Structural basis for AMPA receptor activation and ligand selectivity: Crystal structures of five agonist complexes with the GluR2 ligand-binding core

Journal of Molecular Biology

Volumn 322, Issue 1, 2002, Pages 93-109

  Hogner, A ^a   Kastrup, J S ^a   Jin, R ^b   Liljefors, T ^a   Mayer, M L ^c   Egebjerg, J ^d   Larsen, I K ^a   Gouaux, E ^b  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b Och Spine at New York Presbyterian Hospitals   (United States)

^c EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^d AARHUS UNIVERSITY   (Denmark)

Author keywords

Electrophysiology; Glutamate receptors; Ligand binding; Selectivity; X ray structures

Indexed keywords

2 AMINO 3 (3 CARBOXY 5 METHYLISOXAZOL 4 YL)PROPIONIC ACID; 2 AMINO 3 (4 BROMO 3 HYDROXYISOXAZOL 5 YL)PROPIONIC ACID; 2 AMINO 3 [3 HYDROXY 5 (2 METHYL 2H TETRAZOL 5 YL)ISOXAZOL 4 YL]PROPIONIC AID; AMPA RECEPTOR; GLUTAMATE RECEPTOR; ISOXAZOLE; LIGAND; PROPIONIC ACID DERIVATIVE; RECEPTOR SUBUNIT; UNCLASSIFIED DRUG;

ARTICLE; BINDING ASSAY; COMPLEX FORMATION; CORRELATION ANALYSIS; CRYSTAL STRUCTURE; ELECTROPHYSIOLOGY; LIGAND BINDING; MOLECULAR BIOLOGY; MUTANT; OOCYTE; PRIORITY JOURNAL; RECEPTOR BINDING; STRUCTURE ANALYSIS; X RAY ANALYSIS;

MAMMALIA;

EID: 0036968894     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(02)00650-2     Document Type: Article

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