Activation of peroxisome proliferator-activated receptor-γ by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells

Laboratory Investigation

Volumn 88, Issue 5, 2008, Pages 529-540

  Lin, Jianguo ^a   Chen, Anping ^a  

^a SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Gene expression; Hepatic fibrosis; Hepatic stellate cell; Oxidative stress; Signaling pathways

Indexed keywords

CURCUMIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTAMATE CYSTEINE LIGASE; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL ACTIVATION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVATION; FIBROGENESIS; GENE EXPRESSION; IN VITRO STUDY; LIVER CELL; LIVER FIBROSIS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; CELL PROLIFERATION; CELLS, CULTURED; CURCUMIN; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTAMATE-CYSTEINE LIGASE; GLUTATHIONE; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; MALE; PHOSPHORYLATION; PLATELET-DERIVED GROWTH FACTOR; PPAR GAMMA; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, EPIDERMAL GROWTH FACTOR; RECEPTOR, PLATELET-DERIVED GROWTH FACTOR BETA; SIGNAL TRANSDUCTION;

EID: 42549114387     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.2008.20     Document Type: Article

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