Crystal structures of the kainate receptor GluR5 ligand binding core dimer with novel GluR5-selective antagonists

Journal of Neuroscience

Volumn 26, Issue 11, 2006, Pages 2852-2861

  Mayer, Mark L ^a,c   Ghosal, Alokesh ^a   Dolman, Nigel P ^b   Jane, David E ^b  

^a EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Antagonist; Crystallography; Gating; Glutamate receptor; Kainate; Structure

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMPA RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR 2; GLUTAMATE RECEPTOR 5; GLUTAMATE RECEPTOR 6; GLUTAMATE RECEPTOR ANTAGONIST; ION CHANNEL; KAINIC ACID RECEPTOR; KAINIC ACID RECEPTOR AGONIST; KAINIC ACID RECEPTOR ANTAGONIST; UBP 302; UBP 310; UNCLASSIFIED DRUG;

ARTICLE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ISOTOPE LABELING; LIGAND BINDING; MEMBRANE CURRENT; PRIORITY JOURNAL;

6-CYANO-7-NITROQUINOXALINE-2,3-DIONE; ALANINE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; HYDROGEN BONDING; MODELS, MOLECULAR; OOCYTES; PATCH-CLAMP TECHNIQUES; PROTEIN BINDING; PROTEIN CONFORMATION; QUINOXALINES; RATS; RECEPTORS, AMPA; RECEPTORS, KAINIC ACID; RECOMBINANT FUSION PROTEINS; THYMINE; XENOPUS LAEVIS;

EID: 33644999815     PISSN: 02706474     EISSN: 02706474     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.0123-06.2005     Document Type: Article

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