메뉴 건너뛰기




Volumn 88, Issue 1, 2008, Pages 125-172

Hepatic stellate cells: Protean, multifunctional, and enigmatic cells of the liver

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; APOLIPOPROTEIN; CELL NUCLEUS RECEPTOR; CYTOGLOBIN; CYTOKINE; GLUTATHIONE SYNTHASE; GROWTH FACTOR; LIPID; LIPOPROTEIN; OXIDOREDUCTASE; PROTEOME; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RETINOID; RETINOL; TRANSCRIPTION FACTOR JUND; TRANSCRIPTOME;

EID: 35948954244     PISSN: 00319333     EISSN: 15221210     Source Type: Journal    
DOI: 10.1152/physrev.00013.2007     Document Type: Review
Times cited : (2337)

References (443)
  • 1
    • 34247198341 scopus 로고    scopus 로고
    • The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells
    • Adachi M, Osawa Y, Uchinami H, Kitamura T, Accili D, Brenner DA. The forkhead transcription factor FoxO1 regulates proliferation and transdifferentiation of hepatic stellate cells. Gastroenterology 132: 1434-1446, 2007.
    • (2007) Gastroenterology , vol.132 , pp. 1434-1446
    • Adachi, M.1    Osawa, Y.2    Uchinami, H.3    Kitamura, T.4    Accili, D.5    Brenner, D.A.6
  • 2
    • 20044393839 scopus 로고    scopus 로고
    • NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells
    • Adachi T, Togashi H, Suzuki A, Kasai S, Ito J, Sugahara K, Kawata S. NAD(P)H oxidase plays a crucial role in PDGF-induced proliferation of hepatic stellate cells. Hepatology 41: 1272-1281, 2005.
    • (2005) Hepatology , vol.41 , pp. 1272-1281
    • Adachi, T.1    Togashi, H.2    Suzuki, A.3    Kasai, S.4    Ito, J.5    Sugahara, K.6    Kawata, S.7
  • 4
    • 0036301212 scopus 로고    scopus 로고
    • Impaired liver regeneration in mice by lipopolysaccharide via TNF-alpha/kallikrein-mediated activation of latent TGF-beta
    • Akita K, Okuno M, Enya M, Imai S, Moriwaki H, Kawada N, Suzuki Y, Kojima S. Impaired liver regeneration in mice by lipopolysaccharide via TNF-alpha/kallikrein-mediated activation of latent TGF-beta. Gastroenterology 123: 352-364, 2002.
    • (2002) Gastroenterology , vol.123 , pp. 352-364
    • Akita, K.1    Okuno, M.2    Enya, M.3    Imai, S.4    Moriwaki, H.5    Kawada, N.6    Suzuki, Y.7    Kojima, S.8
  • 7
    • 0035871817 scopus 로고    scopus 로고
    • Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells
    • Anania FA, Womack L, Jiang M, Saxena NK. Aldehydes potentiate alpha(2)(I) collagen gene activity by JNK in hepatic stellate cells. Free Radical Biol Med 30: 846-857, 2001.
    • (2001) Free Radical Biol Med , vol.30 , pp. 846-857
    • Anania, F.A.1    Womack, L.2    Jiang, M.3    Saxena, N.K.4
  • 11
    • 0033980284 scopus 로고    scopus 로고
    • Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells
    • Ankoma-Sey V, Wang Y, Dai Z. Hypoxic stimulation of vascular endothelial growth factor expression in activated rat hepatic stellate cells. Hepatology 31: 141-148, 2000.
    • (2000) Hepatology , vol.31 , pp. 141-148
    • Ankoma-Sey, V.1    Wang, Y.2    Dai, Z.3
  • 13
    • 0242349254 scopus 로고    scopus 로고
    • Stellate cell activation in alcoholic pancreatitis
    • Apte MV, Wilson JS. Stellate cell activation in alcoholic pancreatitis. Pancreas 27: 316-320, 2003.
    • (2003) Pancreas , vol.27 , pp. 316-320
    • Apte, M.V.1    Wilson, J.S.2
  • 15
    • 0029024766 scopus 로고
    • Collagenases and liver fibrosis
    • Arthur MJ. Collagenases and liver fibrosis. J Hepatol 22: 43-48, 1995.
    • (1995) J Hepatol , vol.22 , pp. 43-48
    • Arthur, M.J.1
  • 16
    • 0033858063 scopus 로고    scopus 로고
    • Arthur MJ. Fibrogenesis. II. Metalloproteinases and their inhibitors in liver fibrosis. Am J Physiol Gastrointest Liver Physiol 279: G245-G249, 2000.
    • Arthur MJ. Fibrogenesis. II. Metalloproteinases and their inhibitors in liver fibrosis. Am J Physiol Gastrointest Liver Physiol 279: G245-G249, 2000.
  • 17
    • 0026453596 scopus 로고
    • Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity
    • Arthur MJ, Stanley A, Iredale JP, Rafferty JA, Hembry RM, Friedman SL. Secretion of 72 kDa type IV collagenase/gelatinase by cultured human lipocytes. Analysis of gene expression, protein synthesis and proteinase activity. Biochem J 287: 701-707, 1992.
    • (1992) Biochem J , vol.287 , pp. 701-707
    • Arthur, M.J.1    Stanley, A.2    Iredale, J.P.3    Rafferty, J.A.4    Hembry, R.M.5    Friedman, S.L.6
  • 19
    • 0036084546 scopus 로고    scopus 로고
    • Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver
    • Asahina K, Sato H, Yamasaki C, Kataoka M, Shiokawa M, Katayama S, Tateno C, Yoshizato K. Pleiotrophin/heparin-binding growth-associated molecule as a mitogen of rat hepatocytes and its role in regeneration and development of liver. Am J Pathol 160: 2191-2205, 2002.
    • (2002) Am J Pathol , vol.160 , pp. 2191-2205
    • Asahina, K.1    Sato, H.2    Yamasaki, C.3    Kataoka, M.4    Shiokawa, M.5    Katayama, S.6    Tateno, C.7    Yoshizato, K.8
  • 20
    • 33646787070 scopus 로고    scopus 로고
    • Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation
    • Asai K, Tamakawa S, Yamamoto M, Yoshie M, Tokusashi Y, Yaginuma Y, Kasai S, Ogawa K. Activated hepatic stellate cells overexpress p75NTR after partial hepatectomy and undergo apoptosis on nerve growth factor stimulation. Liver Int 26: 595-603, 2006.
    • (2006) Liver Int , vol.26 , pp. 595-603
    • Asai, K.1    Tamakawa, S.2    Yamamoto, M.3    Yoshie, M.4    Tokusashi, Y.5    Yaginuma, Y.6    Kasai, S.7    Ogawa, K.8
  • 22
    • 33847054368 scopus 로고    scopus 로고
    • Genetics, genomics, proteomics: Implications for the diagnosis and the treatment of chronic hepatitis C
    • Asselah T, Bieche I, Paradis V, Bedossa P, Vidaud M, Marcellin P. Genetics, genomics, proteomics: implications for the diagnosis and the treatment of chronic hepatitis C. Semin Liver Dis 27: 13-27, 2007.
    • (2007) Semin Liver Dis , vol.27 , pp. 13-27
    • Asselah, T.1    Bieche, I.2    Paradis, V.3    Bedossa, P.4    Vidaud, M.5    Marcellin, P.6
  • 23
    • 0022725426 scopus 로고
    • The parasinusoidal cells of the liver: A historical account
    • Aterman K. The parasinusoidal cells of the liver: a historical account. Histochem J 18: 279-305, 1986.
    • (1986) Histochem J , vol.18 , pp. 279-305
    • Aterman, K.1
  • 24
    • 0028229648 scopus 로고
    • Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine
    • Athari A, Hanecke K, Jungermann K. Prostaglandin F2 alpha and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine. Hepatology 20: 142-148, 1994.
    • (1994) Hepatology , vol.20 , pp. 142-148
    • Athari, A.1    Hanecke, K.2    Jungermann, K.3
  • 27
    • 84945733905 scopus 로고
    • The role of thrombocytes in liver fibrogenesis: Effects of platelet lysate and thrombocyte-derived growth factors on the mitogenic activity and glycosaminoglycan synthesis of cultured rat liver fat storing cells
    • Bachem MG, Melchior R, Gressner AM. The role of thrombocytes in liver fibrogenesis: effects of platelet lysate and thrombocyte-derived growth factors on the mitogenic activity and glycosaminoglycan synthesis of cultured rat liver fat storing cells. J Clin Chem Clin Biochem 27: 555-565, 1989.
    • (1989) J Clin Chem Clin Biochem , vol.27 , pp. 555-565
    • Bachem, M.G.1    Melchior, R.2    Gressner, A.M.3
  • 28
    • 0026527581 scopus 로고
    • Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis
    • Bachem MG, Meyer D, Melchior R, Sell KM, Gressner AM. Activation of rat liver perisinusoidal lipocytes by transforming growth factors derived from myofibroblastlike cells. A potential mechanism of self perpetuation in liver fibrogenesis. J Clin Invest 89: 19-27, 1992.
    • (1992) J Clin Invest , vol.89 , pp. 19-27
    • Bachem, M.G.1    Meyer, D.2    Melchior, R.3    Sell, K.M.4    Gressner, A.M.5
  • 29
    • 33747588068 scopus 로고    scopus 로고
    • Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis
    • Bachem MG, Zhou Z, Zhou S, Siech M. Role of stellate cells in pancreatic fibrogenesis associated with acute and chronic pancreatitis. J Gastroenterol Hepatol 21 Suppl 3: S92-S96, 2006.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.SUPPL. 3
    • Bachem, M.G.1    Zhou, Z.2    Zhou, S.3    Siech, M.4
  • 30
    • 0027958521 scopus 로고
    • Ito cell heterogeneity: Desmin-negative Ito cells in normal rat liver
    • Ballardini G, Groff P, Badiali dGL, Schuppan D, Bianchi FB. Ito cell heterogeneity: desmin-negative Ito cells in normal rat liver. Hepatology 19: 440-446, 1994.
    • (1994) Hepatology , vol.19 , pp. 440-446
    • Ballardini, G.1    Groff, P.2    dGL, B.3    Schuppan, D.4    Bianchi, F.B.5
  • 32
    • 33746310348 scopus 로고    scopus 로고
    • A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis
    • Bartley PB, Ramm GA, Jones MK, Ruddell RG, Li Y, McManus DP. A contributory role for activated hepatic stellate cells in the dynamics of Schistosoma japonicum egg-induced fibrosis. Int J Parasitol 36: 993-1001, 2006.
    • (2006) Int J Parasitol , vol.36 , pp. 993-1001
    • Bartley, P.B.1    Ramm, G.A.2    Jones, M.K.3    Ruddell, R.G.4    Li, Y.5    McManus, D.P.6
  • 33
    • 33745831633 scopus 로고    scopus 로고
    • Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes
    • Basu A, Saito K, Meyer K, Ray RB, Friedman SL, Chang YH, Ray R. Stellate cell apoptosis by a soluble mediator from immortalized human hepatocytes. Apoptosis 11: 1391-1400, 2006.
    • (2006) Apoptosis , vol.11 , pp. 1391-1400
    • Basu, A.1    Saito, K.2    Meyer, K.3    Ray, R.B.4    Friedman, S.L.5    Chang, Y.H.6    Ray, R.7
  • 39
    • 0023332888 scopus 로고
    • A marginal vitamin A status alters the distribution of vitamin A among parenchymal and stellate cells in rat liver
    • Batres RO, Olson JA. A marginal vitamin A status alters the distribution of vitamin A among parenchymal and stellate cells in rat liver. J Nutr 117: 874-879, 1987.
    • (1987) J Nutr , vol.117 , pp. 874-879
    • Batres, R.O.1    Olson, J.A.2
  • 40
    • 33847636334 scopus 로고    scopus 로고
    • Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries
    • Beaussier M, Wendum D, Schiffer E, Dumont S, Rey C, Lienhart A, Housset C. Prominent contribution of portal mesenchymal cells to liver fibrosis in ischemic and obstructive cholestatic injuries. Lab Invest. 87: 292-303, 2007.
    • (2007) Lab Invest , vol.87 , pp. 292-303
    • Beaussier, M.1    Wendum, D.2    Schiffer, E.3    Dumont, S.4    Rey, C.5    Lienhart, A.6    Housset, C.7
  • 41
    • 32944473282 scopus 로고    scopus 로고
    • Nuclear receptors in lipid metabolism: Targeting the heart of dyslipidemia
    • Beaven SW, Tontonoz P. Nuclear receptors in lipid metabolism: targeting the heart of dyslipidemia. Annu Rev Med 57: 313-329, 2006.
    • (2006) Annu Rev Med , vol.57 , pp. 313-329
    • Beaven, S.W.1    Tontonoz, P.2
  • 42
    • 0028181393 scopus 로고
    • Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: A link to tissue fibrosis?
    • Bedossa P, Houglum K, Trautwein C, Holstege A, Chojkier M. Stimulation of collagen alpha 1(I) gene expression is associated with lipid peroxidation in hepatocellular injury: a link to tissue fibrosis? Hepatology 19: 1262-1271, 1994.
    • (1994) Hepatology , vol.19 , pp. 1262-1271
    • Bedossa, P.1    Houglum, K.2    Trautwein, C.3    Holstege, A.4    Chojkier, M.5
  • 44
    • 0036580778 scopus 로고    scopus 로고
    • Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis
    • Beljaars L, Meijer DK, Poelstra K. Targeting hepatic stellate cells for cell-specific treatment of liver fibrosis. Front Biosci 7: e214-e222, 2002.
    • (2002) Front Biosci , vol.7
    • Beljaars, L.1    Meijer, D.K.2    Poelstra, K.3
  • 45
    • 0034724911 scopus 로고    scopus 로고
    • Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor
    • Beljaars L, Molema G, Schuppan D, Geerts A, De Bleser PJ, Weert B, Meijer DK, Poelstra K. Successful targeting to rat hepatic stellate cells using albumin modified with cyclic peptides that recognize the collagen type VI receptor. J Biol Chem 275: 12743-12751, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 12743-12751
    • Beljaars, L.1    Molema, G.2    Schuppan, D.3    Geerts, A.4    De Bleser, P.J.5    Weert, B.6    Meijer, D.K.7    Poelstra, K.8
  • 47
    • 0028941488 scopus 로고
    • Lipoxygenase inhibitors block PDGF-induced mitogenesis: A MAPK-independent mechanism that blocks fos and egr
    • Beno DW, Mullen J, Davis BH. Lipoxygenase inhibitors block PDGF-induced mitogenesis: a MAPK-independent mechanism that blocks fos and egr. Am J Physiol Cell Physiol 268: C604-C610, 1995.
    • (1995) Am J Physiol Cell Physiol , vol.268
    • Beno, D.W.1    Mullen, J.2    Davis, B.H.3
  • 48
    • 30944441952 scopus 로고    scopus 로고
    • Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat
    • Benten D, Kumaran V, Joseph B, Schattenberg J, Popov Y, Schuppan D, Gupta S. Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat. Hepatology 42: 1072-1081, 2005.
    • (2005) Hepatology , vol.42 , pp. 1072-1081
    • Benten, D.1    Kumaran, V.2    Joseph, B.3    Schattenberg, J.4    Popov, Y.5    Schuppan, D.6    Gupta, S.7
  • 49
    • 0034814405 scopus 로고    scopus 로고
    • Extracellular matrix degradation and the role of hepatic stellate cells
    • Benyon RC, Arthur MJ. Extracellular matrix degradation and the role of hepatic stellate cells. Semin Liver Dis 21: 373-384, 2001.
    • (2001) Semin Liver Dis , vol.21 , pp. 373-384
    • Benyon, R.C.1    Arthur, M.J.2
  • 50
    • 0030030039 scopus 로고    scopus 로고
    • Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver
    • Benyon RC, Iredale JP, Goddard S, Winwood PJ, Arthur MJ. Expression of tissue inhibitor of metalloproteinases 1 and 2 is increased in fibrotic human liver. Gastroenterology 110: 821-831, 1996.
    • (1996) Gastroenterology , vol.110 , pp. 821-831
    • Benyon, R.C.1    Iredale, J.P.2    Goddard, S.3    Winwood, P.J.4    Arthur, M.J.5
  • 53
    • 0035860820 scopus 로고    scopus 로고
    • Kruppel-like factors: Three fingers in many pies
    • Bieker JJ. Kruppel-like factors: three fingers in many pies. J Biol Chem 276: 34355-34358, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 34355-34358
    • Bieker, J.J.1
  • 54
    • 33750999322 scopus 로고    scopus 로고
    • Role of Kupffer cells in host defense and liver disease
    • Bilzer M, Roggel F, Gerbes AL. Role of Kupffer cells in host defense and liver disease. Liver Int 26: 1175-1186, 2006.
    • (2006) Liver Int , vol.26 , pp. 1175-1186
    • Bilzer, M.1    Roggel, F.2    Gerbes, A.L.3
  • 56
    • 0033019481 scopus 로고    scopus 로고
    • Sex and hepatic fibrosis
    • Bissell DM. Sex and hepatic fibrosis. Hepatology 29: 988-989, 1999.
    • (1999) Hepatology , vol.29 , pp. 988-989
    • Bissell, D.M.1
  • 57
    • 0029159792 scopus 로고
    • Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation
    • Bissell DM, Wang SS, Jarnagin WR, Roll FJ. Cell-specific expression of transforming growth factor-beta in rat liver. Evidence for autocrine regulation of hepatocyte proliferation. J Clin Invest 96: 447-455, 1995.
    • (1995) J Clin Invest , vol.96 , pp. 447-455
    • Bissell, D.M.1    Wang, S.S.2    Jarnagin, W.R.3    Roll, F.J.4
  • 58
    • 0022198149 scopus 로고
    • Retinoids, retinoid binding proteins and retinyl palmitate hydrolase distributions in different types of rat liver cells
    • Blaner WS, Hendriks HFJ, Brouwer A, de Leeuw AM, Knook DL, Goodman DS. Retinoids, retinoid binding proteins and retinyl palmitate hydrolase distributions in different types of rat liver cells. J Lipid Res 26: 1241-1251, 1985.
    • (1985) J Lipid Res , vol.26 , pp. 1241-1251
    • Blaner, W.S.1    Hendriks, H.F.J.2    Brouwer, A.3    de Leeuw, A.M.4    Knook, D.L.5    Goodman, D.S.6
  • 60
    • 0023722394 scopus 로고
    • Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol binding protein
    • Blomhoff R, Berg T, Norum KR. Transfer of retinol from parenchymal to stellate cells in liver is mediated by retinol binding protein. Proc Natl Acad Sci USA 85: 3455-3458, 1988.
    • (1988) Proc Natl Acad Sci USA , vol.85 , pp. 3455-3458
    • Blomhoff, R.1    Berg, T.2    Norum, K.R.3
  • 62
    • 0020406127 scopus 로고
    • In vivo uptake of chylomicron [3H]retinyl ester by rat liver: Evidence for retinol transfer from parenchymal to nonparenchymal cells
    • Blomhoff R, Helgerud P, Rasmussen M, Berg T, Norum KR. In vivo uptake of chylomicron [3H]retinyl ester by rat liver: evidence for retinol transfer from parenchymal to nonparenchymal cells. Proc Natl Acad Sci USA 79: 7326-7330, 1982.
    • (1982) Proc Natl Acad Sci USA , vol.79 , pp. 7326-7330
    • Blomhoff, R.1    Helgerud, P.2    Rasmussen, M.3    Berg, T.4    Norum, K.R.5
  • 63
    • 0022270776 scopus 로고
    • 3H]retinol bound to the serum retinol binding protein involves both parenchymal and perisinusoidal stellate cells
    • 3H]retinol bound to the serum retinol binding protein involves both parenchymal and perisinusoidal stellate cells. J Biol Chem 260: 13571-13575, 1985.
    • (1985) J Biol Chem , vol.260 , pp. 13571-13575
    • Blomhoff, R.1    Norum, K.R.2    Berg, T.3
  • 64
    • 33745203970 scopus 로고    scopus 로고
    • Transcriptional profiling reveals novel markers of liver fibrogenesis: Gremlin and insulin-like growth factor-binding proteins
    • Boers W, Aarrass S, Linthorst C, Pinzani M, Elferink RO, Bosma P. Transcriptional profiling reveals novel markers of liver fibrogenesis: gremlin and insulin-like growth factor-binding proteins. J Biol Chem 281: 16289-16295, 2006.
    • (2006) J Biol Chem , vol.281 , pp. 16289-16295
    • Boers, W.1    Aarrass, S.2    Linthorst, C.3    Pinzani, M.4    Elferink, R.O.5    Bosma, P.6
  • 71
    • 0030012527 scopus 로고    scopus 로고
    • Characterization of insulin-like growth factor (IGF)-I-receptor binding sites during in vitro transformation of rat hepatic stellate cells to myofibroblasts
    • Brenzel A, Gressner AM. Characterization of insulin-like growth factor (IGF)-I-receptor binding sites during in vitro transformation of rat hepatic stellate cells to myofibroblasts. Eur J Clin Chem Clin Biochem 34: 401-409, 1996.
    • (1996) Eur J Clin Chem Clin Biochem , vol.34 , pp. 401-409
    • Brenzel, A.1    Gressner, A.M.2
  • 72
    • 0042855012 scopus 로고    scopus 로고
    • The CCN family: A new stimulus package
    • Brigstock DR. The CCN family: a new stimulus package. J Endocrinol 178: 169-175, 2003.
    • (2003) J Endocrinol , vol.178 , pp. 169-175
    • Brigstock, D.R.1
  • 73
    • 0030824876 scopus 로고    scopus 로고
    • Liver granulomas in schistosomiasis: Mast cell-dependent induction of SCF expression in hepatic stellate cells is mediated by TNF-α
    • Brito JM, Borojevic R. Liver granulomas in schistosomiasis: mast cell-dependent induction of SCF expression in hepatic stellate cells is mediated by TNF-α. J Leukoc Biol 62: 389-396, 1997.
    • (1997) J Leukoc Biol , vol.62 , pp. 389-396
    • Brito, J.M.1    Borojevic, R.2
  • 74
    • 0013973606 scopus 로고
    • Fat-storing cells (lipocytes) in human liver
    • Bronfenmajer S, Schaffner F, Popper H. Fat-storing cells (lipocytes) in human liver. Arch Path 82: 447-453, 1966.
    • (1966) Arch Path , vol.82 , pp. 447-453
    • Bronfenmajer, S.1    Schaffner, F.2    Popper, H.3
  • 78
    • 1942454310 scopus 로고    scopus 로고
    • Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics
    • Callewaert N, Van Vlierberghe H, Van Hecke A, Laroy W, Delanghe J, Contreras R. Noninvasive diagnosis of liver cirrhosis using DNA sequencer-based total serum protein glycomics. Nat Med 10: 429-434, 2004.
    • (2004) Nat Med , vol.10 , pp. 429-434
    • Callewaert, N.1    Van Vlierberghe, H.2    Van Hecke, A.3    Laroy, W.4    Delanghe, J.5    Contreras, R.6
  • 79
    • 0030864817 scopus 로고    scopus 로고
    • Multivesicular stellate cells in primary biliary cirrhosis
    • Cameron RG, Neuman MG, Blendis LM. Multivesicular stellate cells in primary biliary cirrhosis. Hepatology 26: 550-553, 1997.
    • (1997) Hepatology , vol.26 , pp. 550-553
    • Cameron, R.G.1    Neuman, M.G.2    Blendis, L.M.3
  • 80
    • 1342329725 scopus 로고    scopus 로고
    • The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse
    • Canbay A, Feldstein A, Baskin-Bey E, Bronk SF, Gores GJ. The caspase inhibitor IDN-6556 attenuates hepatic injury and fibrosis in the bile duct ligated mouse. J Pharmacol Exp Ther 308: 1191-1196, 2004.
    • (2004) J Pharmacol Exp Ther , vol.308 , pp. 1191-1196
    • Canbay, A.1    Feldstein, A.2    Baskin-Bey, E.3    Bronk, S.F.4    Gores, G.J.5
  • 82
    • 1242336980 scopus 로고    scopus 로고
    • Apoptosis: The nexus of liver injury and fibrosis
    • Canbay A, Friedman S, Gores GJ. Apoptosis: the nexus of liver injury and fibrosis. Hepatology 39: 273-278, 2004.
    • (2004) Hepatology , vol.39 , pp. 273-278
    • Canbay, A.1    Friedman, S.2    Gores, G.J.3
  • 83
    • 0036788277 scopus 로고    scopus 로고
    • Fas enhances fibrogenesis in the bile duct ligated mouse: A link between apoptosis and fibrosis
    • Canbay A, Higuchi H, Bronk SF, Taniai M, Sebo TJ, Gores GJ. Fas enhances fibrogenesis in the bile duct ligated mouse: a link between apoptosis and fibrosis. Gastroenterology 123: 1323-1330, 2002.
    • (2002) Gastroenterology , vol.123 , pp. 1323-1330
    • Canbay, A.1    Higuchi, H.2    Bronk, S.F.3    Taniai, M.4    Sebo, T.J.5    Gores, G.J.6
  • 85
    • 33645964631 scopus 로고    scopus 로고
    • DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction
    • Cao Q, Mak KM, Lieber CS. DLPC and SAMe combined prevent leptin-stimulated TIMP-1 production in LX-2 human hepatic stellate cells by inhibiting HO-mediated signal transduction. Liver Int 26: 221-231, 2006.
    • (2006) Liver Int , vol.26 , pp. 221-231
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 86
    • 33749234968 scopus 로고    scopus 로고
    • DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione
    • Cao Q, Mak KM, Lieber CS. DLPC and SAMe prevent alpha1(I) collagen mRNA up-regulation in human hepatic stellate cells, whether caused by leptin or menadione. Biochem Biophys Res Commun 350: 50-55, 2006.
    • (2006) Biochem Biophys Res Commun , vol.350 , pp. 50-55
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 87
    • 30044443872 scopus 로고    scopus 로고
    • Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H(2)O(2)-dependent MAPK pathways
    • Cao Q, Mak KM, Lieber CS. Leptin enhances alpha1(I) collagen gene expression in LX-2 human hepatic stellate cells through JAK-mediated H(2)O(2)-dependent MAPK pathways. J Cell Biochem 97: 188-197, 2006.
    • (2006) J Cell Biochem , vol.97 , pp. 188-197
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 88
    • 34548162930 scopus 로고    scopus 로고
    • Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells
    • Cao Q, Mak KM, Lieber CS. Leptin represses matrix metalloproteinase-1 gene expression in LX2 human hepatic stellate cells. J Hepatol 46: 124-133, 2007.
    • (2007) J Hepatol , vol.46 , pp. 124-133
    • Cao, Q.1    Mak, K.M.2    Lieber, C.S.3
  • 90
    • 0029913735 scopus 로고    scopus 로고
    • Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells
    • Carloni V, Romanelli RG, Pinzani M, Laffi G, Gentilini P. Expression and function of integrin receptors for collagen and laminin in cultured human hepatic stellate cells. Gastroenterology 110: 1127-1136, 1996.
    • (1996) Gastroenterology , vol.110 , pp. 1127-1136
    • Carloni, V.1    Romanelli, R.G.2    Pinzani, M.3    Laffi, G.4    Gentilini, P.5
  • 93
    • 0035200716 scopus 로고    scopus 로고
    • Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors
    • Cassiman D, Denef C, Desmet VJ, Roskams T. Human and rat hepatic stellate cells express neurotrophins and neurotrophin receptors. Hepatology 33: 148-158, 2001.
    • (2001) Hepatology , vol.33 , pp. 148-158
    • Cassiman, D.1    Denef, C.2    Desmet, V.J.3    Roskams, T.4
  • 94
    • 0036965876 scopus 로고    scopus 로고
    • The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3
    • Cassiman D, Libbrecht L, Sinelli N, Desmet V, Denef C, Roskams T. The vagal nerve stimulates activation of the hepatic progenitor cell compartment via muscarinic acetylcholine receptor type 3. Am J Pathol 161: 521-530, 2002.
    • (2002) Am J Pathol , vol.161 , pp. 521-530
    • Cassiman, D.1    Libbrecht, L.2    Sinelli, N.3    Desmet, V.4    Denef, C.5    Roskams, T.6
  • 95
    • 0025855367 scopus 로고
    • Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alpha therapy
    • Castilla A, Prieto J, Fausto N. Transforming growth factors beta 1 and alpha in chronic liver disease. Effects of interferon alpha therapy. N Engl J Med 324: 933-940, 1991.
    • (1991) N Engl J Med , vol.324 , pp. 933-940
    • Castilla, A.1    Prieto, J.2    Fausto, N.3
  • 96
    • 33747605553 scopus 로고    scopus 로고
    • Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells
    • Cederbaum AI. Cytochrome P450 2E1-dependent oxidant stress and upregulation of anti-oxidant defense in liver cells. J Gastroenterol Hepatol 21 Suppl 3: S22-S25, 2006.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.SUPPL. 3
    • Cederbaum, A.I.1
  • 98
    • 33644504204 scopus 로고    scopus 로고
    • Hepatic stellate cells in human Schistosomiasis mansoni: A comparative immunohistochemical study with liver cirrhosis
    • Chang D, Ramalho LN, Ramalho FS, Martinelli AL, Zucoloto S. Hepatic stellate cells in human Schistosomiasis mansoni: a comparative immunohistochemical study with liver cirrhosis. Acta Trop 97: 318-323, 2006.
    • (2006) Acta Trop , vol.97 , pp. 318-323
    • Chang, D.1    Ramalho, L.N.2    Ramalho, F.S.3    Martinelli, A.L.4    Zucoloto, S.5
  • 99
    • 32144454172 scopus 로고    scopus 로고
    • The many roles of chemokines and chemokine receptors in inflammation
    • Charo IF, Ransohoff RM. The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354: 610-621, 2006.
    • (2006) N Engl J Med , vol.354 , pp. 610-621
    • Charo, I.F.1    Ransohoff, R.M.2
  • 101
    • 0024581798 scopus 로고
    • Isolation, culture and main characteristics of mouse fat-storing cells: Interaction with viruses
    • Chen W, Gendrault JL, Steffan AM, Jeandidier E, Kirn A. Isolation, culture and main characteristics of mouse fat-storing cells: interaction with viruses. Hepatology 9: 352-362, 1989.
    • (1989) Hepatology , vol.9 , pp. 352-362
    • Chen, W.1    Gendrault, J.L.2    Steffan, A.M.3    Jeandidier, E.4    Kirn, A.5
  • 103
    • 33748440540 scopus 로고    scopus 로고
    • Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cells
    • Choudhury J, Mirshahi F, Murthy KS, Yager DR, Sanyal AJ. Physiologic concentrations of leptin increase collagen production by non-immortalized human hepatic stellate cells. Metabolism 55: 1317-1322, 2006.
    • (2006) Metabolism , vol.55 , pp. 1317-1322
    • Choudhury, J.1    Mirshahi, F.2    Murthy, K.S.3    Yager, D.R.4    Sanyal, A.J.5
  • 104
    • 13644256160 scopus 로고    scopus 로고
    • An adipocentric view of liver fibrosis and cirrhosis
    • Chuang JH, Wang PW, Tai MH. An adipocentric view of liver fibrosis and cirrhosis. Chang Gung Med J 27: 855-868, 2004.
    • (2004) Chang Gung Med J , vol.27 , pp. 855-868
    • Chuang, J.H.1    Wang, P.W.2    Tai, M.H.3
  • 105
    • 26244441014 scopus 로고    scopus 로고
    • The Farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, Staels B, Kuipers F. The Farnesoid X receptor: a molecular link between bile acid and lipid and glucose metabolism. Arterioscler Thromb Vasc Biol 25: 2020-2030, 2005.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 106
    • 0036168357 scopus 로고    scopus 로고
    • Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: A potential mechanism for liver regeneration failure in experimental cirrhosis
    • Corpechot C, Barbu V, Wendum D, Chignard N, Housset C, Poupon R, Rosmorduc O. Hepatocyte growth factor and c-Met inhibition by hepatic cell hypoxia: a potential mechanism for liver regeneration failure in experimental cirrhosis. Am J Pathol 160: 613-620, 2002.
    • (2002) Am J Pathol , vol.160 , pp. 613-620
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Chignard, N.4    Housset, C.5    Poupon, R.6    Rosmorduc, O.7
  • 107
    • 0036234428 scopus 로고    scopus 로고
    • Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis
    • Corpechot C, Barbu V, Wendum D, Kinnman N, Rey C, Poupon R, Housset C, Rosmorduc O. Hypoxia-induced VEGF and collagen I expressions are associated with angiogenesis and fibrogenesis in experimental cirrhosis. Hepatology 35: 1010-1021, 2002.
    • (2002) Hepatology , vol.35 , pp. 1010-1021
    • Corpechot, C.1    Barbu, V.2    Wendum, D.3    Kinnman, N.4    Rey, C.5    Poupon, R.6    Housset, C.7    Rosmorduc, O.8
  • 110
    • 0028117414 scopus 로고
    • Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease
    • Czaja MJ, Geerts A, Xu J, Schmiedeberg P, Ju Y. Monocyte chemoattractant protein 1 (MCP-1) expression occurs in toxic rat liver injury and human liver disease. J Leukoc Biol 55: 120-126, 1994.
    • (1994) J Leukoc Biol , vol.55 , pp. 120-126
    • Czaja, M.J.1    Geerts, A.2    Xu, J.3    Schmiedeberg, P.4    Ju, Y.5
  • 112
    • 0023710442 scopus 로고
    • Transforming growth factor beta responsiveness is modulated by the extracellular collagen matrix during hepatic ito cell culture
    • Davis BH. Transforming growth factor beta responsiveness is modulated by the extracellular collagen matrix during hepatic ito cell culture. J Cell Physiol 136: 547-553, 1988.
    • (1988) J Cell Physiol , vol.136 , pp. 547-553
    • Davis, B.H.1
  • 113
    • 0027424676 scopus 로고
    • Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: A post-receptor mechanism independent of raf/fos/jun/egr activation
    • Davis BH, Coll D, Beno DW. Retinoic acid suppresses the response to platelet-derived growth factor in human hepatic Ito-cell-like myofibroblasts: a post-receptor mechanism independent of raf/fos/jun/egr activation. Biochem J 294: 785-791, 1993.
    • (1993) Biochem J , vol.294 , pp. 785-791
    • Davis, B.H.1    Coll, D.2    Beno, D.W.3
  • 114
    • 0025688897 scopus 로고
    • Retinoic acid modulates rat Ito cell proliferation, collagen, transforming growth factor beta production
    • Davis BH, Kramer RT, Davidson NO. Retinoic acid modulates rat Ito cell proliferation, collagen, transforming growth factor beta production. J Clin Invest 86: 2062-2070, 1990.
    • (1990) J Clin Invest , vol.86 , pp. 2062-2070
    • Davis, B.H.1    Kramer, R.T.2    Davidson, N.O.3
  • 115
    • 0029048875 scopus 로고
    • Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factorbeta in cocultures with sinusoidal endothelial cells
    • De Bleser PJ, Jannes P, van Buul-Offers SC, Hoogerbrugge CM, van Schravendijk CF, Niki T, Rogiers V, van den Brande JL, Wisse E, Geerts A. Insulin-like growth factor-II/mannose 6-phosphate receptor is expressed on CCl4-exposed rat fat-storing cells and facilitates activation of latent transforming growth factorbeta in cocultures with sinusoidal endothelial cells. Hepatology 21: 1429-1437, 1995.
    • (1995) Hepatology , vol.21 , pp. 1429-1437
    • De Bleser, P.J.1    Jannes, P.2    van Buul-Offers, S.C.3    Hoogerbrugge, C.M.4    van Schravendijk, C.F.5    Niki, T.6    Rogiers, V.7    van den Brande, J.L.8    Wisse, E.9    Geerts, A.10
  • 116
    • 0030992053 scopus 로고    scopus 로고
    • Transforming growth factor-beta gene expression in normal and fibrotic rat liver
    • De Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol 26: 886-893, 1997.
    • (1997) J Hepatol , vol.26 , pp. 886-893
    • De Bleser, P.J.1    Niki, T.2    Rogiers, V.3    Geerts, A.4
  • 117
    • 0033607653 scopus 로고    scopus 로고
    • Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells
    • De Bleser PJ, Xu G, Rombouts K, Rogiers V, Geerts A. Glutathione levels discriminate between oxidative stress and transforming growth factor-beta signaling in activated rat hepatic stellate cells. J Biol Chem 274: 33881-33887, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 33881-33887
    • De Bleser, P.J.1    Xu, G.2    Rombouts, K.3    Rogiers, V.4    Geerts, A.5
  • 119
    • 38349045634 scopus 로고    scopus 로고
    • Gene expression profiles during hepatic stellate cell activation in culture and in vivo (Abstract)
    • De Minicis S, Seki E, Uchinami H, Brenner DA, Schwabe RF. Gene expression profiles during hepatic stellate cell activation in culture and in vivo (Abstract). Hepatology 44: 265A, 2006.
    • (2006) Hepatology , vol.44
    • De Minicis, S.1    Seki, E.2    Uchinami, H.3    Brenner, D.A.4    Schwabe, R.F.5
  • 120
    • 0032437131 scopus 로고    scopus 로고
    • Glutathione defense in non-parenchymal cells
    • DeLeve LD. Glutathione defense in non-parenchymal cells. Semin Liver Dis 18: 403-413, 1998.
    • (1998) Semin Liver Dis , vol.18 , pp. 403-413
    • DeLeve, L.D.1
  • 121
    • 28944453205 scopus 로고    scopus 로고
    • Cannabinoid signalling
    • Demuth DG, Molleman A. Cannabinoid signalling. Life Sci 78: 549-563, 2006.
    • (2006) Life Sci , vol.78 , pp. 549-563
    • Demuth, D.G.1    Molleman, A.2
  • 125
    • 19544378172 scopus 로고    scopus 로고
    • The roles of leptin and adiponectin: A novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology
    • Ding X, Saxena NK, Lin S, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. Am J Pathol 166: 1655-1669, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 1655-1669
    • Ding, X.1    Saxena, N.K.2    Lin, S.3    Xu, A.4    Srinivasan, S.5    Anania, F.A.6
  • 126
    • 0034094837 scopus 로고    scopus 로고
    • Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts
    • Dooley S, Delvoux B, Lahme B, Mangasser-Stephan K, Gressner AM. Modulation of transforming growth factor beta response and signaling during transdifferentiation of rat hepatic stellate cells to myofibroblasts. Hepatology 31: 1094-1106, 2000.
    • (2000) Hepatology , vol.31 , pp. 1094-1106
    • Dooley, S.1    Delvoux, B.2    Lahme, B.3    Mangasser-Stephan, K.4    Gressner, A.M.5
  • 128
    • 0034804663 scopus 로고    scopus 로고
    • Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts
    • Dooley S, Streckert M, Delvoux B, Gressner AM. Expression of Smads during in vitro transdifferentiation of hepatic stellate cells to myofibroblasts. Biochem Biophys Res Commun 283: 554-562, 2001.
    • (2001) Biochem Biophys Res Commun , vol.283 , pp. 554-562
    • Dooley, S.1    Streckert, M.2    Delvoux, B.3    Gressner, A.M.4
  • 129
    • 31444431754 scopus 로고    scopus 로고
    • Reliability and reproducibility issues in DNA microarray measurements
    • Draghici S, Khatri P, Eklund AC, Szallasi Z. Reliability and reproducibility issues in DNA microarray measurements. Trends Genet 22: 101-109, 2006.
    • (2006) Trends Genet , vol.22 , pp. 101-109
    • Draghici, S.1    Khatri, P.2    Eklund, A.C.3    Szallasi, Z.4
  • 132
    • 0032873465 scopus 로고    scopus 로고
    • Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: Down-regulation by cAMP
    • Duncan MR, Frazier KS, Abramson S, Williams S, Klapper H, Huang X, Grotendorst GR. Connective tissue growth factor mediates transforming growth factor beta-induced collagen synthesis: down-regulation by cAMP. FASEB J 13: 1774-1786, 1999.
    • (1999) FASEB J , vol.13 , pp. 1774-1786
    • Duncan, M.R.1    Frazier, K.S.2    Abramson, S.3    Williams, S.4    Klapper, H.5    Huang, X.6    Grotendorst, G.R.7
  • 133
    • 0037213346 scopus 로고    scopus 로고
    • Mechanisms controlling early development of the liver
    • Duncan SA. Mechanisms controlling early development of the liver. Mech Dev 120: 19-33, 2003.
    • (2003) Mech Dev , vol.120 , pp. 19-33
    • Duncan, S.A.1
  • 134
    • 33846978784 scopus 로고    scopus 로고
    • Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting
    • Dupuy A, Simon RM. Critical review of published microarray studies for cancer outcome and guidelines on statistical analysis and reporting. J Natl Cancer Inst 99: 147-157, 2007.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 147-157
    • Dupuy, A.1    Simon, R.M.2
  • 137
    • 21044445446 scopus 로고    scopus 로고
    • Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics
    • Elrick LJ, Leel V, Blaylock MG, Duncan L, Drever MR, Strachan G, Charlton KA, Koruth M, Porter AJ, Wright MC. Generation of a monoclonal human single chain antibody fragment to hepatic stellate cells - a potential mechanism for targeting liver anti-fibrotic therapeutics. J Hepatol 42: 888-896, 2005.
    • (2005) J Hepatol , vol.42 , pp. 888-896
    • Elrick, L.J.1    Leel, V.2    Blaylock, M.G.3    Duncan, L.4    Drever, M.R.5    Strachan, G.6    Charlton, K.A.7    Koruth, M.8    Porter, A.J.9    Wright, M.C.10
  • 138
    • 24644488751 scopus 로고    scopus 로고
    • The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis
    • Elsharkawy AM, Oakley F, Mann DA. The role and regulation of hepatic stellate cell apoptosis in reversal of liver fibrosis. Apoptosis 10: 927-939, 2005.
    • (2005) Apoptosis , vol.10 , pp. 927-939
    • Elsharkawy, A.M.1    Oakley, F.2    Mann, D.A.3
  • 139
    • 0034813009 scopus 로고    scopus 로고
    • Transcriptional regulation in hepatic stellate cells
    • Eng FJ, Friedman SL. Transcriptional regulation in hepatic stellate cells. Semin Liver Dis 21: 385-395, 2001.
    • (2001) Semin Liver Dis , vol.21 , pp. 385-395
    • Eng, F.J.1    Friedman, S.L.2
  • 140
    • 0001972098 scopus 로고    scopus 로고
    • Morphological aspects of hepatic fibrosis and Ito cells (hepatic stellate cells), with special reference to their myofibroblastic transformation
    • edited by Tanikawa K, Ueno T. Tokyo: Springer-Verlag
    • Enzan H, Hayashi Y, Miyazaki E, Naruse K, Tao R, Kuroda N, Nakayama H, Kiyoku H, Hiroi M, Saibara T. Morphological aspects of hepatic fibrosis and Ito cells (hepatic stellate cells), with special reference to their myofibroblastic transformation. In: Liver Diseases and Hepatic Sinusoidal Cells, edited by Tanikawa K, Ueno T. Tokyo: Springer-Verlag, 1999, p. 219-231.
    • (1999) Liver Diseases and Hepatic Sinusoidal Cells , pp. 219-231
    • Enzan, H.1    Hayashi, Y.2    Miyazaki, E.3    Naruse, K.4    Tao, R.5    Kuroda, N.6    Nakayama, H.7    Kiyoku, H.8    Hiroi, M.9    Saibara, T.10
  • 141
    • 0028176887 scopus 로고
    • Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma
    • Enzan H, Himeno H, Iwamura S, Onishi S, Saibara T, Yamamoto Y, Hara H. Alpha-smooth muscle actin-positive perisinusoidal stromal cells in human hepatocellular carcinoma. Hepatology 19: 895-903, 1994.
    • (1994) Hepatology , vol.19 , pp. 895-903
    • Enzan, H.1    Himeno, H.2    Iwamura, S.3    Onishi, S.4    Saibara, T.5    Yamamoto, Y.6    Hara, H.7
  • 142
    • 0028954143 scopus 로고
    • Sequential changes in human Ito cells and their relation to postnecrotic liver fibrosis in massive and submassive hepatic necrosis
    • Enzan H, Himeno H, Iwamura S, Saibara T, Onishi S, Yamamoto Y, Miyazaki E, Hara H. Sequential changes in human Ito cells and their relation to postnecrotic liver fibrosis in massive and submassive hepatic necrosis. Virchows Archiv 426: 95-101, 1995.
    • (1995) Virchows Archiv , vol.426 , pp. 95-101
    • Enzan, H.1    Himeno, H.2    Iwamura, S.3    Saibara, T.4    Onishi, S.5    Yamamoto, Y.6    Miyazaki, E.7    Hara, H.8
  • 143
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans RM, Barish GD, Wang YX. PPARs and the complex journey to obesity. Nat Med 10: 355-361, 2004.
    • (2004) Nat Med , vol.10 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.X.3
  • 144
    • 0034076888 scopus 로고    scopus 로고
    • The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease
    • Everett L, Galli A, Crabb D. The role of hepatic peroxisome proliferator-activated receptors (PPARs) in health and disease. Liver 20: 191-199, 2000.
    • (2000) Liver , vol.20 , pp. 191-199
    • Everett, L.1    Galli, A.2    Crabb, D.3
  • 145
    • 1542374741 scopus 로고    scopus 로고
    • Reversal of liver fibrosis and cirrhosis - an emerging reality
    • Fallowfield JA, Iredale JP. Reversal of liver fibrosis and cirrhosis - an emerging reality. Scott Med J 49: 3-6, 2004.
    • (2004) Scott Med J , vol.49 , pp. 3-6
    • Fallowfield, J.A.1    Iredale, J.P.2
  • 147
    • 27744523526 scopus 로고    scopus 로고
    • NK cells in HIV infection: Paradigm for protection or targets for ambush
    • Fauci AS, Mavilio D, Kottilil S. NK cells in HIV infection: paradigm for protection or targets for ambush. Nat Rev Immunol 5: 835-843, 2005.
    • (2005) Nat Rev Immunol , vol.5 , pp. 835-843
    • Fauci, A.S.1    Mavilio, D.2    Kottilil, S.3
  • 148
    • 0034768777 scopus 로고    scopus 로고
    • Upregulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts
    • Fehrenbach H, Weiskirchen R, Kasper M, Gressner AM. Upregulated expression of the receptor for advanced glycation end products in cultured rat hepatic stellate cells during transdifferentiation to myofibroblasts. Hepatology 34: 943-952, 2001.
    • (2001) Hepatology , vol.34 , pp. 943-952
    • Fehrenbach, H.1    Weiskirchen, R.2    Kasper, M.3    Gressner, A.M.4
  • 150
    • 0033055875 scopus 로고    scopus 로고
    • Functions of the fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet-derived growth factor
    • Fibbi G, Pucci M, Grappone C, Pellegrini G, Salzano R, Casini A, Milani S, Del Rosso M. Functions of the fibrinolytic system in human Ito cells and its control by basic fibroblast and platelet-derived growth factor. Hepatology 29: 868-878, 1999.
    • (1999) Hepatology , vol.29 , pp. 868-878
    • Fibbi, G.1    Pucci, M.2    Grappone, C.3    Pellegrini, G.4    Salzano, R.5    Casini, A.6    Milani, S.7    Del Rosso, M.8
  • 151
    • 0030587173 scopus 로고    scopus 로고
    • Complement C4 protein expression by rat hepatic stellate cells
    • Fimmel CJ, Brown KE, O'Neill R, Kladney RD. Complement C4 protein expression by rat hepatic stellate cells. J Immunol 157: 2601-2609, 1996.
    • (1996) J Immunol , vol.157 , pp. 2601-2609
    • Fimmel, C.J.1    Brown, K.E.2    O'Neill, R.3    Kladney, R.D.4
  • 154
    • 22944449688 scopus 로고    scopus 로고
    • A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis
    • Fiorucci S, Rizzo G, Antonelli E, Renga B, Mencarelli A, Riccardi L, Orlandi S, Pruzanski M, Morelli A, Pellicciari R. A farnesoid X receptor-small heterodimer partner regulatory cascade modulates tissue metalloproteinase inhibitor-1 and matrix metalloprotease expression in hepatic stellate cells and promotes resolution of liver fibrosis. J Pharmacol Exp Ther 314: 584-595, 2005.
    • (2005) J Pharmacol Exp Ther , vol.314 , pp. 584-595
    • Fiorucci, S.1    Rizzo, G.2    Antonelli, E.3    Renga, B.4    Mencarelli, A.5    Riccardi, L.6    Orlandi, S.7    Pruzanski, M.8    Morelli, A.9    Pellicciari, R.10
  • 155
    • 0036724910 scopus 로고    scopus 로고
    • Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells
    • Fischer R, Cariers A, Reinehr R, Haussinger D. Caspase 9-dependent killing of hepatic stellate cells by activated Kupffer cells. Gastroenterology 123: 845-861, 2002.
    • (2002) Gastroenterology , vol.123 , pp. 845-861
    • Fischer, R.1    Cariers, A.2    Reinehr, R.3    Haussinger, D.4
  • 159
    • 0026085410 scopus 로고
    • Apolipoprotein E is secreted by cultured lipocytes of the rat liver
    • Friedman G, Liu LM, Friedman SL, Boyles JK. Apolipoprotein E is secreted by cultured lipocytes of the rat liver. J Lipid Res 32: 107-114, 1991.
    • (1991) J Lipid Res , vol.32 , pp. 107-114
    • Friedman, G.1    Liu, L.M.2    Friedman, S.L.3    Boyles, J.K.4
  • 160
    • 0032794576 scopus 로고    scopus 로고
    • Cytokines and fibrogenesis
    • Friedman SL. Cytokines and fibrogenesis. Semin Liver Dis 19: 129-140, 1999.
    • (1999) Semin Liver Dis , vol.19 , pp. 129-140
    • Friedman, S.L.1
  • 161
    • 13744261157 scopus 로고    scopus 로고
    • Mac the knife? Macrophages-the double-edged sword of hepatic fibrosis
    • Friedman SL. Mac the knife? Macrophages-the double-edged sword of hepatic fibrosis. J Clin Invest 115: 29-32, 2005.
    • (2005) J Clin Invest , vol.115 , pp. 29-32
    • Friedman, S.L.1
  • 162
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 163
    • 7044231639 scopus 로고    scopus 로고
    • Stellate cells: A moving target in hepatic fibrogenesis
    • Friedman SL. Stellate cells: a moving target in hepatic fibrogenesis. Hepatology 40: 1041-1043, 2004.
    • (2004) Hepatology , vol.40 , pp. 1041-1043
    • Friedman, S.L.1
  • 164
    • 33747611690 scopus 로고    scopus 로고
    • Transcriptional regulation of stellate cell activation
    • Friedman SL. Transcriptional regulation of stellate cell activation. J Gastroenterol Hepatol 21 Suppl 3: S79-S83, 2006.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.SUPPL. 3
    • Friedman, S.L.1
  • 165
    • 0024852111 scopus 로고
    • Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors
    • Friedman SL, Arthur MJ. Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest 84: 1780-1785, 1989.
    • (1989) J Clin Invest , vol.84 , pp. 1780-1785
    • Friedman, S.L.1    Arthur, M.J.2
  • 167
    • 33644499498 scopus 로고    scopus 로고
    • Reversal of hepatic fibrosis: Fact or fantasy?
    • Friedman SL, Bansal MB. Reversal of hepatic fibrosis: fact or fantasy? Hepatology 43: S82-S88, 2006.
    • (2006) Hepatology , vol.43
    • Friedman, S.L.1    Bansal, M.B.2
  • 168
    • 0026537533 scopus 로고
    • Isolated hepatic lipocytes and Kupffer cells from normal human liver: Morphological and functional characteristics in primary culture
    • Friedman SL, Rockey DC, McGuire RF, Maher JJ, Boyles JK, Yamasaki G. Isolated hepatic lipocytes and Kupffer cells from normal human liver: morphological and functional characteristics in primary culture. Hepatology 15: 234-243, 1992.
    • (1992) Hepatology , vol.15 , pp. 234-243
    • Friedman, S.L.1    Rockey, D.C.2    McGuire, R.F.3    Maher, J.J.4    Boyles, J.K.5    Yamasaki, G.6
  • 169
    • 0023113248 scopus 로고
    • Isolation and culture of hepatic lipocytes, Kupffer cells, sinusoidal endothelial cells by density gradient centrifugation with Stractan
    • Friedman SL, Roll FJ. Isolation and culture of hepatic lipocytes, Kupffer cells, sinusoidal endothelial cells by density gradient centrifugation with Stractan. Anal Biochem 161: 207-218, 1987.
    • (1987) Anal Biochem , vol.161 , pp. 207-218
    • Friedman, S.L.1    Roll, F.J.2
  • 170
    • 0024314801 scopus 로고
    • Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix
    • Friedman SL, Roll FJ, Boyles J, Arenson DM, Bissell DM. Maintenance of differentiated phenotype of cultured rat hepatic lipocytes by basement membrane matrix. J Biol Chem 264: 10756-10762, 1989.
    • (1989) J Biol Chem , vol.264 , pp. 10756-10762
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Arenson, D.M.4    Bissell, D.M.5
  • 171
    • 0001520008 scopus 로고
    • Hepatic lipocytes: The principal collagen-producing cells of normal rat liver
    • Friedman SL, Roll FJ, Boyles J, Bissell DM. Hepatic lipocytes: the principal collagen-producing cells of normal rat liver. Proc Natl Acad Sci USA 82: 8681-8685, 1985.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 8681-8685
    • Friedman, S.L.1    Roll, F.J.2    Boyles, J.3    Bissell, D.M.4
  • 172
    • 0027210834 scopus 로고
    • Retinol release by activated rat hepatic lipocytes: Regulation by Kupffer cell-conditioned medium and PDGF
    • Friedman SL, Wei S, Blaner WS. Retinol release by activated rat hepatic lipocytes: regulation by Kupffer cell-conditioned medium and PDGF. Am J Physiol Gastrointest Liver Physiol 264: G947-G952, 1993.
    • (1993) Am J Physiol Gastrointest Liver Physiol , vol.264
    • Friedman, S.L.1    Wei, S.2    Blaner, W.S.3
  • 173
    • 0028289518 scopus 로고
    • Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo
    • Friedman SL, Yamasaki G, Wong L. Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. J Biol Chem 269: 10551-10558, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 10551-10558
    • Friedman, S.L.1    Yamasaki, G.2    Wong, L.3
  • 174
    • 0028276073 scopus 로고
    • Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat
    • Fujio K, Evarts RP, Hu Z, Marsden ER, Thorgeirsson SS. Expression of stem cell factor and its receptor, c-kit, during liver regeneration from putative stem cells in adult rat. Lab Invest 70: 511-516, 1994.
    • (1994) Lab Invest , vol.70 , pp. 511-516
    • Fujio, K.1    Evarts, R.P.2    Hu, Z.3    Marsden, E.R.4    Thorgeirsson, S.S.5
  • 175
    • 33746696162 scopus 로고    scopus 로고
    • Interferon-gamma down-regulates expression of tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats
    • Fujita T, Maesawa C, Oikawa K, Nitta H, Wakabayashi G, Masuda T. Interferon-gamma down-regulates expression of tumor necrosis factor-alpha converting enzyme/a disintegrin and metalloproteinase 17 in activated hepatic stellate cells of rats. Int J Mol Med 17: 605-616, 2006.
    • (2006) Int J Mol Med , vol.17 , pp. 605-616
    • Fujita, T.1    Maesawa, C.2    Oikawa, K.3    Nitta, H.4    Wakabayashi, G.5    Masuda, T.6
  • 177
    • 0036189530 scopus 로고    scopus 로고
    • Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors
    • Gaca MD, Zhou X, Benyon RC. Regulation of hepatic stellate cell proliferation and collagen synthesis by proteinase-activated receptors. J Hepatol 36: 362-369, 2002.
    • (2002) J Hepatol , vol.36 , pp. 362-369
    • Gaca, M.D.1    Zhou, X.2    Benyon, R.C.3
  • 178
    • 2642545495 scopus 로고    scopus 로고
    • Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: Evidence for matrix-dependent deactivation of stellate cells
    • Gaca MD, Zhou X, Issa R, Kiriella K, Iredale JP, Benyon RC. Basement membrane-like matrix inhibits proliferation and collagen synthesis by activated rat hepatic stellate cells: evidence for matrix-dependent deactivation of stellate cells. Matrix Biol 22: 229-239, 2003.
    • (2003) Matrix Biol , vol.22 , pp. 229-239
    • Gaca, M.D.1    Zhou, X.2    Issa, R.3    Kiriella, K.4    Iredale, J.P.5    Benyon, R.C.6
  • 179
    • 0017641814 scopus 로고
    • The rate of synthesis of glycosaminoglycans and collagen by fibroblasts cultured from adult human liver biopsies
    • Galambos JT, Hollingsworth MA, Falek A, Warren WD, McCain JR. The rate of synthesis of glycosaminoglycans and collagen by fibroblasts cultured from adult human liver biopsies. J Clin Invest 60: 107-114, 1977.
    • (1977) J Clin Invest , vol.60 , pp. 107-114
    • Galambos, J.T.1    Hollingsworth, M.A.2    Falek, A.3    Warren, W.D.4    McCain, J.R.5
  • 180
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factorinduced proliferation of human hepatic stellate cells
    • Galli A, Crabb D, Price D, Ceni E, Salzano R, Surrenti C, Casini A. Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factorinduced proliferation of human hepatic stellate cells. Hepatology 31: 101-108, 2000.
    • (2000) Hepatology , vol.31 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3    Ceni, E.4    Salzano, R.5    Surrenti, C.6    Casini, A.7
  • 182
    • 1542305557 scopus 로고    scopus 로고
    • Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan
    • Gao R, Brigstock DR. Connective tissue growth factor (CCN2) induces adhesion of rat activated hepatic stellate cells by binding of its C-terminal domain to integrin alpha(v)beta(3) and heparan sulfate proteoglycan. J Biol Chem 279: 8848-8855, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 8848-8855
    • Gao, R.1    Brigstock, D.R.2
  • 183
    • 0242690484 scopus 로고    scopus 로고
    • Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells
    • Gao R, Brigstock DR. Low density lipoprotein receptor-related protein (LRP) is a heparin-dependent adhesion receptor for connective tissue growth factor (CTGF) in rat activated hepatic stellate cells. Hepatol Res 27: 214-220, 2003.
    • (2003) Hepatol Res , vol.27 , pp. 214-220
    • Gao, R.1    Brigstock, D.R.2
  • 184
    • 34548608548 scopus 로고    scopus 로고
    • Alternative splicing: Therapeutic target and tool
    • Garcia-Blanco MA. Alternative splicing: therapeutic target and tool. Prog Mol Subcell Biol 44: 47-64, 2006.
    • (2006) Prog Mol Subcell Biol , vol.44 , pp. 47-64
    • Garcia-Blanco, M.A.1
  • 185
    • 0037163121 scopus 로고    scopus 로고
    • Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells
    • Garcia-Ruiz I, de la Torre P, Diaz T, Esteban E, Fernandez I, Munoz-Yague T, Solis-Herruzo JA. Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells. J Biol Chem 277: 30551-30558, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 30551-30558
    • Garcia-Ruiz, I.1    de la Torre, P.2    Diaz, T.3    Esteban, E.4    Fernandez, I.5    Munoz-Yague, T.6    Solis-Herruzo, J.A.7
  • 186
    • 0033053458 scopus 로고    scopus 로고
    • Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbetadependent mechanism in rat hepatic stellate cells
    • Garcia-Trevijano ER, Iraburu MJ, Fontana L, Dominguez-Rosales JA, Auster A, Covarrubias-Pinedo A, Rojkind M. Transforming growth factor beta1 induces the expression of alpha1(I) procollagen mRNA by a hydrogen peroxide-C/EBPbetadependent mechanism in rat hepatic stellate cells. Hepatology 29: 960-970, 1999.
    • (1999) Hepatology , vol.29 , pp. 960-970
    • Garcia-Trevijano, E.R.1    Iraburu, M.J.2    Fontana, L.3    Dominguez-Rosales, J.A.4    Auster, A.5    Covarrubias-Pinedo, A.6    Rojkind, M.7
  • 187
    • 0038713221 scopus 로고    scopus 로고
    • The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells
    • Gascon-Barre M, Demers C, Mirshahi A, Neron S, Zalzal S, Nanci A. The normal liver harbors the vitamin D nuclear receptor in nonparenchymal and biliary epithelial cells. Hepatology 37: 1034-1042, 2003.
    • (2003) Hepatology , vol.37 , pp. 1034-1042
    • Gascon-Barre, M.1    Demers, C.2    Mirshahi, A.3    Neron, S.4    Zalzal, S.5    Nanci, A.6
  • 188
    • 27244448966 scopus 로고    scopus 로고
    • Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation
    • Gawrieh S, Papouchado BG, Burgart LJ, Kobayashi S, Charlton MR, Gores GJ. Early hepatic stellate cell activation predicts severe hepatitis C recurrence after liver transplantation. Liver Transpl 11: 1207-1213, 2005.
    • (2005) Liver Transpl , vol.11 , pp. 1207-1213
    • Gawrieh, S.1    Papouchado, B.G.2    Burgart, L.J.3    Kobayashi, S.4    Charlton, M.R.5    Gores, G.J.6
  • 189
    • 0034808310 scopus 로고    scopus 로고
    • History, heterogeneity, developmental biology, functions of quiescent hepatic stellate cells
    • Geerts A. History, heterogeneity, developmental biology, functions of quiescent hepatic stellate cells. Semin Liver Dis 21: 311-335, 2001.
    • (2001) Semin Liver Dis , vol.21 , pp. 311-335
    • Geerts, A.1
  • 190
    • 1642491768 scopus 로고    scopus 로고
    • On the origin of stellate cells: Mesodermal, endodermal or neuro-ectodermal?
    • Geerts A. On the origin of stellate cells: mesodermal, endodermal or neuro-ectodermal? J Hepatol 40: 331-334, 2004.
    • (2004) J Hepatol , vol.40 , pp. 331-334
    • Geerts, A.1
  • 191
    • 0025361283 scopus 로고
    • Ultrastructure and function of hepatic fat-storing and pit cells
    • Geerts A, Bouwens L, Wisse E. Ultrastructure and function of hepatic fat-storing and pit cells. J Electr Micr Tech 14: 247-256, 1990.
    • (1990) J Electr Micr Tech , vol.14 , pp. 247-256
    • Geerts, A.1    Bouwens, L.2    Wisse, E.3
  • 192
    • 0024339217 scopus 로고
    • In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion
    • Geerts A, Vrijsen R, Rauterberg J, Burt A, Schellinck P, Wisse E. In vitro differentiation of fat-storing cells parallels marked increase of collagen synthesis and secretion. J Hepatol 9: 59-68, 1989.
    • (1989) J Hepatol , vol.9 , pp. 59-68
    • Geerts, A.1    Vrijsen, R.2    Rauterberg, J.3    Burt, A.4    Schellinck, P.5    Wisse, E.6
  • 193
    • 33644750470 scopus 로고    scopus 로고
    • Rimonabant: A selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors
    • Gelfand EV, Cannon CP. Rimonabant: a selective blocker of the cannabinoid CB1 receptors for the management of obesity, smoking cessation and cardiometabolic risk factors. Expert Opin Invest Drugs 15: 307-315, 2006.
    • (2006) Expert Opin Invest Drugs , vol.15 , pp. 307-315
    • Gelfand, E.V.1    Cannon, C.P.2
  • 194
    • 0033607304 scopus 로고    scopus 로고
    • In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: A potential new therapy for hepatic fibrosis
    • George J, Roulot D, Koteliansky VE, Bissell DM. In vivo inhibition of rat stellate cell activation by soluble transforming growth factor beta type II receptor: a potential new therapy for hepatic fibrosis. Proc Natl Acad Sci USA 96: 12719-12724, 1999.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 12719-12724
    • George, J.1    Roulot, D.2    Koteliansky, V.E.3    Bissell, D.M.4
  • 195
    • 0033874135 scopus 로고    scopus 로고
    • Transforming growth factor-beta initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform
    • George J, Wang SS, Sevcsik AM, Sanicola M, Cate RL, Koteliansky VE, Bissell DM. Transforming growth factor-beta initiates wound repair in rat liver through induction of the EIIIA-fibronectin splice isoform. Am J Pathol 156: 115-124, 2000.
    • (2000) Am J Pathol , vol.156 , pp. 115-124
    • George, J.1    Wang, S.S.2    Sevcsik, A.M.3    Sanicola, M.4    Cate, R.L.5    Koteliansky, V.E.6    Bissell, D.M.7
  • 196
    • 0025811045 scopus 로고
    • Liver damage caused by therapeutic vitamin A administration: Estimate of dose-related toxicity in 41 cases
    • Geubel AP, De Galocsy C, Alves N, Rahier J, Dive C. Liver damage caused by therapeutic vitamin A administration: estimate of dose-related toxicity in 41 cases. Gastroenterology 100: 1701-1709, 1991.
    • (1991) Gastroenterology , vol.100 , pp. 1701-1709
    • Geubel, A.P.1    De Galocsy, C.2    Alves, N.3    Rahier, J.4    Dive, C.5
  • 198
    • 21644478895 scopus 로고    scopus 로고
    • Immunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infection
    • Giannelli G, Antonaci S. Immunological and molecular aspects of liver fibrosis in chronic hepatitis C virus infection. Histol Histopathol 20: 939-944, 2005.
    • (2005) Histol Histopathol , vol.20 , pp. 939-944
    • Giannelli, G.1    Antonaci, S.2
  • 201
    • 0031927609 scopus 로고    scopus 로고
    • Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand
    • Gong W, Pecci A, Roth S, Lahme B, Beato M, Gressner AM. Transformation-dependent susceptibility of rat hepatic stellate cells to apoptosis induced by soluble Fas ligand. Hepatology 28: 492-502, 1998.
    • (1998) Hepatology , vol.28 , pp. 492-502
    • Gong, W.1    Pecci, A.2    Roth, S.3    Lahme, B.4    Beato, M.5    Gressner, A.M.6
  • 204
    • 0033965330 scopus 로고    scopus 로고
    • Hydrogen peroxide: A link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells
    • Greenwel P, Dominguez-Rosales JA, Mavi G, Rivas-Estilla AM, Rojkind M. Hydrogen peroxide: a link between acetaldehyde-elicited alpha1(I) collagen gene up-regulation and oxidative stress in mouse hepatic stellate cells. Hepatology 31: 109-116, 2000.
    • (2000) Hepatology , vol.31 , pp. 109-116
    • Greenwel, P.1    Dominguez-Rosales, J.A.2    Mavi, G.3    Rivas-Estilla, A.M.4    Rojkind, M.5
  • 205
    • 0027251069 scopus 로고
    • Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, connexin 43
    • Greenwel P, Rubin J, Schwartz M, Hertzberg EL, Rojkind M. Liver fat-storing cell clones obtained from a CCl4-cirrhotic rat are heterogeneous with regard to proliferation, expression of extracellular matrix components, interleukin-6, connexin 43. Lab Invest 69: 210-216, 1993.
    • (1993) Lab Invest , vol.69 , pp. 210-216
    • Greenwel, P.1    Rubin, J.2    Schwartz, M.3    Hertzberg, E.L.4    Rojkind, M.5
  • 206
    • 0029026661 scopus 로고
    • Cytokines and cellular crosstalk involved in the activation of fat-storing cells
    • Gressner AM. Cytokines and cellular crosstalk involved in the activation of fat-storing cells. J Hepatol 22: 28-36, 1995.
    • (1995) J Hepatol , vol.22 , pp. 28-36
    • Gressner, A.M.1
  • 207
    • 0029997830 scopus 로고    scopus 로고
    • Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: A key event in hepatic fibrogenesis
    • Gressner AM. Transdifferentiation of hepatic stellate cells (Ito cells) to myofibroblasts: a key event in hepatic fibrogenesis. Kidney Int Suppl 54: S39-S45, 1996.
    • (1996) Kidney Int Suppl , vol.54
    • Gressner, A.M.1
  • 208
    • 0028876152 scopus 로고
    • Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells
    • Gressner AM, Lahme B, Brenzel A. Molecular dissection of the mitogenic effect of hepatocytes on cultured hepatic stellate cells. Hepatology 22: 1507-1518, 1995.
    • (1995) Hepatology , vol.22 , pp. 1507-1518
    • Gressner, A.M.1    Lahme, B.2    Brenzel, A.3
  • 209
    • 33644882743 scopus 로고    scopus 로고
    • Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells
    • Gressner AM, Lahme B, Meurer SK, Gressner O, Weiskirchen R. Variable expression of cystatin C in cultured trans-differentiating rat hepatic stellate cells. World J Gastroenterol 12: 731-738, 2006.
    • (2006) World J Gastroenterol , vol.12 , pp. 731-738
    • Gressner, A.M.1    Lahme, B.2    Meurer, S.K.3    Gressner, O.4    Weiskirchen, R.5
  • 211
    • 34848865661 scopus 로고    scopus 로고
    • Differential effects of TGF-β on connective tissue growth factor expression in hepatic stellate cells and hepatocytes
    • Gressner O, Lahme B, Gressner AM, Demirci I, Weiskirchen W. Differential effects of TGF-β on connective tissue growth factor expression in hepatic stellate cells and hepatocytes. J Hepatol. 47: 699-710, 2007.
    • (2007) J Hepatol , vol.47 , pp. 699-710
    • Gressner, O.1    Lahme, B.2    Gressner, A.M.3    Demirci, I.4    Weiskirchen, W.5
  • 212
    • 33644529130 scopus 로고    scopus 로고
    • Capturing complex 3D tissue physiology in vitro
    • Griffith LG, Swartz MA. Capturing complex 3D tissue physiology in vitro. Nat Rev Mol Cell Biol 7: 211-224, 2006.
    • (2006) Nat Rev Mol Cell Biol , vol.7 , pp. 211-224
    • Griffith, L.G.1    Swartz, M.A.2
  • 213
    • 20444457447 scopus 로고    scopus 로고
    • The origin of hepatocytes
    • Grompe M. The origin of hepatocytes. Gastroenterology 128: 2158-2160, 2005.
    • (2005) Gastroenterology , vol.128 , pp. 2158-2160
    • Grompe, M.1
  • 214
    • 0031225015 scopus 로고    scopus 로고
    • Connective tissue growth factor: A mediator of TGF-beta action on fibroblasts
    • Grotendorst GR. Connective tissue growth factor: a mediator of TGF-beta action on fibroblasts. Cytokine Growth Factor Rev 8: 171-179, 1997.
    • (1997) Cytokine Growth Factor Rev , vol.8 , pp. 171-179
    • Grotendorst, G.R.1
  • 215
    • 0030854654 scopus 로고    scopus 로고
    • Hepatic stellate cell immunodetection and cirrhotic evolution of viral hepatitis in liver allografts
    • Guido M, Rugge M, Leandro G, Fiel IM, Thung SN. Hepatic stellate cell immunodetection and cirrhotic evolution of viral hepatitis in liver allografts. Hepatology 26: 310-314, 1997.
    • (1997) Hepatology , vol.26 , pp. 310-314
    • Guido, M.1    Rugge, M.2    Leandro, G.3    Fiel, I.M.4    Thung, S.N.5
  • 216
    • 34047241724 scopus 로고    scopus 로고
    • Liver fibrosis: Searching for cell model answers
    • Gutierrez-Ruiz MC, Gomez-Quiroz LE. Liver fibrosis: searching for cell model answers. Liver Int 27: 434-439, 2007.
    • (2007) Liver Int , vol.27 , pp. 434-439
    • Gutierrez-Ruiz, M.C.1    Gomez-Quiroz, L.E.2
  • 218
    • 33751508804 scopus 로고    scopus 로고
    • Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices
    • Guyot C, Combe C, Balabaud C, Bioulac-Sage P, Desmouliere A. Fibrogenic cell fate during fibrotic tissue remodelling observed in rat and human cultured liver slices. J Hepatol 46: 142-150, 2007.
    • (2007) J Hepatol , vol.46 , pp. 142-150
    • Guyot, C.1    Combe, C.2    Balabaud, C.3    Bioulac-Sage, P.4    Desmouliere, A.5
  • 220
    • 21244493649 scopus 로고    scopus 로고
    • Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity
    • Habens F, Srinivasan N, Oakley F, Mann DA, Ganesan A, Packham G. Novel sulfasalazine analogues with enhanced NF-kB inhibitory and apoptosis promoting activity. Apoptosis 10: 481-491, 2005.
    • (2005) Apoptosis , vol.10 , pp. 481-491
    • Habens, F.1    Srinivasan, N.2    Oakley, F.3    Mann, D.A.4    Ganesan, A.5    Packham, G.6
  • 222
    • 33747613545 scopus 로고    scopus 로고
    • Matrix metalloproteinases, the pros and cons, in liver fibrosis
    • Han YP. Matrix metalloproteinases, the pros and cons, in liver fibrosis. J Gastroenterol Hepatol 21 Suppl 3: S88-S91, 2006.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.SUPPL. 3
    • Han, Y.P.1
  • 223
    • 34250322265 scopus 로고    scopus 로고
    • A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in transdifferentiation in the three-dimensional extracellular matrix
    • Han YP, Yan C, Zhou L, Qin L, Tsukamoto H. A matrix metalloproteinase-9 activation cascade by hepatic stellate cells in transdifferentiation in the three-dimensional extracellular matrix. J Biol Chem 282: 12928-12939, 2007.
    • (2007) J Biol Chem , vol.282 , pp. 12928-12939
    • Han, Y.P.1    Yan, C.2    Zhou, L.3    Qin, L.4    Tsukamoto, H.5
  • 224
    • 1042289741 scopus 로고    scopus 로고
    • Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen
    • Han YP, Zhou L, Wang J, Xiong S, Garner WL, French SW, Tsukamoto H. Essential role of matrix metalloproteinases in interleukin-1-induced myofibroblastic activation of hepatic stellate cell in collagen. J Biol Chem 279: 4820-4828, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 4820-4828
    • Han, Y.P.1    Zhou, L.2    Wang, J.3    Xiong, S.4    Garner, W.L.5    French, S.W.6    Tsukamoto, H.7
  • 228
    • 0037541161 scopus 로고    scopus 로고
    • Serum biomarkers of hepatitis B virus infected liver inflammation: A proteomic study
    • He QY, Lau GK, Zhou Y, Yuen ST, Lin MC, Kung HF, Chiu JF. Serum biomarkers of hepatitis B virus infected liver inflammation: a proteomic study. Proteomics 3: 666-674, 2003.
    • (2003) Proteomics , vol.3 , pp. 666-674
    • He, Q.Y.1    Lau, G.K.2    Zhou, Y.3    Yuen, S.T.4    Lin, M.C.5    Kung, H.F.6    Chiu, J.F.7
  • 229
    • 33845329178 scopus 로고    scopus 로고
    • Signalling via integrins: Implications for cell survival and anticancer strategies
    • Hehlgans S, Haase M, Cordes N. Signalling via integrins: implications for cell survival and anticancer strategies. Biochim Biophys Acta 1775: 163-180, 2007.
    • (2007) Biochim Biophys Acta , vol.1775 , pp. 163-180
    • Hehlgans, S.1    Haase, M.2    Cordes, N.3
  • 230
    • 0025736293 scopus 로고
    • Differential expression of platelet-derived growth factor alpha- and beta-receptors on fat-storing cells and endothelial cells of rat liver
    • Heldin P, Pertoft H, Nordlinder H, Heldin CH, Laurent TC. Differential expression of platelet-derived growth factor alpha- and beta-receptors on fat-storing cells and endothelial cells of rat liver. Exp Cell Res 193: 364-369, 1991.
    • (1991) Exp Cell Res , vol.193 , pp. 364-369
    • Heldin, P.1    Pertoft, H.2    Nordlinder, H.3    Heldin, C.H.4    Laurent, T.C.5
  • 231
    • 0033044052 scopus 로고    scopus 로고
    • All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially
    • Hellemans K, Grinko I, Rombouts K, Schuppan D, Geerts A. All-trans and 9-cis retinoic acid alter rat hepatic stellate cell phenotype differentially. Gut 45: 134-142, 1999.
    • (1999) Gut , vol.45 , pp. 134-142
    • Hellemans, K.1    Grinko, I.2    Rombouts, K.3    Schuppan, D.4    Geerts, A.5
  • 234
    • 0029665279 scopus 로고    scopus 로고
    • Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells
    • Hellerbrand Wang SC, Tsukamoto H, Brenner DA, Rippe RA. Expression of intracellular adhesion molecule 1 by activated hepatic stellate cells. Hepatology 24: 670-676, 1996.
    • (1996) Hepatology , vol.24 , pp. 670-676
    • Hellerbrand Wang, S.C.1    Tsukamoto, H.2    Brenner, D.A.3    Rippe, R.A.4
  • 235
    • 0028151421 scopus 로고
    • Induction of hepatic Ito cell nitric oxide production after acute endotoxemia
    • Helyar L, Bundschuh DS, Laskin JD, Laskin DL. Induction of hepatic Ito cell nitric oxide production after acute endotoxemia. Hepatology 20: 1509-1515, 1994.
    • (1994) Hepatology , vol.20 , pp. 1509-1515
    • Helyar, L.1    Bundschuh, D.S.2    Laskin, J.D.3    Laskin, D.L.4
  • 237
    • 0023867364 scopus 로고
    • Distributions of retinoids, retinoid-binding proteins and related parameters in different types of liver cells isolated from young and old rats
    • Hendriks HF, Blaner WS, Wennekers HM, Piantedosi R, Brouwer A, de Leeuw AM, Goodman DS, Knook DL. Distributions of retinoids, retinoid-binding proteins and related parameters in different types of liver cells isolated from young and old rats. Eur J Biochem 171: 237-244, 1988.
    • (1988) Eur J Biochem , vol.171 , pp. 237-244
    • Hendriks, H.F.1    Blaner, W.S.2    Wennekers, H.M.3    Piantedosi, R.4    Brouwer, A.5    de Leeuw, A.M.6    Goodman, D.S.7    Knook, D.L.8
  • 239
    • 0027404472 scopus 로고
    • In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury
    • Hines JE, Johnson SJ, Burt AD. In vivo responses of macrophages and perisinusoidal cells to cholestatic liver injury. Am J Pathol 142: 511-518, 1993.
    • (1993) Am J Pathol , vol.142 , pp. 511-518
    • Hines, J.E.1    Johnson, S.J.2    Burt, A.D.3
  • 241
    • 0022899793 scopus 로고
    • Early alcoholic liver injury. Activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in the Disse space
    • Horn T, Junge J, Christoffersen P. Early alcoholic liver injury. Activation of lipocytes in acinar zone 3 and correlation to degree of collagen formation in the Disse space. J Hepatol 3: 333-340, 1986.
    • (1986) J Hepatol , vol.3 , pp. 333-340
    • Horn, T.1    Junge, J.2    Christoffersen, P.3
  • 242
    • 0027496798 scopus 로고
    • Endothelin receptors in rat liver: Lipocytes as a contractile target for endothelin 1
    • Housset C, Rockey DC, Bissell DM. Endothelin receptors in rat liver: lipocytes as a contractile target for endothelin 1. Proc Natl Acad Sci USA 90: 9266-9270, 1993.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9266-9270
    • Housset, C.1    Rockey, D.C.2    Bissell, D.M.3
  • 243
    • 0026016577 scopus 로고
    • Cyclosporin A renders target cells resistant to immune cytolysis
    • Hudnall SD. Cyclosporin A renders target cells resistant to immune cytolysis. Eur J Immunol 21: 221-226, 1991.
    • (1991) Eur J Immunol , vol.21 , pp. 221-226
    • Hudnall, S.D.1
  • 245
    • 0029996247 scopus 로고    scopus 로고
    • Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, other fibrotic skin disorders
    • Igarashi A, Nashiro K, Kikuchi K, Sato S, Ihn H, Fujimoto M, Grotendorst GR, Takehara K. Connective tissue growth factor gene expression in tissue sections from localized scleroderma, keloid, other fibrotic skin disorders. J Invest Dermatol 106: 729-733, 1996.
    • (1996) J Invest Dermatol , vol.106 , pp. 729-733
    • Igarashi, A.1    Nashiro, K.2    Kikuchi, K.3    Sato, S.4    Ihn, H.5    Fujimoto, M.6    Grotendorst, G.R.7    Takehara, K.8
  • 247
    • 0033061550 scopus 로고    scopus 로고
    • In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation
    • Ikeda K, Wakahara T, Wang YQ, Kadoya H, Kawada N, Kaneda K. In vitro migratory potential of rat quiescent hepatic stellate cells and its augmentation by cell activation. Hepatology 29: 1760-1767, 1999.
    • (1999) Hepatology , vol.29 , pp. 1760-1767
    • Ikeda, K.1    Wakahara, T.2    Wang, Y.Q.3    Kadoya, H.4    Kawada, N.5    Kaneda, K.6
  • 249
    • 0034927064 scopus 로고    scopus 로고
    • Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals
    • Ikejima K, Honda H, Yoshikawa M, Hirose M, Kitamura T, Takei Y, Sato N. Leptin augments inflammatory and profibrogenic responses in the murine liver induced by hepatotoxic chemicals. Hepatology 34: 288-297, 2001.
    • (2001) Hepatology , vol.34 , pp. 288-297
    • Ikejima, K.1    Honda, H.2    Yoshikawa, M.3    Hirose, M.4    Kitamura, T.5    Takei, Y.6    Sato, N.7
  • 252
    • 0030810959 scopus 로고    scopus 로고
    • 9,13-Di-cis-retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90
    • Imai S, Okuno M, Moriwaki H, Muto Y, Murakami K, Shudo K, Suzuki Y, Kojima S. 9,13-Di-cis-retinoic acid induces the production of tPA and activation of latent TGF-beta via RAR alpha in a human liver stellate cell line, LI90. FEBS Lett 411: 102-106, 1997.
    • (1997) FEBS Lett , vol.411 , pp. 102-106
    • Imai, S.1    Okuno, M.2    Moriwaki, H.3    Muto, Y.4    Murakami, K.5    Shudo, K.6    Suzuki, Y.7    Kojima, S.8
  • 254
    • 0035120166 scopus 로고    scopus 로고
    • Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells
    • Inagaki Y, Mamura M, Kanamaru Y, Greenwel P, Nemoto T, Takehara K, Ten Dijke P, Nakao A. Constitutive phosphorylation and nuclear localization of Smad3 are correlated with increased collagen gene transcription in activated hepatic stellate cells. J Cell Physiol 187: 117-123, 2001.
    • (2001) J Cell Physiol , vol.187 , pp. 117-123
    • Inagaki, Y.1    Mamura, M.2    Kanamaru, Y.3    Greenwel, P.4    Nemoto, T.5    Takehara, K.6    Ten Dijke, P.7    Nakao, A.8
  • 256
    • 33846951514 scopus 로고    scopus 로고
    • Emerging insights into transforming growth factor beta smad signal in hepatic fibrogenesis
    • Inagaki Y, Okazaki I. Emerging insights into transforming growth factor beta smad signal in hepatic fibrogenesis. Gut 56: 284-292, 2007.
    • (2007) Gut , vol.56 , pp. 284-292
    • Inagaki, Y.1    Okazaki, I.2
  • 257
    • 0028978771 scopus 로고
    • Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver
    • Inagaki Y, Truter S, Greenwel P, Rojkind M, Unoura M, Kobayashi K, Ramirez F. Regulation of the alpha 2(I) collagen gene transcription in fat-storing cells derived from a cirrhotic liver. Hepatology 22: 573-579, 1995.
    • (1995) Hepatology , vol.22 , pp. 573-579
    • Inagaki, Y.1    Truter, S.2    Greenwel, P.3    Rojkind, M.4    Unoura, M.5    Kobayashi, K.6    Ramirez, F.7
  • 258
    • 0024995840 scopus 로고
    • Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis
    • Inuzuka S, Ueno T, Torimura T, Sata M, Abe H, Tanikawa K. Immunohistochemistry of the hepatic extracellular matrix in acute viral hepatitis. Hepatology 12: 249-256, 1990.
    • (1990) Hepatology , vol.12 , pp. 249-256
    • Inuzuka, S.1    Ueno, T.2    Torimura, T.3    Sata, M.4    Abe, H.5    Tanikawa, K.6
  • 259
    • 0034809414 scopus 로고    scopus 로고
    • Hepatic stellate cell behavior during resolution of liver injury
    • Iredale JP. Hepatic stellate cell behavior during resolution of liver injury. Semin Liver Dis 21: 427-436, 2001.
    • (2001) Semin Liver Dis , vol.21 , pp. 427-436
    • Iredale, J.P.1
  • 260
    • 33847363203 scopus 로고    scopus 로고
    • Models of liver fibrosis: Exploring the dynamic nature of inflammation and repair in a solid organ
    • Iredale JP. Models of liver fibrosis: exploring the dynamic nature of inflammation and repair in a solid organ. J Clin Invest 117: 539-548, 2007.
    • (2007) J Clin Invest , vol.117 , pp. 539-548
    • Iredale, J.P.1
  • 261
    • 0035083958 scopus 로고    scopus 로고
    • Apoptosis of hepatic stellate cells: Involvement in resolution of biliary fibrosis and regulation by soluble growth factors
    • Issa R, Williams E, Trim N, Kendall T, Arthur MJ, Reichen J, Benyon RC, Iredale JP. Apoptosis of hepatic stellate cells: involvement in resolution of biliary fibrosis and regulation by soluble growth factors. Gut 48: 548-557, 2001.
    • (2001) Gut , vol.48 , pp. 548-557
    • Issa, R.1    Williams, E.2    Trim, N.3    Kendall, T.4    Arthur, M.J.5    Reichen, J.6    Benyon, R.C.7    Iredale, J.P.8
  • 262
    • 28144432694 scopus 로고    scopus 로고
    • Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells
    • Itagaki T, Shimizu I, Cheng X, Yuan Y, Oshio A, Tamaki K, Fukuno H, Honda H, Okamura Y, Ito S. Opposing effects of oestradiol and progesterone on intracellular pathways and activation processes in the oxidative stress induced activation of cultured rat hepatic stellate cells. Gut 54: 1782-1789, 2005.
    • (2005) Gut , vol.54 , pp. 1782-1789
    • Itagaki, T.1    Shimizu, I.2    Cheng, X.3    Yuan, Y.4    Oshio, A.5    Tamaki, K.6    Fukuno, H.7    Honda, H.8    Okamura, Y.9    Ito, S.10
  • 263
    • 0012231510 scopus 로고
    • Cytological studies on stellate cells of Kupffer and fat storing cells in the capillary wall of human liver
    • Ito T. Cytological studies on stellate cells of Kupffer and fat storing cells in the capillary wall of human liver. Acta Anat Nippon 26: 2, 1951.
    • (1951) Acta Anat Nippon , vol.26 , pp. 2
    • Ito, T.1
  • 265
    • 0032915059 scopus 로고    scopus 로고
    • Soluble Arg-Gly-Asp peptides reduce collagen accumulation in cultured rat hepatic stellate cells
    • Iwamoto H, Sakai H, Kotoh K, Nakamuta M, Nawata H. Soluble Arg-Gly-Asp peptides reduce collagen accumulation in cultured rat hepatic stellate cells. Dig Dis Sci 44: 1038-1045, 1999.
    • (1999) Dig Dis Sci , vol.44 , pp. 1038-1045
    • Iwamoto, H.1    Sakai, H.2    Kotoh, K.3    Nakamuta, M.4    Nawata, H.5
  • 266
    • 0032212692 scopus 로고    scopus 로고
    • Inhibition of integrin signaling with Arg-Gly-Asp motifs in rat hepatic stellate cells
    • Iwamoto H, Sakai H, Nawata H. Inhibition of integrin signaling with Arg-Gly-Asp motifs in rat hepatic stellate cells. J Hepatol 29: 752-759, 1998.
    • (1998) J Hepatol , vol.29 , pp. 752-759
    • Iwamoto, H.1    Sakai, H.2    Nawata, H.3
  • 267
    • 0028596335 scopus 로고
    • Expression of variant fibronectins in wound healing: Cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis
    • Jarnagin WR, Rockey DC, Koteliansky VE, Wang SS, Bissell DM. Expression of variant fibronectins in wound healing: cellular source and biological activity of the EIIIA segment in rat hepatic fibrogenesis. J Cell Biol 127: 2037-2048, 1994.
    • (1994) J Cell Biol , vol.127 , pp. 2037-2048
    • Jarnagin, W.R.1    Rockey, D.C.2    Koteliansky, V.E.3    Wang, S.S.4    Bissell, D.M.5
  • 269
    • 0030771436 scopus 로고    scopus 로고
    • Multiple and essential Sp1 binding sites in the promoter for transforming growth factor-beta type I receptor
    • Ji C, Casinghino S, McCarthy TL, Centrella M. Multiple and essential Sp1 binding sites in the promoter for transforming growth factor-beta type I receptor. J Biol Chem 272: 21260-21267, 1997.
    • (1997) J Biol Chem , vol.272 , pp. 21260-21267
    • Ji, C.1    Casinghino, S.2    McCarthy, T.L.3    Centrella, M.4
  • 270
    • 33746511526 scopus 로고    scopus 로고
    • Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation
    • Jiang F, Parsons CJ, Stefanovic B. Gene expression profile of quiescent and activated rat hepatic stellate cells implicates Wnt signaling pathway in activation. J Hepatol 45: 401-409, 2006.
    • (2006) J Hepatol , vol.45 , pp. 401-409
    • Jiang, F.1    Parsons, C.J.2    Stefanovic, B.3
  • 271
    • 17844367093 scopus 로고    scopus 로고
    • Endocannabinoids and liver disease
    • Jimenez W. Endocannabinoids and liver disease. Hepatology 41: 983-985, 2005.
    • (2005) Hepatology , vol.41 , pp. 983-985
    • Jimenez, W.1
  • 273
    • 0035971432 scopus 로고    scopus 로고
    • AP-1 in mouse development and tumorigenesis
    • Jochum W, Passegue E, Wagner EF. AP-1 in mouse development and tumorigenesis. Oncogene 20: 2401-2412, 2001.
    • (2001) Oncogene , vol.20 , pp. 2401-2412
    • Jochum, W.1    Passegue, E.2    Wagner, E.F.3
  • 274
    • 0026579161 scopus 로고
    • Macrophage and perisinusoidal cell kinetics in acute liver injury
    • Johnson SJ, Hines JE, Burt AD. Macrophage and perisinusoidal cell kinetics in acute liver injury. J Pathol 166: 351-358, 1992.
    • (1992) J Pathol , vol.166 , pp. 351-358
    • Johnson, S.J.1    Hines, J.E.2    Burt, A.D.3
  • 277
    • 0037223568 scopus 로고    scopus 로고
    • Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury
    • Kalinichenko VV, Bhattacharyya D, Zhou Y, Gusarova GA, Kim W, Shin B, Costa RH. Foxf1 +/- mice exhibit defective stellate cell activation and abnormal liver regeneration following CCl4 injury. Hepatology 37: 107-117, 2003.
    • (2003) Hepatology , vol.37 , pp. 107-117
    • Kalinichenko, V.V.1    Bhattacharyya, D.2    Zhou, Y.3    Gusarova, G.A.4    Kim, W.5    Shin, B.6    Costa, R.H.7
  • 278
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri R, Neilson EG. Epithelial-mesenchymal transition and its implications for fibrosis. J Clin Invest 112: 1776-1784, 2003.
    • (2003) J Clin Invest , vol.112 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 280
    • 0026717172 scopus 로고
    • Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: Association of lipid peroxidation with liver fibrogenesis
    • Kamimura S, Gaal K, Britton RS, Bacon BR, Triadafilopoulos G, Tsukamoto H. Increased 4-hydroxynonenal levels in experimental alcoholic liver disease: association of lipid peroxidation with liver fibrogenesis. Hepatology 16: 448-453, 1992.
    • (1992) Hepatology , vol.16 , pp. 448-453
    • Kamimura, S.1    Gaal, K.2    Britton, R.S.3    Bacon, B.R.4    Triadafilopoulos, G.5    Tsukamoto, H.6
  • 283
    • 0029854153 scopus 로고    scopus 로고
    • Morphological study of endothelin-1-induced contraction of cultured hepatic stellate cells on hydrated collagen gels
    • Kawada N, Harada K, Ikeda K, Kaneda K. Morphological study of endothelin-1-induced contraction of cultured hepatic stellate cells on hydrated collagen gels. Cell Tissue Res 286: 477-486, 1996.
    • (1996) Cell Tissue Res , vol.286 , pp. 477-486
    • Kawada, N.1    Harada, K.2    Ikeda, K.3    Kaneda, K.4
  • 284
    • 0026764692 scopus 로고
    • Eicosanoid-mediated contractility of hepatic stellate cells
    • Kawada N, Klein H, Decker K. Eicosanoid-mediated contractility of hepatic stellate cells. Biochem J 285: 367-371, 1992.
    • (1992) Biochem J , vol.285 , pp. 367-371
    • Kawada, N.1    Klein, H.2    Decker, K.3
  • 285
    • 0035816696 scopus 로고    scopus 로고
    • Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells
    • Kawada N, Kristensen DB, Asahina K, Nakatani K, Minamiyama Y, Seki S, Yoshizato K. Characterization of a stellate cell activation-associated protein (STAP) with peroxidase activity found in rat hepatic stellate cells. J Biol Chem 276: 25318-25323, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 25318-25323
    • Kawada, N.1    Kristensen, D.B.2    Asahina, K.3    Nakatani, K.4    Minamiyama, Y.5    Seki, S.6    Yoshizato, K.7
  • 287
    • 0033590105 scopus 로고    scopus 로고
    • ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1
    • Kawada N, Seki S, Kuroki T, Kaneda K. ROCK inhibitor Y-27632 attenuates stellate cell contraction and portal pressure increase induced by endothelin-1. Biochem Biophys Res Commun 266: 296-300, 1999.
    • (1999) Biochem Biophys Res Commun , vol.266 , pp. 296-300
    • Kawada, N.1    Seki, S.2    Kuroki, T.3    Kaneda, K.4
  • 289
    • 0842308111 scopus 로고    scopus 로고
    • Pioglitazone prevents hepatic steatosis, fibrosis, enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet
    • Kawaguchi K, Sakaida I, Tsuchiya M, Omori K, Takami T, Okita K. Pioglitazone prevents hepatic steatosis, fibrosis, enzyme-altered lesions in rat liver cirrhosis induced by a choline-deficient L-amino acid-defined diet. Biochem Biophys Res Commun 315: 187-195, 2004.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 187-195
    • Kawaguchi, K.1    Sakaida, I.2    Tsuchiya, M.3    Omori, K.4    Takami, T.5    Okita, K.6
  • 290
  • 292
    • 0017188555 scopus 로고
    • Vitamin A containing lipocytes and formation of type III collagen in liver injury
    • Kent G, Gay S, Inouye T, Bahu R, Minick OT, Popper H. Vitamin A containing lipocytes and formation of type III collagen in liver injury. Proc Natl Acad Sci USA 73: 3719-3722, 1976.
    • (1976) Proc Natl Acad Sci USA , vol.73 , pp. 3719-3722
    • Kent, G.1    Gay, S.2    Inouye, T.3    Bahu, R.4    Minick, O.T.5    Popper, H.6
  • 294
    • 33644863963 scopus 로고    scopus 로고
    • What do -omics mean for the science and policy of the nutritional sciences?
    • Keusch GT. What do -omics mean for the science and policy of the nutritional sciences? Am J Clin Nutr 83: 520S-522S, 2006.
    • (2006) Am J Clin Nutr , vol.83
    • Keusch, G.T.1
  • 296
    • 0035672819 scopus 로고    scopus 로고
    • Malondialdehyde-acetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cells
    • Kharbanda KK, Todero SL, Shubert KA, Sorrell MF, Tuma DJ. Malondialdehyde-acetaldehyde-protein adducts increase secretion of chemokines by rat hepatic stellate cells. Alcohol 25: 123-128, 2001.
    • (2001) Alcohol , vol.25 , pp. 123-128
    • Kharbanda, K.K.1    Todero, S.L.2    Shubert, K.A.3    Sorrell, M.F.4    Tuma, D.J.5
  • 297
    • 0029587205 scopus 로고
    • Desmin expressing nonhematopoietic liver cells during rat liver development: An immunohistochemical and morphometric study
    • Kiassov AP, Van Eyken P, van Pelt JF, Depla E, Fevery J, Desmet VJ, Yap SH. Desmin expressing nonhematopoietic liver cells during rat liver development: an immunohistochemical and morphometric study. Differentiation 59: 253-258, 1995.
    • (1995) Differentiation , vol.59 , pp. 253-258
    • Kiassov, A.P.1    Van Eyken, P.2    van Pelt, J.F.3    Depla, E.4    Fevery, J.5    Desmet, V.J.6    Yap, S.H.7
  • 298
    • 17644408445 scopus 로고    scopus 로고
    • Role of CD44 in epithelial wound repair: Migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6
    • Kikuchi S, Griffin CT, Wang SS, Bissell DM. Role of CD44 in epithelial wound repair: migration of rat hepatic stellate cells utilizes hyaluronic acid and CD44v6. J Biol Chem 280: 15398-15404, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 15398-15404
    • Kikuchi, S.1    Griffin, C.T.2    Wang, S.S.3    Bissell, D.M.4
  • 299
    • 0035798603 scopus 로고    scopus 로고
    • N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity
    • Kim KY, Rhim T, Choi I, Kim SS. N-acetylcysteine induces cell cycle arrest in hepatic stellate cells through its reducing activity. J Biol Chem 276: 40591-40598, 2001.
    • (2001) J Biol Chem , vol.276 , pp. 40591-40598
    • Kim, K.Y.1    Rhim, T.2    Choi, I.3    Kim, S.S.4
  • 300
    • 0033971360 scopus 로고    scopus 로고
    • Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration
    • Kim TH, Mars WM, Stolz DB, Michalopoulos GK. Expression and activation of pro-MMP-2 and pro-MMP-9 during rat liver regeneration. Hepatology 31: 75-82, 2000.
    • (2000) Hepatology , vol.31 , pp. 75-82
    • Kim, T.H.1    Mars, W.M.2    Stolz, D.B.3    Michalopoulos, G.K.4
  • 301
    • 0030874711 scopus 로고    scopus 로고
    • Extracellular matrix remodeling at the early stages of liver regeneration in the rat
    • Kim TH, Mars WM, Stolz DB, Petersen BE, Michalopoulos GK. Extracellular matrix remodeling at the early stages of liver regeneration in the rat. Hepatology 26: 896-904, 1997.
    • (1997) Hepatology , vol.26 , pp. 896-904
    • Kim, T.H.1    Mars, W.M.2    Stolz, D.B.3    Petersen, B.E.4    Michalopoulos, G.K.5
  • 302
    • 17144366279 scopus 로고    scopus 로고
    • Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis
    • Kim WH, Matsumoto K, Bessho K, Nakamura T. Growth inhibition and apoptosis in liver myofibroblasts promoted by hepatocyte growth factor leads to resolution from liver cirrhosis. Am J Pathol 166: 1017-1028, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 1017-1028
    • Kim, W.H.1    Matsumoto, K.2    Bessho, K.3    Nakamura, T.4
  • 303
    • 0032509217 scopus 로고    scopus 로고
    • Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury
    • Kim Y, Ratziu V, Choi SG, Lalazar A, Theiss G, Dang Q, Kim SJ, Friedman SL. Transcriptional activation of transforming growth factor beta1 and its receptors by the Kruppel-like factor Zf9/core promoter-binding protein and Sp1. Potential mechanisms for autocrine fibrogenesis in response to injury. J Biol Chem 273: 33750-33758, 1998.
    • (1998) J Biol Chem , vol.273 , pp. 33750-33758
    • Kim, Y.1    Ratziu, V.2    Choi, S.G.3    Lalazar, A.4    Theiss, G.5    Dang, Q.6    Kim, S.J.7    Friedman, S.L.8
  • 304
    • 0037329896 scopus 로고    scopus 로고
    • The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis
    • Kinnman N, Francoz C, Barbu V, Wendum D, Rey C, Hultcrantz R, Poupon R, Housset C. The myofibroblastic conversion of peribiliary fibrogenic cells distinct from hepatic stellate cells is stimulated by platelet-derived growth factor during liver fibrogenesis. Lab Invest 83: 163-173, 2003.
    • (2003) Lab Invest , vol.83 , pp. 163-173
    • Kinnman, N.1    Francoz, C.2    Barbu, V.3    Wendum, D.4    Rey, C.5    Hultcrantz, R.6    Poupon, R.7    Housset, C.8
  • 305
    • 0035209823 scopus 로고    scopus 로고
    • Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury
    • Kinnman N, Goria O, Wendum D, Gendron MC, Rey C, Poupon R, Housset C. Hepatic stellate cell proliferation is an early platelet-derived growth factor-mediated cellular event in rat cholestatic liver injury. Lab Invest 81: 1709-1716, 2001.
    • (2001) Lab Invest , vol.81 , pp. 1709-1716
    • Kinnman, N.1    Goria, O.2    Wendum, D.3    Gendron, M.C.4    Rey, C.5    Poupon, R.6    Housset, C.7
  • 306
    • 0036484205 scopus 로고    scopus 로고
    • Peribiliary myofibroblasts in biliary type liver fibrosis
    • Kinnman N, Housset C. Peribiliary myofibroblasts in biliary type liver fibrosis. Front Biosci 7: D496-503, 2002.
    • (2002) Front Biosci , vol.7
    • Kinnman, N.1    Housset, C.2
  • 307
    • 0034086195 scopus 로고    scopus 로고
    • PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury
    • Kinnman N, Hultcrantz R, Barbu V, Rey C, Wendum D, Poupon R, Housset C. PDGF-mediated chemoattraction of hepatic stellate cells by bile duct segments in cholestatic liver injury. Lab Invest 80: 697-707, 2000.
    • (2000) Lab Invest , vol.80 , pp. 697-707
    • Kinnman, N.1    Hultcrantz, R.2    Barbu, V.3    Rey, C.4    Wendum, D.5    Poupon, R.6    Housset, C.7
  • 309
    • 34047131602 scopus 로고    scopus 로고
    • Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre-LoxP system to antagonise hepatic fibrosis
    • Kinoshita K, Iimuro Y, Fujimoto J, Inagaki Y, Namikawa K, Kiyama H, Nakajima Y, Otogawa K, Kawada N, Friedman SL, Ikeda K. Targeted and regulable expression of transgenes in hepatic stellate cells and myofibroblasts in culture and in vivo using an adenoviral Cre-LoxP system to antagonise hepatic fibrosis. Gut 56: 396-404, 2007.
    • (2007) Gut , vol.56 , pp. 396-404
    • Kinoshita, K.1    Iimuro, Y.2    Fujimoto, J.3    Inagaki, Y.4    Namikawa, K.5    Kiyama, H.6    Nakajima, Y.7    Otogawa, K.8    Kawada, N.9    Friedman, S.L.10    Ikeda, K.11
  • 310
    • 33747584867 scopus 로고    scopus 로고
    • Hepatic stellate cells and the reversal of fibrosis
    • Kisseleva T, Brenner DA. Hepatic stellate cells and the reversal of fibrosis. J Gastroenterol Hepatol 21 Suppl 3: S84-S87, 2006.
    • (2006) J Gastroenterol Hepatol , vol.21 , Issue.SUPPL. 3
    • Kisseleva, T.1    Brenner, D.A.2
  • 313
    • 0035232487 scopus 로고    scopus 로고
    • Cooperation of liver cells in health and disease
    • Kmiec Z. Cooperation of liver cells in health and disease. Adv Anat Embryol Cell Biol 161: 1-151, 2001.
    • (2001) Adv Anat Embryol Cell Biol , vol.161 , pp. 1-151
    • Kmiec, Z.1
  • 314
    • 0030056244 scopus 로고    scopus 로고
    • Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair
    • Knittel T, Aurisch S, Neubauer K, Eichhorst S, Ramadori G. Cell-type-specific expression of neural cell adhesion molecule (N-CAM) in Ito cells of rat liver. Up-regulation during in vitro activation and in hepatic tissue repair. Am J Pathol 149: 449-462, 1996.
    • (1996) Am J Pathol , vol.149 , pp. 449-462
    • Knittel, T.1    Aurisch, S.2    Neubauer, K.3    Eichhorst, S.4    Ramadori, G.5
  • 315
    • 0032948229 scopus 로고    scopus 로고
    • Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: Involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair
    • Knittel T, Dinter C, Kobold D, Neubauer K, Mehde M, Eichhorst S, Ramadori G. Expression and regulation of cell adhesion molecules by hepatic stellate cells (HSC) of rat liver: involvement of HSC in recruitment of inflammatory cells during hepatic tissue repair. Am J Pathol 154: 153-167, 1999.
    • (1999) Am J Pathol , vol.154 , pp. 153-167
    • Knittel, T.1    Dinter, C.2    Kobold, D.3    Neubauer, K.4    Mehde, M.5    Eichhorst, S.6    Ramadori, G.7
  • 316
    • 0030794868 scopus 로고    scopus 로고
    • The complement-activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo
    • Knittel T, Fellmer P, Neubauer K, Kawakami M, Grundmann A, Ramadori G. The complement-activating protease P100 is expressed by hepatocytes and is induced by IL-6 in vitro and during the acute phase reaction in vivo. Lab Invest 77: 221-230, 1997.
    • (1997) Lab Invest , vol.77 , pp. 221-230
    • Knittel, T.1    Fellmer, P.2    Neubauer, K.3    Kawakami, M.4    Grundmann, A.5    Ramadori, G.6
  • 317
    • 0029841151 scopus 로고    scopus 로고
    • Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver
    • Knittel T, Fellmer P, Ramadori G. Gene expression and regulation of plasminogen activator inhibitor type I in hepatic stellate cells of rat liver. Gastroenterology 111: 745-754, 1996.
    • (1996) Gastroenterology , vol.111 , pp. 745-754
    • Knittel, T.1    Fellmer, P.2    Ramadori, G.3
  • 318
    • 0019952768 scopus 로고
    • Fat-storing cells of the rat liver. Their isolation and purification
    • Knook DL, Seffelaar AM, de Leeuw AM. Fat-storing cells of the rat liver. Their isolation and purification. Exp Cell Res 139: 468-471, 1982.
    • (1982) Exp Cell Res , vol.139 , pp. 468-471
    • Knook, D.L.1    Seffelaar, A.M.2    de Leeuw, A.M.3
  • 320
    • 33845455662 scopus 로고    scopus 로고
    • Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration
    • Koenig S, Probst I, Becker H, Krause P. Zonal hierarchy of differentiation markers and nestin expression during oval cell mediated rat liver regeneration. Histochem Cell Biol 2006.
    • (2006) Histochem Cell Biol
    • Koenig, S.1    Probst, I.2    Becker, H.3    Krause, P.4
  • 321
    • 20444385819 scopus 로고    scopus 로고
    • Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts
    • Kopp J, Preis E, Said H, Hafemann B, Wickert L, Gressner AM, Pallua N, Dooley S. Abrogation of transforming growth factor-beta signaling by SMAD7 inhibits collagen gel contraction of human dermal fibroblasts. J Biol Chem 280: 21570-21576, 2005.
    • (2005) J Biol Chem , vol.280 , pp. 21570-21576
    • Kopp, J.1    Preis, E.2    Said, H.3    Hafemann, B.4    Wickert, L.5    Gressner, A.M.6    Pallua, N.7    Dooley, S.8
  • 322
    • 33748368701 scopus 로고    scopus 로고
    • N-acetyl-L-cysteine abrogates fibrogenic properties of fibroblasts isolated from Dupuytren's disease by blunting TGF-beta signalling
    • Kopp J, Seyhan H, Muller B, Lanczak J, Pausch E, Gressner AM, Dooley S, Horch RE. N-acetyl-L-cysteine abrogates fibrogenic properties of fibroblasts isolated from Dupuytren's disease by blunting TGF-beta signalling. J Cell Mol Med 10: 157-165, 2006.
    • (2006) J Cell Mol Med , vol.10 , pp. 157-165
    • Kopp, J.1    Seyhan, H.2    Muller, B.3    Lanczak, J.4    Pausch, E.5    Gressner, A.M.6    Dooley, S.7    Horch, R.E.8
  • 327
    • 34748839595 scopus 로고    scopus 로고
    • Identification and characterization of vitamin-A storing cells in fetal liver: Implication of functional importance of hepatic stellate cells in development and hematopoiesis
    • Kubota H, Yao H, Reid LM. Identification and characterization of vitamin-A storing cells in fetal liver: implication of functional importance of hepatic stellate cells in development and hematopoiesis. Stem Cells. 25: 2339-2349, 2007.
    • (2007) Stem Cells , vol.25 , pp. 2339-2349
    • Kubota, H.1    Yao, H.2    Reid, L.M.3
  • 328
    • 0032729264 scopus 로고    scopus 로고
    • The discovery of endogenous cannabinoids
    • Kunos G. The discovery of endogenous cannabinoids. Brain Res Bull 50: 359-360, 1999.
    • (1999) Brain Res Bull , vol.50 , pp. 359-360
    • Kunos, G.1
  • 329
    • 33746211196 scopus 로고    scopus 로고
    • OMICS-driven biomarker discovery in nutrition and health
    • Kussmann M, Raymond F, Affolter M. OMICS-driven biomarker discovery in nutrition and health. J Biotechnol 124: 758-787, 2006.
    • (2006) J Biotechnol , vol.124 , pp. 758-787
    • Kussmann, M.1    Raymond, F.2    Affolter, M.3
  • 331
    • 0030858905 scopus 로고    scopus 로고
    • Early genes induced in hepatic stellate cells during wound healing
    • Lalazar A, Wong L, Yamasaki G, Friedman SL. Early genes induced in hepatic stellate cells during wound healing. Gene 195: 235-243, 1997.
    • (1997) Gene , vol.195 , pp. 235-243
    • Lalazar, A.1    Wong, L.2    Yamasaki, G.3    Friedman, S.L.4
  • 333
    • 22844448053 scopus 로고    scopus 로고
    • Somatostatin inhibits pro-inflammatory cytokine secretion from rat hepatic stellate cells
    • Lang A, Sakhnini E, Fidder HH, Maor Y, Bar-Meir S, Chowers Y. Somatostatin inhibits pro-inflammatory cytokine secretion from rat hepatic stellate cells. Liver Int 25: 808-816, 2005.
    • (2005) Liver Int , vol.25 , pp. 808-816
    • Lang, A.1    Sakhnini, E.2    Fidder, H.H.3    Maor, Y.4    Bar-Meir, S.5    Chowers, Y.6
  • 334
    • 23044515033 scopus 로고    scopus 로고
    • Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis
    • Lau DT, Luxon BA, Xiao SY, Beard MR, Lemon SM. Intrahepatic gene expression profiles and alpha-smooth muscle actin patterns in hepatitis C virus induced fibrosis. Hepatology 42: 273-281, 2005.
    • (2005) Hepatology , vol.42 , pp. 273-281
    • Lau, D.T.1    Luxon, B.A.2    Xiao, S.Y.3    Beard, M.R.4    Lemon, S.M.5
  • 335
    • 27744479643 scopus 로고    scopus 로고
    • Involvement of the serine/threonine p70(S6) kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells
    • Le Pabic H, L'Helgoualc'h A, Coutant A, Wewer UM, Baffet G, Clement B, Theret N. Involvement of the serine/threonine p70(S6) kinase in TGF-beta1-induced ADAM12 expression in cultured human hepatic stellate cells. J Hepatol 43: 1038-1044, 2005.
    • (2005) J Hepatol , vol.43 , pp. 1038-1044
    • Le Pabic, H.1    L'Helgoualc'h, A.2    Coutant, A.3    Wewer, U.M.4    Baffet, G.5    Clement, B.6    Theret, N.7
  • 338
    • 19544389673 scopus 로고    scopus 로고
    • Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblasts
    • Lee JS, Kang Decker N, Chatterjee S, Yao J, Friedman S, Shah V. Mechanisms of nitric oxide interplay with Rho GTPase family members in modulation of actin membrane dynamics in pericytes and fibroblasts. Am J Pathol 166: 1861-1870, 2005.
    • (2005) Am J Pathol , vol.166 , pp. 1861-1870
    • Lee, J.S.1    Kang Decker, N.2    Chatterjee, S.3    Yao, J.4    Friedman, S.5    Shah, V.6
  • 339
    • 33947414087 scopus 로고    scopus 로고
    • Sinusoidal remodeling and angiogenesis: A new function for the liver-specific pericyte?
    • Lee JS, Semela D, Iredale J, Shah VH. Sinusoidal remodeling and angiogenesis: a new function for the liver-specific pericyte? Hepatology 45: 817-825, 2007.
    • (2007) Hepatology , vol.45 , pp. 817-825
    • Lee, J.S.1    Semela, D.2    Iredale, J.3    Shah, V.H.4
  • 340
    • 0028258561 scopus 로고
    • Cellular sources of glutathione S-transferase P in primary cultured rat hepatocytes: Localization by in situ hybridization
    • Lee SJ, Friedman SL, Whalen R, Boyer TD. Cellular sources of glutathione S-transferase P in primary cultured rat hepatocytes: localization by in situ hybridization. Biochem J 299: 79-83, 1994.
    • (1994) Biochem J , vol.299 , pp. 79-83
    • Lee, S.J.1    Friedman, S.L.2    Whalen, R.3    Boyer, T.D.4
  • 341
    • 27744458509 scopus 로고    scopus 로고
    • The hedgehog signalling pathway in the gastrointestinal tract: Implications for development, homeostasis, disease
    • Lees C, Howie S, Sartor RB, Satsangi J. The hedgehog signalling pathway in the gastrointestinal tract: implications for development, homeostasis, disease. Gastroenterology 129: 1696-1710, 2005.
    • (2005) Gastroenterology , vol.129 , pp. 1696-1710
    • Lees, C.1    Howie, S.2    Sartor, R.B.3    Satsangi, J.4
  • 342
    • 16644375655 scopus 로고    scopus 로고
    • CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis
    • Leicester KL, Olynyk JK, Brunt EM, Britton RS, Bacon BR. CD14-positive hepatic monocytes/macrophages increase in hereditary hemochromatosis. Liver Int 24: 446-451, 2004.
    • (2004) Liver Int , vol.24 , pp. 446-451
    • Leicester, K.L.1    Olynyk, J.K.2    Brunt, E.M.3    Britton, R.S.4    Bacon, B.R.5
  • 344
    • 0029998086 scopus 로고    scopus 로고
    • The plasminogen-activating system in hepatic stellate cells
    • Leyland H, Gentry J, Arthur MJ, Benyon RC. The plasminogen-activating system in hepatic stellate cells. Hepatology 24: 1172-1178, 1996.
    • (1996) Hepatology , vol.24 , pp. 1172-1178
    • Leyland, H.1    Gentry, J.2    Arthur, M.J.3    Benyon, R.C.4
  • 346
    • 4444249489 scopus 로고    scopus 로고
    • Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts
    • Li L, Julien B, Grenard P, Teixeira-Clerc F, Mallat A, Lotersztajn S. Molecular mechanisms regulating the antifibrogenic protein heme-oxygenase-1 in human hepatic myofibroblasts. J Hepatol 41: 407-413, 2004.
    • (2004) J Hepatol , vol.41 , pp. 407-413
    • Li, L.1    Julien, B.2    Grenard, P.3    Teixeira-Clerc, F.4    Mallat, A.5    Lotersztajn, S.6
  • 348
    • 0035990952 scopus 로고    scopus 로고
    • The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver
    • Libbrecht L, Cassiman D, Desmet V, Roskams T. The correlation between portal myofibroblasts and development of intrahepatic bile ducts and arterial branches in human liver. Liver 22: 252-258, 2002.
    • (2002) Liver , vol.22 , pp. 252-258
    • Libbrecht, L.1    Cassiman, D.2    Desmet, V.3    Roskams, T.4
  • 349
    • 33846408369 scopus 로고    scopus 로고
    • Switch of cadherin expression from Eto N-type during the activation of rat hepatic stellate cells
    • Lim YS, Lee HC, Lee HS. Switch of cadherin expression from Eto N-type during the activation of rat hepatic stellate cells. Histochem Cell Biol 127: 149-160, 2007.
    • (2007) Histochem Cell Biol , vol.127 , pp. 149-160
    • Lim, Y.S.1    Lee, H.C.2    Lee, H.S.3
  • 350
    • 0034053863 scopus 로고    scopus 로고
    • Regulation of collagen alpha1(I) expression in hepatic stellate cells
    • Lindquist J, Stefanovic B, Brenner D. Regulation of collagen alpha1(I) expression in hepatic stellate cells. J Gastroenterol 35 Suppl 12: 80-83, 2000.
    • (2000) J Gastroenterol , vol.35 , Issue.SUPPL. 12 , pp. 80-83
    • Lindquist, J.1    Stefanovic, B.2    Brenner, D.3
  • 351
    • 2542465060 scopus 로고    scopus 로고
    • Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3-untranslated region
    • Lindquist JN, Parsons CJ, Stefanovic B, Brenner DA. Regulation of alpha1(I) collagen messenger RNA decay by interactions with alphaCP at the 3-untranslated region. J Biol Chem 279: 23822-23829, 2004.
    • (2004) J Biol Chem , vol.279 , pp. 23822-23829
    • Lindquist, J.N.1    Parsons, C.J.2    Stefanovic, B.3    Brenner, D.A.4
  • 352
    • 0027331512 scopus 로고
    • 1,25-Dihydroxyvitamin D3 activates Raf kinase and Raf perinuclear translocation via a protein kinase C-dependent pathway
    • Lissoos TW, Beno DW, Davis BH. 1,25-Dihydroxyvitamin D3 activates Raf kinase and Raf perinuclear translocation via a protein kinase C-dependent pathway. J Biol Chem 268: 25132-25138, 1993.
    • (1993) J Biol Chem , vol.268 , pp. 25132-25138
    • Lissoos, T.W.1    Beno, D.W.2    Davis, B.H.3
  • 353
    • 0037837754 scopus 로고    scopus 로고
    • Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent
    • Liu C, Gaca MD, Swenson ES, Vellucci VF, Reiss M, Wells RG. Smads 2 and 3 are differentially activated by transforming growth factor-beta (TGF-beta) in quiescent and activated hepatic stellate cells. Constitutive nuclear localization of Smads in activated cells is TGF-beta-independent. J Biol Chem 278: 11721-11728, 2003.
    • (2003) J Biol Chem , vol.278 , pp. 11721-11728
    • Liu, C.1    Gaca, M.D.2    Swenson, E.S.3    Vellucci, V.F.4    Reiss, M.5    Wells, R.G.6
  • 354
    • 4444352605 scopus 로고    scopus 로고
    • Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model
    • Liu QH, Li DG, Huang X, Zong CH, Xu QF, Lu HM. Suppressive effects of 17beta-estradiol on hepatic fibrosis in CCl4-induced rat model. World J Gastroenterol 10: 1315-1320, 2004.
    • (2004) World J Gastroenterol , vol.10 , pp. 1315-1320
    • Liu, Q.H.1    Li, D.G.2    Huang, X.3    Zong, C.H.4    Xu, Q.F.5    Lu, H.M.6
  • 355
    • 33645960124 scopus 로고    scopus 로고
    • Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis
    • Liu X, Hu H, Yin JQ. Therapeutic strategies against TGF-beta signaling pathway in hepatic fibrosis. Liver Int 26: 8-22, 2006.
    • (2006) Liver Int , vol.26 , pp. 8-22
    • Liu, X.1    Hu, H.2    Yin, J.Q.3
  • 356
    • 2942704183 scopus 로고    scopus 로고
    • Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA microarray
    • Liu XJ, Yang L, Luo FM, Wu HB, Qiang Q. Association of differentially expressed genes with activation of mouse hepatic stellate cells by high-density cDNA microarray. World J Gastroenterol 10: 1600-1607, 2004.
    • (2004) World J Gastroenterol , vol.10 , pp. 1600-1607
    • Liu, X.J.1    Yang, L.2    Luo, F.M.3    Wu, H.B.4    Qiang, Q.5
  • 357
    • 33644638349 scopus 로고    scopus 로고
    • Renal fibrosis: New insights into the pathogenesis and therapeutics
    • Liu Y. Renal fibrosis: new insights into the pathogenesis and therapeutics. Kidney Int 69: 213-217, 2006.
    • (2006) Kidney Int , vol.69 , pp. 213-217
    • Liu, Y.1
  • 363
    • 7044284840 scopus 로고    scopus 로고
    • A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations
    • Magness ST, Bataller R, Yang L, Brenner DA. A dual reporter gene transgenic mouse demonstrates heterogeneity in hepatic fibrogenic cell populations. Hepatology 40: 1151-1159, 2004.
    • (2004) Hepatology , vol.40 , pp. 1151-1159
    • Magness, S.T.1    Bataller, R.2    Yang, L.3    Brenner, D.A.4
  • 364
    • 0027264871 scopus 로고
    • Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride
    • Maher JJ. Cell-specific expression of hepatocyte growth factor in liver. Upregulation in sinusoidal endothelial cells after carbon tetrachloride. J Clin Invest 91: 2244-2252, 1993.
    • (1993) J Clin Invest , vol.91 , pp. 2244-2252
    • Maher, J.J.1
  • 365
    • 0034809664 scopus 로고    scopus 로고
    • Interactions between hepatic stellate cells and the immune system
    • Maher JJ. Interactions between hepatic stellate cells and the immune system. Semin Liver Dis 21: 417-426, 2001.
    • (2001) Semin Liver Dis , vol.21 , pp. 417-426
    • Maher, J.J.1
  • 366
    • 0027537868 scopus 로고
    • Parenchymal and nonparenchymal cell interactions in the liver
    • Maher JJ, Friedman SL. Parenchymal and nonparenchymal cell interactions in the liver. Semin Liver Dis 13: 13-20, 1993.
    • (1993) Semin Liver Dis , vol.13 , pp. 13-20
    • Maher, J.J.1    Friedman, S.L.2
  • 367
    • 0023901817 scopus 로고
    • Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture
    • Maher JJ, Friedman SL, Roll FJ, Bissell DM. Immunolocalization of laminin in normal rat liver and biosynthesis of laminin by hepatic lipocytes in primary culture. Gastroenterology 94: 1053-1062, 1988.
    • (1988) Gastroenterology , vol.94 , pp. 1053-1062
    • Maher, J.J.1    Friedman, S.L.2    Roll, F.J.3    Bissell, D.M.4
  • 368
    • 0031754502 scopus 로고    scopus 로고
    • Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo
    • Maher JJ, Lozier JS, Scott MK. Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. Am J Physiol Gastrointest Liver Physiol 275: G847-G853, 1998.
    • (1998) Am J Physiol Gastrointest Liver Physiol , vol.275
    • Maher, J.J.1    Lozier, J.S.2    Scott, M.K.3
  • 369
    • 0030801348 scopus 로고    scopus 로고
    • Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis
    • Maher JJ, Neuschwander-Tetri BA. Manipulation of glutathione stores in rat hepatic stellate cells does not alter collagen synthesis. Hepatology 26: 618-623, 1997.
    • (1997) Hepatology , vol.26 , pp. 618-623
    • Maher, J.J.1    Neuschwander-Tetri, B.A.2
  • 370
    • 0030971808 scopus 로고    scopus 로고
    • Glutathione regulation in rat hepatic stellate cells Comparative studies in primary culture and in liver injury in vivo
    • Maher JJ, Saito JM, Neuschwander-Tetri BA. Glutathione regulation in rat hepatic stellate cells Comparative studies in primary culture and in liver injury in vivo. Biochem Pharmacol 53: 637-641, 1997.
    • (1997) Biochem Pharmacol , vol.53 , pp. 637-641
    • Maher, J.J.1    Saito, J.M.2    Neuschwander-Tetri, B.A.3
  • 373
    • 3142635537 scopus 로고    scopus 로고
    • Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: A cyclic adenosine monophosphate-mediated pathway Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors
    • Mallat A, Preaux AM, Serradeil-Le Gal C, Raufaste D, Gallois C, Brenner DA, Bradham C, Maclouf J, Iourgenko V, Fouassier L, Dhumeaux D, Mavier P, Lotersztajn S. Growth inhibitory properties of endothelin-1 in activated human hepatic stellate cells: a cyclic adenosine monophosphate-mediated pathway Inhibition of both extracellular signal-regulated kinase and c-Jun kinase and upregulation of endothelin B receptors. J Clin Invest 98: 2771-2778, 1996.
    • (1996) J Clin Invest , vol.98 , pp. 2771-2778
    • Mallat, A.1    Preaux, A.M.2    Serradeil-Le Gal, C.3    Raufaste, D.4    Gallois, C.5    Brenner, D.A.6    Bradham, C.7    Maclouf, J.8    Iourgenko, V.9    Fouassier, L.10    Dhumeaux, D.11    Mavier, P.12    Lotersztajn, S.13
  • 374
    • 0026785133 scopus 로고
    • Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine-induced cirrhosis. An immunohistochemical study
    • Mancini R, Jezequel AM, Benedetti A, Paolucci F, Trozzi L, Orlandi F. Quantitative analysis of proliferating sinusoidal cells in dimethylnitrosamine-induced cirrhosis. An immunohistochemical study. J Hepatol 15: 361-366, 1992.
    • (1992) J Hepatol , vol.15 , pp. 361-366
    • Mancini, R.1    Jezequel, A.M.2    Benedetti, A.3    Paolucci, F.4    Trozzi, L.5    Orlandi, F.6
  • 375
    • 0036107548 scopus 로고    scopus 로고
    • Transcriptional regulation of hepatic stellate cell activation
    • Mann DA, Smart DE. Transcriptional regulation of hepatic stellate cell activation. Gut 50: 891-896, 2002.
    • (2002) Gut , vol.50 , pp. 891-896
    • Mann, D.A.1    Smart, D.E.2
  • 376
    • 33846200332 scopus 로고    scopus 로고
    • Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: Implications for wound healing and fibrogenesis
    • Mann J, Oakley F, Akiboye F, Elsharkawy A, Thorne AW, Mann DA. Regulation of myofibroblast transdifferentiation by DNA methylation and MeCP2: implications for wound healing and fibrogenesis. Cell Death Differ 14: 275-285, 2006.
    • (2006) Cell Death Differ , vol.14 , pp. 275-285
    • Mann, J.1    Oakley, F.2    Akiboye, F.3    Elsharkawy, A.4    Thorne, A.W.5    Mann, D.A.6
  • 378
    • 33847056763 scopus 로고    scopus 로고
    • Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule
    • March S, Graupera M, Rosa Sarrias M, Lozano F, Pizcueta P, Bosch J, Engel P. Identification and functional characterization of the hepatic stellate cell CD38 cell surface molecule. Am J Pathol 170: 176-187, 2007.
    • (2007) Am J Pathol , vol.170 , pp. 176-187
    • March, S.1    Graupera, M.2    Rosa Sarrias, M.3    Lozano, F.4    Pizcueta, P.5    Bosch, J.6    Engel, P.7
  • 380
    • 0742295936 scopus 로고    scopus 로고
    • Chemokines in liver inflammation and fibrosis
    • Marra F. Chemokines in liver inflammation and fibrosis. Front Biosci 7: d1899-1914, 2002.
    • (2002) Front Biosci , vol.7
    • Marra, F.1
  • 382
    • 0028085979 scopus 로고
    • Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells
    • Marra F, Choudhury GG, Pinzani M, Abboud HE. Regulation of platelet-derived growth factor secretion and gene expression in human liver fat-storing cells. Gastroenterology 107: 1110-1117, 1994.
    • (1994) Gastroenterology , vol.107 , pp. 1110-1117
    • Marra, F.1    Choudhury, G.G.2    Pinzani, M.3    Abboud, H.E.4
  • 386
    • 0029098308 scopus 로고
    • Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: Potential role in liver injury
    • Marra F, Grandaliano G, Valente AJ, Abboud HE. Thrombin stimulates proliferation of liver fat-storing cells and expression of monocyte chemotactic protein-1: potential role in liver injury. Hepatology 22: 780-787, 1995.
    • (1995) Hepatology , vol.22 , pp. 780-787
    • Marra, F.1    Grandaliano, G.2    Valente, A.J.3    Abboud, H.E.4
  • 388
    • 0036051963 scopus 로고    scopus 로고
    • Role of hepatic stellate cells in the pathogenesis of portal hypertension
    • Marra F, Pinzani M. Role of hepatic stellate cells in the pathogenesis of portal hypertension. Nefrologia 22 Suppl 5: 34-40, 2002.
    • (2002) Nefrologia , vol.22 , Issue.SUPPL. 5 , pp. 34-40
    • Marra, F.1    Pinzani, M.2
  • 390
    • 0027360267 scopus 로고
    • Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines
    • Marra F, Valente AJ, Pinzani M, Abboud HE. Cultured human liver fat-storing cells produce monocyte chemotactic protein-1. Regulation by proinflammatory cytokines. J Clin Invest 92: 1674-1680, 1993.
    • (1993) J Clin Invest , vol.92 , pp. 1674-1680
    • Marra, F.1    Valente, A.J.2    Pinzani, M.3    Abboud, H.E.4
  • 391
    • 0029929227 scopus 로고    scopus 로고
    • Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor
    • Mars WM, Kim TH, Stolz DB, Liu ML, Michalopoulos GK. Presence of urokinase in serum-free primary rat hepatocyte cultures and its role in activating hepatocyte growth factor. Cancer Res 56: 2837-2843, 1996.
    • (1996) Cancer Res , vol.56 , pp. 2837-2843
    • Mars, W.M.1    Kim, T.H.2    Stolz, D.B.3    Liu, M.L.4    Michalopoulos, G.K.5
  • 392
    • 0026480808 scopus 로고
    • Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation
    • Marsden ER, Hu Z, Fujio K, Nakatsukasa H, Thorgeirsson SS, Evarts RP. Expression of acidic fibroblast growth factor in regenerating liver and during hepatic differentiation. Lab Invest 67: 427-433, 1992.
    • (1992) Lab Invest , vol.67 , pp. 427-433
    • Marsden, E.R.1    Hu, Z.2    Fujio, K.3    Nakatsukasa, H.4    Thorgeirsson, S.S.5    Evarts, R.P.6
  • 393
    • 0021131587 scopus 로고
    • The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver
    • Martinez-Hernandez A. The hepatic extracellular matrix. I. Electron immunohistochemical studies in normal rat liver. Lab Invest 51: 57-74, 1984.
    • (1984) Lab Invest , vol.51 , pp. 57-74
    • Martinez-Hernandez, A.1
  • 394
    • 32944468985 scopus 로고    scopus 로고
    • Goutassociated uric acid crystals activate the NALP3 inflammasome
    • Martinon F, Petrilli V, Mayor A, Tardivel A, Tschopp J. Goutassociated uric acid crystals activate the NALP3 inflammasome. Nature 440: 237-241, 2006.
    • (2006) Nature , vol.440 , pp. 237-241
    • Martinon, F.1    Petrilli, V.2    Mayor, A.3    Tardivel, A.4    Tschopp, J.5
  • 395
    • 0033583773 scopus 로고    scopus 로고
    • Inhibition of hepatic stellate cell contraction during activation in vitro by vascular endothelial growth factor in association with upregulation of FLT tyrosine kinase receptor family, FLT-1
    • Mashiba S, Mochida S, Ishikawa K, Inao M, Matsui A, Ohno A, Ikeda H, Nagoshi S, Shibuya M, Fujiwara K. Inhibition of hepatic stellate cell contraction during activation in vitro by vascular endothelial growth factor in association with upregulation of FLT tyrosine kinase receptor family, FLT-1. Biochem Biophys Res Commun 258: 674-678, 1999.
    • (1999) Biochem Biophys Res Commun , vol.258 , pp. 674-678
    • Mashiba, S.1    Mochida, S.2    Ishikawa, K.3    Inao, M.4    Matsui, A.5    Ohno, A.6    Ikeda, H.7    Nagoshi, S.8    Shibuya, M.9    Fujiwara, K.10
  • 397
    • 0028331093 scopus 로고
    • Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury
    • Mathew J, Hines JE, James OF, Burt AD. Non-parenchymal cell responses in paracetamol (acetaminophen)-induced liver injury. J Hepatol 20: 537-541, 1994.
    • (1994) J Hepatol , vol.20 , pp. 537-541
    • Mathew, J.1    Hines, J.E.2    James, O.F.3    Burt, A.D.4
  • 398
    • 0035914069 scopus 로고    scopus 로고
    • Liver organogenesis promoted by endothelial cells prior to vascular function
    • Matsumoto K, Yoshitomi H, Rossant J, Zaret KS. Liver organogenesis promoted by endothelial cells prior to vascular function. Science 294: 559-563, 2001.
    • (2001) Science , vol.294 , pp. 559-563
    • Matsumoto, K.1    Yoshitomi, H.2    Rossant, J.3    Zaret, K.S.4
  • 399
    • 0025272893 scopus 로고
    • Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: Implication for a pathogenetic role in alcoholic liver fibrogenesis
    • Matsuoka M, Tsukamoto H. Stimulation of hepatic lipocyte collagen production by Kupffer cell-derived transforming growth factor beta: implication for a pathogenetic role in alcoholic liver fibrogenesis. Hepatology 11: 599-605, 1990.
    • (1990) Hepatology , vol.11 , pp. 599-605
    • Matsuoka, M.1    Tsukamoto, H.2
  • 400
    • 0025272680 scopus 로고
    • Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: Implication in alcoholic liver fibrogenesis
    • Matsuoka M, Zhang MY, Tsukamoto H. Sensitization of hepatic lipocytes by high-fat diet to stimulatory effects of Kupffer cell-derived factors: implication in alcoholic liver fibrogenesis. Hepatology 11: 173-182, 1990.
    • (1990) Hepatology , vol.11 , pp. 173-182
    • Matsuoka, M.1    Zhang, M.Y.2    Tsukamoto, H.3
  • 402
    • 33644896789 scopus 로고    scopus 로고
    • GFAP promoter directs lacZ expression specifically in a rat hepatic stellate cell line
    • Maubach G, Lim MC, Zhang CY, Zhuo L. GFAP promoter directs lacZ expression specifically in a rat hepatic stellate cell line. World J Gastroenterol 12: 723-730, 2006.
    • (2006) World J Gastroenterol , vol.12 , pp. 723-730
    • Maubach, G.1    Lim, M.C.2    Zhang, C.Y.3    Zhuo, L.4
  • 403
    • 0036708281 scopus 로고    scopus 로고
    • Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration
    • Mazzocca A, Carloni V, Sciammetta S, Cordella C, Pantaleo P, Caldini A, Gentilini P, Pinzani M. Expression of transmembrane 4 superfamily (TM4SF) proteins and their role in hepatic stellate cell motility and wound healing migration. J Hepatol 37: 322-330, 2002.
    • (2002) J Hepatol , vol.37 , pp. 322-330
    • Mazzocca, A.1    Carloni, V.2    Sciammetta, S.3    Cordella, C.4    Pantaleo, P.5    Caldini, A.6    Gentilini, P.7    Pinzani, M.8
  • 404
    • 0015324098 scopus 로고
    • The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury
    • McGee JO, Patrick RS. The role of perisinusoidal cells in hepatic fibrogenesis. An electron microscopic study of acute carbon tetrachloride liver injury. Lab Invest 264: 429-440, 1972.
    • (1972) Lab Invest , vol.264 , pp. 429-440
    • McGee, J.O.1    Patrick, R.S.2
  • 405
    • 0035858292 scopus 로고    scopus 로고
    • Disease-induced drug targeting using novel peptide-ligand albumins
    • Meijer DK, Beljaars L, Molema G, Poelstra K. Disease-induced drug targeting using novel peptide-ligand albumins. J Control Release 72: 157-164, 2001.
    • (2001) J Control Release , vol.72 , pp. 157-164
    • Meijer, D.K.1    Beljaars, L.2    Molema, G.3    Poelstra, K.4
  • 408
    • 33644807897 scopus 로고    scopus 로고
    • i-independent contractile force generation by rat hepatic stellate cells in response to endothelin-1
    • i-independent contractile force generation by rat hepatic stellate cells in response to endothelin-1. Am J Physiol Gastrointest Liver Physiol 290: G7-G13, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Melton, A.C.1    Datta, A.2    Yee Jr, H.F.3
  • 409
    • 34250346521 scopus 로고    scopus 로고
    • Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis
    • Melton AC, Yee HF. Hepatic stellate cell protrusions couple platelet-derived growth factor-BB to chemotaxis. Hepatology. 45: 1446-1453, 2007.
    • (2007) Hepatology , vol.45 , pp. 1446-1453
    • Melton, A.C.1    Yee, H.F.2
  • 411
    • 0025072820 scopus 로고
    • Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type beta 1 and type alpha
    • Meyer DH, Bachem MG, Gressner AM. Modulation of hepatic lipocyte proteoglycan synthesis and proliferation by Kupffer cell-derived transforming growth factors type beta 1 and type alpha. Biochem Biophys Res Commun 171: 1122-1129, 1990.
    • (1990) Biochem Biophys Res Commun , vol.171 , pp. 1122-1129
    • Meyer, D.H.1    Bachem, M.G.2    Gressner, A.M.3
  • 412
    • 0026755719 scopus 로고
    • Biglycan and decorin gene expression in normal and fibrotic rat liver: Cellular localization and regulatory factors
    • Meyer DH, Krull N, Dreher KL, Gressner AM. Biglycan and decorin gene expression in normal and fibrotic rat liver: cellular localization and regulatory factors. Hepatology 16: 204-216, 1992.
    • (1992) Hepatology , vol.16 , pp. 204-216
    • Meyer, D.H.1    Krull, N.2    Dreher, K.L.3    Gressner, A.M.4
  • 414
    • 33749252188 scopus 로고    scopus 로고
    • Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion
    • Mikula M, Proell V, Fischer AN, Mikulits W. Activated hepatic stellate cells induce tumor progression of neoplastic hepatocytes in a TGF-beta dependent fashion. J Cell Physiol 209: 560-567, 2006.
    • (2006) J Cell Physiol , vol.209 , pp. 560-567
    • Mikula, M.1    Proell, V.2    Fischer, A.N.3    Mikulits, W.4
  • 416
    • 0020579923 scopus 로고
    • The role of fat-storing cells in Disse space fibrogenesis in alcoholic liver disease
    • Minato Y, Hasumura Y, Takeuchi J. The role of fat-storing cells in Disse space fibrogenesis in alcoholic liver disease. Hepatology 3: 559-566, 1983.
    • (1983) Hepatology , vol.3 , pp. 559-566
    • Minato, Y.1    Hasumura, Y.2    Takeuchi, J.3
  • 418
    • 0032404112 scopus 로고    scopus 로고
    • Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum
    • Mizobuchi Y, Shimizu I, Yasuda M, Hori H, Shono M, Ito S. Retinyl palmitate reduces hepatic fibrosis in rats induced by dimethylnitrosamine or pig serum. J Hepatol 29: 933-943, 1998.
    • (1998) J Hepatol , vol.29 , pp. 933-943
    • Mizobuchi, Y.1    Shimizu, I.2    Yasuda, M.3    Hori, H.4    Shono, M.5    Ito, S.6
  • 420
    • 0024215032 scopus 로고
    • Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets
    • Moriwaki H, Blaner WS, Piantedosi R, Goodman DS. Effects of dietary retinoid and triglyceride on the lipid composition of rat liver stellate cells and stellate cell lipid droplets. J Lipid Res 29: 1523-1534, 1988.
    • (1988) J Lipid Res , vol.29 , pp. 1523-1534
    • Moriwaki, H.1    Blaner, W.S.2    Piantedosi, R.3    Goodman, D.S.4
  • 422
    • 0027992661 scopus 로고
    • Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration
    • Mullhaupt B, Feren A, Fodor E, Jones A. Liver expression of epidermal growth factor RNA. Rapid increases in immediate-early phase of liver regeneration. J Biol Chem 269: 19667-19670, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 19667-19670
    • Mullhaupt, B.1    Feren, A.2    Fodor, E.3    Jones, A.4
  • 424
    • 0037192866 scopus 로고    scopus 로고
    • Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: Implications for reversibility of liver fibrosis
    • Murphy FR, Issa R, Zhou X, Ratnarajah S, Nagase H, Arthur MJ, Benyon C, Iredale JP. Inhibition of apoptosis of activated hepatic stellate cells by tissue inhibitor of metalloproteinase-1 is mediated via effects on matrix metalloproteinase inhibition: implications for reversibility of liver fibrosis. J Biol Chem 277: 11069-11076, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 11069-11076
    • Murphy, F.R.1    Issa, R.2    Zhou, X.3    Ratnarajah, S.4    Nagase, H.5    Arthur, M.J.6    Benyon, C.7    Iredale, J.P.8
  • 425
    • 33846146019 scopus 로고    scopus 로고
    • Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation
    • Myung SJ, Yoon JH, Gwak GY, Kim W, Yang JI, Lee SH, Jang JJ, Lee HS. Bile acid-mediated thrombospondin-1 induction in hepatocytes leads to transforming growth factor-beta-dependent hepatic stellate cell activation. Biochem Biophys Res Commun 353: 1091-1096, 2007.
    • (2007) Biochem Biophys Res Commun , vol.353 , pp. 1091-1096
    • Myung, S.J.1    Yoon, J.H.2    Gwak, G.Y.3    Kim, W.4    Yang, J.I.5    Lee, S.H.6    Jang, J.J.7    Lee, H.S.8
  • 428
    • 0004525783 scopus 로고
    • Ito's fat storing cell of the mouse liver
    • Nakane PK. Ito's fat storing cell of the mouse liver. Anat Rec 145: 265-266, 1963.
    • (1963) Anat Rec , vol.145 , pp. 265-266
    • Nakane, P.K.1
  • 430
    • 0030048097 scopus 로고    scopus 로고
    • Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver
    • Nakatani K, Seki S, Kawada N, Kobayashi K, Kaneda K. Expression of neural cell adhesion molecule (N-CAM) in perisinusoidal stellate cells of the human liver. Cell Tissue Res 283: 159-165, 1996.
    • (1996) Cell Tissue Res , vol.283 , pp. 159-165
    • Nakatani, K.1    Seki, S.2    Kawada, N.3    Kobayashi, K.4    Kaneda, K.5
  • 431
    • 33645827552 scopus 로고    scopus 로고
    • Expression of NCAM in activated portal fibroblasts during regeneration of the rat liver after partial hepatectomy
    • Nakatani K, Tanaka H, Ikeda K, Sakabe M, Kadoya H, Seki S, Kaneda K, Nakajima Y. Expression of NCAM in activated portal fibroblasts during regeneration of the rat liver after partial hepatectomy. Arch Histol Cytol 69: 61-72, 2006.
    • (2006) Arch Histol Cytol , vol.69 , pp. 61-72
    • Nakatani, K.1    Tanaka, H.2    Ikeda, K.3    Sakabe, M.4    Kadoya, H.5    Seki, S.6    Kaneda, K.7    Nakajima, Y.8
  • 436
    • 0037385387 scopus 로고    scopus 로고
    • Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with nonalcoholic steatohepatitis
    • Neuschwander-Tetri BA, Brunt EM, Wehmeier KR, Sponseller CA, Hampton K, Bacon BR. Interim results of a pilot study demonstrating the early effects of the PPAR-gamma ligand rosiglitazone on insulin sensitivity, aminotransferases, hepatic steatosis and body weight in patients with nonalcoholic steatohepatitis. J Hepatol 38: 434-440, 2003.
    • (2003) J Hepatol , vol.38 , pp. 434-440
    • Neuschwander-Tetri, B.A.1    Brunt, E.M.2    Wehmeier, K.R.3    Sponseller, C.A.4    Hampton, K.5    Bacon, B.R.6
  • 438
    • 0037155835 scopus 로고    scopus 로고
    • Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells
    • Nieto N, Friedman SL, Cederbaum AI. Cytochrome P450 2E1-derived reactive oxygen species mediate paracrine stimulation of collagen I protein synthesis by hepatic stellate cells. J Biol Chem 277: 9853-9864, 2002.
    • (2002) J Biol Chem , vol.277 , pp. 9853-9864
    • Nieto, N.1    Friedman, S.L.2    Cederbaum, A.I.3
  • 439
    • 0036139102 scopus 로고    scopus 로고
    • Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species
    • Nieto N, Friedman SL, Cederbaum AI. Stimulation and proliferation of primary rat hepatic stellate cells by cytochrome P450 2E1-derived reactive oxygen species. Hepatology 35: 62-73, 2002.
    • (2002) Hepatology , vol.35 , pp. 62-73
    • Nieto, N.1    Friedman, S.L.2    Cederbaum, A.I.3
  • 440
    • 0032835657 scopus 로고    scopus 로고
    • CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells
    • Nieto N, Friedman SL, Greenwel P, Cederbaum AI. CYP2E1-mediated oxidative stress induces collagen type I expression in rat hepatic stellate cells. Hepatology 30: 987-996, 1999.
    • (1999) Hepatology , vol.30 , pp. 987-996
    • Nieto, N.1    Friedman, S.L.2    Greenwel, P.3    Cederbaum, A.I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.