Alternative Wnt signaling is initiated by distinct receptors

Science Signaling

Volumn 1, Issue 35, 2008, Pages

  Van Amerongen, Renée ^a   Mikels, Amanda ^a   Nusse, Roel ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA CATENIN; FRIZZLED PROTEIN; PROTEIN TYROSINE KINASE; WNT PROTEIN;

ANIMAL; CELL MEMBRANE; HUMAN; METABOLISM; PHYSIOLOGY; PROTEIN BINDING; REVIEW; SIGNAL TRANSDUCTION;

ANIMALS; BETA CATENIN; CELL MEMBRANE; FRIZZLED RECEPTORS; HUMANS; PROTEIN BINDING; RECEPTOR PROTEIN-TYROSINE KINASES; SIGNAL TRANSDUCTION; WNT PROTEINS;

EID: 55749102279     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.135re9     Document Type: Review

References (69)

1. C. Y. Logan, R. Nusse, The Wnt signaling pathway in development and disease. Annu. Rev. Cell Dev. Biol. 20, 781-810 (2004).
2. C. J. Neumann, S. M. Cohen, Long-range action of Wingless organizes the dorsal-ventral axis of the Drosophila wing. Development 124, 871-880 (1997).
3. T. Reya, H. Clevers, Wnt signalling in stem cells and cancer. Nature 434, 843-850 (2005).
4. M. Zecca, K. Basler, G. Struhl, Direct and longrange action of a wingless morphogen gradient. Cell 87, 833-844 (1996).
5. M. Hendrickx, L. Leyns, Non-conventional Frizzled ligands and Wnt receptors. Dev. Growth Differ. 50, 229-243 (2008).
6. B. T. Macdonald, M. V. Semenov, X. He, Snap-Shot: Wnt/beta-catenin signaling. Cell 131, 1204.e1-1204.e2 (2007).
7. M. V. Semenov, R. Habas, B. T. Macdonald, X. He, SnapShot: Noncanonical Wnt signaling pathways. Cell 131, 1378.e1-1378.e2 (2007).
8. M. T. Veeman, J. D. Axelrod, R. T. Moon, A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Dev. Cell 5, 367-377 (2003).
9. S. J. Du, S. M. Purcell, J. L. Christian, L. L. Mc-Grew, R. T. Moon, Identification of distinct classes and functional domains of Wnts through expression of wild-type and chimeric proteins in Xenopus embryos. Mol. Cell. Biol. 15, 2625-2634 (1995).
10. D. J. Olson, J. Papkoff, Regulated expression of Wnt family members during proliferation of C57mg mammary cells. Cell Growth Differ. 5, 197-206 (1994).
11. H. Shimizu, M. A. Julius, M. Giarre, Z. Zheng, A. M. Brown, J. Kitajewski, Transformation by Wnt family proteins correlates with regulation of betacatenin. Cell Growth Differ. 8, 1349-1358 (1997).
12. D. C. Slusarski, V. G. Corces, R. T. Moon, Interaction of Wnt and a Frizzled homologue triggers G-protein-linked phosphatidylinositol signalling. Nature 390, 410-413 (1997).
13. G. T. Wong, B. J. Gavin, A. P. McMahon, Differential transformation of mammary epithelial cells by Wnt genes. Mol. Cell. Biol. 14, 6278-6286 (1994).
14. C. P. Heisenberg, M. Tada, G. J. Rauch, L. Saude, M. L. Concha, R. Geisler, D. L. Stemple, J. C. Smith, S. W. Wilson, Silberblick/Wnt11 mediates convergent extension movements during zebrafish gastrulation. Nature 405, 76-81 (2000).
15. B. Kilian, H. Mansukoski, F. C. Barbosa, F. Ulrich, M. Tada, C. P. Heisenberg, The role of Ppt/Wnt5 in regulating cell shape and movement during zebrafish gastrulation. Mech. Dev. 120, 467-476 (2003).
16. J. B. Wallingford, K. M. Vogeli, R. M. Harland, Regulation of convergent extension in Xenopus by Wnt5a and Frizzled-8 is independent of the canonical Wnt pathway. Int. J. Dev. Biol. 45, 225-227 (2001).
17. X. He, J. P. Saint-Jeannet, Y. Wang, J. Nathans, I. Dawid, H. Varmus, A member of the Frizzled protein family mediating axis induction by Wnt-5A. Science 275, 1652-1654 (1997).
18. G. Liu, A. Bafico, V. K. Harris, S. A. Aaronson, A novel mechanism for Wnt activation of canonical signaling through the LRP6 receptor. Mol. Cell. Biol. 23, 5825-5835 (2003).
19. A. J. Mikels, R. Nusse, Purified Wnt5a protein activates or inhibits beta-catenin-TCF signaling depending on receptor context. PLoS Biol. 4, e115 (2006).
20. K. Tamai, X. Zeng, C. Liu, X. Zhang, Y. Harada, Z. Chang, X. He, A mechanism for Wnt coreceptor activation. Mol. Cell 13, 149-156 (2004).
21. G. Liu, A. Bafico, S. A. Aaronson, The mechanism of endogenous receptor activation functionally distinguishes prototype canonical and noncanonical wnts. Mol. Cell. Biol. 25, 3475-3482 (2005).
22. S. L. Holmen, A. Salic, C. R. Zylstra, M. W. Kirschner, B. O. Williams, A novel set of Wnt-Frizzled fusion proteins identifies receptor components that activate beta-catenin-dependent signaling. J. Biol. Chem. 277, 34727-34735 (2002).
23. R. Nusse, A. van Ooyen, D. Cox, Y. K. Fung, H. Varmus, Mode of proviral activation of a putative mammary oncogene (int-1) on mouse chromosome 15. Nature 307, 131-136 (1984).
24. F. Marlow, J. Topczewski, D. Sepich, L. Solnica-Krezel, Zebrafish Rho kinase 2 acts downstream of Wnt11 to mediate cell polarity and effective convergence and extension movements. Curr. Biol. 12, 876-884 (2002).
25. L. Smit, A. Baas, J. Kuipers, H. Korswagen, M. van de Wetering, H. Clevers, Wnt activates the Tak1/Nemo-like kinase pathway. J. Biol. Chem. 279, 17232-17240 (2004).
26. Q. Tao, C. Yokota, H. Puck, M. Kofron, B. Birsoy, D. Yan, M. Asashima, C. C. Wylie, X. Lin, J. Heasman, Maternal wnt11 activates the canonical wnt signaling pathway required for axis formation in Xenopus embryos. Cell 120, 857-871 (2005).
27. P. Bhanot, M. Brink, C. H. Samos, J. C. Hsieh, Y. Wang, J. P. Macke, D. Andrew, J. Nathans, R. Nusse, A new member of the frizzled family from Drosophila functions as a Wingless receptor. Nature 382, 225-230 (1996).
28. M. Wehrli, S. T. Dougan, K. Caldwell, L. O'Keefe, S. Schwartz, D. Vaizel-Ohayon, E. Schejter, A. Tomlinson, S. DiNardo, arrow encodes an LDL-receptor-related protein essential for Wingless signalling. Nature 407, 527-530 (2000).
29. J. Yang-Snyder, J. R. Miller, J. D. Brown, C. J. Lai, R. T. Moon, A frizzled homolog functions in a vertebrate Wnt signaling pathway. Curr. Biol. 6, 1302-1306 (1996).
30. M. D. Gordon, R. Nusse, Wnt signaling: Multiple pathways, multiple receptors, and multiple transcription factors. J. Biol. Chem. 281, 22429-22433 (2006).
31. H. Clevers, Wnt/beta-catenin signaling in development and disease. Cell 127, 469-480 (2006).
32. R. U. de Iongh, H. E. Abud, G. R. Hime, WNT/Frizzled signaling in eye development and disease. Front. Biosci. 11, 2442-2464 (2006).
33. S. Fox, A. Dharmarajan, WNT signaling in malignant mesothelioma. Front. Biosci. 11, 2106-2112 (2006).
34. V. Krishnan, H. U. Bryant, O. A. Macdougald, Regulation of bone mass by Wnt signaling. J. Clin. Invest. 116, 1202-1209 (2006).
35. P. Polakis, Wnt signaling and cancer. Genes Dev. 14, 1837-1851 (2000).
36. W. S. Chen, D. Antic, M. Matis, C. Y. Logan, M. Povelones, G. A. Anderson, R. Nusse, J. D. Axelrod, Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Cell 133, 1093-1105 (2008).
37. P. A. Lawrence, J. Casal, G. Struhl, Towards a model of the organisation of planar polarity and pattern in the Drosophila abdomen. Development 129, 2749-2760 (2002).
38. J. A. Zallen, Planar polarity and tissue morphogenesis. Cell 129, 1051-1063 (2007).
39. J. R. Seifert, M. Mlodzik, Frizzled/PCP signalling: A conserved mechanism regulating cell polarity and directed motility. Nat. Rev. Genet. 8, 126-138 (2007).
40. Y. Wang, J. Nathans, Tissue/planar cell polarity in vertebrates: New insights and new questions. Development 134, 647-658 (2007).
41. D. Qian, C. Jones, A. Rzadzinska, S. Mark, X. Zhang, K. P. Steel, X. Dai, P. Chen, Wnt5a functions in planar cell polarity regulation in mice. Dev. Biol. (2007).
42. A. Dabdoub, M. J. Donohue, A. Brennan, V. Wolf, M. Montcouquiol, D. A. Sassoon, J. C. Hseih, J. S. Rubin, P. C. Salinas, M. W. Kelley, Wnt signaling mediates reorientation of outer hair cell stereociliary bundles in the mammalian cochlea. Development 130, 2375-2384 (2003).
43. A. Dabdoub, M. W. Kelley, Planar cell polarity and a potential role for a Wnt morphogen gradient in stereociliary bundle orientation in the mammalian inner ear. J. Neurobiol. 64, 446-457 (2005).
44. A. D. Kohn, R. T. Moon, Wnt and calcium signaling: Beta-catenin- independent pathways. Cell Calcium 38, 439-446 (2005).
45. M. Kuhl, L. C. Sheldahl, C. C. Malbon, R. T. Moon, Ca(2+)/calmodulin- dependent protein kinase II is stimulated by Wnt and Frizzled homologs and promotes ventral cell fates in Xenopus. J. Biol. Chem. 275, 12701-12711 (2000).
46. P. Pandur, D. Maurus, M. Kuhl, Increasingly complex: New players enter the Wnt signaling network. Bioessays 24, 881-884 (2002).
47. L. C. Sheldahl, M. Park, C. C. Malbon, R. T. Moon, Protein kinase C is differentially stimulated by Wnt and Frizzled homologs in a G-protein-dependent manner. Curr. Biol. 9, 695-698 (1999).
48. D. C. Slusarski, J. Yang-Snyder, W. B. Busa, R. T. Moon, Modulation of embryonic intracellular Ca2+ signaling by Wnt-5A. Dev. Biol. 182, 114-120 (1997).
49. H. Clevers, Wnt signaling: Ig-norrin the dogma. Curr. Biol. 14, R436-R437 (2004).
50. Q. Xu, Y. Wang, A. Dabdoub, P. M. Smallwood, J. Williams, C. Woods, M. W. Kelley, L. Jiang, W. Tasman, K. Zhang, J. Nathans, Vascular development in the retina and inner ear: Control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair. Cell 116, 883-895 (2004).
51. M. Kroiher, M. A. Miller, R. E. Steele, Deceiving appearances: Signaling by "dead" and "fractured" receptor protein-tyrosine kinases. Bioessays 23, 69-76 (2001).
52. J. C. Hsieh, L. Kodjabachian, M. L. Rebbert, A. Rattner, P. M. Smallwood, C. H. Samos, R. Nusse, I. B. Dawid, J. Nathans, A new secreted protein that binds to Wnt proteins and inhibits their activities. Nature 398, 431-436 (1999).
53. K. E. Harris, S. K. Beckendorf, Different Wnt signals act through the Frizzled and RYK receptors during Drosophila salivary gland migration. Development 134, 2017-2025 (2007).
54. S. Yoshikawa, R. D. McKinnon, M. Kokel, J. B. Thomas, Wnt-mediated axon guidance via the Drosophila Derailed receptor. Nature 422, 583-588 (2003).
55. R. R. Wouda, M. R. Bansraj, A. W. de Jong, J. N. Noordermeer, L. G. Fradkin, Src family kinases are required for WNT5 signaling through the Derailed/RYK receptor in the Drosophila embryonic central nervous system. Development 135, 2277-2287 (2008).
56. W. C. Forrester, The Ror receptor tyrosine kinase family. Cell. Mol. Life Sci. 59, 83-96 (2002).
57. I. Oishi, H. Suzuki, N. Onishi, R. Takada, S. Kani, B. Ohkawara, I. Koshida, K. Suzuki, G. Yamada, G. C. Schwabe, S. Mundlos, H. Shibuya, S. Takada, Y. Minami, The receptor tyrosine kinase Ror2 is involved in non-canonical Wnt5a/JNK signalling pathway. Genes Cells 8, 645-654 (2003).
58. A. Schambony, D. Wedlich, Wnt-5A/Ror2 regulate expression of XPAPC through an alternative noncanonical signaling pathway. Dev. Cell 12, 779-792 (2007).
59. Y. K. Xu, R. Nusse, The Frizzled CRD domain is conserved in diverse proteins including several receptor tyrosine kinases. Curr. Biol. 8, R405-R406 (1998).
60. S. Yamamoto, O. Nishimura, K. Misaki, M. Nishita, Y. Minami, S. Yonemura, H. Tarui, H. Sasaki, Cthrc1 selectively activates the planar cell polarity pathway of Wnt signaling by stabilizing the Wnt-receptor complex. Dev. Cell 15, 23-36 (2008).
61. A. M. Wolf, A. I. Lyuksyutova, A. G. Fenstermaker, B. Shafer, C. G. Lo, Y. Zou, Phosphatidylinositol-3-kinase-atypical protein kinase C signaling is required for Wnt attraction and anterior-posterior axon guidance. J. Neurosci. 28, 3456-3467 (2008).
62. E. S. Witze, E. S. Litman, G. M. Argast, R. T. Moon, N. G. Ahn, Wnt5a control of cell polarity and directional movement by polarized redistribution of adhesion receptors. Science 320, 365-369 (2008).
63. M. D. Castellone, H. Teramoto, B. O. Williams, K. M. Druey, J. S. Gutkind, Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-beta-catenin signaling axis. Science 310, 1504-1510 (2005).
64. A. E. Chen, D. D. Ginty, C. M. Fan, Protein kinase A signalling via CREB controls myogenesis induced by Wnt proteins. Nature 433, 317-322 (2005).
65. O. Pourquie, Signal transduction: A new canon. Nature 433, 208-209 (2005).
66. S. L. LaPorte, Z. S. Juo, J. Vaclavikova, L. A. Colf, X. Qi, N. M. Heller, A. D. Keegan, K. C. Garcia, Molecular and structural basis of cytokine receptor pleiotropy in the interleukin-4/13 system. Cell 132, 259-272 (2008).
67. W. Lu, V. Yamamoto, B. Ortega, D. Baltimore, Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell 119, 97-108 (2004).
68. H. Lickert, A. Kispert, S. Kutsch, R. Kemler, Expression patterns of Wnt genes in mouse gut development. Mech. Dev. 105, 181-184 (2001).
69. A. Kusserow, K. Pang, C. Sturm, M. Hrouda, J. Lentfer, H. A. Schmidt, U. Technau, A. von Haeseler, B. Hobmayer, M. Q. Martindale, T. W. Holstein, Unexpected complexity of the Wnt gene family in a sea anemone. Nature 433, 156-160 (2005).