Connective tissue growth factor induces c-fos gene activation and cell proliferation through p44/42 MAP kinase in primary rat hepatic stellate cells

Journal of Hepatology

Volumn 40, Issue 3, 2004, Pages 431-438

  Gao, Runping ^a,b   Ball, DeAnna K ^a,b   Perbal, Bernard ^c   Brigstock, David R ^a,b  

^a THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

^b OHIO STATE UNIVERSITY   (United States)

^c UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

c fos; CCN2; Cell proliferation; Connective tissue growth factor; Extracellular signal regulated kinase; Hepatic stellate cell

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CONNECTIVE TISSUE GROWTH FACTOR; FOCAL ADHESION KINASE; HEPARIN; LUCIFERASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN P44; SMAD7 PROTEIN; THYMIDINE DERIVATIVE; TRANSCRIPTION FACTOR ELK 1; TRANSFORMING GROWTH FACTOR BETA; TRITIUM;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL ACTIVATION; CELL ADHESION; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DNA TRANSCRIPTION; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENE ACTIVATION; GENE EXPRESSION REGULATION; LIVER PERFUSION; MALE; NONHUMAN; NORTHERN BLOTTING; ONCOGENE C FOS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL PROCESSING; SIGNAL TRANSDUCTION; STELLATE CELL; WESTERN BLOTTING;

EID: 1242292348     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2003.11.012     Document Type: Article

References (59)

1. Gressner A.M., Bachem M.G. Cellular communications and cell-matrix interactions in the pathogenesis of fibroproliferative diseases: liver fibrosis as a paradigm. Ann Biol Clin (Paris). 52:1994;205-226.
2. Pinzani M. Novel insights into the biology and physiology of the Ito cell. Pharmacol Ther. 66:1995;387-412.
3. Eng F.J., Friedman S.L., Fibrogenesis I. New insights into hepatic stellate cell activation: the simple becomes complex. Am J Physiol Gastrointest Liver Physiol. 279:2000;G7-G11.
4. Friedman S.L. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem. 275:2000;2247-2250.
5. Gaca M.D., Zhou X., Benyon R.C. Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol. 36:2002;362-369.
6. Pinzani M., Gesualdo L., Sabbah G.M., Abboud H.E. Effects of platelet-derived growth factor and other polypeptide mitogens on DNA synthesis and growth of cultured rat liver fat-storing cells. J Clin Invest. 84:1989;1786-1793.
7. Friedman S.L. Cytokines and fibrogenesis. Semin Liver Dis. 19:1999;129-140.
8. Brigstock D.R. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family. Endocr Rev. 20:1999;189-206.
9. Igarashi A., Nashiro K., Kikuchi K., Sato S., Ihn H., Fujimoto M., et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin disorders. J Invest Dermatol. 106:1996;729-733.
10. Lasky J.A., Ortiz L.A., Tonthat B., Hoyle G.W., Corti M., Athas G., et al. Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol. 275:1998;L365-L371.
11. Abou-Shady M., Friess H., Zimmermann A., di Mola F.F., Guo X.Z., Baer H.U., Buchler M.W. Connective tissue growth factor in human liver cirrhosis. Liver. 20:2000;296-304.
12. Williams E.J., Gaca M.D., Brigstock D.R., Arthur M.J., Benyon R.C. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol. 32:2000;754-761.
13. Paradis V., Dargere D., Vidaud M., De Gouville A.C., Huet S., Martinez V., et al. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology. 30:1999;968-976.
14. Paradis V., Dargere D., Bonvoust F., Vidaud M., Segarini P., Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest. 82:2002;767-774.
15. Ball D.K., Wilson A.W., Kemper S.A., Brigstock D.R. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol. 176:2003;R1-R7.
16. Rachfal A.W., Brigstock D.R. Connective tissue growth factor (CTGF/CCN2) in hepatic fibrosis. Hepatol Res. 26:2003;1-9.
17. Gao R., Brigstock D. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated stellate cells. Hepatol Res. 27:2003;214-220.
18. Sheng M., Greenberg M.E. The regulation and function of c-fos and other immediate early genes in the nervous system. Neuron. 4:1990;477-485.
19. Herschman H.R. Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem. 60:1991;281-319.
20. Pinzani M., Milani S., De Franco R., Grappone C., Caligiuri A., Gentilini A., et al. Endothelin 1 is overexpressed in human cirrhotic liver and exerts multiple effects on activated hepatic stellate cells. Gastroenterology. 110:1996;534-548.
21. Yang S.H., Yates P.R., Mo Y., Sharrocks A.D. The ETS-domain transcription factors: lessons from the TCF subfamily. Gen Ther Mol Biol. 3:1999;355-371.
22. Mo Y., Ho W., Johnston K., Marmorstein R. Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex. J Mol Biol. 314:2001;495-506.
23. Marshall C.J. MAP kinase kinase kinase, MAP kinase kinase and MAP kinase. Curr Opin Genet Dev. 4:1994;82-89.
24. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell. 80:1995;179-185.
25. Whitmarsh A.J., Davis R.J. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med. 74:1996;589-607.
26. Oldenhof A.D., Shynlova O.P., Liu M., Langille B.L., Lye S.J. Mitogen-activated protein kinases mediate stretch-induced c-fos mRNA expression in myometrial smooth muscle cells. Am J Physiol Cell Physiol. 283:2002;C1530-C1539.
27. Pages G., Lenormand P., L'Allemain G., Chambard J.C., Meloche S., Pouyssegur J. Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. Proc Natl Acad Sci USA. 90:1993;8319-8323.
28. Marra F., Pinzani M., DeFranco R., Laffi G., Gentilini P. Involvement of phosphatidylinositol 3-kinase in the activation of extracellular signal-regulated kinase by PDGF in hepatic stellate cells. Fed Eur Biochem Soc Lett. 376:1995;141-145.
29. Iredale J.P., Murphy G., Hembry R.M., Friedman S.L., Arthur M.J. Human hepatic lipocytes synthesize tissue inhibitor of metalloproteinases-1. Implications for regulation of matrix degradation in liver. J Clin Invest. 90:1992;282-287.
30. Dignam J.D., Lebovitz R.M., Roeder R.G. Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11:1983;1475-1489.
31. Li W.X., Martinerie C., Zumkeller W., Westphal M., Perbal B. Differential expression of novH and CTGF in human glioma cell lines. Mol Pathol. 49:1996;M91-M97.
32. Ball D.K., Moussad E.E., Rageh M.A., Kemper S.A., Brigstock D.R. Establishment of a recombinant expression system for connective tissue growth factor (CTGF) that models CTGF processing in utero. Reproduction. 125:2003;271-284.
33. Benyon R.C., Hovell C.J., Da Gaca M., Jones E.H., Iredale J.P., Arthur M.J. Progelatinase A is produced and activated by rat hepatic stellate cells and promotes their proliferation. Hepatology. 30:1999;977-986.
34. Treisman R. Identification and purification of a polypeptide that binds to the c-fos serum response element. Eur Mol Biol Org J. 6:1987;2711-2717.
35. Marais R., Wynne J., Treisman R. The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain. Cell. 73:1993;381-393.
36. Rivera V.M., Miranti C.K., Misra R.P., Ginty D.D., Chen R.H., Blenis J., Greenberg M.E. A growth factor-induced kinase phosphorylates the serum response factor at a site that regulates its DNA-binding activity. Mol Cell Biol. 13:1993;6260-6273.
37. Leask A., Holmes A., Black C.M., Abraham D.J. Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-β2 in fibroblasts. J Biol Chem. 278:2003;13008-13015.
38. Holmes A., Abraham D.J., Sa S., Shiwen X., Black C.M., Leask A. CTGF and SMADs, maintenance of scleroderma phenotype is independent of SMAD signaling. J Biol Chem. 276:2001;10594-10601.
39. Grotendorst G.R., Okochi H., Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ. 7:1996;469-480.
40. Hayashi N., Kakimuma T., Soma Y., Grotendorst G.R., Tamaki K., Harada M., Igarashi A. Connective tissue growth factor is directly related to liver fibrosis. Hepatogastroenterology. 49:2002;133-135.
41. Mann D.A., Smart D.E. Transcriptional regulation of hepatic stellate cell activation. Gut. 50:2002;891-896.
42. Shaulian E., Karin M. AP-1 in cell proliferation and survival. Oncogene. 20:2001;2390-2400.
43. Kovary K., Bravo R. Existence of different Fos/Jun complexes during the G0-to-G1 transition and during exponential growth in mouse fibroblasts: differential role of Fos proteins. Mol Cell Biol. 12:1992;5015-5023.
44. Acquaviva C., Brockly F., Ferrara P., Bossis G., Salvat C., Jariel-Encontre I., Piechaczyk M. Identification of a C-terminal tripeptide motif involved in the control of rapid proteasomal degradation of c-Fos proto-oncoprotein during the G(0)-to-S phase transition. Oncogene. 20:2001;7563-7572.
45. Bahr M.J., Vincent K.J., Arthur M.J., Fowler A.V., Smart D.E., Wright M.C., et al. Control of the tissue inhibitor of metalloproteinases-1 promoter in culture-activated rat hepatic stellate cells: regulation by activator protein-1 DNA binding proteins. Hepatology. 29:1999;839-848.
46. Yosimichi G., Nakanishi T., Nishida T., Hattori T., Takano-Yamamoto T., Takigawa M. CTGF/Hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38 MAPK), and proliferation through a p44/42 MAPK/extracellular-signal regulated kinase (ERK). Eur J Biochem. 268:2001;6058-6065.
47. Friedman S.L. Liver fibrosis - from bench to bedside. J Hepatol. 38:2003;S38-S53.
48. Pinzani M., Marra F. Cytokine receptors and signaling in hepatic stellate cells. Semin Liver Dis. 21:2001;397-416.
49. Crean J.K., Finlay D., Murphy M., Moss C., Godson C., Martin F., Brady H.R. The role of p42/44 MAPK and protein kinase B in connective tissue growth factor induced extracellular matrix protein production, cell migration, and actin cytoskeletal rearrangement in human mesangial cells. J Biol Chem. 277:2002;44187-44194.
50. Chen C.C., Chen N., Lau L.F. The angiogenic factors Cyr61 and connective tissue growth factor induce adhesive signaling in primary human skin fibroblasts. J Biol Chem. 276:2001;10443-10452.
51. Nishida T., Kubota S., Fukunaga T., Kondo S., Yosimichi G., Nakanishi T., et al. CTGF/Hcs24, hypertrophic chondrocyte-specific gene product, interacts with perlecan in regulating the proliferation and differentiation of chondrocytes. J Cell Physiol. 196:2003;265-275.
52. Lau L.F., Lam S.C. The CCN family of angiogenic regulators: the integrin connection. Exp Cell Res. 248:1999;44-57.
53. Iwamoto H., Sakai H., Nawata H. Inhibition of integrin signaling with Arg-Gly-Asp motifs in rat hepatic stellate cells. J Hepatol. 29:1998;752-759.
54. Levine D., Rockey D.C., Milner T.A., Breuss J.M., Fallon J.T., Schnapp L.M. Expression of the integrin alpha8beta1 during pulmonary and hepatic fibrosis. Am J Pathol. 156:2000;1927-1935.
55. Shore P., Bisset L. Characterization of the Elk-1 ETS DNA-binding domain. J Biol Chem. 270:1995;5805-5811.
56. Shore P. Determinants of DNA-binding specificity of ETS-domain transcription factors. Mol Cell Biol. 16:1996;3338-3349.
57. Ling Y., Lakey J.H. Molecular characterization of the B-box protein-protein interaction motif of the ETS domain transcription factor ELK-1. Eur Mol Biol Org J. 16:1997;2431-2440.
58. Cahill M.A., Janknecht R., Nordheim A. Signaling pathways: Jack of all cascades. Curr Biol. 6:1996;16-19.
59. Reeves H.L., Dack C.L., Peak M., Burt A.D., Day C.P. Stress-activated protein kinases in the activation of rat hepatic stellate cells in culture. J Hepatol. 32:2000;465-472.