Probing the function, conformational plasticity, and dimer - dimer contacts of the GluR2 ligand-binding core: Studies of 5-substituted willardiines and GluR2 S1S2 in the crystal

Biochemistry

Volumn 42, Issue 18, 2003, Pages 5201-5213

  Jin, Rongsheng ^a   Gouaux, Eric ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CONFORMATIONS; CRYSTAL LATTICES; PLASTICITY;

CONFORMATIONAL PLASTICITY;

DIMERS;

ALPHA AMINO ACID; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; DIMER; IONOTROPIC RECEPTOR; TETRAMER; WILLARDIINE;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DESENSITIZATION; DRUG EFFICACY; DRUG POTENCY; LIGAND BINDING; MOLECULAR INTERACTION; PLASTICITY; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

ALANINE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; EXCITATORY AMINO ACID AGONISTS; KAINIC ACID; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; PROTEIN CONFORMATION; PYRIMIDINONES; QUINOXALINES; RATS; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; URACIL;

EID: 0038219813     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020632t     Document Type: Article

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