The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARγ in rat activated hepatic stellate cell in vitro

Laboratory Investigation

Volumn 87, Issue 5, 2007, Pages 488-498

  Zhou, Yajun ^a   Zheng, Shizhong ^b   Lin, Jianguo ^b   Zhang, Qian Jin ^c   Chen, Anping ^b  

^a NANTONG UNIVERSITY   (China)

^b SAINT LOUIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOUISIANA STATE UNIVERSITY HEALTH SCIENCES CENTER   (United States)

Author keywords

Gene expression; Hepatic fibrosis; Hepatic stellate cell; Polyphenol; Signal pathways

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CURCUMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; MITOGEN ACTIVATED PROTEIN KINASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; PROTEIN KINASE B; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL ACTIVATION; CELL CYCLE ARREST; CELL GROWTH; CONTROLLED STUDY; GENE EXPRESSION; IN VITRO STUDY; LIVER CELL; MOLECULAR MECHANICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; STELLATE CELL;

ANIMALS; APOPTOSIS; CELL PROLIFERATION; CELLS, CULTURED; CURCUMIN; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EPIDERMAL GROWTH FACTOR; GENE EXPRESSION; GENE EXPRESSION REGULATION; KUPFFER CELLS; MACROPHAGE ACTIVATION; PLATELET-DERIVED GROWTH FACTOR; PPAR GAMMA; PROTEIN KINASES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 34247390710     PISSN: 00236837     EISSN: 15300307     Source Type: Journal    
DOI: 10.1038/labinvest.3700532     Document Type: Article

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