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Volumn 292, Issue 1, 2007, Pages

Disruption of transforming growth factor-β signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-γ in rat hepatic stellate cells

Author keywords

Collagen; Fibrogenesis; Phytochemicals; Signal transduction

Indexed keywords

CURCUMIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; SMAD3 PROTEIN; SMAD4 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 33846146367     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.00200.2006     Document Type: Article
Times cited : (66)

References (40)
  • 1
    • 0030775109 scopus 로고    scopus 로고
    • From receptor to nucleus: The Smad pathway
    • Baker JC, Harland RM. From receptor to nucleus: the Smad pathway. Curr Opin Genet Dev 7: 467-473, 1997.
    • (1997) Curr Opin Genet Dev , vol.7 , pp. 467-473
    • Baker, J.C.1    Harland, R.M.2
  • 2
    • 0035958441 scopus 로고    scopus 로고
    • TGFbeta1 in liver fibrosis: Time to change paradigms?
    • Bauer M, Schuppan D. TGFbeta1 in liver fibrosis: time to change paradigms? FEBS Lett 502: 1-3, 2001.
    • (2001) FEBS Lett , vol.502 , pp. 1-3
    • Bauer, M.1    Schuppan, D.2
  • 3
    • 0031939554 scopus 로고    scopus 로고
    • Hepatic fibrosis as wound repair: A progress report
    • Bissell DM. Hepatic fibrosis as wound repair: a progress report. J Gastroenterol 33: 295-302, 1998.
    • (1998) J Gastroenterol , vol.33 , pp. 295-302
    • Bissell, D.M.1
  • 4
    • 0032897278 scopus 로고    scopus 로고
    • UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells
    • Chen A, Davis BH. UV irradiation activates JNK and increases alphaI(I) collagen gene expression in rat hepatic stellate cells. J Biol Chem 274: 158-164, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 158-164
    • Chen, A.1    Davis, B.H.2
  • 5
    • 0033544896 scopus 로고    scopus 로고
    • 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent caco-2 cell differentiation
    • Chen A, Davis BH, Bissonnette M, Scaglione-Sewell B, Brasitus TA. 1,25-Dihydroxyvitamin D(3) stimulates activator protein-1-dependent caco-2 cell differentiation. J Biol Chem 274: 35505-35513, 1999.
    • (1999) J Biol Chem , vol.274 , pp. 35505-35513
    • Chen, A.1    Davis, B.H.2    Bissonnette, M.3    Scaglione-Sewell, B.4    Brasitus, T.A.5
  • 6
    • 0347297564 scopus 로고    scopus 로고
    • The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression
    • Chen A, Zhang L, Xu J, Tang J. The antioxidant (-)-epigallocatechin-3-gallate inhibits activated hepatic stellate cell growth and suppresses acetaldehyde-induced gene expression. Biochem J 368: 695-704, 2002.
    • (2002) Biochem J , vol.368 , pp. 695-704
    • Chen, A.1    Zhang, L.2    Xu, J.3    Tang, J.4
  • 7
    • 0033801316 scopus 로고    scopus 로고
    • Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats
    • Chuang SE, Cheng AL, Lin JK, Kuo ML. Inhibition by curcumin of diethylnitrosamine-induced hepatic hyperplasia, inflammation, cellular gene products and cell-cycle-related proteins in rats. Food Chem Toxicol 38: 991-995, 2000.
    • (2000) Food Chem Toxicol , vol.38 , pp. 991-995
    • Chuang, S.E.1    Cheng, A.L.2    Lin, J.K.3    Kuo, M.L.4
  • 8
    • 0030992053 scopus 로고    scopus 로고
    • Transforming growth factor-beta gene expression in normal and fibrotic rat liver
    • De Bleser PJ, Niki T, Rogiers V, Geerts A. Transforming growth factor-beta gene expression in normal and fibrotic rat liver. J Hepatol 26: 886-893, 1997.
    • (1997) J Hepatol , vol.26 , pp. 886-893
    • De Bleser, P.J.1    Niki, T.2    Rogiers, V.3    Geerts, A.4
  • 10
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler S, Itoh S, Vivien D, ten Dijke P, Huet S, Gauthier JM. Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J 17: 3091-3100, 1998.
    • (1998) EMBO J , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 12
    • 1542314236 scopus 로고    scopus 로고
    • Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element
    • Frederick JP, Liberati NT, Waddell DS, Shi Y, Wang XF. Transforming growth factor beta-mediated transcriptional repression of c-myc is dependent on direct binding of Smad3 to a novel repressive Smad binding element. Mol Cell Biol 24: 2546-2559, 2004.
    • (2004) Mol Cell Biol , vol.24 , pp. 2546-2559
    • Frederick, J.P.1    Liberati, N.T.2    Waddell, D.S.3    Shi, Y.4    Wang, X.F.5
  • 13
    • 0034723290 scopus 로고    scopus 로고
    • Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury
    • Friedman SL. Molecular regulation of hepatic fibrosis, an integrated cellular response to tissue injury. J Biol Chem 275: 2247-2250, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 2247-2250
    • Friedman, S.L.1
  • 14
    • 0028289518 scopus 로고
    • Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo
    • Friedman SL, Yamasaki G, Wong L. Modulation of transforming growth factor beta receptors of rat lipocytes during the hepatic wound healing response. Enhanced binding and reduced gene expression accompany cellular activation in culture and in vivo. J Biol Chem 269: 10551-10558, 1994.
    • (1994) J Biol Chem , vol.269 , pp. 10551-10558
    • Friedman, S.L.1    Yamasaki, G.2    Wong, L.3
  • 15
    • 0037444798 scopus 로고    scopus 로고
    • Early stimulation and late inhibition of peroxisome proliferator- activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: Role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads
    • Fu M, Zhang J, Lin Y, Zhu X, Zhao L, Ahmad M, Ehrengruber MU, Chen YE. Early stimulation and late inhibition of peroxisome proliferator- activated receptor gamma (PPAR gamma) gene expression by transforming growth factor beta in human aortic smooth muscle cells: role of early growth-response factor-1 (Egr-1), activator protein 1 (AP1) and Smads. Biochem J 370: 1019-1025, 2003.
    • (2003) Biochem J , vol.370 , pp. 1019-1025
    • Fu, M.1    Zhang, J.2    Lin, Y.3    Zhu, X.4    Zhao, L.5    Ahmad, M.6    Ehrengruber, M.U.7    Chen, Y.E.8
  • 16
    • 3042766204 scopus 로고    scopus 로고
    • Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells
    • Gaedeke J, Noble NA, Border WA. Curcumin blocks multiple sites of the TGF-beta signaling cascade in renal cells. Kidney Int 66: 112-120, 2004.
    • (2004) Kidney Int , vol.66 , pp. 112-120
    • Gaedeke, J.1    Noble, N.A.2    Border, W.A.3
  • 17
    • 0033962940 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells
    • Galli A, Crabb D, Price D, Ceni E, Salzano R, Surrenti C, Casini A. Peroxisome proliferator-activated receptor gamma transcriptional regulation is involved in platelet-derived growth factor-induced proliferation of human hepatic stellate cells. Hepatology 31: 101-108, 2000.
    • (2000) Hepatology , vol.31 , pp. 101-108
    • Galli, A.1    Crabb, D.2    Price, D.3    Ceni, E.4    Salzano, R.5    Surrenti, C.6    Casini, A.7
  • 19
    • 0033968252 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma
    • Han J, Hajjar DP, Tauras JM, Feng J, Gotto AM Jr, and Nicholson AC. Transforming growth factor-beta1 (TGF-beta1) and TGF-beta2 decrease expression of CD36, the type B scavenger receptor, through mitogen-activated protein kinase phosphorylation of peroxisome proliferator-activated receptor-gamma. J Biol Chem 275: 1241-1246, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 1241-1246
    • Han, J.1    Hajjar, D.P.2    Tauras, J.M.3    Feng, J.4    Gotto Jr, A.M.5    Nicholson, A.C.6
  • 20
    • 1642524221 scopus 로고    scopus 로고
    • PPARgamma induces a phenotypic switch from activated to quiescent hepatic stellate cells
    • Hazra S, Xiong S, Wang J, Rippe R, Chatterjee VK, Tsukamoto H. PPARgamma induces a phenotypic switch from activated to quiescent hepatic stellate cells. J Biol Chem 279: 11392-11401, 2003.
    • (2003) J Biol Chem , vol.279 , pp. 11392-11401
    • Hazra, S.1    Xiong, S.2    Wang, J.3    Rippe, R.4    Chatterjee, V.K.5    Tsukamoto, H.6
  • 21
    • 0036010783 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: A review
    • Houseknecht KL, Cole BM, Steele PJ. Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review. Domest Anim Endocrinol 22: 1-23, 2002.
    • (2002) Domest Anim Endocrinol , vol.22 , pp. 1-23
    • Houseknecht, K.L.1    Cole, B.M.2    Steele, P.J.3
  • 22
    • 0025344028 scopus 로고
    • TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence
    • Kerr LD, Miller DB, Matrisian LM. TGF-beta 1 inhibition of transin/stromelysin gene expression is mediated through a Fos binding sequence. Cell 61: 267-278, 1990.
    • (1990) Cell , vol.61 , pp. 267-278
    • Kerr, L.D.1    Miller, D.B.2    Matrisian, L.M.3
  • 24
    • 0034654497 scopus 로고    scopus 로고
    • Controlling TGF-beta signaling
    • Massague J, Chen YG. Controlling TGF-beta signaling. Genes Dev 14: 627-644, 2000.
    • (2000) Genes Dev , vol.14 , pp. 627-644
    • Massague, J.1    Chen, Y.G.2
  • 27
    • 0036281460 scopus 로고    scopus 로고
    • Effects and regulation of connective tissue growth factor on hepatic stellate cells
    • Paradis V, Dargere D, Bonvoust F, Vidaud M, Segarini P, Bedossa P. Effects and regulation of connective tissue growth factor on hepatic stellate cells. Lab Invest 82: 767-774, 2002.
    • (2002) Lab Invest , vol.82 , pp. 767-774
    • Paradis, V.1    Dargere, D.2    Bonvoust, F.3    Vidaud, M.4    Segarini, P.5    Bedossa, P.6
  • 29
    • 0033996571 scopus 로고    scopus 로고
    • Protective effect of curcumin in rat liver injury induced by carbon tetrachloride
    • Park EJ, Jeon CH, Ko G, Kim J, Sohn DH. Protective effect of curcumin in rat liver injury induced by carbon tetrachloride. J Pharm Pharmacol 52: 437-440, 2000.
    • (2000) J Pharm Pharmacol , vol.52 , pp. 437-440
    • Park, E.J.1    Jeon, C.H.2    Ko, G.3    Kim, J.4    Sohn, D.H.5
  • 32
    • 0034668118 scopus 로고    scopus 로고
    • Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: Comparison of endpoint and real-time methods
    • Schmittgen TD, Zakrajsek BA, Mills AG, Gorn V, Singer MJ, Reed MW. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal Biochem 285: 194-204, 2000.
    • (2000) Anal Biochem , vol.285 , pp. 194-204
    • Schmittgen, T.D.1    Zakrajsek, B.A.2    Mills, A.G.3    Gorn, V.4    Singer, M.J.5    Reed, M.W.6
  • 33
    • 0029118995 scopus 로고
    • Alcohol and liver fibrosis - pathobiochemistry and treatment
    • Schuppan D, Atkinson J, Ruehl M, Riecken EO. Alcohol and liver fibrosis - pathobiochemistry and treatment. Z Gastroenterol 33: 546-550, 1995.
    • (1995) Z Gastroenterol , vol.33 , pp. 546-550
    • Schuppan, D.1    Atkinson, J.2    Ruehl, M.3    Riecken, E.O.4
  • 34
    • 0032483544 scopus 로고    scopus 로고
    • Crystal structure of a Smad MH1 domain bound to DNA: Insights on DNA binding in TGF-beta signaling
    • Shi Y, Wang YF, Jayaraman L, Yang H, Massague J, Pavletich NP. Crystal structure of a Smad MH1 domain bound to DNA: insights on DNA binding in TGF-beta signaling. Cell 94: 585-594, 1998.
    • (1998) Cell , vol.94 , pp. 585-594
    • Shi, Y.1    Wang, Y.F.2    Jayaraman, L.3    Yang, H.4    Massague, J.5    Pavletich, N.P.6
  • 35
    • 24344500807 scopus 로고    scopus 로고
    • Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization
    • Uemura M, Swenson ES, Gaca MD, Giordano FJ, Reiss M, Wells RG. Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization. Mol Biol Cell 16: 4214-4224, 2005.
    • (2005) Mol Biol Cell , vol.16 , pp. 4214-4224
    • Uemura, M.1    Swenson, E.S.2    Gaca, M.D.3    Giordano, F.J.4    Reiss, M.5    Wells, R.G.6
  • 36
    • 1342268326 scopus 로고    scopus 로고
    • Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis
    • Weber AA, Neuhaus T, Skach RA, Hescheler J, Ahn HY, Schror K, Ko Y, Sachinidis A. Mechanisms of the inhibitory effects of epigallocatechin-3 gallate on platelet-derived growth factor-BB-induced cell signaling and mitogenesis. FASEB J 18: 128-130, 2004.
    • (2004) FASEB J , vol.18 , pp. 128-130
    • Weber, A.A.1    Neuhaus, T.2    Skach, R.A.3    Hescheler, J.4    Ahn, H.Y.5    Schror, K.6    Ko, Y.7    Sachinidis, A.8
  • 37
    • 0037663778 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator- activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth
    • Xu J, Fu Y, Chen A. Activation of peroxisome proliferator- activated receptor-gamma contributes to the inhibitory effects of curcumin on rat hepatic stellate cell growth. Am J Physiol Gastrointest Liver Physiol 285: G20-G30, 2003.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Xu, J.1    Fu, Y.2    Chen, A.3
  • 39
    • 9444252295 scopus 로고    scopus 로고
    • Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro
    • Zheng S, Chen A. Activation of PPARgamma is required for curcumin to induce apoptosis and to inhibit the expression of extracellular matrix genes in hepatic stellate cells in vitro. Biochem J 384: 149-157, 2004.
    • (2004) Biochem J , vol.384 , pp. 149-157
    • Zheng, S.1    Chen, A.2
  • 40
    • 33645803853 scopus 로고    scopus 로고
    • Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor
    • Zheng S, Chen A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am J Physiol Gastrointest Liver Physiol 290: G883-G893, 2006.
    • (2006) Am J Physiol Gastrointest Liver Physiol , vol.290
    • Zheng, S.1    Chen, A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.