Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-β-dependent hepatic stellate cell activation

Biochemical and Biophysical Research Communications

Volumn 353, Issue 4, 2007, Pages 1091-1096

  Myung, Sun Jung ^a   Yoon, Jung Hwan ^a   Gwak, Geum Youn ^a   Kim, Won ^a   Yang, Jong In ^a   Lee, Sung Hee ^a   Jang, Ja June ^a   Lee, Hyo Suk ^a  

^a Seoul National University College of Medicine   (South Korea)

Author keywords

Bile acid; Cholestasis; Hepatic stellate cell; Thrombospondin 1; Transforming growth factor

Indexed keywords

3 (PYRIDIN 2 YL) 4 (4 QUINONYL) 1H PYRAZOLE; BILE ACID; CHENODEOXYCHOLIC ACID; COLLAGEN TYPE 1; PROTEIN INHIBITOR; PYRAZOLE DERIVATIVE; SMAD2 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL ACTIVATION; CHOLESTASIS; COCULTURE; COLLAGEN SYNTHESIS; CONTROLLED STUDY; CULTURE MEDIUM; HUMAN; HUMAN CELL; LIVER CELL CULTURE; LIVER FIBROSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PHOSPHORYLATION; REGULATORY MECHANISM; STELLATE CELL; TRANSCRIPTION REGULATION;

BILE ACIDS AND SALTS; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CHENODEOXYCHOLIC ACID; COCULTURE TECHNIQUES; COLLAGEN TYPE I; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME-LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HEPATOCYTES; HUMANS; IMMUNOBLOTTING; LIVER; PHOSPHORYLATION; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; SMAD2 PROTEIN; THROMBOSPONDIN 1; TRANSFORMING GROWTH FACTOR BETA;

EID: 33846146019     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.12.157     Document Type: Article

References (27)

1. Faubion W.A., Guicciardi M.E., Miyoshi H., Bronk S.F., Roberts P.J., Svingen P.A., Kaufmann S.H., and Gores G.J. Toxic bile salts induce rodent hepatocyte apoptosis via direct activation of Fas. J. Clin. Invest. 103 (1999) 137-145
2. Higuchi H., Yoon J.H., Grambihler A., Werneburg N., Bronk S.F., and Gores G.J. Bile acids stimulate cFLIP phosphorylation enhancing TRAIL-mediated apoptosis. J. Biol. Chem. 278 (2003) 454-461
3. Friedman S.L. Seminars in medicine of the Beth Israel Hospital, Boston. The cellular basis of hepatic fibrosis. Mechanisms and treatment strategies. N. Engl. J. Med. 328 (1993) 1828-1835
4. Bataller R., and Brenner D.A. Hepatic stellate cells as a target for the treatment of liver fibrosis. Semin. Liver Dis. 21 (2001) 437-451
5. Wu J., and Zern M.A. Hepatic stellate cells: a target for the treatment of liver fibrosis. J. Gastroenterol. 35 (2000) 665-672
6. Taimr P., Higuchi H., Kocova E., Rippe R.A., Friedman S., and Gores G.J. Activated stellate cells express the TRAIL receptor-2/death receptor-5 and undergo TRAIL-mediated apoptosis. Hepatology 37 (2003) 87-95
7. Makishima M., Okamoto A.Y., Repa J.J., Tu H., Learned R.M., Luk A., Hull M.V., Lustig K.D., Mangelsdorf D.J., and Shan B. Identification of a nuclear receptor for bile acids. Science 284 (1999) 1362-1365
8. Fiorucci S., Antonelli E., Rizzo G., Renga B., Mencarelli A., Riccardi L., Orlandi S., Pellicciari R., and Morelli A. The nuclear receptor SHP mediates inhibition of hepatic stellate cells by FXR and protects against liver fibrosis. Gastroenterology 127 (2004) 1497-1512
9. Jones B.A., Rao Y.P., Stravitz R.T., and Gores G.J. Bile salt-induced apoptosis of hepatocytes involves activation of protein kinase C. Am. J. Physiol. 272 (1997) G1109-G1115
10. Kim K.M., Yoon J.H., Gwak G.Y., Kim W., Lee S.H., Jang J.J., and Lee H.S. Bile acid-mediated induction of cyclooxygenase-2 and Mcl-1 in hepatic stellate cells. Biochem. Biophys. Res. Commun. 342 (2006) 1108-1113
11. Svegliati-Baroni G., Ridolfi F., Hannivoort R., Saccomanno S., Homan M., De Minicis S., Jansen P.L., Candelaresi C., Benedetti A., and Moshage H. Bile acids induce hepatic stellate cell proliferation via activation of the epidermal growth factor receptor. Gastroenterology 128 (2005) 1042-1055
12. Gressner A.M., Weiskirchen R., Breitkopf K., and Dooley S. Roles of TGF-beta in hepatic fibrosis. Front. Biosci. 7 (2002) d793-d807
13. Annes J.P., Munger J.S., and Rifkin D.B. Making sense of latent TGFbeta activation. J. Cell Sci. 116 (2003) 217-224
14. Crawford S.E., Stellmach V., Murphy-Ullrich J.E., Ribeiro S.M., Lawler J., Hynes R.O., Boivin G.P., and Bouck N. Thrombospondin-1 is a major activator of TGF-beta1 in vivo. Cell 93 (1998) 1159-1170
15. Bornstein P. Thrombospondins as matricellular modulators of cell function. J. Clin. Invest. 107 (2001) 929-934
16. El-Youssef M., Mu Y., Huang L., Stellmach V., and Crawford S.E. Increased expression of transforming growth factor-beta1 and thrombospondin-1 in congenital hepatic fibrosis: possible role of the hepatic stellate cell. J. Pediatr. Gastroenterol. Nutr. 28 (1999) 386-392
17. Hayashi K., Kurohiji T., and Shirouzu K. Localization of thrombospondin in hepatocellular carcinoma. Hepatology 25 (1997) 569-574
18. Kondou H., Mushiake S., Etani Y., Miyoshi Y., Michigami T., and Ozono K. A blocking peptide for transforming growth factor-beta1 activation prevents hepatic fibrosis in vivo. J. Hepatol. 39 (2003) 742-748
19. Breitkopf K., Sawitza I., and Gressner A.M. Characterization of intracellular pathways leading to coinduction of thrombospondin-1 and TGF-beta1 expression in rat hepatic stellate cells. Growth Factors 23 (2005) 77-85
20. Breitkopf K., Sawitza I., Westhoff J.H., Wickert L., Dooley S., and Gressner A.M. Thrombospondin 1 acts as a strong promoter of transforming growth factor beta effects via two distinct mechanisms in hepatic stellate cells. Gut 54 (2005) 673-681
21. Higuchi H., Bronk S.F., Takikawa Y., Werneburg N., Takimoto R., El-Deiry W., and Gores G.J. The bile acid glycochenodeoxycholate induces trail-receptor 2/DR5 expression and apoptosis. J. Biol. Chem. 276 (2001) 38610-38618
22. Li M.K., and Crawford J.M. The pathology of cholestasis. Semin. Liver Dis. 24 (2004) 21-42
23. Kim S.A., Um S.J., Kang J.H., and Hong K.J. Expression of thrombospondin-1 in human hepatocarcinoma cell lines and its regulation by transcription factor Jun/AP-1. Mol. Cell Biochem. 216 (2001) 21-29
24. Kang J.H., Kim S.A., and Hong K.J. Induction of TSP1 gene expression by heat shock is mediated via an increase in mRNA stability. FEBS Lett. 580 (2006) 510-516
25. Okamoto M., Ono M., Uchiumi T., Ueno H., Kohno K., Sugimachi K., and Kuwano M. Up-regulation of thrombospondin-1 gene by epidermal growth factor and transforming growth factor beta in human cancer cells-transcriptional activation and messenger RNA stabilization. Biochim. Biophys. Acta 1574 (2002) 24-34
26. Werneburg N.W., Yoon J.H., Higuchi H., and Gores G.J. Bile acids activate EGF receptor via a TGF-alpha-dependent mechanism in human cholangiocyte cell lines. Am. J. Physiol. Gastrointest. Liver Physiol. 285 (2003) G31-G36
27. Nakao A., Imamura T., Souchelnytskyi S., Kawabata M., Ishisaki A., Oeda E., Tamaki K., Hanai J., Heldin C.H., Miyazono K., and ten Dijke P. TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4. EMBO J. 16 (1997) 5353-5362