Increased expression of connective tissue growth factor in fibrotic human liver and in activated hepatic stellate cells

Journal of Hepatology

Volumn 32, Issue 5, 2000, Pages 754-761

  Williams, Elizabeth J ^b   Gaça, Marianna D A ^c   Brigstock, David R ^a   Arthur, Michael J P ^c   Benyon, R Christopher ^c  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^c NONE

Author keywords

Connective tissue growth factor; Fibrosis; Hepatic stellate cell; Liver; Transforming growth factor

Indexed keywords

CONNECTIVE TISSUE GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CELL ACTIVATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FIBROGENESIS; GENE CONTROL; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL; LIVER CIRRHOSIS; LIVER FIBROSIS; MITOGENESIS; PRIORITY JOURNAL; STELLATE CELL;

EID: 0342264463     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-8278(00)80244-5     Document Type: Article

References (46)

1. Franklin TJ. Therapeutic approaches to organ fibrosis. Int J Biochem Cell Biol. 29:1997;79-89.
2. Bradham DM, Igarashi A, Potter RL, Grotendorst GR. Connective tissue growth factor: a cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10. J Cell Biol. 114:1991;1285-1294.
3. Brigstock DR. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed family. Endocr Rev. 20:1999;189-206.
4. Bork P. The modular architecture of a new family of growth regulators related to connective tissue growth factor. FEBS Lett. 327:1993;125-130.
5. Ryseck RP, MacDonald-Bravo H, Mattei M-G, Bravo R. Structure, mapping and expression of fisp-12, a growth-factor-inducible gene encoding a secreted cysteine-rich protein. Cell Growth Differ. 2:1991;225-233.
6. Brunner A, Chinn J, Neubauer M, Purchio AF. Identification of a gene family regulated by transforming growth factor-β DNA Cell Biol. 10:1991;293-300.
7. Igarashi A, Okochi H, Bradham DM, Grotendorst GR. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair. Mol Cell Biol. 4:1993;637-645.
8. Kikuchi K, Kadono T, Ihn H, Sato S, Igarashi A, Nakagawa H, et al. Growth-regulation in scleroderma fibroblasts; increased response to transforming growth factor-β1. J Invest Dermatol. 105:1995;128-132.
9. Nakanishi T, Kimura Y, Tamura T, Ichikawa H, Yamaai Y, Sugimoto T, et al. Cloning of a mRNA preferentially expressed in chrondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA. Biochem Biophys Res Commun. 234:1997;206-210.
10. Frazier K, Williams S, Kothapalli D, Klapper H, Grotendorst GR. Stimulation of fibroblast cell growth, matrix production and granulation tissue formation by connective tissue growth factor. J Invest Dermatol. 107:1996;404-411.
11. Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Grotendorst GR, et al. Significant correlation between connective tissue growth factor gene expression and skin sclerosis in tissue sections from patients with systemic sclerosis. J Invest Dermatol. 105:1995;280-284.
12. Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, et al. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, and other fibrotic skin diseases. J Invest Dermatol. 106:1996;729-733.
13. Ito Y, Aten J, Bende RJ, Oemar BS, Rabelink TJ, Weening JJ, et al. Expression of connective tissue growth factor in human renal fibrosis. Kidney Int. 53:1998;853-861.
14. Shinozaki M, Kawara S, Hayashi N, Kakinuma T, Igarashi A, Takehara K. Induction of subcutaneous tissue fibrosis in newborn mice by transforming growth factor β - simultaneous application with basic fibroblast growth factor causes persistent fibrosis. Biochem Biophys Res Commun. 237:1997;292-296.
15. Lasky JA, Ortiz LA, Tonthat B, Hoyle GW, Corti M, Athas G, et al. Connective tissue growth factor mRNA expression is upregulated in bleomycin-induced lung fibrosis. Am J Physiol. 275:1998;L365-L371.
16. Czaja MJ, Weiner FR, Flanders KC, Giambrone MA, Wind R, Biernpica L, et al. In vitro and in vivo association of transforming growth factor beta-1 with hepatic fibrosis. J Cell Biol. 108:1989;2477-2482.
17. Nakatsukasa H, Nagy P, Evarts RP, Hsia CC, Marsden E, Thorgeirsson SS. Cellular distribution of transforming growth factorbeta 1 and procollagen types I, III, and IV transcripts in carbon tetrachloride-induced rat liver fibrosis. J Clin Invest. 85:1990;1833-1843.
18. Nakatsukasa H, Evarts RP, Hsia CC, Thorgeirsson SS. Transforming growth factor-beta 1 and type I procollagen transcripts during regeneration and early fibrosis of rat liver. Lab Invest. 63:1990;171-180.
19. Armendariz-Borunda J, Seyer JM, Kang AH, Raghow R. Regulation of TGF-beta gene expression in rat liver intoxicated with carbon tetrachloride. FASEB J. 4:1990;215-221.
20. Castilla A, Prieto J, Fausto N. Transforming growth factors beta-1 and alpha in chronic liver disease: effects of interferon therapy. N Engl J Med. 324:1991;933-940.
21. Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology. 11:1990;599-605.
22. Bayer EM, Herr W, Kanzler S, Waldmann C, Meyer Zum Büschenfelde KH, Dienes HP, et al. Transforming growth factor-beta1 in autoimmune hepatitis: correlation of liver tissue expression and serum levels with disease activity. J Hepatol. 28:1998;803-811.
23. Edwards DR, Murphy G, Reynolds JJ, Whitham SE, Docherty AJ, Angel P, et al. Transforming growth factor beta modulates the expression of collagenase and metalloproteinase inhibitor. EMBO J. 6:1987;1899-1904.
24. Knittel T, Medhe M, Kobold D, Saile B, Dinter C, Ramadori G. Expression patterns of matrix metalloproteinases and their inhibitors in parenchymal and non-parenchymal cells of rat liver: regulation by TNF-α and TGF-β1. J Hepatol. 30:1999;48-60.
25. Sime PJ, Xing Z, Graham FL, Csaky KG, Gauldie J. Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung. J Clin Invest. 100:1997;776.
26. Sanderson N, Factor V, Nagy P, Kopp J, Kondaiah P, Wakefield L, et al. Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci USA. 92:1995;2572-2576.
27. Clouthier DE, Comerford SA, Hammer RE. Hepatic fibrosis, glomerulosclerosis, and a lipodystrophy-like syndrome in PEPCK-TGF-β1 transgenic mice. J Clin Invest. 100:1997;2697-2713.
28. Border WA, Okuda S, Languino LR, Sporn MB, Ruoslahti E. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature. 346:1990;371-374.
29. Shah M, Foreman DM, Ferguson MWJ. Control of scarring in adult wounds by neutralising antibody to transforming growth factor beta. Lancet. 339:1992;213-214.
30. Border WA, Noble NA, Yamamoto T, Harper JR, Yamaguchi Y, Pierschbacher MD, et al. Natural inhibitor of transforming growth factor-beta protects against scarring in experimental kidney disease. Nature. 360:1992;361-364.
31. George J, Roulot D, Koteliansky VE, Bissell MD. Inhibition of rat hepatic fibrogenesis by a soluble TGF beta type II receptor. [abstract] Hepatology. 28:1998;312A.
32. Shull MM, Ormsby I, Kier AB, Pawlowski S, Diebold RJ, Yin M, et al. Targeted disruption of the mouse transforming growth factor-beta1 gene results in multifocal inflammatory disease. Nature. 359:1992;693-699.
33. Tamatani T, Hiroyuki K, Tezuka K, Sakamoto S, Suzuki K, Nakanishi T, et al. Establishment of the enzyme-linked immunosorbent assay for connective tissue growth factor (CTGF) and its detection in the sera of biliary atresia. Biochem Biophys Res Commun. 251:1998;748-752.
34. Iredale JP, Benyon RC, Arthur MJP, Ferris WF, Alcolado R, Winwood PJ, et al. Tissue inhibitor of metalloproteinase-1 messenger RNA expression is enhanced relative to interstitial collagenase messenger RNA in experimental liver injury and fibrosis. Hepatology. 24:1996;176-184.
35. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem. 162:1987;156-159.
36. Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJP. Expression of tissue inhibitor of metalloproteinases-1 and -2 in increased in fibrotic human liver. Gastroenterology. 110:1996;821-831.
37. Vyas SK, Leyland H, Gentry J, Arthur MJP. Transin (stromelysin) is expressed in early rat lipocyte primary culture. Gastroenterology. 109:1995;889-898.
38. Steffen CL, Ball-Mirth DK, Harding PA, Bhattacharyya N, Pillai S, Brigstock DR. Characterization of cell-associated and soluble forms of connective tissue growth factor (CTGF) produced by fibroblast cells in vitro. Growth Factors. 15:1998;199-213.
39. Oemar BS, Werner A, Garnier J-M, Do D-D, Godoy N, Nauck M, et al. Human connective tissue growth factor is expressed in advanced atherosclerotic lesions. Circulation. 95:1997;831-839.
40. Grotendorst GR, Okochi H, Hayashi N. A novel transforming growth factor β response element controls the expression of the connective tissue growth factor gene. Cell Growth & Differentiation. 7:1996;469-480.
41. Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest. 96:1995;447-455.
42. 4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factor-beta in co-cultures with sinusoidal endothelial cells. Hepatology. 21:1995;1429-1437.
43. Debleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol. 26:1997;886-893.
44. Brigstock DR, Steffen CL, Kim GY, Vegunta RK, Diehl JR, Harding PA. Purification and characterisation of novel heparinbinding growth factors in uterine secretory fluids. J Biol Chem. 272:1997;20275-20282.
45. Surveyor GA, Wilson AK, Brigstock DR. Localization of connective tissue growth factor during the period of embryo implantation in the mouse. Biol Reprod. 59:1998;1207-1213.
46. Ball DK, Surveyor GA, Diehl JR, Steffen CL, Uzumcu M, Mirando MA, et al. Characterization of 16- to 20-kilodalton (kDa) connective tissue growth factors (CTGFs) and demonstration of proteolytic activity for 38-kDa CTGF in pig uterine luminal flushings. Biol Reprod. 59:1998;828-835.