION REDUCTION REACTION; OXIDATIVE STRESS; REVIEW; SCAR FORMATION; SECOND MESSENGER; STELLATE CELL; TRANSCRIPTION REGULATION; WOUND HEALING;

AGING; ANIMALS; ANTIOXIDANTS; GENE EXPRESSION REGULATION; HUMANS; HYDROGEN PEROXIDE; LIVER CIRRHOSIS; MICE; NADPH OXIDASE; OXIDATIVE STRESS; SUPEROXIDE DISMUTASE; TRANSCRIPTION FACTORS; WOUND HEALING;

EID: 0036866057     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/PL00012511     Document Type: Review

References (251)

1. Burdon R. H. (1995) Superoxide and hydrogen peroxide in relation to mammalian cell proliferation. Free Radic. Biol. Med. 18: 775-794
2. Kaplowitz N. and Tsukamoto H. (1996) Oxidative stress and liver disease. Prog. Liver Dis. 14: 131-159
3. Berlett B. S. and Stadtman E. R. (1997) Protein oxidation in aging, disease, and oxidative stress. J. Biol. Chem. 272: 20313-20316
4. Dalton P. T.., Shertzer H. G. and Puga A. (1999) Regulation of gene expression by reactive oxygen. Annu. Rev. Pharmacol. Toxicol. 39: 67-101
5. Schulz H. U., Niederau C., Klonowski-Stumpe H., Halangk W., Luthen R. and Lippert H. (1999) Oxidative stress in acute pancreatitis. Hepatogastroenterology 46: 2736-2750
6. Thannickal V. J. and Fanburg B. L. (2000) Reactive oxygen species in cell signaling. Am. J. Physiol. Lung Cell. Mol. Physiol. 279: L1005-L1028
7. Spector A. W. (2000) Oxidative stress and disease. J. Ocul. Pharmacol. Ther. 6: 193-201
8. Shackelford R. E., Kaufmann W. K. and Paules R. S. (2000) Oxidative stress and cell cycle checkpoint function. Free Radic. Biol. Med. 28: 1387-1404
9. Jones R. D., Hancock J. T. and Morice A. H. (2000) NADPH oxidase: A universal oxygen sensor? Free. Radic. Biol. Med. 29: 416-424
10. Poli G. (2000) Pathogenesis of liver fibrosis: Role of oxidative stress. Mol. Aspects Med. 21: 49-98
11. Bai J. and Cederbaum A. I. (2001) Mitochondrial catalase and oxidative injury. Biol. Signals Recept. 10: 189-199
12. Forsberg L., Faire U. de and Morgenstern R. (2001) Oxidative stress, human genetic variation, and disease. Arch. Biochem. Biophys. 389: 84-93
13. Williams K. J., Cowen R. L. and Stratford I. J. (2001) Hypoxia and oxidative stress: Tumour hypoxia - Therapeutic considerations. Breast. Cancer Res. 3: 328-331
14. Brown N. S. and Bicknell R. (2001) Hypoxia and oxidative stress in breast cancer. Oxidative stress: Its effects on the growth, metastatic potential and response to therapy of breast cancer. Breast. Cancer Res. 3: 323-327
15. Knowles H. J. and Harris A. L. (2001) Hypoxia and oxidative stress in breast cancer: Hypoxia and tumourigenesis. Breast Cancer Res. 3: 318-322
16. Pugh C. W., Gleadle J. and Maxwell P. H. (2001) Hypoxia and oxidative stress in breast cancer: Hypoxia signaling pathways. Breast Cancer Res. 3: 313-317
17. Berg R. van den, Haenen G. R., Berg H van den and Bast A. (2001) Transcription factor NF-kappaB as a potential biomarker for oxidative stress. Br. J. Nutr. 86: S121-S127
18. Wilcox C. S. and Welch W. J. (2001) Oxidative stress: Cause or consequence of hypertension. Exp. Biol. Med. 226: 619-620
19. Gilgun-Sherki Y., Melamed E. and Offen D. (2001) Oxidative stress induced-neurodegenerative diseases: The need for antioxidants that penetrate the blood brain barrier. Neuropharmacology 40: 959-975
20. Parthasarathy S., Khan-Merchant N., Penumetcha M. and Santanam N. (2001) Oxidative stress in cardiovascular disease. J. Nucl. Cardiol. 8: 379-389
21. Sun A. Y., Ingelman-Sundberg M., Neve E., Matsumoto H., Nishitani Y., Minowa Y. et al. (2001) Ethanol and oxidative stress. Alcohol Clin. Exp. Res. 25: 237S-243S
22. Jobsis Q., Raatgeep H. C., Schellekens S. L., Kroesbergen A., Hop W. C. and Jongste J. C. de (2000) Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. Eur. Respir. J. 16: 95-100
23. Antczak A., Kurmanowska Z., Kasielski M. and Nowak D. (2000) Inhaled glucocorticosteroids decrease hydrogen peroxide level in expired air condensate in asthmatic patients. Respir. Med. 94: 416-421
24. Halliwell B., Clement M. V. and Long L. H. (2000) Hydrogen peroxide in the human body. FEBS. Lett. 486: 10-13
25. Long L. H. and Halliwell B. (2000) Coffee drinking increases levels of urinary hydrogen peroxide detected in healthy human volunteers. Free Radic. Res. 32: 463-467
26. Wilhelm J., Frydrychova M. and Vizek M. (1999) Hydrogen peroxide in the breath of rats: The effects of hypoxia and paraquat. Physiol. Res. 48: 445-449
27. Pritsos C. A. (2000) Cellular distribution, metabolism and regulation of the xanthine oxidoreductase enzyme system. Chemico-Biol. Interact. 129: 195-208
28. Vazquez-Vivar J. and Kalyanaraman B. (2000) Generation of superoxide from nitric oxide synthase. FEBS Lett. 481: 304-307
29. Bayraktutan U., Blayney L. and Shah A. M. (1999) Molecular characterization and localization of the NAD(P)H oxidase components gp91-phox and p22-phox in endothelial cells. Arterioscler. Thromb. Vasc. Biol. 20: 1903-1911
30. Demiryurek A. T. and Wadsworth R. M. (1999) Superoxide in the pulmonary circulation. Pharmacol. Ther. 84: 355-365
31. Wright R. M., Riley M. G., Weigel L. K., Ginger L. A., Constantino D. A. and Mcmanaman J. L. (2000) Activation of the human aldehyde oxidase (hoax) promoter by tandem cooperative Sp1/Sp3 binding sites: Identification of complex architecture in the hOAX upstream DNA that includes a proximal promoter, distal activation sites, and a silencer element. DNA Cell Biol. 19: 459-461
32. 2 produced by monoamine oxidase. Kidney Int. 59: 76-86
33. Cohen G., Farooqui R. and Kesler N. (1997) Parkinson disease: A new link between monoamine oxidase and mitochondrial electron flow. Proc. Natl. Acad. Sci. USA 94: 4890-4894
34. Raimondi L., Banchelli G., Sgromo L. Pirisino R., Ner M., Parini A. et al. (2000) Hydrogen peroxide generation by monoamine oxidases in rat white adipocytes: Role on cAMP production. Eur. J. Pharmacol. 395: 177-182
35. Vindis C., Seguelas M. H., Bianchi P., Parini A. and Cambon C. (2000) Monoamine oxidase B induces ERK-dependent cell mitogenesis by hydrogen peroxide generation. Biochem. Biophys. Res. Commun. 271: 181-185
36. Li W., Liu G., Chou I. N. and Kagan H. M. (2000) Hydrogen peroxide-mediated, lysyl oxidase-dependent chemotaxis of vascular smooth muscle cells. J. Cell. Biochem. 78: 550-557
37. Kiningham K. K., Oberley T. D., Lin S., Mattingly C. A. and St Clair D. K. (1999) Overexpression of manganese superoxide dismutase protects against mitochondrial-initiated poly(ADP-ribose) polymerase-mediated cell death. FASEB J. 13: 1601-1610
38. Cunningham C. C. and Bailey S. M. (2001) Ethanol consumption and liver mitochondria function. Biol. Signals Recept. 10: 271-282
39. Greenwel P. (1999) Acetaldehyde-mediated collagen regulation in hepatic stellate cells. Alcohol Clin. Exp. Res. 23: 930-933
40. Pagano P. J., Chanock S. J., Siwuk D. A., Colucci W. S. and Clark J. K. (1998) Angiotensin II induces p67phox mRNA expression and NADPH oxidase superoxide generation in rabbit aortic adventitial fibroblasts. Hypertension 32: 331-337
41. Moulton P. J., Goldring M. B. and Hancock J. T. (1998) NADPH oxidase of chondrocytes contains an isoform of the gp91phox subunit. Biochem. J. 329: 449-451
42. Babior B. M. (1999) NADPH oxidase: An update. Blood 93: 1464-1476
43. Gorlach A., Brandes R. P., Nguyen K., Amidi M., Dehghani F. and Busse R. (2000) A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical in the arterial wall. Circ. Res. 87: 26-32
44. Gorlach A., Brandes R. P., Bassus S., Kronemann N., Kirchmaier C. M. and Schini-Kerth B. (2000) Oxidative stress and expression of p22phox are involved in the up-regulation of tissue factor in vascular smooth muscle cells in response to activated platelets. FASEB. J. 14: 1518-1528
45. Jones R. D., Hanckock J. T. and Morice A. H. (2000) NADPH: A universal oxygen sensor? Free Radical Biol. Med. 29: 416-424
46. Smith K. R., Klei L. R. and Barchowsky A. (2001) Arsenite stimulates plasma membrane NADPH oxidase in vascular endothelial cells. Am. J. Physiol. Lung Cell. Mol. Physiol. 280: L442-L449
47. -), superoxide dismutases, and related matters. J. Biol. Chem. 272: 18515-18517
48. Folz R. J., Guan J., Seldin M. F., Oury S. T., Enghild J. J. and Crapo J. D. (1997) Mouse extracellular superoxide dismutase: Primary structure, tissue-specific gene expression, chromosomal localization, and lung in situ hybridization. Am. J. Respir. Cell. Mol. Biol. 17: 393-403
49. Oury T. D., Chang L. Y., Marklund S. L., Day B. J. and Crapo J. D. (1994) Immunocytochemical localization of extracellular superoxide dismutase in human lung. Lab. Invest. 70: 889-898
50. Landmesser U., Merten R., Spiekermann S., Buttner K., Drexler H. and Hornig B. (2000) Vascular extracellular superoxide dismutase activity in patients with coronary artery disease: Relation to endothelium-dependent vasodilation. Circulation 101: 2264-2270
51. Folz R. J., Abushamaa A. M. and Suliman H. B. (1999) Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. J. Clin. Invest. 103: 1055-1066
52. Tsan M. F. White J. E., Caska B., Epstein C. J. and Lee Y. L. (1998) Susceptibility of heterozygous MnSOD gene knockout mice to oxygen toxicity. Am. J. Respir. Cell. Mol. Biol. 19: 114-120
53. Mates J. M. (2000) Effects of antioxidant enzymes in the molecular control of reactive oxygen species toxicology. Toxicology 153: 83-104
54. Jaarsma D., Haasdijk E. D., Grashorn J. A. C., Hawkins R., Van Dujin W., Verspaget H. W. et al. (2000) Human Cu/Zn superoxide dismutase (SOD1) overexpression in mice causes mitochondrial vacuolization, axonal degeneration and premature motoneuron death and accelerates motoneuron disease in mice expressing a familial amyotrophic lateral sclerosis mutant SOD1. Neurobiol. Dis. 6: 623-643
55. Flood D. G., Recume A. G., Gruner J. A., Hoffman E. K., Hirsch J. D., Lin Y. G. et al. (1999) Hindlimb motor neurons require Cu/Zn superoxide dismutase for maintenance of neuromuscular junctions. Am. J. Pathol. 155: 663-672
56. Smith-Mungo L. I. and Kagan H. M. (1998) Lysyl oxidase: Properties, regulation and multiple functions in biology. Matrix Biol. 16: 387-398
57. Rucker R. B., Kosonen T. Clegg M. S., Mitchell A. E., Rucker B. R., Uriu-Hare J. Y. et al. (1998) Copper, lysyl oxidase, and extracellular matrix protein cross-linking. Am. J. Clin. Nutr. 67: 996S-1002S
58. I Kagan H. M. (2000) Intra- and extracellular enzymes of collagen biosynthesis as biological and chemical targets in the control of fibrosis. Acta. Trop. 77: 147-152
59. Garcia-Trevijano E. R., Iraburu M. J., Fontana L., Dominguez-Rosales J. A., Auster A., Covarrubias-Pinedo A. et al. (1999) Transforming growth factor beta 1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbeta-dependent mechanism in rat hepatic stellate cells. Hepatology 29: 960-970
60. Greenwel P., Dominguez-Rosales J. A., Mavi G., Rivas-Estilla A. M. and Rojkind M. (2000) Hydrogen peroxide: A link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology 31: 109-116
61. Clerck L. S. de, Dequeker J., Francx L. and Demedts M. (1987) D-penicillamine therapy and interstitial lung disease in scleroderma: A long-term followup study. Arthritis Rheum. 30: 643-650
62. Geismar L. S., Hennessey S., Reiser K. M. and Last J. A. (1986) D-penicillamine prevents collagen accumulation in lungs of rats given bleomycin. Chest 89: 153S-154S
63. Tang S. S., Chichester C. O. and Kagan H. M. (1989) Comparative sensitivities of purified preparations of lysyl oxidase and other amine oxidases to active site-directed enzyme inhibitors. Connect. Tissue Res. 19: 93-103
64. Young I. S. and Woodside J. V. (2001) Antioxidants in health and disease. J. Clin. Pathol. 54: 176-186
65. Gabbita S. P., Robinson K. A., Stewart C. A., Floyd R. A. and Hensley K. (2000) Redox regulatory mechanisms of cellular signal transduction. Arch. Biochem. Biophys. 376: 1-13
66. Hunt C. R., Sim J. E., Suilivan S. J., Featherstone T., Golden W., Von Kapp-Herr C. et al. (1998) Genomic instabitity and catalase gene amplification induced by chronic exposure to oxidative stress. Cancer Res. 58: 3986-3992
67. Arthur J. R. (2000) The glutathione peroxidases. Cell. Mol. Life Sci. 57: 1825-1835
68. Holben D. H. and Smith A. M. (1999) The diverse role of selenium within selenoproteins: A review. J. Am. Diet. Assoc. 99: 836-843
69. Gibson D. D., Hawrylko J. and McCay P. B. (1985) GSH-dependent inhibition of lipid peroxidation: Properties of a potent cytosolic system which protects cell membranes. Lipids 20: 704-711
70. Carr A. and Frei B. (1999) Does vitamin C act as a pro-oxidant under physiological conditions? FASEB J. 13: 1007-1024
71. Carr A. C. and Frei B. (1999) Toward a new recommended dietary allowance for vitamin C based on antioxidant and health effects in humans. Am. J. Clin. Nutr. 69: 1086-1107
72. Neuzil J., Thomas S. R. and Stocker R. (1997) Requirement for promotion or inhibition by alpha-tocopherol of radical-induced initiation of plasma lipoprotein lipid peroxidation. Free Radic. Biol. Med. 22: 57-71
73. Palace V. P., Khaper N., Qin Q. and Singal P. K. (1999) Antioxidant potentials of vitamin A and carotenoids and their relevance to heart disease. Free Radic. Biol. Med. 26: 746-761
74. Young A. J. and Lowe G. M. (2001) Antioxidant and prooxidant properties of carotenoids. Arch. Biochem. Biophys 385: 20-27
75. Middleton E. Jr, Kandaswami C. and Theoharides T. C. (2000) The effects of plant flavonoids on mammalian cells: Implications for inflammation, heart disease, and cancer. Pharmacol. Rev. 52: 673-751
76. Kandaswami C. and Middleton E. Jr (1994) Free radical scavenging and antioxidant activity of plant flavonoids. Adv. Exp. Med. Biol. 366: 351-376
77. Bergendi L., Benes L., Durackova Z. and Ferencik M. (1999) Chemistry, physiology and pathology of free radicals. Life Sci. 65: 1865-1874
78. Hoshi T. and Heinemann S. (2001) Regulation of cell function by methionine oxidation and reduction. J. Physiol. 531: 1-11
79. Powis G. and Montfort W. R. (2001) Properties and biological activities of thioredoxins. Annu. Rev. Pharmacol. Toxicol. 41: 261-295
80. Deneke S. M. (2000) Thiol-based antioxidants. Curr. Top. Cell. Regul. 36: 151-180
81. O'Donovan D. J. and Fernandez C. J. (2000) Mitochondrial glutathione and oxidative stress: Implications for pulmonary oxygen toxicity in premature infants. Mol. Genet. Metab. 71: 352-358
82. Lu S. C. (1999) Regulation of hepatic glutathione synthesis: Current concepts and controversies. FASEB J. 13: 1169-1183
83. Stocks J., Gutteridge J. M., Sharp R. J. and Dormandy T. L. (1974) The inhibition of lipid autoxidation by human serum and its relation to serum proteins and alpha-tocopherol. Clin. Sci. Mol. Med. 47: 223-233
84. Goldstein I. M., Kaplan H. B., Edelson H. S. and Weissmann G. (1982) Ceruloplasmin: An acute phase reactant that scavenges oxygen-derived free radicals. Ann. N. Y. Acad. Sci. 389: 368-379
85. Park Y. S., Suzuki K., Taniguchi N., and Gutteridge J. M. (1999) Glutathione peroxidase-like activity of caeruloplasmin as an important lung antioxidant. FEBS Lett. 458: 133-136
86. Fox P. L., Mukhopadhyay C. and Ehrenwald E. (1995) Structure, oxidant activity, and cardiovascular mechanisms of human ceruloplasmin. Life Sci. 56: 1749-1758
87. Kim R. H., Park J. E. and Park J. W. (2000) Ceruloplasmin enhances DNA damage induced by hydrogen peroxide in vitro. Free Radic. Res. 33: 81-89
88. Choi S. Y., Kwon H. Y., Kwon O. B., Eum W. S. and Kang J. H. (2000) Fragmentation of human ceruloplasmin induced by hydrogen peroxide. Biochimie 82: 175-80
89. Scott M. D., Meshnick S. R. and Eaton J. W. (1989) Superoxide dismutase amplifies organismal sensitivity to ionizing radiation. J. Biol. Chem. 264: 2498-2501
90. Canavese C., Stratta P. and Vercellone A. (1988) The case for oxygen free radicals in the pathogenesis of ischemic acute renal failure. Nephron 49: 9-15
91. Bratell S., Folmerz P., Hansson R.Jonsson O., Lundstam S., Pettersson S. et al. (1988) Effects of oxygen free radical scavengers, xanthine oxidase inhibition and calcium entry-blockers on leakage of albumin after ischaemia: An experimental study in rabbit kidneys. Acta Physiol. Scand. 134: 35-41
92. Gonzalez-Flecha B., Evelson P., Sterin-Speziale N. and Boveris A. (1993) Hydrogen peroxide metabolism and oxidative stress in cortical, medullary and papillary zones of rat kidney. Biochim. Biophys. Acta 1157: 155-161
93. Greenacre S. A. and Ischiropoulos H. (2001) Tyrosine nitration: Localisation, quantification, consequences for protein function and signal transduction. Free Radic. Res. 34: 541-581
94. Stamler J. S., Lamas S. and Fang F. C. (2001) Nitrosylation: The prototypic redox-based signaling mechanism. Cell 106: 675-683
95. Mannick J. B., Schonhoff C., Papeta N., Ghafourifar P., Szibor M., Fang K. et al. (2001) S-nitrosylation of mitochondrial caspases. J. Cell. Biol. 154: 1111-1116
96. Sarkela T. M., Berthiaume J., Elfering S., Gybina A. A. and Giulivi C. (2001) The modulation of oxygen radical production by nitric oxide in mitochondria. J. Biol. Chem. 276: 6945-6949
97. Kim J. R., Yoon H. W., Kwon K. S., Lee S. R., and Rhee S. G. (2000) Identification of proteins containing cysteine residues that are sensitive to oxidation by hydrogen peroxide at neutral pH. Anal. Biochem. 283: 214-221
98. Lasch P., Petras T. Ullrich O., Backmann J., Naumann D. and Grune T. (2001) Hydrogen peroxide-induced structural alterations of RNAse A. J. Biol. Chem. 276: 9492-9502
99. Milzani A., Rossi R., Di Simplicio P., Giustarini D., Colombo R. and DalleDonne I. (2000) The oxidation produced by hydrogen peroxide on Ca-ATP-G-actin. Protein Sci. 9: 1774-1782
100. Sun Y. and Oberley L. W. (1996) Redox regulation of transcriptional activators. Free Radical. Biol. Med. 21: 335-348
101. Morel Y. and Barouki R. (1999) Repression of gene expression by oxidative stress. Biochem. J. 342: 481-496
102. Gius D., Botero A., Shah S. and Curry H. A. (1999) Intracellular oxidation/reduction status in the regulation of transcription factors NF-kappaB and AP-1. Toxicol. Lett. 106: 93-106
103. Toone W. M., Morgan B. A. and Jones N. (2001) Redox control of AP-1-like factors in yeast and beyond. Oncogene 20: 2336-2346
104. Lavrovsky Y., Chatterjee B., Clark R. A. and Roy A. K. (2000) Role of redox-regulated transcription factors in inflammation, aging and age-related diseases. Exp. Gerontol. 35: 521-532
105. Hensley K., Robinson K. A., Gabbita S. P., Salsman S. and Floyd R. A. (2000) Reactive oxygen species, cell signaling, and cell injury. Free Radical. Biol. Med. 28: 1456-1462
106. Gabbita S. P., Robinson K. A., Stewart C. A., Floyd R. A. and Hensley K. (2000) Redox regulatory mechanisms of cellular signal transduction. Arch. Biochem. Biophys. 376: 1-13
107. Wisdom R. (1999) AP-1: One switch for many signals. Exp. Cell Res. 253: 180-185
108. Vincenti M. P., White L. A., Schroen D. J., Benbow U. and Brinckerhoff C. E. (1996) Regulating expression of the gene for matrix metalloproteinase-1 (collagenase): Mechanisms that control enzyme activity, transcription, and mRNA stability. Crit. Rev. Eukaryot. Gene Expr. 6: 391-411
109. Borden P. and Heller R. A. (1997) Transcriptional control of matrix metalloproteinases and the tissue inhibitors of matrix metalloproteinases. Crit. Rev. Eukaryot. Gene Expr. 7: 159-178
110. Armendariz-Borunda J., Simkevich C. P., Roy N., Raghow R., Kang A. H. and Seyer J. M. (1994) Activation of Ito cells involves regulation of AP-1 binding proteins and induction of type I collagen gene expression. Biochem. J. 304: 817-824
111. Kim S. J., Denhez F., Kim K. Y., Holt J. T., Sporn M. B. and Roberts A. B. (1989). Activation of the second promoter of the transforming growth factor-beta 1 gene by transforming growth factor-beta 1 and phorbol ester occurs through the same target sequences. J. Biol. Chem. 264: 19373-19378
112. Hsu T. C., Young M. R., Cmarik J. and Colburn N. H. (2000) Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis. Free Radical Biol. Med. 28: 1338-1348
113. Xanthoudakis S. and Curran T. (1994) Analysis of c-Fos and c-Jun redox-dependent DNA binding activity. Methods Enzymol. 234: 163-174
114. Xanthoudakis S., Miao G., Wang F., Pan Y. C. and Curran T. (1992) Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme. EMBO J. 11: 3323-3335
115. Xanthoudakis S. and Curran T. (1996) Redox regulation of AP-1: A link between transcription factor signaling and DNA repair. Adv. Exp. Med. Biol. 387: 69-75
116. Fritz G. (2000) Human APE/Ref-1 protein. Int. J. Biochem. Cell. Biol. 32: 925-929
117. Ghosh S. (1999) Regulation of inducible gene expression by the transcription factor NF-kappaB. Immunol. Res. 19: 183-189
118. Mercurio F. and Manning A. M. (1999) NF-kappaB as a primary regulator of the stress response. Oncogene 18: 6163-6171
119. Karin M. (1999) How NF-kappaB is activated: The role of the IkappaB kinase (IKK) complex. Oncogene 18: 6867-6874
120. Li N. and Karin M. (1999) Is NF-kappaB the sensor of oxidative stress? FASEB J. 13: 1137-1143
121. Bowie A. and O'Neill L. A. (2000) Oxidative stress and nuclear factor-kappaB activation: A reassessment of the evidence in the light of recent discoveries. Biochem. Pharmacol. 59: 13-23
122. Janssen-Heininger Y. M., Poynter M. E. and Baeuerle P. A. (2000) Recent advances towards understanding redox mechanisms in the activation of nuclear factor kappaB. Free Radical Biol. Med. 28: 1317-1327
123. Schreck R., Rieber P. and Baeuerle P. A. (1991) Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1. EMBO J. 10: 2247-2258
124. Schreck R., Meier B., Mannel D. N., Droge W. and Baeuerle P. A. (1992) Dithiocarbamates as potent inhibitors of nuclear factor kappa B activation in intact cells. J. Exp. Med. 175: 1181-1194
125. 2 and antioxidants have opposite effects on activation of NF-kappa B and AP-1 in intact cells: AP-1 as secondary antioxidant-responsive factor. EMBO J. 12: 2005-2015
126. Schmidt K. N., Amstad P., Cerutti P. and Baeuerle P. A. (1995) The roles of hydrogen peroxide and superoxide as messengers in the activation of transcription factor NF-kappa B. Chem. Biol. 2: 13-22
127. Brigelius-Flohe R., Friedrichs B., Maurer S., Schultz M. and Streicher R. (1997) Interleukin-1-induced nuclear factor kappa B activation is inhibited by overexpression of phospholipid hydroperoxide glutathione peroxidase in a human endothelial cell line. Biochem. J. 328: 199-203
128. Manna S. K., Zhang H. J., Yan T., Oberley L. W. and Aggarwal B. B. (1998) Overexpression of manganese superoxide dismutase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappaB and activated protein-1. J. Biol. Chem. 273: 13245-13254
129. Bonizzi G., Piette J., Schoonbroodt S., Greimers R., Havard L., Merville M. P. et al. (1999) Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity. Mol. Cell. Biol. 19: 1950-1960
130. Berg J. M. (1992) Sp1 and the subfamily of zinc finger proteins with guanine-rich binding sites. Proc. Natl. Acad. Sci. USA 89: 11109-11110
131. Inagaki Y., Truter S. and Ramirez F. (1994) Transforming growth factor-beta stimulates alpha 2(I) collagen gene expression through a cis-acting element that contains an Sp1-binding site. J. Biol. Chem. 269: 14828-14834
132. Li L., Artlett C., M., Jimenez S. A., Hall D. J. and Varga J. (1995) Positive regulation of human alpha 1 (I) collagen promoter activity by transcription factor Sp1. Gene 164: 229-234
133. Ihn H., Ohnishi K., Tamaki T., LeRoy E. C. and Trojanowska M. (1996) Transcriptional regulation of the human alpha2(I) collagen gene: Combined action of upstream stimulatory and inhibitory cis-acting elements. J. Biol. Chem. 271: 26717-26723
134. Greenwel P., Inagaki Y., Hu W. Walsh M. and Ramirez F. (1997) Sp1 is required for the early response of alpha2(I) collagen to transforming growth factor-beta1. J. Biol. Chem. 272: 19738-19745
135. Black A. R., Black J. D. and Azizkhan-Clifford J. (2001) Sp1 and kruppel-like factor family of transcription factors in cell growth regulation and cancer. J. Cell. Physiol. 188: 143-160
136. Wu X., Bishopric N. H., Discher D. J., Murphy B. J. and Webster K. A. (1996) Physical and functional sensitivity of zinc finger transcription factors to redox change. Mol. Cell. Biol. 16: 1035-1046
137. Knoepfel L., Steinkuhler C., Carri M. T. and Rotilio G. (1994) Role of zinc-coordination and of the glutathione redox couple in the redox susceptibility of human transcription factor Sp1. Biochem. Biophys. Res. Commun. 201: 871-877
138. Ammendola R., Mesuraca M., Russo T. and Cimino F. (1992) Sp1 DNA binding efficiency is highly reduced in nuclear extracts from aged rat tissues. J. Biol. Chem. 267: 17944-17948.
139. Ammendola R., Mesuraca M., Russo T. and Cimino F. (1994) The DNA-binding efficiency of Sp1 is affected by redox changes. Eur. J. Biochem. 225: 483-489
140. Gronostajski R. M. (2000) Roles of the NFI/CTF gene family in transcription and development. Gene 249: 31-45
141. Bandyopadhyay S. and Gronostajski R. M. (1994) Identification of a conserved oxidation-sensitive cysteine residue in the NFI family of DNA-binding proteins. J. Biol. Chem. 269: 29949-29955
142. Morel Y. and Barouki R. (1998) Down-regulation of cytochrome P450 1A1 gene promoter by oxidative stress: Critical contribution of nuclear factor 1. J. Biol. Chem. 273: 26969-26976
143. Morel Y., Coumoul X., Nalpas A. and Barouki R. (2000) Nuclear factor I/CCAAT box transcription factor trans-activating domain is a negative sensor of cellular stress. Mol. Pharmacol. 58: 1239-1246
144. Kanei-Ishii C., Nomura T., Ogata K., Sarai A., Yasukawa T., Tashiro S. et al. (1996) Structure and function of the proteins encoded by the myb gene family. Curr. Top. Microbiol. Immunol. 211: 89-98
145. Oh I. H. and Reddy E. P. (1999) The myb gene family in cell growth, differentiation and apoptosis. Oncogene 18: 3017-3033
146. Ness S. A. (1999) Myb binding proteins: Regulators and cohorts in transformation. Oncogene 18: 3039-3046
147. Eng F. J. and Friedman S. L. (2001) Transcriptional regulation in hepatic stellate cells. Semin. Liver Dis. 21: 385-395
148. Guehmann S., Vorbrueggen G., Kalkbrenner F. and Moelling K. (1992) Reduction of a conserved Cys is essential for Myb DNA-binding. Nucleic Acids Res. 20: 2279-2286
149. Myrset A. H., Bostad A., Jamin N., Lirsac P. N., Toma F. and Gabrielsen O. S. (1993) DNA and redox state induced conformational changes in the DNA-binding domain of the Myb oncoprotein. EMBO J. 12: 4625-4633
150. 2-induced block of glycolysis as an active ADP-ribosylation reaction protecting cells from apoptosis. FASEB J. 14: 2266-2276
151. Tretter L. and Adam-Vizi V. (2000) Inhibition of Krebs cycle enzymes by hydrogen peroxide: A key role of [alpha]-ketoglutarate dehydrogenase in limiting NADH production under oxidative stress. J. Neurosci. 20: 8972-8979
152. Maher J. J. (1999) Leukocytes as modulators of stellate cell activation. Alcohol Clin. Exp. Res. 23: 917-921
153. Iimuro Y., Bradford B. U., Yamashina S., Rusyn I., Nakagami M., Enomoto N. et al. (2000) The glutathione precursor L-2-oxothiazolidine-4-carboxylic acid protects against liver injury due to chronic enteral ethanol exposure in the rat. Hepatology 31: 391-398
154. Jarvelainen H. A., Fang C., Ingelman-Sundberg M., Lukkari T. A., Sippel H. and Lindros K. O. (2000) Kupffer cell inactivation alleviates ethanol-induced steatosis and CYP2E1 induction but not inflammatory responses in rat liver. J. Hepatol. 32: 900-910
155. Ramadori G. and Armbrust T. (2001) Cytokines in the liver. Eur. J. Gastroenterol. Hepatol. 13: 777-784
156. Kurosaka K., Watanabe N. and Kobayashi Y. (2001) Production of proinflammatory cytokines by resident tissue macrophages after phagocytosis of apoptotic cells. Cell. Immunol. 211: 1-7
157. Shi M. M., Chong I., Godleski J. J. and Paulauskis J. D. (1999) Regulation of macrophage inflammatory protein-2 gene expression by oxidative stress in rat alveolar macrophages. Immunology 97: 309-315
158. De Bleser P. J., Xu G., Rombouts K., Rogiers V. and Geerts A. (1999) Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J. Biol. Chem. 274: 33881-33887
159. Wolf G., Hannken T., Schroeder R., Zahner G., Ziyadeh F. N. and Stahl R. A. (2001) Antioxidant treatment induces transcription and expression of transforming growth factor beta in cultured renal proximal tubular cells. FEBS Lett. 488: 154-159
160. Henderson J. P., Byun J., Williams M. V., Mueller D. M., McCormick M. L. and Heinecke J. W. (2001) Production of brominating intermediates by myeloperoxidase: A transhalogenation pathway for generating mutagenic nucleobases during inflammation. J. Biol. Chem. 276: 7867-7875
161. Henderson J. P., Byun J., Williams M. V., McCormick M. L., Parks W. C., Ridnour L. A. et al. (2001) Bromination of deoxycytidine by eosinophil peroxidase: A mechanism for mutagenesis by oxidative damage of nucleotide precursors. Proc. Natl. Acad. Sci. USA 98: 1631-1636
162. Henderson J. P., Byun J., Mueller D. M. and Heinecke J. W. (2001) The eosinophil peroxidase-hydrogen peroxide-bromide system of human eosinophils generates 5-bromouracil, a mutagenic thymine analogue. Biochemistry 40: 2052-2059
163. Nagata M., Yamamoto H., Shibasaki M., Sakamoto Y. and Matsuo H. (2000) Hydrogen peroxide augments eosinophil adhesion via beta2 integrin. Immunology 101: 412-418
164. Bruck R., Hershkoviz R., Lider O., Shirin H., Aeed H. and Halpern Z. (2000) Non-peptidic analogs of the cell adhesion motif RGD prevent experimental liver injury. Isr. Med, Assoc. J. 2 (suppl): 74-80
165. Lee M. and Yea S. S. (2000) Hydrogen peroxide inhibits the immune response to lipopolysaccharide by attenuating signaling through c-Jun N-terminal kinase and p38 associated with protein kinase C. Immunopharmacology 48: 165-172
166. 2+ in TGF-beta 1-induced IL-6 expression. J. Immunol. 165: 2190-2197
167. 2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 276: 2531-2537
168. Park S. K., Kim J., Seomun Y., Choi J., Kim D. H., Han I. O. et al. (2001) Hydrogen peroxide is a novel inducer of connective tissue growth factor. Biochem. Biophys. Res. Commun. 284: 966-971
169. 2 production requires the activation of phosphatidylinositol 3-kinase. J. Biol. Chem. 275: 10527-10531
170. 2. Biochem. Biophys. Res. Commun. 280: 1279-1285
171. 2 production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. J. Biol. Chem. 276: 29251-29256
172. 2 and phosphorylation of 30 kilodalton proteins as early responses of cell cycle-dependent inhibition of DNA synthesis by transforming growth factor beta 1. Cell Growth. Differ, 2: 583-591
173. Bohler T., Waiser J., Hepburn H., Gaedeke J., Lehmann C., Hambach P. et al. (2000) TNF-alpha and IL-1alpha induce apoptosis in subconfluent rat mesangial cells: Evidence for the involvement of hydrogen peroxide and lipid peroxidation as second messengers. Cytokine 12: 986-991
174. 2 generation in liver mitochondria. Carcinogenesis 21: 983-989
175. Lieber C. S. (2000) Alcoholic liver disease: New insights in pathogenesis lead to new treatments. J. Hepatol. 32: 113-128
176. Miwa H., Fujii J., Kanno H., Taniguchi N. and Aozasa K. (2000) Pyruvate secreted by human lymphoid cell lines protects cells from hydrogen peroxide mediated cell death. Free Radical Res. 33: 45-56
177. Shostak A., Gotloib L., Kushnier R. and Wajsbrot V. (2000) Protective effect of pyruvate upon cultured mesothelial cells exposed to 2 mM hydrogen peroxide. Nephron 84: 362-366
178. Bailey S. M. and Cunningham C. C. (1998) Acute and chronic ethanol
179. Bedossa P., Houglum K., Trautwein C., Holstege A. and Chojkier M. (1994) Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis? Hepatology 19: 1262-1271
180. Parola M., Pinzani M., Casini A., Leonarduzzi G., Marra F., Caligiuri A. et al. (1996) Induction of procollagen type I gene expression and synthesis in human hepatic stellate cells by 4-hydroxy-2,3-nonenal and other 4-hydroxy-2,3-alkenals is related to their molecular structure. Biochem. Biophys. Res. Commun. 222: 261-264
181. Anania F. A., Womack L., Jiang M. and Saxena N. K. (2001) Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells. Free. Radical Biol. Med. 30: 846-857
182. Nieto N., Friedman S. L., Greenwel P. and Cederbaum A. I. (1999) CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology 30: 987-996
183. 2 and cyclooxygenase-2. J. Biol. Chem. 275: 20136-20145
184. Kono H., Bradford B. U., Yin M., Sulik K. K., Koop D. R., Peters J. M. et al. (1999) CYP2E1 is not involved in early alcohol-induced liver injury. Am. J. Physiol. 277: G1259-G1267
185. Kono H., Rusyn I., Yin M., Gabele E., Yamashina S., Dikalova A. et al. (2000) NADPH oxidase-derived free radicals are key oxidants in alcohol-induced liver disease. J. Clin. Invest. 106: 867-872
186. Enomoto N., Ikejima K., Bradford B. U. Rivera C. A., Kono H., Goto M. et al. (2000) Role of Kupffer cells and gut-derived endotoxins in alcoholic liver injury. J. Gastroenterol. Hepatol. 15: (suppl): D20-D25
187. Wheeler M. D., Kono H., Yin M., Nakagami M., Uesugi T., Arteel G. E. et al. (2001) The role of Kupffer cell oxidant production in early ethanol-induced liver disease. Free Radical Biol. Med. 31: 1544-1549
188. Islam K. N., Kayanoki Y., Kaneto H., Suzuki K., Asahi M., Fujii J., et al. (1997) TGF-beta1 triggers oxidative modifications and enhances apoptosis in HIT cells through accumulation of reactive oxygen species by suppression of catalase and glutathione peroxidase. Free Radical Biol. Med. 22: 1007-1017
189. Rojkind M. and Greenwel P. (2001) Pathophysiology of liver fibrosis. In: The Liver Biology and Pathobiology, 4th Ed., pp. 721-738, Arias I. M., Boyer J. L., Chisari F. V., Fausto N., Schachter D. and Shafritz D. A., (eds), Lippincott Williams & Willkins, Philadelphia
190. Kuppusamy P. and Zweier J. L. (1989) Characterization of free radical generation by xanthine oxidase: Evidence for hydroxyl radical generation. J. Biol. Chem. 264: 9880-9884
191. Lieber C. S. (1997) Role of oxidative stress and antioxidant therapy in alcoholic and nonalcoholic liver diseases. Adv. Pharmacol. 38: 601-628
192. Castro G. D., Delgado de Layno A. M., Costantini M. H. and Castro J. A. (2001) Cytosolic xanthine oxidoreductase mediated bioactivation of ethanol to acetaldehyde and free radicals in rat breast tissue: Its potential role in alcohol-promoted mammary cancer. Toxicology 160: 11-18
193. Israel Y. and Orrego H. (1984) Hypermetabolic state and hypoxic liver damage. Recent. Dev. Alcohol. 2: 119-133
194. Bailey S. M., Patel V. B., Young T. A., Asayama K. and Cunningham C. C. (2001) Chronic ethanol consumption alters the glutathione/glutathione peroxidase-1 system and protein oxidation status in rat liver. Alcohol Clin. Exp. Res. 25: 726-733
195. Takahashi T., Lasker J. M., Rosman A. S. and Lieber C. S. (1993) Induction of cytochrome P-4502E1 in the human liver by ethanol is caused by a corresponding increase in encoding messenger RNA. Hepatology 17: 236-245
196. Kera Y., Penttila K. E. and Lindros K. O. (1988) Glutathione replenishment capacity is lower in isolated perivenous than in periportal hepatocytes. Biochem. J. 254: 411-417
197. Castilla A., Prieto J. and Fausto N. (1991) Transforming growth factors beta 1 and alpha in chronic liver disease: Effects of interferon alfa therapy. N. Engl. J. Med. 324: 933-940
198. Sanderson N., Factor V., Nagy P., Kopp J., Kondaiah P., Wakefield L. et al. (1995) Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc. Natl. Acad. Sci. USA 92: 2572-2576
199. Hellerbrand C., Stefanovic B., Giordano F., Burchardt E. R. and Brenner D. A. (1999) The role of TGFbeta1 in initiating hepatic stellate cell activation in vivo. J. Hepatol. 30: 77-87
200. Mayer D. C. and Leinwand L. A. (1997) Sarcomeric gene expression and contractility in myofibroblasts. J. Cell. Biol. 139: 1477-1484
201. Racine-Samson L., Rockey D. C. and Bissell D. M. (1997) The role of alpha 1 beta1 integrin in wound contraction: A quantitative analysis of liver myofibroblasts in vivo and in primary culture. J. Biol. Chem. 272: 30911-30917
202. Serini G. and Gabbiani G. (1999) Mechanisms of myofibroblast activity and phenotypic modulation. Exp. Cell Res. 250: 273-283
203. Yanase M., Ikeda H., Matsui A., Maekawa H., Noiri E., Tomiya T. et al. (2000) Lysophosphatidic acid enhances collagen gel contraction by hepatic stellate cells: Association with rho-kinase. Biochem. Biophys. Res. Commun. 277: 72-78
204. Rockey D. C. (2000) The cell and molecular biology of hepatic fibrogenesis: Clinical and therapeutic implications. Clin. Liver Dis. 4: 319-355
205. Hinz B., Mastrangelo D., Iselin C. E., Chaponnier C. and Gabbiani G. (2001) Mechanical tension controls granulation tissue contractile activity and myofibroblast differentiation. Am. J. Pathol. 159: 1009-1020
206. Zhu Y. K., Liu X. D., Skold M. C., Umino T., Wang H., Romberger D. J. et al. (2001) Cytokine inhibition of fibroblast-induced gel contraction is mediated by PGE(2) and NO acting through separate parallel pathways. Am. J. Respir. Cell. Mol. Biol. 25: 245-253
207. Liu X. D., Umino T., Ertl R., Veys T., Skold C. M., Takigawa K. et al. (2001) Persistence of TGF-beta1 induction of increased fibroblast contractility. In Vitro Cell. Dev. Biol. Anim. 37: 193-201
208. Albanis E. and Friedman S. L. (2001) Hepatic fibrosis: Pathogenesis and principles of therapy. Clin. Liver Dis. 5: 315-334
209. Dave S. A., Banducci D. R., Graham W. P. 3rd, Allison G. M. and Ehrlich H. P. (2001) Differences in alpha smooth muscle actin expression between fibroblasts derived from Dupuytren's nodules or cords. Exp. Mol. Pathol. 71: 147-155
210. Rockey D. C. (2001) Hepatic blood flow regulation by stellate cells in normal and injured liver. Semin. Liver Dis. 21: 337-349
211. Geerts A. (2001) History, heterogeneity, developmental biology, and functions of quiescent hepatic stellate cells. Semin. Liver Dis. 21: 311-335
212. Ogata I., Saez C. G., Greenwel P., Ponce M. D., Geerts A., Leinwand L. A. et al. (1993) Rat liver fat-storing cell lines express sarcomeric myosin heavy chain mRNA and protein. Cell Motil. Cytoskel. 26: 125-132
213. Arora P. D., Narani N. and McCulloch C. A. (1999) The compliance of collagen gels regulates transforming growth factorbeta induction of alpha-smooth muscle actin in fibroblasts. Am. J. Pathol. 154: 871-882
214. Vaughan M. B., Howard E. W. and Tomasek J. J. (2000) Transforming growth factor-beta 1 promotes the morphological and functional differentiation of the myofibroblast. Exp. Cell Res. 257: 180-189
215. Lanning D. A., Diegelmann R. F., Yager D. R., Wallace M. L., Bagwell C. E. and Haynes J. H. (2000) Myofibroblast induction with transforming growth factor-beta 1 and -beta3 in cutaneous fetal excisional wounds. J. Pediatr. Surg. 35: 183-187
216. 2. Life Sci. 66: 291-296
217. Torrecillas G., Boyano-Adanez M. C., Medina J., Parra T., Griera M., Lopez-Ongil S. et al. (2001) The role of hydrogen peroxide in the contractile response to angiotensin II. Mol. Pharmacol. 59: 104-112
218. Chen Q. M., Tu V. C., Catania J., Burton M., Toussaint O. and Dilley T. (2000) Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide. J. Cell Sci. 113: 4087-4097
219. 2-mediated injury of human endothelial cells. J. Biol. Chem. 275: 37187-37193
220. 2-induced filamin redistribution in endothelial cells. J. Cell. Biochem. 68: 511-524
221. 2-induced filamin redistribution in endothelial cells is modulated by the cyclic AMP-dependent protein kinase pathway. J. Cell Physiol. 172: 373-381
222. Merker K., Sitte N. and Grune T. (2000) Hydrogen peroxidemediated protein oxidation in young and old human MRC-5 fibroblasts. Arch. Biochem. Biophys. 375: 50-54
223. Chiueh C. (2000) Reactive oxygen species: From radiation to molecular biology. Ann. N. Y. Acad. Sci. 899: 1-426
224. 2 is required for UVB-induced EGF receptor and downstream signaling pathway activation. Free Radical Biol. Med. 27: 1197-1202
225. 2 are potent inducers of vascular endothelial growth factor expression in cultured keratinocytes. J. Biol. Chem. 271: 21793-21797
226. Cai H. and Harrison D. G. (2000) Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ. Res. 87: 840-844
227. Aviram M. (2000) Review of human studies on oxidative damage and antioxidant protection related to cardiovascular diseases. Free Radic. Res. 33 (suppl): S85-S97
228. Nagase M., Ando K., Nagase T., Kaname S., Sawamura T. and Fujita T. (2001) Redox-sensitive regulation of lox-1 gene ex pression in vascular endothelium. Biochem. Biophys. Res. Commun. 281: 720-725
229. Watanabe T., Pakala R., Katagiri T. and Benedict C. R. (2001) Mildly oxidized low-density lipoprotein acts synergistically with angiotensin II in inducing vascular smooth muscle cell proliferation. J. Hypertens. 19: 1065-1073
230. Lacy F., Kailasam M. T., O'Connor D. T., Schmid-Schonbein G. W. and Parmer R. J. (2000) Plasma hydrogen peroxide production in human essential hypertension: Role of heredity, gender, and ethnicity. Hypertension 36: 878-884
231. McNaught K. S. and Jenner P. (2000) Extracellular accumulation of nitric oxide, hydrogen peroxide, and glutamate in astrocytic cultures following glutathione depletion, complex I inhibition, and/or lipopolysaccharide-induced activation. Biochem. Pharmacol. 60: 979-988
232. Sherer T. B., Betarbet R. and Greenamyre J. T. (2001) Pathogenesis of Parkinson's disease. Curr. Opin. Invest. Drugs 2: 657-662
233. Schapira A. H. (2001) Causes of neuronal death in Parkinson's disease. Adv. Neurol. 86: 155-162
234. Friedman A. and Galazka-Friedman J. (2001) The current state of free radicals in Parkinson's disease: Nigral iron as a trigger of oxidative stress. Adv. Neurol. 86: 137-142
235. Sangerman J., Kakhniashvili D., Brown A., Shartava A. and Goodman S. R. (2001) Spectrin ubiquitination and oxidative stress: Potential roles in blood and neurological disorders. Cell. Mol. Biol. Lett. 6: 607-636
236. Mizuno Y., Hattori N., Mori H., Suzuki T. and Tanaka K. (2001) Parkin and Parkinson's disease. Curr. Opin. Neurol. 14: 477-482
237. Jobsis Q., Raatgeep H. C., Schellekens S. L., Kroesbergen A., Hop W. C. and Jongste J. C. de (2000) Hydrogen peroxide and nitric oxide in exhaled air of children with cystic fibrosis during antibiotic treatment. Eur. Respir. J. 16: 95-100
238. Tamiya S., Wormstone I. M., Marcantonio J. M., Gavrilovic J. and Duncan G. (2000) Induction of matrix metalloproteinases 2 and 9 following stress to the lens. Exp. Eye Res. 71: 591-597
239. Tsai K. J., Hung I. J., Chow C. K., Stern A., Chao S. S. and Chiu D. T. (1998) Impaired production of nitric oxide, superoxide, and hydrogen peroxide in glucose 6-phosphatedehydrogenase-deficient granulocytes. FEBS Lett. 436: 411-414
240. Houglum K., Venkataramani A., Lyche K. and Chojkier M. (1997) A pilot study of the effects of d-alpha-tocopherol on hepatic stellate cell activation in chronic hepatitis C. Gastroenterology 113: 1069-1073
241. Prasad K. N., Cole W. C., Hovland A. R., Prasad K. C., Nahreini P., Kumar B. et al. (1999) Multiple antioxidants in the prevention and treatment of neurodegenerative disease: Analysis of biologic rationale. Curr. Opin. Neurol. 12: 761-770
242. Catapano A. L. and Tragni E. (1999) Antioxidants and coronary artery disease. Curr. Atheroscler. Rep. 1: 221-229
243. Parthasarathy S., Santanam N., Ramachandran S. and Meilhac O. (1999) Oxidants and antioxidants in atherogenesis: An appraisal. J. Lipid. Res. 40: 2143-2157
244. Lamson D. W. and Brignall M. S. (1999) Antioxidants in cancer therapy; their actions and interactions with oncologic therapies. Altern. Med. Rev. 4: 304-329
245. Laight D. W., Carrier M. J. and Anggard E. E. (2000) Antioxidants, diabetes and endothelial dysfunction. Cardiovasc. Res. 47: 457-464
246. Simonini G., Pignone A., Generini S., Falcini F., Cerinic M. M., Gabriele S. et al. (2000) Emerging potentials for an antioxidant therapy as a new approach to the treatment of systemic sclerosis. Toxicology 155: 1-15
247. Lieber C. S. (2000) Alcoholic liver disease: New insights in pathogenesis lead to new treatments. J. Hepatol. 32 (suppl 1): 113-128
248. Wu J. and Zern M. A. (2000) Hepatic stellate cells: A target for the treatment of liver fibrosis. J. Gastroenterol. 35: 665-672
249. Bulger E. M. and Maier R. V. (2001) Antioxidants in critical illness. Arch. Surg. 136: 1201-1207
250. Kelso G. F., Porteous C. M., Coulter C. V., Hughes G., Porteous W. K., Ledgerwood E. C. et al. (2001) Selective targeting of a redox-active ubiquinone to mitochondria within cells: Antioxidant and antiapoptotic properties. J. Biol. Chem. 276: 4588-4596
251. Murphy M. P. (2001) Development of lipophilic cations as therapies for disorders due to mitochondrial dysfunction. Expert. Opin. Biol. Ther. 1: 753-764