Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 290, Issue 5, 2006, Pages

  Zheng, Shizhong ^a,c   Chen, Anping ^a,b  

^a Louisiana State University School of Medicine Shreveport   (United States)

^b LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

^c NANJING MEDICAL UNIVERSITY   (China)

Author keywords

Collagen; Fibrogenesis; Oxidative stress; Phytochemicals; Signal transduction

Indexed keywords

ANTIOXIDANT; COLLAGEN TYPE 1; CONNECTIVE TISSUE GROWTH FACTOR; CURCUMIN; GLUTATHIONE; GLUTATHIONE DISULFIDE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENCY; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE EXPRESSION REGULATION; GENE REPRESSION; GLUTATHIONE METABOLISM; INHIBITION KINETICS; LIVER CELL; MALE; NONHUMAN; OXIDATIVE STRESS; PHARMACOGENETICS; PHYTOCHEMISTRY; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; COLLAGEN TYPE I; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; GLUTATHIONE; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LIVER; MALE; MODELS, BIOLOGICAL; PPAR GAMMA; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, TRANSFORMING GROWTH FACTOR BETA; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA;

EID: 33645803853     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00450.2005     Document Type: Article

References (57)

1. Abou-Shady M, Friess H, Zimmermann A, di Mola FF, Guo XZ, Baer HU, and Buchler MW. Connective tissue growth factor in human liver cirrhosis. Liver 20: 296-304, 2000.
2. Anderson ME and Luo JL. Glutathione therapy: from prodrugs to genes. Semin Liver Dis 18: 415-424, 1998.
3. Araujo CC and Leon LL. Biological activities of Curcuma longa L. Mem Inst Oswaldo Cruz 96: 723-728, 2001.
4. Bae HW, Geiser AG, Kim DH, Chung MT, Burmester JK, Sporn MB, Roberts AB, and Kim SJ. Characterization of the promoter region of the human transforming growth factor-beta type II receptor gene. J Biol Chem 270: 29460-29468, 1995.
5. Baker JC and Harland RM. From receptor to nucleus: the Smad pathway. Curr Opin Genet Dev 7: 467-473, 1997.
6. Ball DK, Rachfal AW, Kemper SA, and Brigstock DR. The heparin-binding 10 kDa fragment of connective tissue growth factor (CTGF) containing module 4 alone stimulates cell adhesion. J Endocrinol 176: R1-R7, 2003.
7. Blom IE, Goldschmeding R, and Leask A. Gene regulation of connective tissue growth factor: new targets for antifibrotic therapy? Matrix Biol 21: 473-482, 2002.
8. Brigstock DR. The connective tissue growth factor/cysteine-rich 61/ nephroblastoma overexpressed (CCN) family. Endocr Rev 20: 189-206, 1999.
9. Brouet I and Ohshima H. Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun 206: 533-540, 1995.
10. Camp HS, Chaudhry A, and Leff T. A novel potent antagonist of peroxisome proliferator-activated receptor gamma blocks adipocyte differentiation but does not revert the phenotype of terminally differentiated adipocytes. Endocrinology 142: 3207-3213, 2001.
11. Chen A and Davis BH. UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells. J Biol Chem 274: 158-164, 1999.
12. 3 stimulates activator protein-1-dependent Caco-2 cell differentiation. J Biol Chem 274: 35505-35513, 1999.
13. Chen A and Zhang l. The antioxidant (-)-epigallocatechin-3-gallate inhibits rat hepatic stellate cell proliferation in vitro by blocking the tyrosine phosphorylation and reducing the gene expression of platelet-derived growth factor-beta receptor. J Biol Chem 278: 23381-23389, 2003.
14. Chen A, Zhang L, Xu J, and Tang Jun. The antioxidant (-)- epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression. Biochem J 368: 695-704, 2002.
15. Chen C and Kong AN. Dietary chemopreventive compounds and ARE/ EpRE signaling. Free Radic Biol Med 36: 1505-1516, 2004.
16. Chen H, Zhang ZS, Zhang YL, and Zhou DY. Curcumin inhibits cell proliferation by interfering with the cell cycle and inducing apoptosis in colon carcinoma cells. Anticancer Res 19: 3675-3680, 1999.
17. De Caestecker MP, Parks WT, Frank CJ, Castagnino P, Bottaro DP, Roberts AB, and Lechleider RJ. Smad2 transduces common signals from receptor serine-threonine and tyrosine kinases. Genes Dev 12: 1587-1592, 1998.
18. Dickinson DA, Iles KE, Zhang H, Blank V, and Forman HJ. Curcumin alters EpRE and AP-1 binding complexes and elevates glutamate-cysteine ligase gene expression. FASEB J 17: 473-475, 2003.
19. Fernandez-Checa JC, Kaplowitz N, Garcia-Ruiz C, and Colell A. Mitochondrial glutathione: importance and transport. Semin Liver Dis 18: 389-401, 1998.
20. Fridovich I. The biology of oxygen radicals. Science 201: 875-880, 1978.
21. Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250, 2000.
22. Fu M, Zhang J, Zhu X, Myles DE, Willson TM, Liu X, and Chen YE. Peroxisome proliferator-activated receptor gamma inhibits transforming growth factor beta-induced connective tissue growth factor expression in human aortic smooth muscle cells by interfering with Smad3. J Biol Chem 276: 45888-45894, 2001.
23. Galli A, Crabb D, Price D, Ceni E, Salzano R, Surrenti C, and Casini A. Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. Hepatology 31: 101-108, 2000.
24. Greenwel P, Dominguez-Rosales JA, Mavi G, Rivas-Estilla AM, and Rojkind M. Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology 31: 109-116, 2000.
25. Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8: 171-179, 1997.
26. Grotendorst GR, Okochi H, and Hayashi N. A novel transforming growth factor beta response element controls the expression of the connective tissue growth factor gene. Cell Growth Differ 7: 469-480, 1996.
27. Guo N, McIntosh C, and Shaw C. Glutathione: new candidate neuropeptide in the central nervous system. Neuroscience 51: 835-842, 1992.
28. Halliwell B. Drug antioxidant effects. A basis for drug selection? Drugs 42: 569-605, 1991.
29. Hazra S, Xiong S, Wang J, Rippe R, Chatterjee VK, and Tsukamoto H. PPARgamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279: 11392-11401, 2003.
30. Ji C, Casinghino S, McCarthy TL, and Centrella M. Cloning, characterization, and expression of the transforming growth factor-beta type I receptor promoter in fetal rat bone cells. J Cell Biochem 63: 478-490, 1996.
31. Joe B and Lokesh BR. Role of capsaicin, curcumin and dietary n-3 fatty acids in lowering the generation of reactive oxygen species in rat peritoneal macrophages. Biochim Biophys Acta 1224: 255-263, 1994.
32. Leask A, Holmes A, Black CM, and Abraham DJ. Connective tissue growth factor gene regulation. Requirements for its induction by transforming growth factor-beta 2 in fibroblasts. J Biol Chem 278: 13008-13015, 2003.
33. Lee KS, Buck M, Houglum K, and Chojkier M. Activation of hepatic stellate cells by TGF alpha and collagen type I is mediated by oxidative stress through c-myb expression. J Clin Invest 96: 2461-2468, 1995.
34. Marra F, Efsen E, Romanelli RG, Caligiuri A, Pastacaldi S, Batignani G, Bonacchi A, Caporale R, Laffi G, Pinzani M, and Gentilini P. Ligands of peroxisome proliferator-activated receptor gamma modulate profibrogenic and proinflammatory actions in hepatic stellate cells. Gastroenterology 119: 466-478, 2000.
35. Massague J and Chen YG. Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000.
36. McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, and Prestwich GD. Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist. Proc Natl Acad Sci USA 100: 131-136, 2003.
37. Miyahara T, Schrum L, Rippe R, Xiong S, Yee HF Jr, Motomura K, Anania FA, Willson TM, and Tsukamoto H. Peroxisome proliferator-activated receptors and hepatic stellate cell activation. J Biol Chem 275: 35715-35722, 2000.
38. Mohan R, Sivak J, Ashton P, Russo LA, Pham BQ, Kasahara N, Raizman MB, and Fini ME. Curcuminoids inhibit the angiogenic response stimulated by fibroblast growth factor-2, including expression of matrix metalloproteinase gelatinase B. J Biol Chem 275: 10405-10412, 2000.
39. Mohandas KM and Desai DC. Epidemiology of digestive tract cancers in India. V. Large and small bowel. Indian J Gastroenterol 18: 118-121, 1999.
40. Myhrstad MC, Carlsen H, Nordstrom O, Blomhoff R, and Moskaug JO. Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter. Free Radic Biol Med 32: 386-393, 2002.
41. Paradis V, Dargere D, Bonvoust F, Vidaud M, Segarini P, and Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 82: 767-774, 2002.
42. Paradis V, Dargere D, Vidaud M, De Gouville AC, Huet S, Martinez V, Gauthier JM, Ba N, Sobesky R, Ratziu V, and Bedossa P. Expression of connective tissue growth factor in experimental rat and human liver fibrosis. Hepatology 30: 968-976, 1999.
43. Pietrangelo A, Gualdi R, Casalgrandi G, Montosi G, and Ventura E. Molecular and cellular aspects of iron-induced hepatic cirrhosis in rodents. J Clin Invest 95: 1824-1831, 1995.
44. Rachfal AW and Brigstock DR. Connective tissue growth factor (CTGF/ CCN2) in hepatic fibrosis. Hepatol Res 26: 1-9, 2003.
45. Rajakumar DV and Rao MN. Antioxidant properties of dehydrozingerone and curcumin in rat brain homogenates. Mol Cell Biochem 140: 73-79, 1994.
46. Ruby AJ, Kuttan G, Babu KD, Rajasekharan KN, and Kuttan R. Anti-tumour and antioxidant activity of natural curcuminoids. Cancer Lett 94: 79-83, 1995.
47. Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, and Reed MW. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285: 194-204, 2000.
48. Sreejayan and Rao MN. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol 46: 1013-1016, 1994.
49. Sreejayan and Rao MN. Curcuminoids as potent inhibitors of lipid peroxidation. J Pharm Pharmacol 46: 1013-1016, 1994.
50. Toffa S, Kunikowska GM, Zeng BY, Jenner P, and Marsden CD. Glutathione depletion in rat brain does not cause nigrostriatal pathway degeneration. J Neural Transm 104: 67-75, 1997.
51. Tsukamoto H. Oxidative stress, antioxidants, and alcoholic liver fibrogenesis. Alcohol 10: 465-467, 1993.
52. Uchio K, Graham M, Dean NM, Rosenbaum J, and Desmouliere A. Down-regulation of connective tissue growth factor and type I collagen mRNA expression by connective tissue growth factor antisense oligonucleotide during experimental liver fibrosis. Wound Repair Regen 12: 60-66, 2004.
53. Williams EJ, Gaca MD, Brigstock DR, Arthur MJ, and Benyon RC. Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells. J Hepatol 32: 754-761, 2000.
54. Wu G, Fang YZ, Yang S, Lupton JR, and Turner ND. Glutathione metabolism and its implications for health. J Nutr 134: 489-492, 2004.
55. Xu J, Fu Y, and Chen A. Activation of peroxisome proliferator-activated receptor-γ contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol 285: G20-G30, 2003.
56. Zheng S and Chen A. Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. Biochem J 384: 149-157, 2004.
57. Zima T, Fialova L, Mestek O, Janebova M, Crkovska J, Malbohan I, Stipek S, Mikulikova L, and Popov P. Oxidative stress, metabolism of ethanol and alcohol-related diseases. J Biomed Sci 8: 59-70, 2001.