Dimensions and ion selectivity of recombinant AMPA and kainate receptor channels and their dependence on Q/R site residues

Journal of Physiology

Volumn 496, Issue 1, 1996, Pages 165-173

  Burnashev, Nail ^a   Villarroel, Alfredo ^a,b   Sakmann, Bert ^a  

^a MAX PLANCK INSTITUTE FOR MEDICAL RESEARCH   (Germany)

^b DALHOUSIE UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AMPA RECEPTOR; ANION; CALCIUM ION; CATION; CESIUM CHLORIDE; KAINIC ACID RECEPTOR; RECEPTOR SUBUNIT; RECOMBINANT PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CHLORIDE CONDUCTANCE; CONTROLLED STUDY; HUMAN; HUMAN CELL; ION CONDUCTANCE; MEMBRANE CHANNEL; MEMBRANE PERMEABILITY; MOLECULAR WEIGHT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

EID: 2542550010     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.1996.sp021674     Document Type: Article

References (21)

1. BRUSA, R., ZIMMERMAN, F., KOH, D.-S., FELDMEYER, D., GASS, P., SEEBURG, P. H. & SPRENGEL, R. (1995). Early-onset epilepsy and postnatal lethality associated with an editing-deficient GluR-B allele in mice. Science 270, 1677-1680.
2. BURNASHEV, N. & SAKMANN, B. (1996). RNA editing makes homomeric GluR6 subunit channels permeable to anions without altering the apparent size of the pore. Biophysical Journal 70, A78.
3. BURNASHEV, N., ZHOU, Z., NEHER, K. & SAKMANN, B. (1995). Fractional calcium currents through recombinant GIuR channels of the NMDA, AMPA, and kainate receptor subtypes. Journal of Physiology 485, 403-418.
4. CULLY, D. F., VASSILATIS, D. K., LIU, K. K., PARESS, P. S., VAN DER PLOEG, L. H. T., SCHAEFFER, J. M. & ARENA, J. P. (1994). Cloning of an avermectin-sensitive glutamate-gated chloride channel from Caenorhabditis elegans. Nature 371, 707-711.
5. DINGLEDINE, R., BOLAND, L. M., CHAMBERLIN, N. L., KAWASAKI, K., KLECKNKR, N. W., TRAYNKLIS, S. F. & VERDOORN, T. A. (1988). Amino acid receptors and uptake systems in the mammalian central nervous system. Critical Reviews in Neurobiology 4, 1-96.
6. DWYER, T. M., ADAMS, D. J. & HILLE, B. (1980). The permeability of the end plate channel to organic cations in frog muscle. Journal of General Physiology 75, 469-492.
7. 2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR6. Proceedings of the National Academy of Sciences of the USA 90, 755-759.
8. FRANOIOLINI, F. & NONNER, W. (1987). Anion and cation permeability of a chloride channel in rat hippocampal neurons. Journal of General Physiology 90, 453-478.
9. HILLE, B. (1992). Ionic Channels of Excitable Membranes. Sinauer Associates Inc., Sunderland, MA, USA.
10. HOLLMANN, M. & HEINEMANN, S. (1994). Cloned glutamate receptors. Annual Reviews of Neuroscience 17, 31-108.
11. HORN, R. (1987). Statistical methods for model discrimination. Applications to gating kinetics and permeation of the acetylcholine receptor channel, Biophysical Journal 51, 255-263.
12. IINO, M., OZAWA, S. & TZUZUKI, K. (1990). Permeation of calcium through excitatory amino acid receptor channels in cultured rat hippocampal neurones. Journal of Physiology 424, 151-165.
13. 2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: Diversity by RNA editing. Neuron 10, 491-500.
14. LEWIS, C. A. (1979). Ion-concentration dependence of the reversal potential and the single channel conductance of ion channels at the frog neuromuscular junction. Journal of Physiology 286, 417-445.
15. A receptor shows a ligand-gated receptor super-family. Nature 328, 221-227.
16. SOMMER, B., KÖHLER, M., SPRENGEL, R. & SEEBURG, P. H. (1991). RNA editing in brain controls a determinant of ion flow in glutamate-gated channels. Cell 67, 11-19.
17. SWANSON, G. T., FELDMEYER, D., KANEDA, M. & CULL-CANDY, S. G. (1996). Effect of RXA editing and subunit co-assembly on single-channel properties of recombinant kainate receptors. Journal of Physiology 492, 129-142.
18. SYGANOW, A. & VON KITZING, K. (1995). Integral weak diffusion and diffusion approximations applied to ion transport through biological ion channels. Journal of Physical Chemistry 99, 12030-12040.
19. VILLARROEL, A., BURNASHEV, N. & SAKMANN, B. (1995). Dimensions of the narrow portion of a recombinant NMDA receptor channel. Biophysical Journal 68, 866-875.
20. VYKLICKY, L. J., KRUSEK, J. & EDWARDS, O. (1988). Differences in the pore sizes of the N-methyl-D-aspartate and kainate cation channels. Neuroscience Letters 89, 313-318.
21. WOLLMUTH, L. P., KUNER, T., SEEBURG, P. H. & SAKMANN, B. (1996). Differential contribution of the NR1- and NR2A-subunits to the selectivity filter of recombinant NMDA receptor channels. Journal of Physiology 491, 779-797.