-
1
-
-
17744387125
-
Ionotropic and metabotropic glutamate receptors - structure and pharmacology
-
Kew, J.N.C.; Kemp, J.A. Ionotropic and metabotropic glutamate receptors - structure and pharmacology. Psychopharmacology, 2005, 179, 4-29.
-
(2005)
Psychopharmacology
, vol.179
, pp. 4-29
-
-
Kew, J.N.C.1
Kemp, J.A.2
-
2
-
-
30844463216
-
Glutamate- and GABA-based CNS therapeutics
-
Foster, A.C.; Kemp, J.A. Glutamate- and GABA-based CNS therapeutics. Curr. Opinion Pharmacol., 2006, 6, 7-17.
-
(2006)
Curr. Opinion Pharmacol.
, vol.6
, pp. 7-17
-
-
Foster, A.C.1
Kemp, J.A.2
-
3
-
-
33646588654
-
Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors
-
Chen, P.E.; Wyllie, D.J. Pharmacological insights obtained from structure-function studies of ionotropic glutamate receptors. Br. J. Pharmacol., 2006, 147, 839-853.
-
(2006)
Br. J. Pharmacol.
, vol.147
, pp. 839-853
-
-
Chen, P.E.1
Wyllie, D.J.2
-
4
-
-
33749441653
-
Pharmacological intervention at ionotropic glutamate receptor complexes
-
Planells-Cases, R.; Lerma, J.; Ferrer-Montiel, A. Pharmacological intervention at ionotropic glutamate receptor complexes. Curr. Pharm. Des., 2006, 12, 3583-3596.
-
(2006)
Curr. Pharm. Des.
, vol.12
, pp. 3583-3596
-
-
Planells-Cases, R.1
Lerma, J.2
Ferrer-Montiel, A.3
-
5
-
-
33747069946
-
New targets for pharmacological intervention in the glutamatergic synapse
-
Gordoni, F.; Di Luca, M. New targets for pharmacological intervention in the glutamatergic synapse. Eur. J. Pharmacol., 2006, 545, 2-10.
-
(2006)
Eur. J. Pharmacol.
, vol.545
, pp. 2-10
-
-
Gordoni, F.1
Di Luca, M.2
-
6
-
-
33847046311
-
The role of glutamate in central nervous system health and disease - a review
-
Platt, S.R. The role of glutamate in central nervous system health and disease - a review. Vet. J., 2007, 173, 278-286.
-
(2007)
Vet. J.
, vol.173
, pp. 278-286
-
-
Platt, S.R.1
-
7
-
-
48849113877
-
Ionotropic glutamate receptors & CNS disorders
-
Bowie, D. Ionotropic glutamate receptors & CNS disorders. CNS Neurol. Disord. Drug Targets, 2008, 7, 129-143.
-
(2008)
CNS Neurol. Disord. Drug Targets
, vol.7
, pp. 129-143
-
-
Bowie, D.1
-
8
-
-
75849152052
-
Glutamate receptors as therapeutic targets for Parkinson's disease
-
Johnson, K.A.; Conn, P.J.; Niswender, C.M. Glutamate receptors as therapeutic targets for Parkinson's disease. CNS Neurol. Disord. Drug Targets, 2009, 8, 475-491.
-
(2009)
CNS Neurol. Disord. Drug Targets
, vol.8
, pp. 475-491
-
-
Johnson, K.A.1
Conn, P.J.2
Niswender, C.M.3
-
9
-
-
77149138329
-
Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: Too little juice or a miswired brain?
-
Marek, G.J.; Behl, B.; Bespalov, A.Y.; Gross, G.; Lee, Y.; Schoemaker, H. Glutamatergic (N-methyl-D-aspartate receptor) hypofrontality in schizophrenia: too little juice or a miswired brain? Mol. Pharmacol., 2010, 77, 317-326.
-
(2010)
Mol. Pharmacol.
, vol.77
, pp. 317-326
-
-
Marek, G.J.1
Behl, B.2
Bespalov, A.Y.3
Gross, G.4
Lee, Y.5
Schoemaker, H.6
-
10
-
-
58049126584
-
A nomenclature for ligand-gated ion channels
-
Collingridge, G.L.; Olsen, R.W.; Peters, J.; Spedding, M. A nomenclature for ligand-gated ion channels. Neuropharmacology, 2009, 56, 2-5.
-
(2009)
Neuropharmacology
, vol.56
, pp. 2-5
-
-
Collingridge, G.L.1
Olsen, R.W.2
Peters, J.3
Spedding, M.4
-
11
-
-
35348840286
-
Ionotropic glutamate-like receptor delta2 binds D-serine and glycine
-
Naur, P.; Hansen, K.B.; Kristensen, A.S.; Dravid, S.M.; Pickering, D.S.; Olsen, L.; Vestergaard, B.; Egebjerg, J.; Gajhede, M.; Traynelis, S.F.; Kastrup, J.S. Ionotropic glutamate-like receptor delta2 binds D-serine and glycine. Proc. Natl. Acad. Sci. U. S. A., 2007, 104, 14116-14121.
-
(2007)
Proc. Natl. Acad. Sci. U. S. A.
, vol.104
, pp. 14116-14121
-
-
Naur, P.1
Hansen, K.B.2
Kristensen, A.S.3
Dravid, S.M.4
Pickering, D.S.5
Olsen, L.6
Vestergaard, B.7
Egebjerg, J.8
Gajhede, M.9
Traynelis, S.F.10
Kastrup, J.S.11
-
12
-
-
53749096977
-
To gate or not to gate: Are the delta subunits in the glutamate receptor family functional ion channels?
-
Schmid, S.M.; Hollmann, M. To gate or not to gate: are the delta subunits in the glutamate receptor family functional ion channels? Mol. Neurobiol., 2008, 37, 126-41.
-
(2008)
Mol. Neurobiol.
, vol.37
, pp. 126-141
-
-
Schmid, S.M.1
Hollmann, M.2
-
13
-
-
0035923431
-
First images of glutamate receptor ion channel: Oligomeric state and molecular dimensions of GluRB homomers
-
Safferling, M.; Tichelaar, W.; Kummerle, G.; Joupilla, A.; Kuusinen, A.; Keinänen, K.; Madden, D.R. First images of glutamate receptor ion channel: oligomeric state and molecular dimensions of GluRB homomers. Biochemistry, 2001, 40, 13948-13953.
-
(2001)
Biochemistry
, vol.40
, pp. 13948-13953
-
-
Safferling, M.1
Tichelaar, W.2
Kummerle, G.3
Joupilla, A.4
Kuusinen, A.5
Keinänen, K.6
Madden, D.R.7
-
14
-
-
7444240214
-
The three-dimensional structure of an ionotropic glutamate receptors reveals dimer of dimers assembly
-
Tichelaar, W.; Safferling, M.; Keinänen, K.; Stark, H.; Madden, D.R. The three-dimensional structure of an ionotropic glutamate receptors reveals dimer of dimers assembly. J. Mol. Biol., 2004, 344, 435-442.
-
(2004)
J. Mol. Biol.
, vol.344
, pp. 435-442
-
-
Tichelaar, W.1
Safferling, M.2
Keinänen, K.3
Stark, H.4
Madden, D.R.5
-
15
-
-
13444302564
-
Structure and different conformational states of native AMPA receptor complexes
-
Nakagawa, T.; Cheng, Y.; Ramm, E.; Sheng, M.; Walz, T. Structure and different conformational states of native AMPA receptor complexes. Nature, 2005, 433, 545-549.
-
(2005)
Nature
, vol.433
, pp. 545-549
-
-
Nakagawa, T.1
Cheng, Y.2
Ramm, E.3
Sheng, M.4
Walz, T.5
-
16
-
-
32344443866
-
Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins
-
Nakagawa, T.; Cheng, Y.; Sheng, M.; Walz, T. Three-dimensional structure of an AMPA receptor without associated stargazin/TARP proteins. Biol. Chem., 2006, 387, 179-187.
-
(2006)
Biol. Chem.
, vol.387
, pp. 179-187
-
-
Nakagawa, T.1
Cheng, Y.2
Sheng, M.3
Walz, T.4
-
17
-
-
50149084710
-
The quaternary structure of a calcium- permeable AMPA receptor: Conservation of shape and symmetry across functionally distinct subunit assemblies
-
Midgett, C.R.; Madden, D.R. The quaternary structure of a calcium- permeable AMPA receptor: conservation of shape and symmetry across functionally distinct subunit assemblies. J. Mol. Biol., 2008, 382, 578-584.
-
(2008)
J. Mol. Biol.
, vol.382
, pp. 578-584
-
-
Midgett, C.R.1
Madden, D.R.2
-
18
-
-
46849101059
-
Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor
-
Kaczor, A.; Kijkowska-Murak, U.; Matosiuk, D. Theoretical studies on the structure and symmetry of the transmembrane region of glutamatergic GluR5 receptor. J. Med. Chem., 2008, 51, 3765- 3776.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 3765-3776
-
-
Kaczor, A.1
Kijkowska-Murak, U.2
Matosiuk, D.3
-
19
-
-
66149186986
-
Modeling of glutamate GluR6 receptor and its interactions with novel non-competitive antagonists
-
Kaczor, A.; Kijkowska-Murak, U.; Kronbach, C.; Unverferth, K.; Matosiuk, D. Modeling of glutamate GluR6 receptor and its interactions with novel non-competitive antagonists. J. Chem. Inf. Model., 2009, 49, 1094-1104.
-
(2009)
J. Chem. Inf. Model.
, vol.49
, pp. 1094-1104
-
-
Kaczor, A.1
Kijkowska-Murak, U.2
Kronbach, C.3
Unverferth, K.4
Matosiuk, D.5
-
20
-
-
67649565613
-
Crystal structure and association behaviour of the GluR2 amino-terminal domain
-
Jin, R.; Singh, S.K.; Gu, S.; Furukawa, H.; Sobolevsky, A.I.; Zhou, J.; Jin, Y.; Gouaux, E. Crystal structure and association behaviour of the GluR2 amino-terminal domain. EMBO J. 2009, 28, 1812- 1823.
-
(2009)
EMBO J.
, vol.28
, pp. 1812-1823
-
-
Jin, R.1
Singh, S.K.2
Gu, S.3
Furukawa, H.4
Sobolevsky, A.I.5
Zhou, J.6
Jin, Y.7
Gouaux, E.8
-
21
-
-
70149087712
-
Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors
-
Clayton, A.; Siebold, C.; Gilbert, R.J.; Sutton, G.C.; Harlos, K.; McIlhinney, R.A.; Jones, E.Y.; Aricescu, A.R. Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors. J. Mol. Biol., 2009, 392, 1125-1132.
-
(2009)
J. Mol. Biol.
, vol.392
, pp. 1125-1132
-
-
Clayton, A.1
Siebold, C.2
Gilbert, R.J.3
Sutton, G.C.4
Harlos, K.5
McIlhinney, R.A.6
Jones, E.Y.7
Aricescu, A.R.8
-
22
-
-
67349285101
-
The N-terminal domain of GluR6-subtype glutamate receptor ion channels
-
Kumar, J.; Schuck, P.; Jin, R.; Mayer, M.L. The N-terminal domain of GluR6-subtype glutamate receptor ion channels. Nat. Struct. Mol. Biol., 2009, 16, 631-638.
-
(2009)
Nat. Struct. Mol. Biol.
, vol.16
, pp. 631-638
-
-
Kumar, J.1
Schuck, P.2
Jin, R.3
Mayer, M.L.4
-
23
-
-
72449151659
-
Structure of the zincbound amino-terminal domain of the NMDA receptor NR2B subunit
-
Karakas, E.; Simorowski, N.; Furukawa, H. Structure of the zincbound amino-terminal domain of the NMDA receptor NR2B subunit. EMBO J., 2009, 28, 3910-3920.
-
(2009)
EMBO J.
, vol.28
, pp. 3910-3920
-
-
Karakas, E.1
Simorowski, N.2
Furukawa, H.3
-
24
-
-
72049124287
-
X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor
-
Sobolevsky, A.I; Rosconi, M.P.; Gouaux, E. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature, 2009, 462, 745-758.
-
(2009)
Nature
, vol.462
, pp. 745-758
-
-
Sobolevsky, A.I.1
Rosconi, M.P.2
Gouaux, E.3
-
25
-
-
77953290924
-
AFM observation of single, functioning ionotropic glutamate receptors reconstituted in lipid bilayers
-
in press [Epub ahead of print]
-
Kasai, N.; Ramanujan, C.S.; Fujimoto, I.; Shimada, A.; Ryan, J.F.; Torimitsu, K. AFM observation of single, functioning ionotropic glutamate receptors reconstituted in lipid bilayers. Biochim. Biophys. Acta, 2010, in press [Epub ahead of print].
-
(2010)
Biochim. Biophys. Acta
-
-
Kasai, N.1
Ramanujan, C.S.2
Fujimoto, I.3
Shimada, A.4
Ryan, J.F.5
Torimitsu, K.6
-
26
-
-
33645321641
-
Glutamate receptors at atomic resolution
-
Mayer, M.L. Glutamate receptors at atomic resolution. Nature, 2006, 440, 456-462.
-
(2006)
Nature
, vol.440
, pp. 456-462
-
-
Mayer, M.L.1
-
27
-
-
34249072281
-
Structure of glutamate receptors
-
Oswald, R.E.; Ahmed, A.; Fenwick, M.K.; Loh, A.P. Structure of glutamate receptors. Curr. Drug Targets, 2007, 8, 573-582.
-
(2007)
Curr. Drug Targets
, vol.8
, pp. 573-582
-
-
Oswald, R.E.1
Ahmed, A.2
Fenwick, M.K.3
Loh, A.P.4
-
28
-
-
40549108925
-
Emerging the role of the structure of brain membrane targets recognizing glutamate
-
Simon, A.; Bencsura, A.; Palló, A.; Héja, L.; Kardos, J. Emerging the role of the structure of brain membrane targets recognizing glutamate. Curr. Drug Discov. Technol., 2008, 5, 70-74.
-
(2008)
Curr. Drug Discov. Technol.
, vol.5
, pp. 70-74
-
-
Simon, A.1
Bencsura, A.2
Palló, A.3
Héja, L.4
Kardos, J.5
-
29
-
-
0036797871
-
Ion channels: Structural bioinformatics and modelling
-
Capener, C.E.; Kim, H.J.; Arinaminpathy, Y.; Sansom, M.S.P. Ion channels: structural bioinformatics and modelling. Hum. Mol. Gen., 2002, 11, 2425-2433.
-
(2002)
Hum. Mol. Gen.
, vol.11
, pp. 2425-2433
-
-
Capener, C.E.1
Kim, H.J.2
Arinaminpathy, Y.3
Sansom, M.S.P.4
-
30
-
-
34247399105
-
Ion channels of glutamate receptors: Structural modeling
-
Tikhonov, D.B. Ion channels of glutamate receptors: structural modeling. Mol. Membr. Biol., 2007, 24, 135-147.
-
(2007)
Mol. Membr. Biol.
, vol.24
, pp. 135-147
-
-
Tikhonov, D.B.1
-
31
-
-
0029966280
-
Three-dimensional model of non-NMDA glutamate receptor
-
Sutcliffe, M.J.; Wo, Z.G.; Oswald, R.E. Three-dimensional model of non-NMDA glutamate receptor. Biophys. J., 1996, 70, 1577- 1589.
-
(1996)
Biophys. J.
, vol.70
, pp. 1577-1589
-
-
Sutcliffe, M.J.1
Wo, Z.G.2
Oswald, R.E.3
-
32
-
-
70349606510
-
Origin and molecular evolution of ionotropic glutamate receptors
-
Tikhonov, D.B.; Magazanik, L.G. Origin and molecular evolution of ionotropic glutamate receptors. Neurosci. Behav. Physiol., 2009, 39, 763-773.
-
(2009)
Neurosci. Behav. Physiol.
, vol.39
, pp. 763-773
-
-
Tikhonov, D.B.1
Magazanik, L.G.2
-
33
-
-
0033216120
-
Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6 and GluR7
-
Cui, C.; Mayer, M.L. Heteromeric kainate receptors formed by the coassembly of GluR5, GluR6 and GluR7. J. Neurosci., 1999, 19, 8281-8291.
-
(1999)
J. Neurosci.
, vol.19
, pp. 8281-8291
-
-
Cui, C.1
Mayer, M.L.2
-
34
-
-
33846920665
-
NMDA receptor subunits: Function and pharmacology
-
Paoletti, P.; Neyton, J. NMDA receptor subunits: function and pharmacology. Curr. Opin. Pharmacol., 2007, 7, 39-47.
-
(2007)
Curr. Opin. Pharmacol.
, vol.7
, pp. 39-47
-
-
Paoletti, P.1
Neyton, J.2
-
35
-
-
33748921093
-
NMDA receptor function: Subunit composition versus spatial distribution
-
Köhr, G.; NMDA receptor function: subunit composition versus spatial distribution. Cell Tissue Res., 2006, 326, 439-446.
-
(2006)
Cell Tissue Res.
, vol.326
, pp. 439-446
-
-
Köhr, G.1
-
36
-
-
34548500800
-
N-Methyl-D-aspartate (NMDA) receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor
-
Atlason, P.T.; Garside, M.L.; Meddows, E.; Whiting, P.; McIlhinney, R.A. N-Methyl-D-aspartate (NMDA) receptor subunit NR1 forms the substrate for oligomeric assembly of the NMDA receptor. J. Biol. Chem., 2007, 282, 25299-25307.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25299-25307
-
-
Atlason, P.T.1
Garside, M.L.2
Meddows, E.3
Whiting, P.4
McIlhinney, R.A.5
-
37
-
-
0032912771
-
The glutamate receptor ion channels
-
Dingledine, R.; Borges, K.; Bowie, D.; Traynelis, S.F. The glutamate receptor ion channels. Pharmacol. Rev., 1999, 51, 7-61.
-
(1999)
Pharmacol. Rev.
, vol.51
, pp. 7-61
-
-
Dingledine, R.1
Borges, K.2
Bowie, D.3
Traynelis, S.F.4
-
38
-
-
0036095463
-
Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons
-
Sasaki, Y.F.; Rothe, T.; Premkumar, L.S.; Das, S.; Cui, J.; Talantova, M.V.; Wong, H.K.; Gong, X.; Chan, S.F.; Zhang, D.; Nakanishi, N.; Sucher, N.J.; Lipton, S.A. Characterization and comparison of the NR3A subunit of the NMDA receptor in recombinant systems and primary cortical neurons. J. Neurophysiol., 2002, 87, 2052-63.
-
(2002)
J. Neurophysiol.
, vol.87
, pp. 2052-2063
-
-
Sasaki, Y.F.1
Rothe, T.2
Premkumar, L.S.3
Das, S.4
Cui, J.5
Talantova, M.V.6
Wong, H.K.7
Gong, X.8
Chan, S.F.9
Zhang, D.10
Nakanishi, N.11
Sucher, N.J.12
Lipton, S.A.13
-
39
-
-
53749093012
-
Shuffling the deck anew: How NR3 tweaks NMDA receptor function
-
Cavara, N.A.; Hollmann, M. Shuffling the deck anew: how NR3 tweaks NMDA receptor function. Mol. Neurobiol., 2008, 38, 16- 26.
-
(2008)
Mol. Neurobiol.
, vol.38
, pp. 16-26
-
-
Cavara, N.A.1
Hollmann, M.2
-
40
-
-
75749112915
-
Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex
-
Kim, K.S.; Yan, D.; Tomita, S. Assembly and stoichiometry of the AMPA receptor and transmembrane AMPA receptor regulatory protein complex. J. Neurosci., 2010, 30, 1064-1072.
-
(2010)
J. Neurosci.
, vol.30
, pp. 1064-1072
-
-
Kim, K.S.1
Yan, D.2
Tomita, S.3
-
41
-
-
0242573188
-
AMPA receptor tetramerization is mediated by Q/R editing
-
Greger, I.H.; Khatri, L.; Kong, F.; Ziff, E.B. AMPA receptor tetramerization is mediated by Q/R editing. Neuron, 2003, 40, 763- 774.
-
(2003)
Neuron
, vol.40
, pp. 763-774
-
-
Greger, I.H.1
Khatri, L.2
Kong, F.3
Ziff, E.B.4
-
42
-
-
34447648920
-
Molecular determinants of AMPA receptor subunit assembly
-
Greger, I.H.; Ziff, E.B.; Penn, A.C. Molecular determinants of AMPA receptor subunit assembly. Trends Neurosci., 2007, 30, 407-416.
-
(2007)
Trends Neurosci.
, vol.30
, pp. 407-416
-
-
Greger, I.H.1
Ziff, E.B.2
Penn, A.C.3
-
43
-
-
0033546277
-
Subtype specific assembly of alphaamino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits is mediated by their N-terminal domain
-
Leenscher, W.D.; Hoch, W. Subtype specific assembly of alphaamino- 3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor subunits is mediated by their N-terminal domain. J. Biol. Chem., 1999, 274, 16907-16916.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 16907-16916
-
-
Leenscher, W.D.1
Hoch, W.2
-
45
-
-
0030810255
-
Rat GluR7 and a carboxy-terminal splice variant GluR7b are functional kainate receptor subunits with a low sensitivity to glutamate
-
Schiffer, H.H.; Swanson, G.T.; Heinemann, S.F. Rat GluR7 and a carboxy-terminal splice variant GluR7b are functional kainate receptor subunits with a low sensitivity to glutamate. Neuron, 1997, 19, 1141-1146.
-
(1997)
Neuron
, vol.19
, pp. 1141-1146
-
-
Schiffer, H.H.1
Swanson, G.T.2
Heinemann, S.F.3
-
46
-
-
0025810536
-
Cloning of a putative high-affinity kainate receptors expressed predominantly in hipocampal CA3 cells
-
Werner, P.; Voigt, M.; Keinänen, K.; Wisden, W.; Seeburg, P.H. Cloning of a putative high-affinity kainate receptors expressed predominantly in hipocampal CA3 cells. Nature, 1991, 351, 742-744.
-
(1991)
Nature
, vol.351
, pp. 742-744
-
-
Werner, P.1
Voigt, M.2
Keinänen, K.3
Wisden, W.4
Seeburg, P.H.5
-
47
-
-
0026530085
-
The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits
-
Herb, A.; Burnasher, N.; Werner, P.; Sakman, B.; Wisden, W.; Seeburg, P.H. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron, 1992, 8, 775-85.
-
(1992)
Neuron
, vol.8
, pp. 775-785
-
-
Herb, A.1
Burnasher, N.2
Werner, P.3
Sakman, B.4
Wisden, W.5
Seeburg, P.H.6
-
48
-
-
0030900752
-
Ionotropic glutamate receptors: New types and concepts
-
Barnard, E.A. Ionotropic glutamate receptors: new types and concepts. Trends Pharmacol. Sci., 1997, 18, 141-148.
-
(1997)
Trends Pharmacol. Sci.
, vol.18
, pp. 141-148
-
-
Barnard, E.A.1
-
49
-
-
0027295942
-
The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins
-
O'Hara, P.J.; Sheppard, P.O.; Thogersen, H.; Venezia, D.; Haldeman, B.A.; McGrane, V.; Houmed, K.M.; Thomsen, C.; Gilbert, T.L.; Mulvihill, E.R. The ligand-binding domain in metabotropic glutamate receptors is related to bacterial periplasmic binding proteins. Neuron, 1993, 11, 41-52.
-
(1993)
Neuron
, vol.11
, pp. 41-52
-
-
O'Hara, P.J.1
Sheppard, P.O.2
Thogersen, H.3
Venezia, D.4
Haldeman, B.A.5
McGrane, V.6
Houmed, K.M.7
Thomsen, C.8
Gilbert, T.L.9
Mulvihill, E.R.10
-
50
-
-
0032032919
-
The macro- and microarchitectures of the ligand-binding domain of glutamate receptors
-
Paas, Y. The macro- and microarchitectures of the ligand-binding domain of glutamate receptors. Trends Neurosci., 1998, 21, 117- 125.
-
(1998)
Trends Neurosci.
, vol.21
, pp. 117-125
-
-
Paas, Y.1
-
51
-
-
0033548125
-
Domain dislocation: A change of core structure in periplasmic binding proteins in their evolutionary history
-
Fukami-Kobayaski, K.; Tateno, Y.; Nishikawa, K. Domain dislocation: a change of core structure in periplasmic binding proteins in their evolutionary history. J. Mol. Biol., 1999, 286, 279-290.
-
(1999)
J. Mol. Biol.
, vol.286
, pp. 279-290
-
-
Fukami-Kobayaski, K.1
Tateno, Y.2
Nishikawa, K.3
-
52
-
-
0037318781
-
Binding modes of noncompetitive AMPA antagonists: A computational approach
-
De Luca, L.; Macchiarulo, A.; Constantino, G.; Barreca, M.L.; Gitto, R.; Chimirri, A.; Pellicciari, R. Binding modes of noncompetitive AMPA antagonists: a computational approach. Il Farmaco, 2003, 58, 107-113.
-
(2003)
Il Farmaco
, vol.58
, pp. 107-113
-
-
De Luca, L.1
Macchiarulo, A.2
Constantino, G.3
Barreca, M.L.4
Gitto, R.5
Chimirri, A.6
Pellicciari, R.7
-
53
-
-
0024563996
-
Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine binding protein in complex with leucine
-
Sach, J.S.; Saper, M.A.; Quiocho, F.A. Periplasmic binding protein structure and function. Refined X-ray structures of the leucine/isoleucine/valine binding protein in complex with leucine. J. Mol. Biol., 1989, 206, 171-191.
-
(1989)
J. Mol. Biol.
, vol.206
, pp. 171-191
-
-
Sach, J.S.1
Saper, M.A.2
Quiocho, F.A.3
-
54
-
-
17844398488
-
Ligand-free and -bound structures of the binding protein (LIVJ) of the Escherichia coli ABC leucine/isoleucine/ valine transport system: Trajectory and dynamics of the interdomain rotation and ligand specificity
-
Trakhanov, S.D.; Vyas, N.K.; Luecke, H.; Kristensen, D.M.; Ma, J.; Quiocho, F.A. Ligand-free and -bound structures of the binding protein (LIVJ) of the Escherichia coli ABC leucine/isoleucine/ valine transport system: trajectory and dynamics of the interdomain rotation and ligand specificity. Biochemistry, 2005, 44, 6597-6608.
-
(2005)
Biochemistry
, vol.44
, pp. 6597-6608
-
-
Trakhanov, S.D.1
Vyas, N.K.2
Luecke, H.3
Kristensen, D.M.4
Ma, J.5
Quiocho, F.A.6
-
55
-
-
0034718925
-
Structural basis of glutamate recognition by a dimeric glutamate receptor
-
Kunishama, N.; Shimada, Y.; Tsuji, Y.; Sato, T.; Yamamoto, M.; Kumasaka, T.; Nakanishi, S.; Jingami, H.; Morikawa, K. Structural basis of glutamate recognition by a dimeric glutamate receptor. Nature, 2000, 407, 971-977.
-
(2000)
Nature
, vol.407
, pp. 971-977
-
-
Kunishama, N.1
Shimada, Y.2
Tsuji, Y.3
Sato, T.4
Yamamoto, M.5
Kumasaka, T.6
Nakanishi, S.7
Jingami, H.8
Morikawa, K.9
-
56
-
-
0037022586
-
3+
-
3+. Proc. Natl. Acad. Sci. U.S.A., 2002, 99, 2660-2665.
-
(2002)
Proc. Natl. Acad. Sci. U.S.A.
, vol.99
, pp. 2660-2665
-
-
Tsuchyia, D.1
Kunishima, N.2
Kamiya, N.3
Jingami, H.4
Morikawa, K.5
-
57
-
-
77955642122
-
-
Unpublished results
-
Dobrovetsky, E.; Khutoreskaya, G.; Seitova, A.; Cossar, D.; Edwards, A.M.; Arrowsmith, C.H.; Bountra, C.; Weigelt, J.; Bochkarev, A. Unpublished results.
-
-
-
Dobrovetsky, E.1
Khutoreskaya, G.2
Seitova, A.3
Cossar, D.4
Edwards, A.M.5
Arrowsmith, C.H.6
Bountra, C.7
Weigelt, J.8
Bochkarev, A.9
-
58
-
-
34247210665
-
Structures of the extracellular regions of the group II/III metabotropic glutamate receptors
-
Muto, T.; Tsuchiya, D.; Morikawa, K.; Jingami, H. Structures of the extracellular regions of the group II/III metabotropic glutamate receptors. Proc. Natl. Acad. Sci. U.S.A., 2007, 104, 3759-3764.
-
(2007)
Proc. Natl. Acad. Sci. U.S.A.
, vol.104
, pp. 3759-3764
-
-
Muto, T.1
Tsuchiya, D.2
Morikawa, K.3
Jingami, H.4
-
59
-
-
0033374623
-
The protein data bank. Bridging the gap between the sequence and 3D structure world
-
Sussman, J.L.; Abola, E.E.; Lin, D.; Jiang, J.; Manning, N.O.; Prilusky, J. The protein data bank. Bridging the gap between the sequence and 3D structure world. Genetica, 1999, 106, 149-158.
-
(1999)
Genetica
, vol.106
, pp. 149-158
-
-
Sussman, J.L.1
Abola, E.E.2
Lin, D.3
Jiang, J.4
Manning, N.O.5
Prilusky, J.6
-
60
-
-
21244435589
-
Roles of N-terminal domain on the function and quaternary structure of the ionotrpic glutamate receptor
-
Matsuda, S.; Kamiya, Y.; Yuzaki, M. Roles of N-terminal domain on the function and quaternary structure of the ionotrpic glutamate receptor. J. Biol. Chem., 2005, 280, 20021-20029.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20021-20029
-
-
Matsuda, S.1
Kamiya, Y.2
Yuzaki, M.3
-
61
-
-
49649122326
-
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding
-
Marinelli, L.; Cosconati, S.; Steinbrecher, T.; Limongelli, V.; Bertamino, V.; Novellino, E.; Case, D.A. Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding. ChemMedChem, 2007, 2, 1498-1510.
-
(2007)
ChemMedChem
, vol.2
, pp. 1498-1510
-
-
Marinelli, L.1
Cosconati, S.2
Steinbrecher, T.3
Limongelli, V.4
Bertamino, V.5
Novellino, E.6
Case, D.A.7
-
62
-
-
0035377311
-
Identification of molecular determinants that are important in the assembly of Nmethyl- D-aspartate receptors
-
Meddows, E.; Le Bourdelles, B.; Grimwood, S.; Wafford, K.; Sandhu, S.; Whiting, P.; McIlhinney, R.A. Identification of molecular determinants that are important in the assembly of Nmethyl- D-aspartate receptors. J. Biol. Chem., 2001, 276, 18795- 18803.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 18795-18803
-
-
Meddows, E.1
Le Bourdelles, B.2
Grimwood, S.3
Wafford, K.4
Sandhu, S.5
Whiting, P.6
McIlhinney, R.A.7
-
63
-
-
2442488034
-
Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors
-
Papadakis, M.; Hawkins, L.M.; Stephenson, F.A. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors. J. Biol. Chem., 2004, 279, 14703-14712.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14703-14712
-
-
Papadakis, M.1
Hawkins, L.M.2
Stephenson, F.A.3
-
64
-
-
17644417156
-
Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subunit-specific receptor assembly
-
Ayalon, G.; Segev, E.; Elgavish, S.; Stern-Bach, Y. Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subunit-specific receptor assembly. J. Biol. Chem., 2005, 280, 15053-15060.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15053-15060
-
-
Ayalon, G.1
Segev, E.2
Elgavish, S.3
Stern-Bach, Y.4
-
65
-
-
21644449030
-
Subunit assembly of N-methyl-D-aspartate receptors analyzed by fluorescence resonance energy transfer
-
Qiu, S.; Hua, Y.; Yang, F.; Chen, Y.; Luo, J. Subunit assembly of N-methyl-D-aspartate receptors analyzed by fluorescence resonance energy transfer. J. Biol. Chem., 2005, 280, 24923-24930.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24923-24930
-
-
Qiu, S.1
Hua, Y.2
Yang, F.3
Chen, Y.4
Luo, J.5
-
66
-
-
0034867583
-
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A
-
Zheng, F.; Erreger, K.; Low, C.M.; Banke, T.; Lee, C.J.; Conn, P.J.; Traynelis, S.F. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat. Neurosci., 2001, 4, 894-901.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 894-901
-
-
Zheng, F.1
Erreger, K.2
Low, C.M.3
Banke, T.4
Lee, C.J.5
Conn, P.J.6
Traynelis, S.F.7
-
67
-
-
12844268621
-
The function of the amino-terminal domain in NMDA receptor modulation,
-
Huggins, D.J.; Grant, G.H. The function of the amino-terminal domain in NMDA receptor modulation, J. Mol. Graph. Model., 2005, 23, 381-388.
-
(2005)
J. Mol. Graph. Model.
, vol.23
, pp. 381-388
-
-
Huggins, D.J.1
Grant, G.H.2
-
68
-
-
70349618426
-
Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies
-
Ng, F.M.; Geballe, M.T.; Snyder, J.P.; Traynelis, S.F.; Low, C.M. Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Mol. Brain, 2008, 1, 16-26.
-
(2008)
Mol. Brain
, vol.1
, pp. 16-26
-
-
Ng, F.M.1
Geballe, M.T.2
Snyder, J.P.3
Traynelis, S.F.4
Low, C.M.5
-
69
-
-
2442488034
-
Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors
-
Papadakis, M.; Hawkins, L.M.; Stephenson, F.A. Appropriate NR1-NR1 disulfide-linked homodimer formation is requisite for efficient expression of functional, cell surface N-methyl-D-aspartate NR1/NR2 receptors. J. Biol. Chem., 2004, 279, 14703-14712.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14703-14712
-
-
Papadakis, M.1
Hawkins, L.M.2
Stephenson, F.A.3
-
70
-
-
70350324907
-
Allosteric modulators of NR2B-containing NMDA receptors: Molecular mechanisms and therapeutic potential
-
Mony, L.; Kew, J.N.C.; Gunthorpe, M.J.; Paoletti, P. Allosteric modulators of NR2B-containing NMDA receptors: molecular mechanisms and therapeutic potential. Br. J. Pharmacol., 2009, 157, 1301-1317.
-
(2009)
Br. J. Pharmacol.
, vol.157
, pp. 1301-1317
-
-
Mony, L.1
Kew, J.N.C.2
Gunthorpe, M.J.3
Paoletti, P.4
-
71
-
-
58849138886
-
Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors
-
Mony, L.; Krzaczkowski, L.; Leonetti, M.; Goff, A.L.; Alarcon, K.; Neyton, J.; Bertrand, H.O.; Acher, F.; Paoletti, P. Structural basis of NR2B-selective antagonist recognition by N-methyl-D-aspartate receptors. Mol. Pharmacol., 2009, 75, 60-74.
-
(2009)
Mol. Pharmacol.
, vol.75
, pp. 60-74
-
-
Mony, L.1
Krzaczkowski, L.2
Leonetti, M.3
Goff, A.L.4
Alarcon, K.5
Neyton, J.6
Bertrand, H.O.7
Acher, F.8
Paoletti, P.9
-
72
-
-
0028964302
-
The importance of the two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6
-
Tygesen, C.K.; Jorgensen, M.; Andersen, P.M. The importance of the two specific domains in ligand binding to the AMPA/kainate glutamate receptors GluR2 and GluR6. FEBS Lett., 1995, 363, 184- 188.
-
(1995)
FEBS Lett.
, vol.363
, pp. 184-188
-
-
Tygesen, C.K.1
Jorgensen, M.2
Andersen, P.M.3
-
73
-
-
4644230563
-
Amino terminal domain regulation of NMDA receptor function
-
Herin, G.A.; Aizenman, E. Amino terminal domain regulation of NMDA receptor function. Eur. J. Pharmacol., 2004, 500, 101-111.
-
(2004)
Eur. J. Pharmacol.
, vol.500
, pp. 101-111
-
-
Herin, G.A.1
Aizenman, E.2
-
74
-
-
0034517709
-
Molecular organization of a zinc-binding Nterminal modulatory domain in a NMDA receptor subunit
-
Paoletti, P.; Perin-Dureau, F.; Fayyazuddin, A.; Le Goff, A.; Callebaut, I.; Neyton, J. Molecular organization of a zinc-binding Nterminal modulatory domain in a NMDA receptor subunit. Neuron, 2000, 28, 911-925.
-
(2000)
Neuron
, vol.28
, pp. 911-925
-
-
Paoletti, P.1
Perin-Dureau, F.2
Fayyazuddin, A.3
Le Goff, A.4
Callebaut, I.5
Neyton, J.6
-
75
-
-
12144257176
-
The micromolar zinc-binding domain on the NMDA receptor subunit NR2B
-
Rachline, J.; Perin-Dureau, F.; Le Goff, A.; Neyton, J.; Paoletti, P. The micromolar zinc-binding domain on the NMDA receptor subunit NR2B. J. Neurosci., 2005, 25, 308-317.
-
(2005)
J. Neurosci.
, vol.25
, pp. 308-317
-
-
Rachline, J.1
Perin-Dureau, F.2
Le Goff, A.3
Neyton, J.4
Paoletti, P.5
-
76
-
-
0037101607
-
Mapping the binding site of the neuroprotective ifenprodil on NMDA receptors
-
Perin-Dureau, F.; Rachline, J.; Neyton, J.; Paoletti, P. Mapping the binding site of the neuroprotective ifenprodil on NMDA receptors. J. Neurosci., 2002, 22, 5955-5965.
-
(2002)
J. Neurosci.
, vol.22
, pp. 5955-5965
-
-
Perin-Dureau, F.1
Rachline, J.2
Neyton, J.3
Paoletti, P.4
-
77
-
-
0344304828
-
Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket
-
Malherbe, P.; Mutel, V.; Broger, C.; Perin-Dureau, F.; Kemp, J.A.; Neyton, J.; Paoletti, P.; Kew, J.N. Identification of critical residues in the amino terminal domain of the human NR2B subunit involved in the RO 25-6981 binding pocket. J. Pharmacol. Exp. Ther., 2003, 307, 897-905.
-
(2003)
J. Pharmacol. Exp. Ther.
, vol.307
, pp. 897-905
-
-
Malherbe, P.1
Mutel, V.2
Broger, C.3
Perin-Dureau, F.4
Kemp, J.A.5
Neyton, J.6
Paoletti, P.7
Kew, J.N.8
-
78
-
-
70349618426
-
Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies
-
Ng, F.M.; Geballe, M.T.; Snyder, J.P.; Traynelis, S.F.; Low, C.M. Structural insights into phenylethanolamines high-affinity binding site in NR2B from binding and molecular modeling studies. Mol. Brain, 2008, 1, 16-26.
-
(2008)
Mol. Brain
, vol.1
, pp. 16-26
-
-
Ng, F.M.1
Geballe, M.T.2
Snyder, J.P.3
Traynelis, S.F.4
Low, C.M.5
-
79
-
-
0029021010
-
Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines
-
Traynelis, S.F.; Hartley, M.; Heinemann, S.F. Control of proton sensitivity of the NMDA receptor by RNA splicing and polyamines. Science, 1995, 268, 873-876.
-
(1995)
Science
, vol.268
, pp. 873-876
-
-
Traynelis, S.F.1
Hartley, M.2
Heinemann, S.F.3
-
80
-
-
0037686667
-
Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating
-
Low, C.M.; Lyuboslavsky, P.; French, A.; Le, P.; Wyatte, K.; Thiel, W.H.; Marchan, E.M.; Igarashi, K.; Kashiwagi, K.; Gernert, K.; Williams, K.; Traynelis, S.F.; Zheng, F. Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol. Pharmacol., 2003, 63, 1212-1222.
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 1212-1222
-
-
Low, C.M.1
Lyuboslavsky, P.2
French, A.3
Le, P.4
Wyatte, K.5
Thiel, W.H.6
Marchan, E.M.7
Igarashi, K.8
Kashiwagi, K.9
Gernert, K.10
Williams, K.11
Traynelis, S.F.12
Zheng, F.13
-
81
-
-
77955624035
-
A regulatory domain (R1- R2) in the amino terminus of the N-methyl-D-aspartate receptor: Effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein
-
Masuko, T.; Kashiwagi, K.; Kuno, T.; Nguyen, N.D.; Pahk, A.J.; Fukuchi, J.; Igarashi, K.; Williams, K. A regulatory domain (R1- R2) in the amino terminus of the N-methyl-D-aspartate receptor: effects of spermine, protons, and ifenprodil, and structural similarity to bacterial leucine/isoleucine/valine binding protein. Mol. Pharmacol., 1995, 55, 557-569.
-
(1995)
Mol. Pharmacol.
, vol.55
, pp. 557-569
-
-
Masuko, T.1
Kashiwagi, K.2
Kuno, T.3
Nguyen, N.D.4
Pahk, A.J.5
Fukuchi, J.6
Igarashi, K.7
Williams, K.8
-
82
-
-
17444426068
-
Modulation of triheteromeric NMDA receptors by N-terminal domain ligands
-
Hatton, C.J.; Paoletti, P. Modulation of triheteromeric NMDA receptors by N-terminal domain ligands. Neuron, 2005, 46, 261- 274.
-
(2005)
Neuron
, vol.46
, pp. 261-274
-
-
Hatton, C.J.1
Paoletti, P.2
-
83
-
-
36348946416
-
The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors
-
Madry, C.; Mesic, I.; Betz, H.; Laube, B. The N-terminal domains of both NR1 and NR2 subunits determine allosteric Zn2+ inhibition and glycine affinity of N-methyl-D-aspartate receptors. Mol. Pharmacol., 2007, 72, 1535-1544.
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 1535-1544
-
-
Madry, C.1
Mesic, I.2
Betz, H.3
Laube, B.4
-
84
-
-
49649122326
-
Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding
-
Marinelli, L.; Cosconati, S.; Steinbrecher, T.; Limongelli, V.; Bertamino, V.; Novellino, E.; Case, D.A. Homology modeling of NR2B modulatory domain of NMDA receptor and analysis of ifenprodil binding. ChemMedChem, 2007, 2, 1498-1510.
-
(2007)
ChemMedChem
, vol.2
, pp. 1498-1510
-
-
Marinelli, L.1
Cosconati, S.2
Steinbrecher, T.3
Limongelli, V.4
Bertamino, V.5
Novellino, E.6
Case, D.A.7
-
85
-
-
37549045649
-
Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition
-
Gielen, M.; Le Goff, A.; Stroebel, D.; Johnson, J.W.; Neyton, J.; Paoletti, P. Structural rearrangements of NR1/NR2A NMDA receptors during allosteric inhibition. Neuron, 2008, 57, 80-93.
-
(2008)
Neuron
, vol.57
, pp. 80-93
-
-
Gielen, M.1
Le Goff, A.2
Stroebel, D.3
Johnson, J.W.4
Neyton, J.5
Paoletti, P.6
-
86
-
-
26944451291
-
Molecular mechanism of AMPA receptor noncompetitive antagonism
-
Balannik, V.; Menniti, F.S.; Paternain, A.V.; Lerma, J.; Stern-Bach, Y. Molecular mechanism of AMPA receptor noncompetitive antagonism. Neuron, 2005, 48, 279-288.
-
(2005)
Neuron
, vol.48
, pp. 279-288
-
-
Balannik, V.1
Menniti, F.S.2
Paternain, A.V.3
Lerma, J.4
Stern-Bach, Y.5
-
87
-
-
0033669537
-
Modulation of α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid receptor desensitization by extracellular protons
-
Ihle, E.C.; Patneau, D.K. Modulation of α-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid receptor desensitization by extracellular protons. Mol. Pharmacol., 2000, 58, 1204-1212.
-
(2000)
Mol. Pharmacol.
, vol.58
, pp. 1204-1212
-
-
Ihle, E.C.1
Patneau, D.K.2
-
88
-
-
0034884750
-
Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions
-
Ayalon, G.; Stern-Bach, Y. Functional assembly of AMPA and kainate receptors is mediated by several discrete protein-protein interactions. Neuron, 2001, 31, 103-113.
-
(2001)
Neuron
, vol.31
, pp. 103-113
-
-
Ayalon, G.1
Stern-Bach, Y.2
-
89
-
-
0035819074
-
Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement
-
Mansour, M.; Nagarajan, N.; Nehring, R.B.; Clements, J.D.; Rosenmund, C. Heteromeric AMPA receptors assemble with a preferred subunit stoichiometry and spatial arrangement. Neuron, 2001, 32, 841-853.
-
(2001)
Neuron
, vol.32
, pp. 841-853
-
-
Mansour, M.1
Nagarajan, N.2
Nehring, R.B.3
Clements, J.D.4
Rosenmund, C.5
-
90
-
-
0032878510
-
Oligomerization and ligand-binding properties of the ectodomain of the alpha- amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluRD
-
Kuusinen, A.; Abele, R.; Madden, D.R.; Keinänen, K. Oligomerization and ligand-binding properties of the ectodomain of the alpha- amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunit GluRD. J. Biol. Chem., 1999, 274, 28937-28943.
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 28937-28943
-
-
Kuusinen, A.1
Abele, R.2
Madden, D.R.3
Keinänen, K.4
-
91
-
-
0036483593
-
The structure and function of glutamate receptor ion channels
-
Madden, D.R. The structure and function of glutamate receptor ion channels. Nat. Rev. Neurosci., 2002, 3, 91-101.
-
(2002)
Nat. Rev. Neurosci.
, vol.3
, pp. 91-101
-
-
Madden, D.R.1
-
92
-
-
17644417156
-
Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subunit-specific receptor assembly
-
Ayalon, G.; Segev, E.; Elgavish, S.; Stern-Bach, Y. Two regions in the N-terminal domain of ionotropic glutamate receptor 3 form the subunit oligomerization interfaces that control subunit-specific receptor assembly. J. Biol. Chem., 2005, 280, 15053-15060.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 15053-15060
-
-
Ayalon, G.1
Segev, E.2
Elgavish, S.3
Stern-Bach, Y.4
-
93
-
-
21244435589
-
Roles of N-terminal domain on the function and quaternary structure of the ionotrpic glutamate receptor
-
Matsuda, S.; Kamiya, Y.; Yuzaki, M. Roles of N-terminal domain on the function and quaternary structure of the ionotrpic glutamate receptor. J. Biol. Chem., 2005, 280, 20021-20029.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 20021-20029
-
-
Matsuda, S.1
Kamiya, Y.2
Yuzaki, M.3
-
94
-
-
56349150863
-
The amino-terminal domain of glutamate receptor delta2 triggers presynaptic differentiation
-
Uemura, T.; Mishina, M. The amino-terminal domain of glutamate receptor delta2 triggers presynaptic differentiation. Biochem. Biophys. Res. Commun., 2008, 377, 1315-1319.
-
(2008)
Biochem. Biophys. Res. Commun.
, vol.377
, pp. 1315-1319
-
-
Uemura, T.1
Mishina, M.2
-
95
-
-
21644449030
-
Subunit assembly of N-methyl-D-aspartate receptors analyzed by fluorescence resonance energy transfer
-
Qiu, S.; Hua, Y.; Yang, F.; Chen, Y.; Luo, J. Subunit assembly of N-methyl-D-aspartate receptors analyzed by fluorescence resonance energy transfer. J. Biol. Chem., 2005, 280, 24923-30.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 24923-24930
-
-
Qiu, S.1
Hua, Y.2
Yang, F.3
Chen, Y.4
Luo, J.5
-
96
-
-
0034867583
-
Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A
-
Zheng, F.; Erreger, K.; Low, C.M.; Banke, T.; Lee, C.J.; Conn, P.J.; Traynelis, S.F. Allosteric interaction between the amino terminal domain and the ligand binding domain of NR2A. Nat. Neurosci., 2001, 4, 894-901.
-
(2001)
Nat. Neurosci.
, vol.4
, pp. 894-901
-
-
Zheng, F.1
Erreger, K.2
Low, C.M.3
Banke, T.4
Lee, C.J.5
Conn, P.J.6
Traynelis, S.F.7
-
97
-
-
4444266942
-
Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding to N-terminal domains
-
Tikhonova, I.G.; Baskin, I.I.; Palyulin, V.A.; Zefirov, N.S. Molecular modeling of N-terminal domains of NMDA-receptor. Study of ligand binding to N-terminal domains. Dokl. Biochem. Biophys., 2004, 397, 242-250.
-
(2004)
Dokl. Biochem. Biophys.
, vol.397
, pp. 242-250
-
-
Tikhonova, I.G.1
Baskin, I.I.2
Palyulin, V.A.3
Zefirov, N.S.4
-
98
-
-
0442279279
-
Structure and function of AMPA receptors
-
Goaux E. Structure and function of AMPA receptors. J. Physiol., 2004, 554, 249-253.
-
(2004)
J. Physiol.
, vol.554
, pp. 249-253
-
-
Goaux, E.1
-
99
-
-
2342462388
-
Structure and function of glutamate receptor ion channels
-
Mayer, M.L.; Armstrong, N. Structure and function of glutamate receptor ion channels. Annu. Rev. Physiol., 2004, 66, 161-181.
-
(2004)
Annu. Rev. Physiol.
, vol.66
, pp. 161-181
-
-
Mayer, M.L.1
Armstrong, N.2
-
100
-
-
20444429431
-
Glutamate receptor ion channels
-
Mayer, M.L. Glutamate receptor ion channels. Curr. Opin. Neurobiol., 2005, 15, 282-288.
-
(2005)
Curr. Opin. Neurobiol.
, vol.15
, pp. 282-288
-
-
Mayer, M.L.1
-
101
-
-
33646588654
-
Pharmacological insight obtained from structure-function studies of ionotropic glutamate receptors
-
Chen, P.E.; Wyllie, D.J.A. Pharmacological insight obtained from structure-function studies of ionotropic glutamate receptors. British J. Pharmacol., 2006, 147, 839-853.
-
(2006)
British J. Pharmacol.
, vol.147
, pp. 839-853
-
-
Chen, P.E.1
Wyllie, D.J.A.2
-
102
-
-
0028559605
-
Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins
-
Stern-Bach, Y.; Bettler, B.; Hartley, M.; Sheppard, P.O.; O'Hara, P.J.; Heinemann, S.F. Agonist selectivity of glutamate receptors is specified by two domains structurally related to bacterial amino acid-binding proteins. Neuron, 1994, 13, 1345-1357.
-
(1994)
Neuron
, vol.13
, pp. 1345-1357
-
-
Stern-Bach, Y.1
Bettler, B.2
Hartley, M.3
Sheppard, P.O.4
O'Hara, P.J.5
Heinemann, S.F.6
-
103
-
-
17144450204
-
Identification of the amino acid subsets accounting for the ligand binding specificity of a glutamate receptor
-
Paas, Y.; Eisenstein, M.; Medevielle, F.; Teichberg, V.I.; Devillers-Thiéry, A. Identification of the amino acid subsets accounting for the ligand binding specificity of a glutamate receptor. Neuron, 1996, 17, 979-990.
-
(1996)
Neuron
, vol.17
, pp. 979-990
-
-
Paas, Y.1
Eisenstein, M.2
Medevielle, F.3
Teichberg, V.I.4
Devillers-Thiéry, A.5
-
104
-
-
0030991790
-
Molecular determinants of agonist discrimination by NMDA receptor subunits: Analysis of the glutamate binding site on the NR2B subunit
-
Laube, B.; Hirai, H.; Sturgess, M.; Betz, H.; Kuhse, J. Molecular determinants of agonist discrimination by NMDA receptor subunits: analysis of the glutamate binding site on the NR2B subunit. Neuron, 1997, 18, 493-503.
-
(1997)
Neuron
, vol.18
, pp. 493-503
-
-
Laube, B.1
Hirai, H.2
Sturgess, M.3
Betz, H.4
Kuhse, J.5
-
105
-
-
0030777076
-
Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors
-
Swanson, G.T.; Gereau, R.W.; Green, T.; Heinemann, S.F. Identification of amino acid residues that control functional behavior in GluR5 and GluR6 kainate receptors. Neuron, 1997, 19, 913-926.
-
(1997)
Neuron
, vol.19
, pp. 913-926
-
-
Swanson, G.T.1
Gereau, R.W.2
Green, T.3
Heinemann, S.F.4
-
106
-
-
0032541434
-
AMPA receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism of ligand recognition
-
Lampinen, M.; Pentikäinen, O.; Johnson, M.S.; Keinänen, K. AMPA receptors and bacterial periplasmic amino acid-binding proteins share the ionic mechanism of ligand recognition. EMBO J., 1998, 17, 4704-4711.
-
(1998)
EMBO J.
, vol.17
, pp. 4704-4711
-
-
Lampinen, M.1
Pentikäinen, O.2
Johnson, M.S.3
Keinänen, K.4
-
107
-
-
0032191104
-
A point mutation in the glutamate binding site blocks desensitization of AMPA receptors
-
Stern-Bach, Y.; Russo, S.; Neuman, M.; Rosenmund, C. A point mutation in the glutamate binding site blocks desensitization of AMPA receptors. Neuron, 1998, 21, 907-918.
-
(1998)
Neuron
, vol.21
, pp. 907-918
-
-
Stern-Bach, Y.1
Russo, S.2
Neuman, M.3
Rosenmund, C.4
-
108
-
-
0032313488
-
Molecular modeling of ligand-gated ion channels
-
Sutcliffe, M.J.; Smeeton, A.H.; Wo, Z.G.; Oswald, R.E. Molecular modeling of ligand-gated ion channels. Methods Enzymol., 1998, 293, 589-620.
-
(1998)
Methods Enzymol.
, vol.293
, pp. 589-620
-
-
Sutcliffe, M.J.1
Smeeton, A.H.2
Wo, Z.G.3
Oswald, R.E.4
-
109
-
-
0002449713
-
How well can molecular modelling predict the crystal structure: The ligand-binding of glutamate receptors
-
Paas, Y.; Devillers-Thiéry, A.; Teichberg, V.I.; Changeux, J.-P.; Eisenstein, M. How well can molecular modelling predict the crystal structure: the ligand-binding of glutamate receptors. Trends Pharm. Sci., 2000, 21, 87-92.
-
(2000)
Trends Pharm. Sci.
, vol.21
, pp. 87-92
-
-
Paas, Y.1
Devillers-Thiéry, A.2
Teichberg, V.I.3
Changeux, J.-P.4
Eisenstein, M.5
-
110
-
-
20444408992
-
Mechanism of partial agonist action at the NR1 subunit of NMDA receptors
-
Inanobe, A.; Furukawa, H.; Gouaux, E. Mechanism of partial agonist action at the NR1 subunit of NMDA receptors. Neuron, 2005, 47, 71-84.
-
(2005)
Neuron
, vol.47
, pp. 71-84
-
-
Inanobe, A.1
Furukawa, H.2
Gouaux, E.3
-
111
-
-
27744500994
-
Subunit arrangement and function in NMDA receptors
-
Furukawa, H.; Singh, S.K.; Mancusso, R.; Gouaux, E. Subunit arrangement and function in NMDA receptors. Nature, 2005, 438, 185-192.
-
(2005)
Nature
, vol.438
, pp. 185-192
-
-
Furukawa, H.1
Singh, S.K.2
Mancusso, R.3
Gouaux, E.4
-
112
-
-
49149095000
-
Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors
-
Yao, Y.; Harrison, C.B.; Freddolino, P.L.; Schulten, K.; Mayer, M.L. Molecular mechanism of ligand recognition by NR3 subtype glutamate receptors. EMBO J., 2008, 27, 2158-2170.
-
(2008)
EMBO J.
, vol.27
, pp. 2158-2170
-
-
Yao, Y.1
Harrison, C.B.2
Freddolino, P.L.3
Schulten, K.4
Mayer, M.L.5
-
113
-
-
0037468424
-
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: Implications for receptor subunit selectivity
-
Lum, M.-L.; Hogner, A.; Stensbol, T.B.; Gouaux, E.; Egebjerg, J.; Kastrop, J.S. Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity. J. Med. Chem., 2003, 46, 872-875.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 872-875
-
-
Lum, M.-L.1
Hogner, A.2
Stensbol, T.B.3
Gouaux, E.4
Egebjerg, J.5
Kastrop, J.S.6
-
114
-
-
24744467813
-
Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
-
Holm, M.M.; Lum, M.L.; Traynelis, S.F.; Kastrup, J.S.; Egebjerg, J. Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2. Proc. Natl. Acad. Sci. U. S. A., 2005, 102, 12053-12058.
-
(2005)
Proc. Natl. Acad. Sci. U. S. A.
, vol.102
, pp. 12053-12058
-
-
Holm, M.M.1
Lum, M.L.2
Traynelis, S.F.3
Kastrup, J.S.4
Egebjerg, J.5
-
115
-
-
0037448433
-
Competitive antagonism of AMPA receptors by ligands of different classes: Crystal structure of ATPO bound to the GluR2 binding core, in comparison with DNQX
-
Hogner, A.; Greenwood, J.R.; Liljefors, T.; Lum, M.L.; Egebjerg, J.; Larsen, I.K.; Gouaux, E.; Kastrup, J.S. Competitive antagonism of AMPA receptors by ligands of different classes: crystal structure of ATPO bound to the GluR2 binding core, in comparison with DNQX. J. Med. Chem., 2003, 46, 214-221.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 214-221
-
-
Hogner, A.1
Greenwood, J.R.2
Liljefors, T.3
Lum, M.L.4
Egebjerg, J.5
Larsen, I.K.6
Gouaux, E.7
Kastrup, J.S.8
-
116
-
-
0038625032
-
Tuning activation of the AMPA sensitive GluR2 ion channel by genetic adjustment of agonist- induced conformational changes
-
Armstrong, N.; Mayer, M.; Gouaux, E. Tuning activation of the AMPA sensitive GluR2 ion channel by genetic adjustment of agonist- induced conformational changes. Proc. Natl. Acad. Sci. U.S.A., 2003, 100, 5736-5741.
-
(2003)
Proc. Natl. Acad. Sci. U.S.A.
, vol.100
, pp. 5736-5741
-
-
Armstrong, N.1
Mayer, M.2
Gouaux, E.3
-
117
-
-
0033636314
-
Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: Crystal structures of the GluR2 ligand binding core
-
Armstrong, N.; Gouaux, E. Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core. Neuron, 2000, 28, 165-181.
-
(2000)
Neuron
, vol.28
, pp. 165-181
-
-
Armstrong, N.1
Gouaux, E.2
-
118
-
-
0036968894
-
Structural basis for AMPA receptor activation and ligand selectivity: Crystal structures of five agonist complexes with the GluR2 ligand-binding core
-
Hogner, A.; Kastrup, J.S.; Jin, R.; Liljefors, T.; Mayer, M.L.; Egebjerg, J.; Larsen, I.K.; Gouaux, E. Structural basis for AMPA receptor activation and ligand selectivity: crystal structures of five agonist complexes with the GluR2 ligand-binding core. J. Mol. Biol., 2002, 322, 93-109.
-
(2002)
J. Mol. Biol.
, vol.322
, pp. 93-109
-
-
Hogner, A.1
Kastrup, J.S.2
Jin, R.3
Liljefors, T.4
Mayer, M.L.5
Egebjerg, J.6
Larsen, I.K.7
Gouaux, E.8
-
119
-
-
0037032411
-
GluR2 ligand-binding core complexes: Importance of isooxazol moiety and 5-substituent for the binding mode of AMPA-type agonists
-
Kasper, C.; Lum, M.-L.; Liljefors, T.; Gouaux, E.; Egebjerg, J.; Kastrup, J.S. GluR2 ligand-binding core complexes: importance of isooxazol moiety and 5-substituent for the binding mode of AMPA-type agonists. FEBS Lett., 2002, 531, 173-178.
-
(2002)
FEBS Lett.
, vol.531
, pp. 173-178
-
-
Kasper, C.1
Lum, M.-L.2
Liljefors, T.3
Gouaux, E.4
Egebjerg, J.5
Kastrup, J.S.6
-
120
-
-
34249018868
-
A tetrazolyl-substituted subtype-selective AMPA receptor agonist
-
Vogensen, S.B.; Frydenvang, K.; Greenwood, J.R.; Postorino, G.; Nielsen, B.; Pickering, D.S.; Ebert, B.; Bolcho, U.; Egebjerg, J.; Gajhede, M.; Kastrup, J.S.; Johansen, T.N.; Clausen, R.P.; Krogsgaard- Larsen, P. A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J. Med. Chem., 2007, 50, 2408-2414.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 2408-2414
-
-
Vogensen, S.B.1
Frydenvang, K.2
Greenwood, J.R.3
Postorino, G.4
Nielsen, B.5
Pickering, D.S.6
Ebert, B.7
Bolcho, U.8
Egebjerg, J.9
Gajhede, M.10
Kastrup, J.S.11
Johansen, T.N.12
Clausen, R.P.13
Krogsgaard-Larsen, P.14
-
121
-
-
41749125709
-
Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4- hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency
-
Beich-Frandsen, M.; Pickering, D.S.; Mirza, O.; Johansen, T.N.; Greenwood, J.; Vestergaard, B.; Schousboe, A.; Gajhede, M.; Liljefors, T.; Kastrup, J.S. Structures of the ligand-binding core of iGluR2 in complex with the agonists (R)- and (S)-2-amino-3-(4- hydroxy-1,2,5-thiadiazol-3-yl)propionic acid explain their unusual equipotency. J. Med. Chem., 2008, 51, 1459-1463.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 1459-1463
-
-
Beich-Frandsen, M.1
Pickering, D.S.2
Mirza, O.3
Johansen, T.N.4
Greenwood, J.5
Vestergaard, B.6
Schousboe, A.7
Gajhede, M.8
Liljefors, T.9
Kastrup, J.S.10
-
122
-
-
17144380833
-
Exploring the GluR2 ligand-binding core with the bicyclal AMPA analogue (S)-4- AHCP
-
Nielsen, A.B.; Pichering, D.S.; Greenwood, J.R.; Brehm, L.; Gajhede, M.; Schousboe, A.; Kastrup, J.S. Exploring the GluR2 ligand-binding core with the bicyclal AMPA analogue (S)-4- AHCP. FEBS J., 2005, 272, 1639-1648.
-
(2005)
FEBS J.
, vol.272
, pp. 1639-1648
-
-
Nielsen, A.B.1
Pichering, D.S.2
Greenwood, J.R.3
Brehm, L.4
Gajhede, M.5
Schousboe, A.6
Kastrup, J.S.7
-
123
-
-
27444434374
-
A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2: A mutagenic kinetic and crystallographic study
-
Holm, M.M.; Naur, P.; Vestergaard, B.; Geballe, M.T.; Gajhede, M.; Kastrup, J.S.; Traynelis, S.F.; Egebjerg, J. A binding site tyrosine shapes desensitization kinetics and agonist potency at GluR2: a mutagenic kinetic and crystallographic study. J. Biol. Chem., 2005, 280, 35469-35476.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35469-35476
-
-
Holm, M.M.1
Naur, P.2
Vestergaard, B.3
Geballe, M.T.4
Gajhede, M.5
Kastrup, J.S.6
Traynelis, S.F.7
Egebjerg, J.8
-
124
-
-
0037118049
-
Mechanism of glutamate receptor desensitization
-
Sun, Y.; Olson, R.; Horning, M.; Armstrong, N.; Mayer, M.; Gouaux, E. Mechanism of glutamate receptor desensitization. Nature, 2002, 417, 245-253.
-
(2002)
Nature
, vol.417
, pp. 245-253
-
-
Sun, Y.1
Olson, R.2
Horning, M.3
Armstrong, N.4
Mayer, M.5
Gouaux, E.6
-
125
-
-
20144365134
-
Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2
-
Frandsen, A.; Pichering, D.S.; Vestergaard, B.; Kasper, C.; Nielsen, B.B.; Greenwood, J.R.; Campiani, G.; Fattorusso, C.; Gajhede, M.; Schousboe, A.; Kastrup, J.S. Tyr702 is an important determinant of agonist binding and domain closure of the ligand-binding core of GluR2. Mol. Pharmacol., 2005, 67, 703-713.
-
(2005)
Mol. Pharmacol.
, vol.67
, pp. 703-713
-
-
Frandsen, A.1
Pichering, D.S.2
Vestergaard, B.3
Kasper, C.4
Nielsen, B.B.5
Greenwood, J.R.6
Campiani, G.7
Fattorusso, C.8
Gajhede, M.9
Schousboe, A.10
Kastrup, J.S.11
-
126
-
-
0032578635
-
Structure of a glutamate receptor ligand-binding core in complex with kainate
-
Armstrong, N.; Sun, Y.; Chen, G.Q.; Gouaux, E. Structure of a glutamate receptor ligand-binding core in complex with kainate. Nature, 1998, 395, 913-917.
-
(1998)
Nature
, vol.395
, pp. 913-917
-
-
Armstrong, N.1
Sun, Y.2
Chen, G.Q.3
Gouaux, E.4
-
127
-
-
38549125923
-
Structural and singlechannel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating
-
Zhang, W.; Cho, Y.; Lolis, E.; Howe, J.R. Structural and singlechannel results indicate that the rates of ligand binding domain closing and opening directly impact AMPA receptor gating. J. Neurosci., 2008, 28, 932-943.
-
(2008)
J. Neurosci.
, vol.28
, pp. 932-943
-
-
Zhang, W.1
Cho, Y.2
Lolis, E.3
Howe, J.R.4
-
128
-
-
66149119419
-
Structure of the S1S2 glutamate binding domain of GLUR3
-
Ahmed, A.H.; Wang, Q.; Sondermann, H.; Oswald, R.E. Structure of the S1S2 glutamate binding domain of GLUR3. Proteins, 2009, 75, 628-637.
-
(2009)
Proteins
, vol.75
, pp. 628-637
-
-
Ahmed, A.H.1
Wang, Q.2
Sondermann, H.3
Oswald, R.E.4
-
129
-
-
68349086837
-
Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2
-
Hald, H.; Ahring, P.K.; Timmermann, D.B.; Liljefors, T.; Gajhede, M.; Kastrup, J.S. Distinct structural features of cyclothiazide are responsible for effects on peak current amplitude and desensitization kinetics at iGluR2. J. Mol. Biol., 2009, 391, 906-917.
-
(2009)
J. Mol. Biol.
, vol.391
, pp. 906-917
-
-
Hald, H.1
Ahring, P.K.2
Timmermann, D.B.3
Liljefors, T.4
Gajhede, M.5
Kastrup, J.S.6
-
130
-
-
33644828489
-
The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)- glutamate abd the antagonist (S)-NS1209
-
Kasper, C.; Pickering, D.S.; Mirza, O.; Olsen, L.; Kristensen, A.S.; Greenwood, J.R.; Liljefors, T.; Schousboe, A.; Watjen, F.; Gajhede, M.; Sigurskjold, B.W.; Kastrup, J.S. The structure of a mixed GluR2 ligand-binding core dimer in complex with (S)- glutamate abd the antagonist (S)-NS1209. J. Mol. Biol., 2006, 357, 1184-201.
-
(2006)
J. Mol. Biol.
, vol.357
, pp. 1184-1201
-
-
Kasper, C.1
Pickering, D.S.2
Mirza, O.3
Olsen, L.4
Kristensen, A.S.5
Greenwood, J.R.6
Liljefors, T.7
Schousboe, A.8
Watjen, F.9
Gajhede, M.10
Sigurskjold, B.W.11
Kastrup, J.S.12
-
131
-
-
77949386630
-
Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA) receptors
-
Ahmad, A.H.; Oswald, R.E. Piracetam defines a new binding site for allosteric modulators of alpha-amino-3-hydroxy-5-methyl-4- isoxazole-propionic acid (AMPA) receptors. J. Med. Chem., 2010, 53, 2197-2203.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 2197-2203
-
-
Ahmad, A.H.1
Oswald, R.E.2
-
132
-
-
77950405049
-
Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: Structures of GluA2 and GluA3 in complexes with PEPA
-
Ahmed, A.H.; Ptak, C.P.; Oswald, R.E. Molecular mechanism of flop selectivity and subsite recognition for an AMPA receptor allosteric modulator: structures of GluA2 and GluA3 in complexes with PEPA. Biochemistry, 2010, 49, 2843-2850.
-
(2010)
Biochemistry
, vol.49
, pp. 2843-2850
-
-
Ahmed, A.H.1
Ptak, C.P.2
Oswald, R.E.3
-
133
-
-
70149112131
-
Probing the allosteric modulator binding site of GluR2 with thiazide derivatives
-
Ptak, C.P.; Ahmed, A.H.; Oswald, R.E. Probing the allosteric modulator binding site of GluR2 with thiazide derivatives. Biochemistry 2009, 48, 8594-8602.
-
(2009)
Biochemistry
, vol.48
, pp. 8594-8602
-
-
Ptak, C.P.1
Ahmed, A.H.2
Oswald, R.E.3
-
134
-
-
36049044772
-
Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites
-
Kaae, B.H.; Harpsoe, K.; Kastrup, J.S.; Sanz, A.C.; Pickering, D.S.; Metzler, B.; Clausen, R.P.; Gajhede, M.; Sauerberg, P.; Liljefors, T.; Madsen, U. Structural proof of a dimeric positive modulator bridging two identical AMPA receptor-binding sites. Chem. Biol., 2007, 14, 1294-1303.
-
(2007)
Chem. Biol.
, vol.14
, pp. 1294-1303
-
-
Kaae, B.H.1
Harpsoe, K.2
Kastrup, J.S.3
Sanz, A.C.4
Pickering, D.S.5
Metzler, B.6
Clausen, R.P.7
Gajhede, M.8
Sauerberg, P.9
Liljefors, T.10
Madsen, U.11
-
135
-
-
0037207136
-
Mechanism of activation and selectivity in a ligand-gated ion channel. Structural and functional studies of GluR2 and quisqualate
-
Jin, R.; Horning, M.; Mayer, M.L.; Gouaux, E. Mechanism of activation and selectivity in a ligand-gated ion channel. Structural and functional studies of GluR2 and quisqualate. Biochemistry, 2002, 41, 15635-41563.
-
(2002)
Biochemistry
, vol.41
, pp. 15635-41563
-
-
Jin, R.1
Horning, M.2
Mayer, M.L.3
Gouaux, E.4
-
136
-
-
25644454403
-
Mechanism of positive allosteric modulators acting on AMPA receptors
-
Jin, R.; Clark, S.; Weeks, A.M.; Dudman, J.T.; Gouaux, E.; Partin, K.M. Mechanism of positive allosteric modulators acting on AMPA receptors. J. Neurosci. 2005, 25, 9027-9036.
-
(2005)
J. Neurosci.
, vol.25
, pp. 9027-9036
-
-
Jin, R.1
Clark, S.2
Weeks, A.M.3
Dudman, J.T.4
Gouaux, E.5
Partin, K.M.6
-
137
-
-
0043033172
-
Structural basis for partial agonist action at ionotropic glutamate receptors
-
Jin, R.; Banke, T.G.; Mayer, M.L.; Traynelis, S.F.; Gouaux, E. Structural basis for partial agonist action at ionotropic glutamate receptors. Nat. Neurosci., 2003, 6, 803-810.
-
(2003)
Nat. Neurosci.
, vol.6
, pp. 803-810
-
-
Jin, R.1
Banke, T.G.2
Mayer, M.L.3
Traynelis, S.F.4
Gouaux, E.5
-
138
-
-
0038219813
-
Probing the function, conformational plasticity and dimer-dimer contacts of the GluR2 ligand-binding core: Studies of 5-substituted willardines and GluR2 S1S2 in the crystal
-
Jin, R.; Gouaux, E. Probing the function, conformational plasticity and dimer-dimer contacts of the GluR2 ligand-binding core: studies of 5-substituted willardines and GluR2 S1S2 in the crystal. Biochemistry, 2003, 42, 5201-5213.
-
(2003)
Biochemistry
, vol.42
, pp. 5201-5213
-
-
Jin, R.1
Gouaux, E.2
-
139
-
-
66149128065
-
Mechanisms of antagonism of the GluR2 AMPA receptor: Structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain
-
Ahmed, A.H.; Thompson, M.D.; Fenwick, M.K.; Romero, B.; Loh, A.P.; Jane, D.E.; Sondermann, H.; Oswald, R.E. Mechanisms of antagonism of the GluR2 AMPA receptor: structure and dynamics of the complex of two willardiine antagonists with the glutamate binding domain. Biochemistry, 2009, 48, 3894-3903.
-
(2009)
Biochemistry
, vol.48
, pp. 3894-3903
-
-
Ahmed, A.H.1
Thompson, M.D.2
Fenwick, M.K.3
Romero, B.4
Loh, A.P.5
Jane, D.E.6
Sondermann, H.7
Oswald, R.E.8
-
140
-
-
38449097102
-
TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists
-
Menuz, K.; Stroud, R.M.; Nicoll, R.A.; Hays, F.A. TARP auxiliary subunits switch AMPA receptor antagonists into partial agonists. Science, 2007, 318, 815-817.
-
(2007)
Science
, vol.318
, pp. 815-817
-
-
Menuz, K.1
Stroud, R.M.2
Nicoll, R.A.3
Hays, F.A.4
-
141
-
-
52449115664
-
6-Azido-7-nitro- 1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor
-
Cruz, L.A.; Estebanez-Perpina, E.; Pfaff, S.; Borngraeber, S.; Bao, N.; Blethrow, J.; Fletterick, R.J.; England, P.M. 6-Azido-7-nitro- 1,4-dihydroquinoxaline-2,3-dione (ANQX) forms an irreversible bond to the active site of the GluR2 AMPA receptor. J. Med. Chem., 2008, 51, 5856-5860.
-
(2008)
J. Med. Chem.
, vol.51
, pp. 5856-5860
-
-
Cruz, L.A.1
Estebanez-Perpina, E.2
Pfaff, S.3
Borngraeber, S.4
Bao, N.5
Blethrow, J.6
Fletterick, R.J.7
England, P.M.8
-
142
-
-
33749059766
-
Measurement of conformational changes accompanying desensitization in ionotropic glutamate receptor
-
Armstrong, N.; Jasti, J.; Beich-Frandsen, M.; Gouaux, E. Measurement of conformational changes accompanying desensitization in ionotropic glutamate receptor. Cell, 2006, 127, 85-97.
-
(2006)
Cell
, vol.127
, pp. 85-97
-
-
Armstrong, N.1
Jasti, J.2
Beich-Frandsen, M.3
Gouaux, E.4
-
143
-
-
33745493837
-
Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis
-
Greger, I.H.; Akamine, P.; Khatri, L.; Ziff, E.B. Developmentally regulated, combinatorial RNA processing modulates AMPA receptor biogenesis. Neuron, 2006, 51, 85-97.
-
(2006)
Neuron
, vol.51
, pp. 85-97
-
-
Greger, I.H.1
Akamine, P.2
Khatri, L.3
Ziff, E.B.4
-
144
-
-
33747054219
-
Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate
-
Weston, M.C.; Gertler, C.; Mayer, M.L.; Rosenmund, C. Interdomain interactions in AMPA and kainate receptors regulate affinity for glutamate. J. Neurosci., 2006, 26, 7650-7658.
-
(2006)
J. Neurosci.
, vol.26
, pp. 7650-7658
-
-
Weston, M.C.1
Gertler, C.2
Mayer, M.L.3
Rosenmund, C.4
-
145
-
-
56649107905
-
Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4
-
Kasper, C.; Frydenvang, K.; Naur, P.; Gajhede, M.; Pickering, D.S.; Kastrup, J.S. Molecular mechanism of agonist recognition by the ligand-binding core of the ionotropic glutamate receptor 4. FEBS Lett., 2008, 582, 4089-4094.
-
(2008)
FEBS Lett.
, vol.582
, pp. 4089-4094
-
-
Kasper, C.1
Frydenvang, K.2
Naur, P.3
Gajhede, M.4
Pickering, D.S.5
Kastrup, J.S.6
-
146
-
-
75349094219
-
Enhanced efficacy without further cleft closure: Reevaluating twist as a source of agonist efficacy in AMPA receptors
-
Birdsey-Benson, A.; Gill, A.; Henderson, L.P.; Madden, D.R. Enhanced efficacy without further cleft closure: reevaluating twist as a source of agonist efficacy in AMPA receptors. J. Neurosci., 2010, 30, 1463-1470.
-
(2010)
J. Neurosci.
, vol.30
, pp. 1463-1470
-
-
Birdsey-Benson, A.1
Gill, A.2
Henderson, L.P.3
Madden, D.R.4
-
147
-
-
58849107686
-
Correlating AMPA receptor activation and cleft closure across subunits: Crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists
-
Gill, A.; Birdsey-Benson, A.; Jones, B.L.; Henderson, L.P.; Madden, D.R. Correlating AMPA receptor activation and cleft closure across subunits: crystal structures of the GluR4 ligand-binding domain in complex with full and partial agonists. Biochemistry, 2008, 47, 13831-13841.
-
(2008)
Biochemistry
, vol.47
, pp. 13831-13841
-
-
Gill, A.1
Birdsey-Benson, A.2
Jones, B.L.3
Henderson, L.P.4
Madden, D.R.5
-
148
-
-
13844266202
-
Crystal structures of the GluR5 and GluR6 ligand binding cores. Molecular mechanisms underlying kainate receptor selectivity
-
Mayer, M.L. Crystal structures of the GluR5 and GluR6 ligand binding cores. Molecular mechanisms underlying kainate receptor selectivity. Neuron, 2005, 45, 539-552.
-
(2005)
Neuron
, vol.45
, pp. 539-552
-
-
Mayer, M.L.1
-
149
-
-
13844272397
-
Crystal structure of the kainate receptor GluR5 binding core in complex with (S)-glutamate
-
Naur, P.; Vestergaard, B.; Skov, L.K.; Egebjerg, J.; Gajhede, M.; Kastrup, J.S. Crystal structure of the kainate receptor GluR5 binding core in complex with (S)-glutamate. FEBS Lett., 2005, 579, 1154-1160.
-
(2005)
FEBS Lett.
, vol.579
, pp. 1154-1160
-
-
Naur, P.1
Vestergaard, B.2
Skov, L.K.3
Egebjerg, J.4
Gajhede, M.5
Kastrup, J.S.6
-
150
-
-
33644999815
-
Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists
-
Mayer, M.L.; Ghosal, A.; Dolman, N.P.; Jane, D.E. Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists. J. Neurosci., 2006, 26, 2852- 2861.
-
(2006)
J. Neurosci.
, vol.26
, pp. 2852-2861
-
-
Mayer, M.L.1
Ghosal, A.2
Dolman, N.P.3
Jane, D.E.4
-
151
-
-
77955619274
-
-
Unpublished results
-
Unno, M.; Shinohara, M.; Takayama, K.; Teruya, K.; Dohura, K.; Sakai, R.; Sasaki, M.; Ikeda-Saito, M. Crystal structures of human GluR5 ligand-binding core in complexes with marine-derived toxins, dysiherbaine and neodysiherbaine A, and their synthetic analogues. Unpublished results.
-
Crystal Structures of Human GluR5 Ligand-Binding Core in Complexes with Marine-Derived Toxins, Dysiherbaine and Neodysiherbaine A, and their Synthetic Analogues
-
-
Unno, M.1
Shinohara, M.2
Takayama, K.3
Teruya, K.4
Dohura, K.5
Sakai, R.6
Sasaki, M.7
Ikeda-Saito, M.8
-
152
-
-
67649771372
-
Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine
-
Frydenvang, K.; Lash, L.L.; Naur, P.; Postila, P.A.; Pickering, D.S.; Smith, C.M.; Gajhede, M.; Sasaki, M.; Sakai, R.; Pentikaïnen, O.T.; Swanson, G.T.; Kastrup, J.S. Full domain closure of the ligand-binding core of the ionotropic glutamate receptor iGluR5 induced by the high affinity agonist dysiherbaine and the functional antagonist 8,9-dideoxyneodysiherbaine. J. Biol. Chem., 2009, 284, 14219-14229.
-
(2009)
J. Biol. Chem.
, vol.284
, pp. 14219-14229
-
-
Frydenvang, K.1
Lash, L.L.2
Naur, P.3
Postila, P.A.4
Pickering, D.S.5
Smith, C.M.6
Gajhede, M.7
Sasaki, M.8
Sakai, R.9
Pentikaïnen, O.T.10
Swanson, G.T.11
Kastrup, J.S.12
-
156
-
-
34548512475
-
Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: Structures of the ligand-binding core in complex with domoic acid and 2- amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid
-
Hald, H.; Naur, P.; Pickering, D.S.; Sprogoe, D.; Madsen, U.; Timmermann, D.B.; Ahring, P.K.; Liljefors, T.; Schousboe, A.; Egebjerg, J.; Gajhede, M.; Kastrup, J.S. Partial agonism and antagonism of the ionotropic glutamate receptor iGLuR5: structures of the ligand-binding core in complex with domoic acid and 2- amino-3-[5-tert-butyl-3-(phosphonomethoxy)-4-isoxazolyl]propionic acid. J. Biol. Chem., 2007, 282, 25726-25736.
-
(2007)
J. Biol. Chem.
, vol.282
, pp. 25726-25736
-
-
Hald, H.1
Naur, P.2
Pickering, D.S.3
Sprogoe, D.4
Madsen, U.5
Timmermann, D.B.6
Ahring, P.K.7
Liljefors, T.8
Schousboe, A.9
Egebjerg, J.10
Gajhede, M.11
Kastrup, J.S.12
-
158
-
-
68649122921
-
The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8- dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8- methyl analogue: Synthesis, molecular pharmacology, and biostructural characterization
-
Clausen, R.P.; Naur, P.; Kristensen, A.S.; Greenwood, J.R.; Strange, M.; Bräuner-Osborne, H.; Jensen, A.A.; Nielsen, A.S.; Geneser, U.; Ringgaard, L.M.; Nielsen, B.; Pickering, D.S.; Brehm, L.; Gajhede, M.; Krogsgaard-Larsen, P.; Kastrup, J.S. The glutamate receptor GluR5 agonist (S)-2-amino-3-(3-hydroxy-7,8- dihydro-6H-cyclohepta[d]isoxazol-4-yl)propionic acid and the 8- methyl analogue: synthesis, molecular pharmacology, and biostructural characterization. J. Med. Chem. 2009, 52, 4911-4922.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 4911-4922
-
-
Clausen, R.P.1
Naur, P.2
Kristensen, A.S.3
Greenwood, J.R.4
Strange, M.5
Bräuner-Osborne, H.6
Jensen, A.A.7
Nielsen, A.S.8
Geneser, U.9
Ringgaard, L.M.10
Nielsen, B.11
Pickering, D.S.12
Brehm, L.13
Gajhede, M.14
Krogsgaard-Larsen, P.15
Kastrup, J.S.16
-
159
-
-
44649169115
-
Molecular basis of kainate receptor modulation by sodium
-
Plested, A.J.; Vijayan, R.; Biggin, P.C.; Mayer, M.L. Molecular basis of kainate receptor modulation by sodium. Neuron, 2008, 58, 720-735.
-
(2008)
Neuron
, vol.58
, pp. 720-735
-
-
Plested, A.J.1
Vijayan, R.2
Biggin, P.C.3
Mayer, M.L.4
-
160
-
-
33847769253
-
Structure and mechanism of kainate receptor modulation by anions
-
Plested A.J.; Mayer, M.L. Structure and mechanism of kainate receptor modulation by anions. Neuron, 2007, 53, 829-841.
-
(2007)
Neuron
, vol.53
, pp. 829-841
-
-
Plested, A.J.1
Mayer, M.L.2
-
161
-
-
67349279392
-
Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization
-
Chaudhry, C.; Weston, M.C.; Schuck, P.; Rosenmund, C.; Mayer, M.L. Stability of ligand-binding domain dimer assembly controls kainate receptor desensitization. EMBO J. 2009, 28, 1518-1530.
-
(2009)
EMBO J.
, vol.28
, pp. 1518-1530
-
-
Chaudhry, C.1
Weston, M.C.2
Schuck, P.3
Rosenmund, C.4
Mayer, M.L.5
-
162
-
-
13444281913
-
Structure of the kainate receptor subunit GluR6 agonist binding domain complexed with domoic acid
-
Nanao, M.H.; Green, T.; Stern-Bach, Y.; Heinemann, S.F.; Choe, S. Structure of the kainate receptor subunit GluR6 agonist binding domain complexed with domoic acid. Proc. Natl. Acad. Sci. U.S.A., 2005, 102, 1708-1713.
-
(2005)
Proc. Natl. Acad. Sci. U.S.A.
, vol.102
, pp. 1708-1713
-
-
Nanao, M.H.1
Green, T.2
Stern-Bach, Y.3
Heinemann, S.F.4
Choe, S.5
-
163
-
-
33845361493
-
Conformational restriction blocks glutamate receptor desensitization
-
Weston, M.C.; Schuck, P.; Ghosal, A.; Rosenmund, C.; Mayer, M.L. Conformational restriction blocks glutamate receptor desensitization. Nat. Struct. Mol. Biol., 2006, 13, 1120-1127.
-
(2006)
Nat. Struct. Mol. Biol.
, vol.13
, pp. 1120-1127
-
-
Weston, M.C.1
Schuck, P.2
Ghosal, A.3
Rosenmund, C.4
Mayer, M.L.5
-
164
-
-
0035943408
-
Mechanisms for ligand binding to GluR0 ion channels: Crystal structures of the glutamate and serine complexes and a closed apo state
-
Mayer, M.L.; Olson, R.; Gouaux, E. Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state. J. Mol. Biol. 2001, 311, 815-836.
-
(2001)
J. Mol. Biol.
, vol.311
, pp. 815-836
-
-
Mayer, M.L.1
Olson, R.2
Gouaux, E.3
-
165
-
-
1242293631
-
Regulation of AMPA receptor gating by ligand binding core dimers
-
Horning, M.S.; Mayer, M.L. Regulation of AMPA receptor gating by ligand binding core dimers. Neuron 2004, 41, 379-388.
-
(2004)
Neuron
, vol.41
, pp. 379-388
-
-
Horning, M.S.1
Mayer, M.L.2
-
166
-
-
14644405595
-
Glutamate receptor gating
-
Erreger, K.; Chen, P.E.; Wyllie, D.J.A.; Traynelis, S.F. Glutamate receptor gating. Crit. Rev. Neurobiol., 2004, 16, 187-224.
-
(2004)
Crit. Rev. Neurobiol.
, vol.16
, pp. 187-224
-
-
Erreger, K.1
Chen, P.E.2
Wyllie, D.J.A.3
Traynelis, S.F.4
-
167
-
-
0036762866
-
Ligand-specific conformations of an ionotropic glutamate receptor
-
Nyikos, L.; Simon, A.; Barábas, P.; Kardos, J. Ligand-specific conformations of an ionotropic glutamate receptor. Prot. Eng. 2002, 15, 717-720.
-
(2002)
Prot. Eng.
, vol.15
, pp. 717-720
-
-
Nyikos, L.1
Simon, A.2
Barábas, P.3
Kardos, J.4
-
168
-
-
21244483189
-
Solution X-ray scattering evidence for agonist- and antagonistinduced modulation of cleft closure in a glutamate receptor ligandbinding domain
-
Madden, DR.; Armstrong, N.; Svergun, D.; Perez, J.; Vachette, P. Solution X-ray scattering evidence for agonist- and antagonistinduced modulation of cleft closure in a glutamate receptor ligandbinding domain. J. Biol. Chem., 2005, 280, 23637-23642.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 23637-23642
-
-
Madden, D.R.1
Armstrong, N.2
Svergun, D.3
Perez, J.4
Vachette, P.5
-
169
-
-
0041656063
-
Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions
-
Jansen, M.; Dannhardt, G. Antagonists and agonists at the glycine site of the NMDA receptor for therapeutic interventions. Eur. J. Med. Chem., 2003, 38, 661-670.
-
(2003)
Eur. J. Med. Chem.
, vol.38
, pp. 661-670
-
-
Jansen, M.1
Dannhardt, G.2
-
170
-
-
33748612166
-
Recent advances in positive allosteric modulators of the AMPA receptor
-
Morrow, J.A.; Maclean, J.K.F.; Jamieson, C. Recent advances in positive allosteric modulators of the AMPA receptor. Curr. Opin. Drug Discov. Devel., 2006, 9, 571-579.
-
(2006)
Curr. Opin. Drug Discov. Devel.
, vol.9
, pp. 571-579
-
-
Morrow, J.A.1
Maclean, J.K.F.2
Jamieson, C.3
-
171
-
-
33749176816
-
Interface interactions modulating desensitization of the kainate-selective ionotropic glutamate receptor subunit GluR6
-
Zhang, Y.; Nayeem, N.; Nanao, M.H.; Green, T. Interface interactions modulating desensitization of the kainate-selective ionotropic glutamate receptor subunit GluR6. J. Neurosci., 2006, 26, 10033- 10042.
-
(2006)
J. Neurosci.
, vol.26
, pp. 10033-10042
-
-
Zhang, Y.1
Nayeem, N.2
Nanao, M.H.3
Green, T.4
-
172
-
-
0037442510
-
Amino acid residues involved in glutamate receptor 6 gating and desensitization
-
Fleck, M.W.; Cornell, E.; Moch, S.J. Amino acid residues involved in glutamate receptor 6 gating and desensitization. J. Neurosci., 2003, 23, 1219-1227.
-
(2003)
J. Neurosci.
, vol.23
, pp. 1219-1227
-
-
Fleck, M.W.1
Cornell, E.2
Moch, S.J.3
-
173
-
-
33645313464
-
Concavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptors
-
Fay, A.-M.L.; Bowie, D. Concavalin-A reports agonist-induced conformational changes in the intact GluR6 kainate receptors. J. Physiol., 2006, 572, 201-213.
-
(2006)
J. Physiol.
, vol.572
, pp. 201-213
-
-
Fay, A.-M.L.1
Bowie, D.2
-
174
-
-
77649208693
-
New fluorinated 1,2,4- benzothiadiazine 1,1-dioxides: Discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3- hydroxy-5-methylisoxazol-4-yl)propionic acid receptors
-
Francotte, P.; Goffin, E.; Fraikin, P.; Lestage, P.; Van Heugen, J.C.; Gillotin, F.; Danober, L.; Thomas, J.Y.; Chiap, P.; Caignard, D.H.; Pirotte, B.; de Tullio, P. New fluorinated 1,2,4- benzothiadiazine 1,1-dioxides: discovery of an orally active cognitive enhancer acting through potentiation of the 2-amino-3-(3- hydroxy-5-methylisoxazol-4-yl)propionic acid receptors. J. Med. Chem., 2010, 53, 1700-1711.
-
(2010)
J. Med. Chem.
, vol.53
, pp. 1700-1711
-
-
Francotte, P.1
Goffin, E.2
Fraikin, P.3
Lestage, P.4
Van Heugen, J.C.5
Gillotin, F.6
Danober, L.7
Thomas, J.Y.8
Chiap, P.9
Caignard, D.H.10
Pirotte, B.11
de Tullio, P.12
-
175
-
-
0026082757
-
+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurons
-
+ sensitivity of excitatory amino acid receptor channels in rat cerebellar granule neurons. J. Physiol., 1991, 433, 727-763.
-
(1991)
J. Physiol.
, vol.433
, pp. 727-763
-
-
Traynelis, S.F.1
Cull-Candy, S.G.2
-
176
-
-
0035023463
-
Positive allosteric modulators of AMPA receptors reduce proton- induced receptor desensitization in rat hippocampal neurons
-
Lei, S.; Orser, B.A.; Thatcher, G.R.; Reynolds, J.N.; MacDonald, J.F. Positive allosteric modulators of AMPA receptors reduce proton- induced receptor desensitization in rat hippocampal neurons. J. Neurophysiol., 2001, 85, 2030-2038.
-
(2001)
J. Neurophysiol.
, vol.85
, pp. 2030-2038
-
-
Lei, S.1
Orser, B.A.2
Thatcher, G.R.3
Reynolds, J.N.4
MacDonald, J.F.5
-
177
-
-
0032529589
-
Extracellular acidity potentiates AMPA receptor-mediated cortical neuronal death
-
McDonald, J.W.; Bhattacharyya, T.; Sensi, S.L.; Lobner, D.; Ying, H.S.; Canzoniero, L.M.; Choi, D.W. Extracellular acidity potentiates AMPA receptor-mediated cortical neuronal death. J. Neurosci., 1998, 18, 6290-629
-
(1998)
J. Neurosci.
, vol.18
, pp. 6290-6629
-
-
McDonald, J.W.1
Bhattacharyya, T.2
Sensi, S.L.3
Lobner, D.4
Ying, H.S.5
Canzoniero, L.M.6
Choi, D.W.7
-
178
-
-
0141858334
-
Molecular modeling of the closed forms of the kainate-binding domains of kainate receptors and qualitative analysis of the structure-activity relationships for some agonists
-
Belenikin, M.S.; Baskin, I.I.; Constantino, G.; Palyulin, V.A.; Pellicciari, R.; Zefirov, N.S. Molecular modeling of the closed forms of the kainate-binding domains of kainate receptors and qualitative analysis of the structure-activity relationships for some agonists. Dokl. Biochem. Biophys. 2002, 386, 239-44.
-
(2002)
Dokl. Biochem. Biophys.
, vol.386
, pp. 239-244
-
-
Belenikin, M.S.1
Baskin, I.I.2
Constantino, G.3
Palyulin, V.A.4
Pellicciari, R.5
Zefirov, N.S.6
-
179
-
-
24044454692
-
Development of a three-dimensional model for the N-methyl-Daspartate NR2A subunit
-
Grazioso, G.; Moretti, L.; Scapozza, L.; De Amici, M.; De Micheli, C. Development of a three-dimensional model for the N-methyl-Daspartate NR2A subunit. J. Med. Chem., 2005, 48, 5489-5494.
-
(2005)
J. Med. Chem.
, vol.48
, pp. 5489-5494
-
-
Grazioso, G.1
Moretti, L.2
Scapozza, L.3
De Amici, M.4
De Micheli, C.5
-
180
-
-
0035451726
-
Molecular dynamics simulations of the glutamate receptor ligand-binding core in the presence of glutamate and kainate
-
Mendieta, J.; Ramirez, G.; Gago, F. Molecular dynamics simulations of the glutamate receptor ligand-binding core in the presence of glutamate and kainate. Proteins, 2001, 44, 460-469.
-
(2001)
Proteins
, vol.44
, pp. 460-469
-
-
Mendieta, J.1
Ramirez, G.2
Gago, F.3
-
181
-
-
0036154304
-
Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2
-
Arinaminpathy, Y.; Sansom, M.S.P.; Biggin, P.C. Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2. Biophys. J., 2002, 82, 676-683.
-
(2002)
Biophys. J.
, vol.82
, pp. 676-683
-
-
Arinaminpathy, Y.1
Sansom, M.S.P.2
Biggin, P.C.3
-
182
-
-
0037671391
-
Interdomain dynamics and ligand binding: Molecular dynamics simulation of glutamine binding protein
-
Pang, A.; Arinaminpathy, Y.; Sansom, M.S.P.; Biggin, P.C. Interdomain dynamics and ligand binding: molecular dynamics simulation of glutamine binding protein. FEBS Lett., 2003, 550, 168-174.
-
(2003)
FEBS Lett.
, vol.550
, pp. 168-174
-
-
Pang, A.1
Arinaminpathy, Y.2
Sansom, M.S.P.3
Biggin, P.C.4
-
183
-
-
33744950385
-
Molecular dynamics simulations of the ligand-binding domain of an N-methyl-Daspartate receptor
-
Kaye, S.L.; Sansom, M.S.P.; Biggin, P.C. Molecular dynamics simulations of the ligand-binding domain of an N-methyl-Daspartate receptor. J. Biol. Chem., 2006, 281, 12736-12742.
-
(2006)
J. Biol. Chem.
, vol.281
, pp. 12736-12742
-
-
Kaye, S.L.1
Sansom, M.S.P.2
Biggin, P.C.3
-
184
-
-
57349195082
-
Interplay between structural rigidity and electrostatic interactions in the ligand binding domain of GluR2
-
Mamonova, T.; Speranskiy, K.; Kurnikova, M. Interplay between structural rigidity and electrostatic interactions in the ligand binding domain of GluR2. Proteins, 2008, 73, 656-671.
-
(2008)
Proteins
, vol.73
, pp. 656-671
-
-
Mamonova, T.1
Speranskiy, K.2
Kurnikova, M.3
-
185
-
-
72149121816
-
Exploring kainate receptor pharmacology using molecular dynamics simulations
-
Postila, P.A.; Swanson, G.T.; Pentikäinen, O.T. Exploring kainate receptor pharmacology using molecular dynamics simulations. Neuropharmacology, 2010, 58, 515-527.
-
(2010)
Neuropharmacology
, vol.58
, pp. 515-527
-
-
Postila, P.A.1
Swanson, G.T.2
Pentikäinen, O.T.3
-
186
-
-
0028242501
-
Transmembrane topology of the glutamate receptor subunit GluR6
-
Roche, K.W.; Raymond, L.A.; Blackstone, C; Huganir, R.L. Transmembrane topology of the glutamate receptor subunit GluR6. J. Biol. Chem., 1994, 269, 11679-11682.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 11679-11682
-
-
Roche, K.W.1
Raymond, L.A.2
Blackstone, C.3
Huganir, R.L.4
-
187
-
-
0033103522
-
NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines
-
Beck, C.; Wollmuth, L.P.; Seeburg, P.H.; Sakmann, B. NMDAR channel segments forming the extracellular vestibule inferred from the accessibility of substituted cysteines. Neuron, 1999, 22, 559- 570.
-
(1999)
Neuron
, vol.22
, pp. 559-570
-
-
Beck, C.1
Wollmuth, L.P.2
Seeburg, P.H.3
Sakmann, B.4
-
188
-
-
0030220889
-
Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines
-
Kuner, T.; Wollmuth, L.P.; Karlin, A.; Seeburg, P.H.; Sakmann, B. Structure of the NMDA receptor channel M2 segment inferred from the accessibility of substituted cysteines. Neuron, 1996, 17, 343-352.
-
(1996)
Neuron
, vol.17
, pp. 343-352
-
-
Kuner, T.1
Wollmuth, L.P.2
Karlin, A.3
Seeburg, P.H.4
Sakmann, B.5
-
189
-
-
33947210066
-
Insight into structure and function of ionotropic glutamate receptor channels: Starting from channel block
-
Sobolevsky, A.I. Insight into structure and function of ionotropic glutamate receptor channels: starting from channel block. Biochemistry (Moscow) Supplement Series A: Mebrane Cell Biol., 2007, 1, 45-56.
-
(2007)
Biochemistry (Moscow) Supplement Series A: Mebrane Cell Biol.
, vol.1
, pp. 45-56
-
-
Sobolevsky, A.I.1
-
190
-
-
0028961509
-
Structural basis for explaining openchannel blockade of the NMDA receptor
-
Zarei, M.M.; Dani, J.A. Structural basis for explaining openchannel blockade of the NMDA receptor. J. Neurosci., 1995, 15, 1446-1454.
-
(1995)
J. Neurosci.
, vol.15
, pp. 1446-1454
-
-
Zarei, M.M.1
Dani, J.A.2
-
191
-
-
0028945477
-
Dimensions of the narrow portion of a recombinant NMDA receptor channel
-
Villarroel, A.; Burnashev, N.; Sakman, B. Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophys. J., 1995, 68, 866-875.
-
(1995)
Biophys. J.
, vol.68
, pp. 866-875
-
-
Villarroel, A.1
Burnashev, N.2
Sakman, B.3
-
192
-
-
0029887686
-
Differerential contribution of the NR1 and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels
-
Wollmuth, L.P.; Kuner, T.; Seeburg, P.H.; Sakman, B. Differerential contribution of the NR1 and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels. J. Physiol., 1996, 491, 779-97.
-
(1996)
J. Physiol.
, vol.491
, pp. 779-797
-
-
Wollmuth, L.P.1
Kuner, T.2
Seeburg, P.H.3
Sakman, B.4
-
193
-
-
2542550010
-
Dimensions and ion selectivity of recombinant AMPA and kainate receptors and their dependence o Q/R site residues
-
Burnashev, N.; Villarroel, A.; Sakman, B. Dimensions and ion selectivity of recombinant AMPA and kainate receptors and their dependence o Q/R site residues. J. Physiol., 1996, 496, 165-173.
-
(1996)
J. Physiol.
, vol.496
, pp. 165-173
-
-
Burnashev, N.1
Villarroel, A.2
Sakman, B.3
-
194
-
-
0033573391
-
Probing of NMDA channels with fast blockers
-
Sobolevsky, A.J.; Koshelev, S.G.; Khodorov, B.I. Probing of NMDA channels with fast blockers. J. Neurosci., 1999, 19, 10611- 10626.
-
(1999)
J. Neurosci.
, vol.19
, pp. 10611-10626
-
-
Sobolevsky, A.J.1
Koshelev, S.G.2
Khodorov, B.I.3
-
195
-
-
0032718035
-
Molecular size and hydrophobicity as factors which determine the efficacy and the blocking action of amino-adamantane derivatives on NMDA channels
-
Sobolevsky, A.I.; Koshelev, S.G.; Khodorov, B.I. Molecular size and hydrophobicity as factors which determine the efficacy and the blocking action of amino-adamantane derivatives on NMDA channels. Membr. Cell Biol., 1999, 13, 79-93.
-
(1999)
Membr. Cell Biol.
, vol.13
, pp. 79-93
-
-
Sobolevsky, A.I.1
Koshelev, S.G.2
Khodorov, B.I.3
-
196
-
-
0033849748
-
Quantitative analysis of tetrapentylammoniuminduced blockade of open N-methyl-D-aspartate channels
-
Sobolevsky, A.I. Quantitative analysis of tetrapentylammoniuminduced blockade of open N-methyl-D-aspartate channels. Biophys. J., 2000, 79, 1324-1335.
-
(2000)
Biophys. J.
, vol.79
, pp. 1324-1335
-
-
Sobolevsky, A.I.1
-
197
-
-
0035003258
-
Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis
-
Panchenko, V.A.; Glasser, C.R.; Mayer, M.L. Structural similarities between glutamate receptor channels and K(+) channels examined by scanning mutagenesis. J. Gen. Physiol., 2001, 117, 345- 360.
-
(2001)
J. Gen. Physiol.
, vol.117
, pp. 345-360
-
-
Panchenko, V.A.1
Glasser, C.R.2
Mayer, M.L.3
-
198
-
-
2542507333
-
Structure and gating of te glutamate receptor ion channel
-
Wollmuth, L.P.; Sobolevsky, A.I. Structure and gating of te glutamate receptor ion channel. Trends Neurosci., 2004, 27, 321-8.
-
(2004)
Trends Neurosci.
, vol.27
, pp. 321-328
-
-
Wollmuth, L.P.1
Sobolevsky, A.I.2
-
199
-
-
0037213506
-
A common architecture for K+ channels and ionotropic glutamate receptors?
-
Kuner, T.; Seeburg, P.H.; Guy, H.R. A common architecture for K+ channels and ionotropic glutamate receptors? Trends Neurosci., 2003, 26, 27-32.
-
(2003)
Trends Neurosci.
, vol.26
, pp. 27-32
-
-
Kuner, T.1
Seeburg, P.H.2
Guy, H.R.3
-
200
-
-
0030795112
-
Gated access to the pore of a voltage-dependent K+ channel
-
Liu, Y.; Holmgren, M.; Jurman, M.E.; Yellen, G. Gated access to the pore of a voltage-dependent K+ channel. Neuron, 1997, 19, 175-184.
-
(1997)
Neuron
, vol.19
, pp. 175-184
-
-
Liu, Y.1
Holmgren, M.2
Jurman, M.E.3
Yellen, G.4
-
201
-
-
0035923745
-
Tight steric closure at the intracellular activation of a voltage-gated K+ channel
-
del Camino, D.; Yellen, G. Tight steric closure at the intracellular activation of a voltage-gated K+ channel. Neuron, 2001, 32, 649- 656.
-
(2001)
Neuron
, vol.32
, pp. 649-656
-
-
del Camino, D.1
Yellen, G.2
-
202
-
-
0041921002
-
Different gating mechanisms in glutamate receptor and K+ channels
-
Sobolevsky, A.I.; Yelshansky, M.V.; Wollmuth, L.P. Different gating mechanisms in glutamate receptor and K+ channels. J. Neurosci., 2003, 23, 7559-7568.
-
(2003)
J. Neurosci.
, vol.23
, pp. 7559-7568
-
-
Sobolevsky, A.I.1
Yelshansky, M.V.2
Wollmuth, L.P.3
-
203
-
-
0037198625
-
The open pore conformation of potassium channels
-
Jiang Y.; Lee, A.; Chen, J.; Cadene, M.; Chait, B.T.; MacKinnon, R. The open pore conformation of potassium channels. Nature, 2002, 417, 523-526.
-
(2002)
Nature
, vol.417
, pp. 523-526
-
-
Jiang, Y.1
Lee, A.2
Chen, J.3
Cadene, M.4
Chait, B.T.5
MacKinnon, R.6
-
204
-
-
0037088901
-
The NMDA receptor M3 segment is a conserved transduction elemnet coupling ligand binding to channel opening
-
Jones, K.S.; Van Dongen, H.M.; Van Dongen, A.M. The NMDA receptor M3 segment is a conserved transduction elemnet coupling ligand binding to channel opening. J. Neurosci., 2002, 22, 2044- 2053.
-
(2002)
J. Neurosci.
, vol.22
, pp. 2044-2053
-
-
Jones, K.S.1
Van Dongen, H.M.2
Van Dongen, A.M.3
-
205
-
-
0037012062
-
Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating
-
Sobolevsky, A.I.; Beck, C.; Wollmuth, L.P. Molecular rearrangements of the extracellular vestibule in NMDAR channels during gating. Neuron, 2002, 33, 75-85.
-
(2002)
Neuron
, vol.33
, pp. 75-85
-
-
Sobolevsky, A.I.1
Beck, C.2
Wollmuth, L.P.3
-
206
-
-
0036896359
-
2+ flux rates in NMDA receptor channels
-
2+ flux rates in NMDA receptor channels. J. Neurosci., 2002, 22, 10209-10216.
-
(2002)
J. Neurosci.
, vol.22
, pp. 10209-10216
-
-
Watanabe, J.1
Beck, C.2
Kuner, T.3
Premkumar, L.S.4
Wollmuth, L.P.5
-
207
-
-
23844438574
-
Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3
-
Yuan, H.; Erreger, K.; Dravid, S.M.; Traynelis, S.F. Conserved structural and functional control of N-methyl-D-aspartate receptor gating by transmembrane domain M3. J. Biol. Chem., 2005, 280, 29708-29716.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 29708-29716
-
-
Yuan, H.1
Erreger, K.2
Dravid, S.M.3
Traynelis, S.F.4
-
208
-
-
33751520281
-
Investigation via ion pore transplantaion of the putative relationship between glutamate receptors and K+ channels
-
Hoffmann, J.; Villmann, C.; Werner, M.; Hollmann, M. Investigation via ion pore transplantaion of the putative relationship between glutamate receptors and K+ channels. Mol. Cell Neurosci., 2006, 33, 358-370.
-
(2006)
Mol. Cell Neurosci.
, vol.33
, pp. 358-370
-
-
Hoffmann, J.1
Villmann, C.2
Werner, M.3
Hollmann, M.4
-
209
-
-
34249809760
-
Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating
-
Sobolevsky, A.I.; Prodromou, M.L.; Yelshansky, M.V.; Wollmuth, L.P. Subunit-specific contribution of pore-forming domains to NMDA receptor channel structure and gating. J. Gen. Physiol., 2007, 129, 509-525.
-
(2007)
J. Gen. Physiol.
, vol.129
, pp. 509-525
-
-
Sobolevsky, A.I.1
Prodromou, M.L.2
Yelshansky, M.V.3
Wollmuth, L.P.4
-
210
-
-
0035237928
-
Molecular modeling of ligand-gated ion channels: Progress and challenges
-
Bertaccini, E.; Trudell, J.R. Molecular modeling of ligand-gated ion channels: progress and challenges. Int. Rev. Neurobiol., 2001, 48, 141-166.
-
(2001)
Int. Rev. Neurobiol.
, vol.48
, pp. 141-166
-
-
Bertaccini, E.1
Trudell, J.R.2
-
211
-
-
0036217710
-
Modeling of the pore domain of the GLUR1 channel: Homology with K+ channel and binding of channel blockers
-
Tikhonov, D.B.; Mellor, J.R.; Usherwood, P.N.R.; Magazanik, L.G. Modeling of the pore domain of the GLUR1 channel: homology with K+ channel and binding of channel blockers. Biophys. J., 2002, 82, 1884-1893.
-
(2002)
Biophys. J.
, vol.82
, pp. 1884-1893
-
-
Tikhonov, D.B.1
Mellor, J.R.2
Usherwood, P.N.R.3
Magazanik, L.G.4
-
212
-
-
3142658017
-
3Dmodel of the ion channel of NMDA receptor: Qualitative and quantitative modeling of the blocker binding
-
Tikhonova, I.G.; Baskin, I.I.; Palyulin, V.A.; Zefirov, N.S. 3Dmodel of the ion channel of NMDA receptor: qualitative and quantitative modeling of the blocker binding. Dokl. Biochem. Biophys., 2004, 396, 551-556.
-
(2004)
Dokl. Biochem. Biophys.
, vol.396
, pp. 551-556
-
-
Tikhonova, I.G.1
Baskin, I.I.2
Palyulin, V.A.3
Zefirov, N.S.4
-
213
-
-
27944452210
-
Non- Markovian stochastic resonance: Three-state model of ion channel gating
-
Goychuk, I.; Hanggi, P.; Vega, J.L.; Miret-Artes, S. Non- Markovian stochastic resonance: three-state model of ion channel gating. Phys. Rev. E, 2005, 71, 061906.
-
(2005)
Phys. Rev. E
, vol.71
, pp. 061906
-
-
Goychuk, I.1
Hanggi, P.2
Vega, J.L.3
Miret-Artes, S.4
-
214
-
-
34247399105
-
Ion channels of glutamate receptors: Structural modeling
-
Tikhonov, D.B. Ion channels of glutamate receptors: structural modeling. Mol. Memb. Biol., 2007, 24, 135-147.
-
(2007)
Mol. Memb. Biol.
, vol.24
, pp. 135-147
-
-
Tikhonov, D.B.1
-
215
-
-
0037414788
-
A site in the fourth membrane-associated domain of the N-methyl-Daspartate receptor regulates desensitization and ion channel gating
-
Ren, H.; Honse, Y.; Karp, B.J.; Lipsky, R.H.; Peoples, R.W. A site in the fourth membrane-associated domain of the N-methyl-Daspartate receptor regulates desensitization and ion channel gating. J. Biol. Chem., 2003, 278, 276-283.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 276-283
-
-
Ren, H.1
Honse, Y.2
Karp, B.J.3
Lipsky, R.H.4
Peoples, R.W.5
-
216
-
-
33645096210
-
Probing N-methyl-D-aspartate receptor desensitization with the substituted-cysteine accessibility method
-
Thomas, C.G.; Krupp, J.J.; Bagley, E.E.; Bauzon, R.; Heinemann, S.F.; Vissel, B.; Westbrook, G.L. Probing N-methyl-D-aspartate receptor desensitization with the substituted-cysteine accessibility method. Mol. Pharmacol., 2006, 69, 1296-1303.
-
(2006)
Mol. Pharmacol.
, vol.69
, pp. 1296-1303
-
-
Thomas, C.G.1
Krupp, J.J.2
Bagley, E.E.3
Bauzon, R.4
Heinemann, S.F.5
Vissel, B.6
Westbrook, G.L.7
-
217
-
-
0037686667
-
Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating
-
Low C.M.; Lyuboslavsky, P.; French, A.; Le, P.; Wyatte, K.; Thiel, W.H.; Marchan, E.M.; Igarashi, K.; Kashiwagi, K.; Gernert, K.; Williams, K.; Traynelis, S.F.; Zheng, F. Molecular determinants of proton-sensitive N-methyl-D-aspartate receptor gating. Mol. Pharmacol., 2003, 63, 1212-1222.
-
(2003)
Mol. Pharmacol.
, vol.63
, pp. 1212-1222
-
-
Low, C.M.1
Lyuboslavsky, P.2
French, A.3
Le, P.4
Wyatte, K.5
Thiel, W.H.6
Marchan, E.M.7
Igarashi, K.8
Kashiwagi, K.9
Gernert, K.10
Williams, K.11
Traynelis, S.F.12
Zheng, F.13
-
218
-
-
2442675355
-
Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain
-
Yelshansky, M.V.; Sobolevsky, A.I.; Jatzke, C.; Wollmuth, L.P. Block of AMPA receptor desensitization by a point mutation outside the ligand-binding domain. J. Neurosci., 2004, 24, 4728-4736.
-
(2004)
J. Neurosci.
, vol.24
, pp. 4728-4736
-
-
Yelshansky, M.V.1
Sobolevsky, A.I.2
Jatzke, C.3
Wollmuth, L.P.4
-
219
-
-
67650252005
-
Modeling of peptides connecting the ligand binding and transmembrane domains in the GluR2 glutamate receptor
-
Speranskiy, K.; Kurnikova, M.G. Modeling of peptides connecting the ligand binding and transmembrane domains in the GluR2 glutamate receptor. Proteins: Str. Funct. Bioinf., 2008, 76, 271-280.
-
(2008)
Proteins: Str. Funct. Bioinf.
, vol.76
, pp. 271-280
-
-
Speranskiy, K.1
Kurnikova, M.G.2
-
220
-
-
0036570035
-
Deletion of the C-terminal domain of the NR2B receptor subunit alters channel properties and synaptic targeting of N-methyl-Daspartate receptors in nascent neocortical synapses
-
Mohrmann, R.; Kohr, G.; Hatt, H.; Sprengel, R.; Gottmann, K. Deletion of the C-terminal domain of the NR2B receptor subunit alters channel properties and synaptic targeting of N-methyl-Daspartate receptors in nascent neocortical synapses. J. Neurosci. Res., 2002, 68, 265-275.
-
(2002)
J. Neurosci. Res.
, vol.68
, pp. 265-275
-
-
Mohrmann, R.1
Kohr, G.2
Hatt, H.3
Sprengel, R.4
Gottmann, K.5
-
221
-
-
38449116745
-
Scaffold proteins (MAGUK, Shank and Homer) in postsynaptic density in the central nervous system
-
Beresewicz, M. Scaffold proteins (MAGUK, Shank and Homer) in postsynaptic density in the central nervous system. Postłpy Biochem., 2007, 53, 188-197.
-
(2007)
Postłpy Biochem.
, vol.53
, pp. 188-197
-
-
Beresewicz, M.1
-
222
-
-
77950680180
-
SAP102 is a highly mobile MAGUK in spines
-
Zheng, C.Y.; Petralia, R.S.; Wang, Y.X.; Kachar, B.; Wenthold, R.J. SAP102 is a highly mobile MAGUK in spines. J. Neurosci., 2010, 30, 4757-4766.
-
(2010)
J. Neurosci.
, vol.30
, pp. 4757-4766
-
-
Zheng, C.Y.1
Petralia, R.S.2
Wang, Y.X.3
Kachar, B.4
Wenthold, R.J.5
-
223
-
-
65249144104
-
Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina
-
Zhang, J.; Diamond, J.S. Subunit- and pathway-specific localization of NMDA receptors and scaffolding proteins at ganglion cell synapses in rat retina. J. Neurosci., 2009, 29, 4274-4286.
-
(2009)
J. Neurosci.
, vol.29
, pp. 4274-4286
-
-
Zhang, J.1
Diamond, J.S.2
-
224
-
-
0036316727
-
ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease
-
Boeckers, T.M.; Bockmann, J.; Kreutz, M.R.; Gundelfinger, E.D. ProSAP/Shank proteins - a family of higher order organizing molecules of the postsynaptic density with an emerging role in human neurological disease. J. Neurochem., 2002, 81, 903-910.
-
(2002)
J. Neurochem.
, vol.81
, pp. 903-910
-
-
Boeckers, T.M.1
Bockmann, J.2
Kreutz, M.R.3
Gundelfinger, E.D.4
-
225
-
-
77955601200
-
Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons
-
Bertaso, F.; Roussignol, G.; Worley, P.; Bockaert, J.; Fagni, L.; Ango, F. Homer1a-dependent crosstalk between NMDA and metabotropic glutamate receptors in mouse neurons. PLoS One, 2010, 5, e9755.
-
(2010)
PLoS One
, vol.5
-
-
Bertaso, F.1
Roussignol, G.2
Worley, P.3
Bockaert, J.4
Fagni, L.5
Ango, F.6
-
226
-
-
33646586998
-
The NMDA/D1 receptor complex as a new target in drug development
-
Missale, C.; Fiorentini, C.; Busi, C.; Collo, G.; Spano, P.F. The NMDA/D1 receptor complex as a new target in drug development. Curr. Top. Med. Chem., 2006, 6, 801-808.
-
(2006)
Curr. Top. Med. Chem.
, vol.6
, pp. 801-808
-
-
Missale, C.1
Fiorentini, C.2
Busi, C.3
Collo, G.4
Spano, P.F.5
-
227
-
-
0842304133
-
Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptors
-
Pei, L.; Lee, F.J.; Moszczynska, A.; Vukusic, B.; Liu, F. Regulation of dopamine D1 receptor function by physical interaction with the NMDA receptors. J. Neurosci., 2004, 24, 1149-1158.
-
(2004)
J. Neurosci.
, vol.24
, pp. 1149-1158
-
-
Pei, L.1
Lee, F.J.2
Moszczynska, A.3
Vukusic, B.4
Liu, F.5
-
228
-
-
73549099758
-
Uncoupling the D1-N-methyl-D-aspartate (NMDA) receptor complex promotes NMDA-dependent long-term potentiation and working memory
-
Nai, Q.; Li, S.; Wang, S.H.; Liu, J.; Lee, F.J.; Frankland, P.W.; Liu, F. Uncoupling the D1-N-methyl-D-aspartate (NMDA) receptor complex promotes NMDA-dependent long-term potentiation and working memory. Biol. Psychiatry, 2010, 67, 246-254.
-
(2010)
Biol. Psychiatry
, vol.67
, pp. 246-254
-
-
Nai, Q.1
Li, S.2
Wang, S.H.3
Liu, J.4
Lee, F.J.5
Frankland, P.W.6
Liu, F.7
-
229
-
-
0037088834
-
External anions and cations distinguish between AMPA and kainate receptor gating mechanisms
-
Bowie, D. External anions and cations distinguish between AMPA and kainate receptor gating mechanisms. J. Physiol., 2002, 539, 725-733.
-
(2002)
J. Physiol.
, vol.539
, pp. 725-733
-
-
Bowie, D.1
-
230
-
-
33744973079
-
External ions are coactivators of kainate receptors
-
Wong, A.Y.; Fay, A.M.; Bowie, D. External ions are coactivators of kainate receptors. J. Neurosci., 2006, 26, 5750-5755.
-
(2006)
J. Neurosci.
, vol.26
, pp. 5750-5755
-
-
Wong, A.Y.1
Fay, A.M.2
Bowie, D.3
-
231
-
-
34250806504
-
Na+/Cl- dipole couples agonist binding to kainate receptor activation
-
Wong, A.Y.; MacLean, D.M.; Bowie, D. Na+/Cl- dipole couples agonist binding to kainate receptor activation. J. Neurosci., 2007, 27, 6800-6809.
-
(2007)
J. Neurosci.
, vol.27
, pp. 6800-6809
-
-
Wong, A.Y.1
MacLean, D.M.2
Bowie, D.3
-
232
-
-
39549094224
-
pH-dependent inhibition of kainate receptors by zinc
-
Mott, D.D.; Benveniste, M.; Dingledine, R.J. pH-dependent inhibition of kainate receptors by zinc. J. Neurosci., 2008, 28, 1659- 1671.
-
(2008)
J. Neurosci.
, vol.28
, pp. 1659-1671
-
-
Mott, D.D.1
Benveniste, M.2
Dingledine, R.J.3
-
233
-
-
22844449702
-
2+ permeability of AMPARs at cerebellar synapses
-
2+ permeability of AMPARs at cerebellar synapses. Nat. Neurosci., 2005, 8, 768-775.
-
(2005)
Nat. Neurosci.
, vol.8
, pp. 768-775
-
-
Liu, S.J.1
Cull-Candy, S.G.2
-
234
-
-
15444362199
-
Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF
-
Gardner, S.M.; Takamiya, K.; Xia, J.; Suh, J.G.; Johnson, R.; Yu, S.; Huganir, R.L. Calcium-permeable AMPA receptor plasticity is mediated by subunit-specific interactions with PICK1 and NSF. Neuron, 2005, 45, 903-915.
-
(2005)
Neuron
, vol.45
, pp. 903-915
-
-
Gardner, S.M.1
Takamiya, K.2
Xia, J.3
Suh, J.G.4
Johnson, R.5
Yu, S.6
Huganir, R.L.7
-
235
-
-
42649135851
-
PICK1: A multi-talented modulator of AMPA receptor trafficking
-
Hanley, J.G. PICK1: a multi-talented modulator of AMPA receptor trafficking. Pharmacol. Ther., 2008, 118, 152-160.
-
(2008)
Pharmacol. Ther.
, vol.118
, pp. 152-160
-
-
Hanley, J.G.1
-
236
-
-
14944366485
-
Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors
-
Priel, A.; Kolleker, A.; Ayalon, G.; Gillor, M.; Osten, P.; Stern-Bach, Y. Stargazin reduces desensitization and slows deactivation of the AMPA-type glutamate receptors. J. Neurosci., 2005, 25, 2682-2686.
-
(2005)
J. Neurosci.
, vol.25
, pp. 2682-2686
-
-
Priel, A.1
Kolleker, A.2
Ayalon, G.3
Gillor, M.4
Osten, P.5
Stern-Bach, Y.6
-
237
-
-
58149475675
-
Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins
-
Sager, C.; Tapken, D.; Kott, S.; Hollmann, M. Functional modulation of AMPA receptors by transmembrane AMPA receptor regulatory proteins. Neuroscience, 2009, 158, 45-54.
-
(2009)
Neuroscience
, vol.158
, pp. 45-54
-
-
Sager, C.1
Tapken, D.2
Kott, S.3
Hollmann, M.4
-
238
-
-
23744486903
-
Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms
-
Turetsky, D.; Garringer, E.; Patneau, D.K. Stargazin modulates native AMPA receptor functional properties by two distinct mechanisms. J. Neurosci., 2005, 25, 7438-7448.
-
(2005)
J. Neurosci.
, vol.25
, pp. 7438-7448
-
-
Turetsky, D.1
Garringer, E.2
Patneau, D.K.3
-
239
-
-
42749086916
-
Stargazin modulates AMPA receptor antagonism
-
Cokił, B.; Stein, V. Stargazin modulates AMPA receptor antagonism. Neuropharmacology, 2008, 54, 1062-1070.
-
(2008)
Neuropharmacology
, vol.54
, pp. 1062-1070
-
-
Cokił, B.1
Stein, V.2
-
240
-
-
1242293628
-
The outer pore of the glutamate receptor channel has 2-fold rotational symmetry
-
Sobolevsky, A.I.; Yelshansky, M.V.; Wollmuth, L.P. The outer pore of the glutamate receptor channel has 2-fold rotational symmetry. Neuron 2004, 41, 367-378.
-
(2004)
Neuron
, vol.41
, pp. 367-378
-
-
Sobolevsky, A.I.1
Yelshansky, M.V.2
Wollmuth, L.P.3
-
241
-
-
66149112273
-
-
San Carlos, CA, USA
-
DeLano, W. L. The PyMOL Molecular Graphics System, DeLano Scientific, San Carlos, CA, USA, 2002.
-
(2002)
The PyMOL Molecular Graphics System, DeLano Scientific
-
-
DeLano, W.L.1
-
242
-
-
0036191007
-
Models@home - distributed computing in bioinformatics using a screensaver based approach
-
Krieger, E.; Vriend, G. Models@Home - Distributed Computing in Bioinformatics Using a Screensaver Based Approach. Bioinformatics, 2002, 18, 315-318.
-
(2002)
Bioinformatics
, vol.18
, pp. 315-318
-
-
Krieger, E.1
Vriend, G.2
-
243
-
-
4043162793
-
VEGA - an Open Platform to Develop Chemo-Bio-Informatics Applications, Using Plug-In Architecture and Script Programming
-
Pedretti, A.; Villa, L.; Vistoli, G. J. VEGA - an Open Platform to Develop Chemo-Bio-Informatics Applications, Using Plug-In Architecture and Script Programming. J. Comput.-Aided Mol. Des., 2004, 18, 167-173.
-
(2004)
J. Comput.-Aided Mol. Des.
, vol.18
, pp. 167-173
-
-
Pedretti, A.1
Villa, L.2
Vistoli, G.J.3
-
244
-
-
4444221565
-
UCSF Chimera - a visualization system for exploratory research and analysis
-
Pettersen, E.F.; Goddard, T.D.; Huang, C.C.; Couch, G.S.; Greenblatt, D.M.; Meng, E.C.; Ferrin, T.E. UCSF Chimera - a visualization system for exploratory research and analysis. J. Comput. Chem., 2004, 25, 1605-1612.
-
(2004)
J. Comput. Chem.
, vol.25
, pp. 1605-1612
-
-
Pettersen, E.F.1
Goddard, T.D.2
Huang, C.C.3
Couch, G.S.4
Greenblatt, D.M.5
Meng, E.C.6
Ferrin, T.E.7
-
245
-
-
0031473847
-
SWISS-MODEL and the Swiss-Pdb viewer: An environment for comparative protein modeling
-
Guex, N.; Peitsch, M.C. SWISS-MODEL and the Swiss-Pdb viewer: An environment for comparative protein modeling. Electrophoresis, 1997, 18, 2714-2723.
-
(1997)
Electrophoresis
, vol.18
, pp. 2714-2723
-
-
Guex, N.1
Peitsch, M.C.2
|